BGC0001760: rimosamide biosynthetic gene cluster from Streptomyces rimosus subsp. rimosus ATCC 10970
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Location: 30,040 - 59,133 nt. (total: 29,094 nt).
This entry is originally from NCBI GenBank NZ_ANSJ01000026.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001760
Short description rimosamide biosynthetic gene cluster from Streptomyces rimosus subsp. rimosus ATCC 10970
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_ANSJ01000026.1
30040 - 59133
via
Compounds
  • rimosamide
Species Streptomyces rimosus subsp. rimosus ATCC 10970 [taxonomy]
References
Chemical products information
rimosamide Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SRIM_RS28595
  • WP_050498799.1
 30040 - 32238 (-) FUSC family protein
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    • SRIM_RS28590
    • WP_004571773.1
    		 32505 - 33305 (+) hypothetical protein
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      • SRIM_RS28585
      • WP_004571774.1
      		 33373 - 34245 (-) TauD/TfdA family dioxygenase
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        • SRIM_RS28580
        • WP_032920603.1
        		 34301 - 34876 (-) hypothetical protein
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          • SRIM_RS28575
          • WP_030179607.1
          		 34998 - 36053 (-) GSCFA domain-containing protein
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            • SRIM_RS28570
            • WP_004571777.1
            		 36131 - 45430 (-) non-ribosomal peptide synthetase
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              • SRIM_RS28565
              • WP_078586793.1
              		 45430 - 49614 (-) non-ribosomal peptide synthetase
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                • SRIM_RS28560
                • WP_004571779.1
                		 50194 - 53211 (+) non-ribosomal peptide synthetase
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                  • SRIM_RS28555
                  • WP_004571780.1
                  		 53230 - 54291 (-) ATP-dependent DNA ligase
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                    • SRIM_RS28550
                    • WP_004571781.1
                    		 54594 - 55598 (+) non-homologous end-joining DNA ligase
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                      • SRIM_RS28545
                      • WP_004571782.1
                      		 55629 - 56351 (-) hypothetical protein
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                        • SRIM_RS28540
                        • WP_050498798.1
                        		 56351 - 56914 (-) SigE family RNA polymerase sigma factor
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                          • SRIM_RS28535
                          • WP_004571784.1
                          		 57239 - 58048 (+) putative glycosyl hydrolase
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                            • SRIM_RS28530
                            • WP_004571785.1
                            		 58192 - 59133 (+) hypothetical protein
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              SRIM_RS28570
                              Substrates
                              isoleucine (evidence: Sequence-based prediction, Structure-based inference)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              SRIM_RS28570
                              Substrates
                              proline (evidence: Sequence-based prediction, Structure-based inference)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              SRIM_RS28560
                              Substrates
                              glycine (evidence: Sequence-based prediction, Structure-based inference)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              SRIM_RS28565
                              Substrates
                              phenylalanine (evidence: Structure-based inference [1])
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2018-08-06
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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