BGC0001762 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001762 (Streptomyces sp. KIB-H033)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	36,216	rubrolone A/rubrolone B	other:other	100%

BGC0001762 - Region 1 - T2PKS

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Location: 1 - 36,216 nt. (total: 36,216 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,217
Label		BGC0001762

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001762	1.00	Alkaloid	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033
BGC0000231	0.31	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001817	0.30	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0002435	0.28	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001616	0.27	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0001850	0.27	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001896	0.26	Other	carbazomycin B	Streptomyces luteoverticillatus
BGC0000707	0.26	Saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000025	0.26	Polyketide	avermectin	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001762	1.00	Alkaloid	rubrolone A, rubrolone B	Streptomyces sp. KIB-H033
BGC0000231	0.64	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001817	0.64	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0002435	0.61	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001616	0.61	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0001850	0.60	Other (Shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001896	0.60	Other	carbazomycin B	Streptomyces luteoverticillatus
BGC0000707	0.59	Saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000025	0.59	Polyketide	avermectin	Streptomyces avermitilis

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

rubE3

PKS_AT (0..279): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 72.6
Methylmalonyl-CoA: 41.2
Methoxymalonyl-CoA: 33.3
Propionyl-CoA: 15.3
Ethylmalonyl-CoA: 14.8
inactive: 14.4
2-Methylbutyryl-CoA: 12.7
Isobutyryl-CoA: 10.6
CHC-CoA: 8.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36216
Starter unit(s):: butyryl-CoA (Score: 480.2; E-value: 1.23e-147)
acetyl-CoA (Score: 71.2; E-value: 1.64e-98)
propionyl-CoA (Score: 71.2; E-value: 1.64e-98)
isobutyryl-CoA (Score: 71.2; E-value: 1.64e-98)
Malonyl elongations:: 7 (Score: 698.9; E-value: 4.1e-213)
Product molecular weight(s):: acetyl-CoA_7: 485 Da
butyryl-CoA_7: 513 Da
isobutyryl-CoA_7: 513 Da
propionyl-CoA_7: 499 Da

rubB: OXY (Score: 435.2; E-value: 7.8e-133)
rubE1: KSIII (Score: 367.9; E-value: 1.1e-112); KSIII BAJ52704.1_FD-594_butyryl-CoA (Score: 409.0; E-value: 1.23e-147)
rubE2: ACP (Score: 71.4; E-value: 1.1e-22)
rubE3: AT (Score: 392.3; E-value: 4.1e-120); AT AAG30190.1_R1128_acetyl-CoA/propionyl-CoA/isobutyryl-CoA/butyryl-CoA (Score: 285.0; E-value: 1.64e-98)
rubE4: ACP (Score: 109.4; E-value: 1.5e-34)
rubE5: CYC C7-C12 (Score: 131.5; E-value: 6.9e-41)
rubE6: CYC C5-C14/C3-C16 (Score: 333.8; E-value: 1.6e-102)
rubE8: KS (Score: 755.7; E-value: 2.7e-230)
rubE9: CLF 7 (Score: 698.9; E-value: 4.1e-213)
rubS7: GT (Score: 321.0; E-value: 3.3e-98)