BGC0001762 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001762 (Streptomyces sp. KIB-H033)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	36,216	High	rubrolone A/rubrolone B	other:other

BGC0001762 - Region 1 - T2PKS

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Location: 1 - 36,216 nt. (total: 36,216 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,217
Label		BGC0001762

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

AOZ61191.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

rubA: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

rubB: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

rubC: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

rubE7: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

rubS1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: acylase glycosyltransferase transferase

AOZ61215.1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

rubE3: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

rubS5: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

rubS7: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: hydrolase

AOZ61217.1: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase dehydratase

rubE5: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

rubS3: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

rubS4: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

rubE1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

rubE8: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rubE9: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001762.3	1.00	other (other)	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000231.5	0.64	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001762.3	1.00	other (other)	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000231.5	0.64	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001276.3	0.59	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

rubE3: mal

PKS_AT (0..279): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 72.6
Methylmalonyl-CoA: 41.2
Methoxymalonyl-CoA: 33.3
Propionyl-CoA: 15.3
Ethylmalonyl-CoA: 14.8
inactive: 14.4
2-Methylbutyryl-CoA: 12.7
Isobutyryl-CoA: 10.6
CHC-CoA: 8.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36216
Starter unit(s):: butyryl-CoA (Score: 480.2; E-value: 1.23e-147)
acetyl-CoA (Score: 71.2; E-value: 1.64e-98)
propionyl-CoA (Score: 71.2; E-value: 1.64e-98)
isobutyryl-CoA (Score: 71.2; E-value: 1.64e-98)
Malonyl elongations:: 7 (Score: 698.9; E-value: 4.1e-213)
Product molecular weight(s):: acetyl-CoA_7: 485 Da
butyryl-CoA_7: 513 Da
isobutyryl-CoA_7: 513 Da
propionyl-CoA_7: 499 Da

rubB: OXY (Score: 435.2; E-value: 7.8e-133)
rubE1: KSIII (Score: 367.9; E-value: 1.1e-112); KSIII BAJ52704.1_FD-594_butyryl-CoA (Score: 409.0; E-value: 1.23e-147)
rubE2: ACP (Score: 71.4; E-value: 1.1e-22)
rubE3: AT (Score: 392.3; E-value: 4.1e-120); AT AAG30190.1_R1128_acetyl-CoA/propionyl-CoA/isobutyryl-CoA/butyryl-CoA (Score: 285.0; E-value: 1.64e-98)
rubE4: ACP (Score: 109.4; E-value: 1.5e-34)
rubE5: CYC C7-C12 (Score: 131.5; E-value: 6.9e-41)
rubE6: CYC C5-C14/C3-C16 (Score: 333.8; E-value: 1.6e-102)
rubE8: KS (Score: 755.7; E-value: 2.7e-230)
rubE9: CLF 7 (Score: 698.9; E-value: 4.1e-213)
rubS7: GT (Score: 321.0; E-value: 3.3e-98)