BGC0001755 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001755 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	103,914	reedsmycin A/reedsmycin B/reedsmycin C/reedsmycin D/reedsmycin E	PKS	100%

BGC0001755 - Region 1 - T1PKS

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Location: 1 - 103,914 nt. (total: 103,914 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 103,915
Label		BGC0001755

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755	1.00	Polyketide	reedsmycins	Streptomyces sp.
BGC0000122	0.33	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.30	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001163	0.29	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001275	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001051	0.29	NRP, Polyketide	thuggacin A	Sorangium cellulosum
BGC0001164	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000046	0.27	Polyketide	depudecin	Alternaria brassicicola

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755	1.00	Polyketide	reedsmycins	Streptomyces sp.
BGC0000122	0.66	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001163	0.63	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001275	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.62	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001051	0.62	NRP, Polyketide	thuggacin A	Sorangium cellulosum
BGC0001164	0.62	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000046	0.61	Polyketide	depudecin	Alternaria brassicicola

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 103914:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-redmal - Me-ccmal) + (ccmal - ohmal - ohmal - ohmal) + (ohmal - ohmal - ohmal - ohmal - ohmal - ccmal) + (ccmal - ccmal - ccmal - ccmal)
Non-colinear ordering:: rdmG + rdmH + rdmI + rdmJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

rdmG

PKS_AT (551..848): pk

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 191.3
Methylmalonyl-CoA: 181.9
Methoxymalonyl-CoA: 162.4
trans-1,2-CPDA: 135.4
2-Methylbutyryl-CoA: 123.1
Propionyl-CoA: 103.2
CHC-CoA: 97.5
Malonyl-CoA: 93.9
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 57.9
Acetyl-CoA: 47.8
fatty_acid: 39.8
inactive: 25.3
3-Methylbutyryl-CoA: 20.7

PKS_AT (1570..1867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.4
Ethylmalonyl-CoA: 163.5
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 129.6
CHC-CoA: 119.5
Propionyl-CoA: 108.0
trans-1,2-CPDA: 105.4
Malonyl-CoA: 85.6
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 49.9
Acetyl-CoA: 40.9
3-Methylbutyryl-CoA: 39.8
fatty_acid: 37.6
inactive: 21.5

PKS_AT (3686..3983): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.5
Ethylmalonyl-CoA: 186.4
Methoxymalonyl-CoA: 163.4
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 131.6
Propionyl-CoA: 117.8
Malonyl-CoA: 103.3
CHC-CoA: 97.2
Isobutyryl-CoA: 66.2
Benzoyl-CoA: 62.7
Acetyl-CoA: 60.0
fatty_acid: 46.9
3-Methylbutyryl-CoA: 42.5
inactive: 29.8

rdmH

PKS_AT (572..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.7
inactive: 86.7
Methoxymalonyl-CoA: 51.2
Methylmalonyl-CoA: 45.6
Propionyl-CoA: 31.3
Acetyl-CoA: 24.2
Isobutyryl-CoA: 19.8
Benzoyl-CoA: 14.3
fatty_acid: 11.2
CHC-CoA: 7.7
Ethylmalonyl-CoA: 2.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2287..2574): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.6
inactive: 91.5
Methoxymalonyl-CoA: 55.0
Methylmalonyl-CoA: 51.2
Acetyl-CoA: 27.9
Isobutyryl-CoA: 26.5
Propionyl-CoA: 24.7
fatty_acid: 15.6
Ethylmalonyl-CoA: 14.4
Benzoyl-CoA: 12.1
CHC-CoA: 7.1
2-Methylbutyryl-CoA: 4.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3831..4118): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.4
inactive: 102.7
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 47.1
Propionyl-CoA: 25.0
Isobutyryl-CoA: 24.4
Acetyl-CoA: 19.7
fatty_acid: 13.1
Benzoyl-CoA: 11.7
CHC-CoA: 9.0
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5370..5657): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 94.9
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 44.9
Isobutyryl-CoA: 28.7
Acetyl-CoA: 24.7
Propionyl-CoA: 21.5
fatty_acid: 11.1
Ethylmalonyl-CoA: 9.4
Benzoyl-CoA: 8.2
CHC-CoA: 5.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

rdmI

PKS_AT (569..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 95.4
Methoxymalonyl-CoA: 53.5
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 37.3
Acetyl-CoA: 27.9
Propionyl-CoA: 23.7
fatty_acid: 12.3
Benzoyl-CoA: 11.1
CHC-CoA: 8.0
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2093..2373): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.5
inactive: 94.7
Methoxymalonyl-CoA: 54.4
Methylmalonyl-CoA: 48.1
Isobutyryl-CoA: 29.4
Propionyl-CoA: 27.6
Acetyl-CoA: 22.2
Benzoyl-CoA: 12.3
fatty_acid: 11.5
2-Methylbutyryl-CoA: 8.9
Ethylmalonyl-CoA: 5.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3633..3920): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.6
inactive: 93.0
Methoxymalonyl-CoA: 52.4
Methylmalonyl-CoA: 48.2
Isobutyryl-CoA: 33.0
Propionyl-CoA: 26.1
Acetyl-CoA: 24.4
fatty_acid: 12.9
Benzoyl-CoA: 10.9
Ethylmalonyl-CoA: 9.9
2-Methylbutyryl-CoA: 7.6
CHC-CoA: 5.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5167..5454): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 100.6
Methoxymalonyl-CoA: 57.2
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 28.8
Acetyl-CoA: 27.0
Propionyl-CoA: 25.8
2-Methylbutyryl-CoA: 14.0
Benzoyl-CoA: 12.4
Ethylmalonyl-CoA: 8.9
fatty_acid: 8.3
CHC-CoA: 7.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6701..6988): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 102.5
Methoxymalonyl-CoA: 47.6
Methylmalonyl-CoA: 41.2
Isobutyryl-CoA: 34.3
Propionyl-CoA: 19.2
Acetyl-CoA: 19.0
fatty_acid: 12.9
Benzoyl-CoA: 11.3
2-Methylbutyryl-CoA: 10.2
CHC-CoA: 8.0
Ethylmalonyl-CoA: 5.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (8228..8515): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.3
inactive: 106.6
Methoxymalonyl-CoA: 50.1
Methylmalonyl-CoA: 42.9
Isobutyryl-CoA: 32.9
Propionyl-CoA: 19.8
Acetyl-CoA: 17.3
fatty_acid: 15.0
Benzoyl-CoA: 12.9
CHC-CoA: 7.2
2-Methylbutyryl-CoA: 5.3
Ethylmalonyl-CoA: 4.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmJ

PKS_AT (588..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.4
inactive: 90.6
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 50.1
Isobutyryl-CoA: 34.4
Propionyl-CoA: 30.8
Acetyl-CoA: 28.2
fatty_acid: 14.0
Ethylmalonyl-CoA: 13.5
Benzoyl-CoA: 11.0
CHC-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2308..2588): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.2
inactive: 93.2
Methoxymalonyl-CoA: 52.8
Methylmalonyl-CoA: 45.6
Isobutyryl-CoA: 32.3
Propionyl-CoA: 26.5
Acetyl-CoA: 25.8
Benzoyl-CoA: 11.8
fatty_acid: 11.7
Ethylmalonyl-CoA: 5.8
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (4030..4311): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.1
inactive: 99.1
Methoxymalonyl-CoA: 51.7
Methylmalonyl-CoA: 43.6
Isobutyryl-CoA: 30.6
Acetyl-CoA: 25.7
Propionyl-CoA: 24.8
Benzoyl-CoA: 11.4
fatty_acid: 8.9
2-Methylbutyryl-CoA: 4.9
CHC-CoA: 4.0
Ethylmalonyl-CoA: 3.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5746..6030): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.0
inactive: 100.4
Methoxymalonyl-CoA: 56.4
Methylmalonyl-CoA: 45.5
Isobutyryl-CoA: 26.7
Propionyl-CoA: 25.1
Acetyl-CoA: 20.2
Benzoyl-CoA: 12.3
fatty_acid: 11.7
2-Methylbutyryl-CoA: 10.4
CHC-CoA: 8.4
Ethylmalonyl-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmN

AMP-binding (26..468): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMGTLGVLAK
Nearest Stachelhaus code(s):: Pca DMGVLGCLMK (79% 8Å match)
Stachelhaus code match:: 70% (weak)