BGC0001759 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001759 (Amycolatopsis sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	113,830	rifamorpholine A/rifamorpholine B/rifamorpholine C/rifamorpholine D/rifamorpholine E	PKS	100%

BGC0001759 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 113,830 nt. (total: 113,830 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 113,831
Label		BGC0001759

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001759	1.25	Polyketide	rifamorpholine A, rifamorpholine B, rifamorpholine C, rifamorpholine D, rifamorpholine E	Amycolatopsis sp.
BGC0000136	0.72	Polyketide	rifamycin	Amycolatopsis mediterranei S699
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001164	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002631	0.63	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001068	0.62	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000160	0.62	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0001276	0.62	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000041	0.61	Polyketide	oronofacic acid	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001759	1.00	Polyketide	rifamorpholine A, rifamorpholine B, rifamorpholine C, rifamorpholine D, rifamorpholine E	Amycolatopsis sp.
BGC0000136	0.80	Polyketide	rifamycin	Amycolatopsis mediterranei S699
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0000844	0.68	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000122	0.68	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001273	0.66	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000160	0.66	Polyketide	terreic acid	Aspergillus terreus NIH2624

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 25167 - 113830:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (ccmal) + (Me-ccmal) + (pk) + (Me-ohmal) + (Me-ccmal - Me-ccmal - Me-ccmal) + (Me-ccmal)
Non-colinear ordering:: AWH12666.1 + AWH12665.1 + AWH12664.1 + AWH12671.1 + AWH12670.1 + AWH12669.1 + AWH12668.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AWH12664.1

PKS_AT (1221..1513): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.2
Ethylmalonyl-CoA: 190.2
Methoxymalonyl-CoA: 167.4
2-Methylbutyryl-CoA: 113.7
trans-1,2-CPDA: 107.3
Malonyl-CoA: 101.1
Propionyl-CoA: 98.2
CHC-CoA: 86.9
Isobutyryl-CoA: 77.1
Benzoyl-CoA: 58.0
Acetyl-CoA: 43.1
inactive: 25.8
fatty_acid: 23.2
3-Methylbutyryl-CoA: 23.1

AWH12665.1

PKS_AT (554..837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.4
inactive: 119.0
Methoxymalonyl-CoA: 71.9
Methylmalonyl-CoA: 55.4
Propionyl-CoA: 33.6
Isobutyryl-CoA: 24.8
Acetyl-CoA: 21.4
fatty_acid: 20.6
Benzoyl-CoA: 20.1
2-Methylbutyryl-CoA: 17.5
trans-1,2-CPDA: 16.4
CHC-CoA: 15.2
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -2.8

AWH12666.1

PKS_AT (41..332): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.5
Ethylmalonyl-CoA: 201.7
Methoxymalonyl-CoA: 163.3
2-Methylbutyryl-CoA: 120.1
trans-1,2-CPDA: 111.2
Propionyl-CoA: 102.0
CHC-CoA: 94.7
Malonyl-CoA: 87.2
Isobutyryl-CoA: 76.6
Benzoyl-CoA: 56.7
Acetyl-CoA: 42.0
fatty_acid: 37.6
inactive: 17.1
3-Methylbutyryl-CoA: 14.5

AWH12668.1

PKS_AT (551..833): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 209.1
Methoxymalonyl-CoA: 167.7
2-Methylbutyryl-CoA: 112.5
trans-1,2-CPDA: 110.8
Propionyl-CoA: 94.8
Malonyl-CoA: 86.9
CHC-CoA: 84.8
Isobutyryl-CoA: 80.7
Benzoyl-CoA: 58.5
Acetyl-CoA: 50.2
fatty_acid: 37.2
inactive: 28.2
3-Methylbutyryl-CoA: 15.0

AWH12669.1

PKS_AT (562..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.4
Ethylmalonyl-CoA: 203.5
Methoxymalonyl-CoA: 175.4
trans-1,2-CPDA: 123.8
2-Methylbutyryl-CoA: 118.4
CHC-CoA: 104.5
Propionyl-CoA: 100.3
Malonyl-CoA: 99.0
Isobutyryl-CoA: 93.3
Benzoyl-CoA: 63.5
Acetyl-CoA: 36.9
fatty_acid: 26.1
3-Methylbutyryl-CoA: 21.8
inactive: 17.6

PKS_AT (2237..2524): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 208.3
Methoxymalonyl-CoA: 172.5
2-Methylbutyryl-CoA: 126.2
trans-1,2-CPDA: 118.3
Propionyl-CoA: 102.3
Malonyl-CoA: 90.4
Isobutyryl-CoA: 78.6
CHC-CoA: 78.1
Benzoyl-CoA: 54.4
Acetyl-CoA: 45.2
fatty_acid: 30.4
inactive: 24.3
3-Methylbutyryl-CoA: 23.4

PKS_AT (3848..4141): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.0
Ethylmalonyl-CoA: 196.5
Methoxymalonyl-CoA: 159.4
2-Methylbutyryl-CoA: 119.3
trans-1,2-CPDA: 103.1
Propionyl-CoA: 93.5
CHC-CoA: 84.3
Malonyl-CoA: 76.8
Isobutyryl-CoA: 74.9
Benzoyl-CoA: 49.7
Acetyl-CoA: 42.9
fatty_acid: 28.5
inactive: 18.9
3-Methylbutyryl-CoA: 9.3

AWH12670.1

PKS_AT (533..824): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.3
Ethylmalonyl-CoA: 196.1
Methoxymalonyl-CoA: 163.5
2-Methylbutyryl-CoA: 121.4
trans-1,2-CPDA: 108.6
Malonyl-CoA: 106.9
Propionyl-CoA: 99.1
CHC-CoA: 90.4
Isobutyryl-CoA: 77.8
Benzoyl-CoA: 51.6
Acetyl-CoA: 38.0
fatty_acid: 20.4
inactive: 20.1
3-Methylbutyryl-CoA: 5.5

AWH12671.1

CAL_domain (33..436): pk

minowa: AHBA

Prediction, score:

AHBA: 478.6
shikimic_acid: 230.4
Acetyl-CoA: 23.3
NH2: 7.4
fatty_acid: 0.0

PKS_AT (1145..1427): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.2
Methylmalonyl-CoA: 209.8
Methoxymalonyl-CoA: 167.1
2-Methylbutyryl-CoA: 124.3
trans-1,2-CPDA: 113.7
Propionyl-CoA: 102.9
Malonyl-CoA: 98.4
CHC-CoA: 80.6
Isobutyryl-CoA: 76.0
Benzoyl-CoA: 56.7
Acetyl-CoA: 47.9
inactive: 34.9
fatty_acid: 31.0
3-Methylbutyryl-CoA: 24.0

PKS_AT (2716..3004): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 104.6
Methoxymalonyl-CoA: 75.0
Methylmalonyl-CoA: 61.1
Propionyl-CoA: 42.5
Isobutyryl-CoA: 35.4
Ethylmalonyl-CoA: 22.7
2-Methylbutyryl-CoA: 22.4
Benzoyl-CoA: 20.3
CHC-CoA: 18.6
Acetyl-CoA: 17.6
trans-1,2-CPDA: 12.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0