BGC0001755 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001755 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	103,914	High	reedsmycin A/reedsmycin B/reedsmycin C/reedsmycin D/reedsmycin E	PKS

BGC0001755 - Region 1 - T1PKS

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Location: 1 - 103,914 nt. (total: 103,914 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 103,915
Label		BGC0001755

Tailoring functions

Ligases: ligase synthase

rdmG: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rdmH: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rdmI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rdmJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rdmN: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755.5	1.00	PKS	reedsmycin A, reedsmycin B, reedsmycin C, reedsmycin D, reedsmycin E	Streptomyces sp.
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001051.5	0.63	NRPS, PKS	thuggacin A	Sorangium cellulosum
BGC0001012.3	0.60	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000094.5	0.58	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0000067.5	0.58	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001755.5	1.00	PKS	reedsmycin A, reedsmycin B, reedsmycin C, reedsmycin D, reedsmycin E	Streptomyces sp.
BGC0001276.3	0.75	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001051.5	0.63	NRPS, PKS	thuggacin A	Sorangium cellulosum
BGC0001012.3	0.60	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000094.5	0.58	PKS, saccharide	methymycin	Streptomyces venezuelae
BGC0000067.5	0.58	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 103914:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-redmal - Me-ccmal) + (ccmal - ohmal - ohmal - ohmal) + (ohmal - ohmal - ohmal - ohmal - ohmal - ccmal) + (ccmal - ccmal - ccmal - ccmal)
Non-colinear ordering:: rdmG + rdmH + rdmI + rdmJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

rdmG: pk - mmal - mmal

PKS_AT (551..848): pk

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 191.3
Methylmalonyl-CoA: 181.9
Methoxymalonyl-CoA: 162.4
trans-1,2-CPDA: 135.4
2-Methylbutyryl-CoA: 123.1
Propionyl-CoA: 103.2
CHC-CoA: 97.5
Malonyl-CoA: 93.9
Isobutyryl-CoA: 76.7
Benzoyl-CoA: 57.9
Acetyl-CoA: 47.8
fatty_acid: 39.8
inactive: 25.3
3-Methylbutyryl-CoA: 20.7

PKS_AT (1570..1867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.4
Ethylmalonyl-CoA: 163.5
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 129.6
CHC-CoA: 119.5
Propionyl-CoA: 108.0
trans-1,2-CPDA: 105.4
Malonyl-CoA: 85.6
Isobutyryl-CoA: 63.7
Benzoyl-CoA: 49.9
Acetyl-CoA: 40.9
3-Methylbutyryl-CoA: 39.8
fatty_acid: 37.6
inactive: 21.5

PKS_AT (3686..3983): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.5
Ethylmalonyl-CoA: 186.4
Methoxymalonyl-CoA: 163.4
2-Methylbutyryl-CoA: 144.3
trans-1,2-CPDA: 131.6
Propionyl-CoA: 117.8
Malonyl-CoA: 103.3
CHC-CoA: 97.2
Isobutyryl-CoA: 66.2
Benzoyl-CoA: 62.7
Acetyl-CoA: 60.0
fatty_acid: 46.9
3-Methylbutyryl-CoA: 42.5
inactive: 29.8

rdmH: mal - mal - mal - mal

PKS_AT (572..853): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.7
inactive: 86.7
Methoxymalonyl-CoA: 51.2
Methylmalonyl-CoA: 45.6
Propionyl-CoA: 31.3
Acetyl-CoA: 24.2
Isobutyryl-CoA: 19.8
Benzoyl-CoA: 14.3
fatty_acid: 11.2
CHC-CoA: 7.7
Ethylmalonyl-CoA: 2.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2287..2574): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.6
inactive: 91.5
Methoxymalonyl-CoA: 55.0
Methylmalonyl-CoA: 51.2
Acetyl-CoA: 27.9
Isobutyryl-CoA: 26.5
Propionyl-CoA: 24.7
fatty_acid: 15.6
Ethylmalonyl-CoA: 14.4
Benzoyl-CoA: 12.1
CHC-CoA: 7.1
2-Methylbutyryl-CoA: 4.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3831..4118): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.4
inactive: 102.7
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 47.1
Propionyl-CoA: 25.0
Isobutyryl-CoA: 24.4
Acetyl-CoA: 19.7
fatty_acid: 13.1
Benzoyl-CoA: 11.7
CHC-CoA: 9.0
trans-1,2-CPDA: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (5370..5657): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.5
inactive: 94.9
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 44.9
Isobutyryl-CoA: 28.7
Acetyl-CoA: 24.7
Propionyl-CoA: 21.5
fatty_acid: 11.1
Ethylmalonyl-CoA: 9.4
Benzoyl-CoA: 8.2
CHC-CoA: 5.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

rdmI: mal - mal - mal - mal - mal - mal

PKS_AT (569..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 95.4
Methoxymalonyl-CoA: 53.5
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 37.3
Acetyl-CoA: 27.9
Propionyl-CoA: 23.7
fatty_acid: 12.3
Benzoyl-CoA: 11.1
CHC-CoA: 8.0
Ethylmalonyl-CoA: 7.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2093..2373): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 213.5
inactive: 94.7
Methoxymalonyl-CoA: 54.4
Methylmalonyl-CoA: 48.1
Isobutyryl-CoA: 29.4
Propionyl-CoA: 27.6
Acetyl-CoA: 22.2
Benzoyl-CoA: 12.3
fatty_acid: 11.5
2-Methylbutyryl-CoA: 8.9
Ethylmalonyl-CoA: 5.1
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3633..3920): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.6
inactive: 93.0
Methoxymalonyl-CoA: 52.4
Methylmalonyl-CoA: 48.2
Isobutyryl-CoA: 33.0
Propionyl-CoA: 26.1
Acetyl-CoA: 24.4
fatty_acid: 12.9
Benzoyl-CoA: 10.9
Ethylmalonyl-CoA: 9.9
2-Methylbutyryl-CoA: 7.6
CHC-CoA: 5.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5167..5454): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.7
inactive: 100.6
Methoxymalonyl-CoA: 57.2
Methylmalonyl-CoA: 49.8
Isobutyryl-CoA: 28.8
Acetyl-CoA: 27.0
Propionyl-CoA: 25.8
2-Methylbutyryl-CoA: 14.0
Benzoyl-CoA: 12.4
Ethylmalonyl-CoA: 8.9
fatty_acid: 8.3
CHC-CoA: 7.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6701..6988): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 102.5
Methoxymalonyl-CoA: 47.6
Methylmalonyl-CoA: 41.2
Isobutyryl-CoA: 34.3
Propionyl-CoA: 19.2
Acetyl-CoA: 19.0
fatty_acid: 12.9
Benzoyl-CoA: 11.3
2-Methylbutyryl-CoA: 10.2
CHC-CoA: 8.0
Ethylmalonyl-CoA: 5.5
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (8228..8515): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.3
inactive: 106.6
Methoxymalonyl-CoA: 50.1
Methylmalonyl-CoA: 42.9
Isobutyryl-CoA: 32.9
Propionyl-CoA: 19.8
Acetyl-CoA: 17.3
fatty_acid: 15.0
Benzoyl-CoA: 12.9
CHC-CoA: 7.2
2-Methylbutyryl-CoA: 5.3
Ethylmalonyl-CoA: 4.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmJ: mal - mal - mal - mal

PKS_AT (588..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.4
inactive: 90.6
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 50.1
Isobutyryl-CoA: 34.4
Propionyl-CoA: 30.8
Acetyl-CoA: 28.2
fatty_acid: 14.0
Ethylmalonyl-CoA: 13.5
Benzoyl-CoA: 11.0
CHC-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2308..2588): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.2
inactive: 93.2
Methoxymalonyl-CoA: 52.8
Methylmalonyl-CoA: 45.6
Isobutyryl-CoA: 32.3
Propionyl-CoA: 26.5
Acetyl-CoA: 25.8
Benzoyl-CoA: 11.8
fatty_acid: 11.7
Ethylmalonyl-CoA: 5.8
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (4030..4311): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.1
inactive: 99.1
Methoxymalonyl-CoA: 51.7
Methylmalonyl-CoA: 43.6
Isobutyryl-CoA: 30.6
Acetyl-CoA: 25.7
Propionyl-CoA: 24.8
Benzoyl-CoA: 11.4
fatty_acid: 8.9
2-Methylbutyryl-CoA: 4.9
CHC-CoA: 4.0
Ethylmalonyl-CoA: 3.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (5746..6030): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.0
inactive: 100.4
Methoxymalonyl-CoA: 56.4
Methylmalonyl-CoA: 45.5
Isobutyryl-CoA: 26.7
Propionyl-CoA: 25.1
Acetyl-CoA: 20.2
Benzoyl-CoA: 12.3
fatty_acid: 11.7
2-Methylbutyryl-CoA: 10.4
CHC-CoA: 8.4
Ethylmalonyl-CoA: 5.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

rdmN: X

AMP-binding (26..468): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMGTLGVLAK
Nearest Stachelhaus code(s):: Pca DMGVLGCLMK (79% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor