{"accession":"BGC0001763","version":5,"changelog":{"releases":[{"version":"1","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2018-08-06","comment":"Submitted"}],"date":"2018-08-06"},{"version":"2","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2019-10-16","comment":"Migrated from v1.4"}],"date":"2019-10-16"},{"version":"3","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-09-15","comment":"Updated bioactivity data"},{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-09-15","comment":"Added NRP substrate specificities"}],"date":"2022-09-15"},{"version":"4","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-10-07","comment":"Update chemical activity to schema version 2.11"}],"date":"2022-10-07"}]},"quality":"questionable","status":"active","completeness":"unknown","loci":[{"accession":"LC257593.1","location":{"from":0,"to":0},"evidence":[]}],"biosynthesis":{"classes":[{"class":"NRPS","subclass":"Type I"},{"class":"PKS","subclass":"Unknown","cyclases":[]}],"modules":[{"type":"nrps-type1","name":"Unk01","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"1-(1,1-dimethylallyl)-tryptophan","structure":"CC(C)(C=C)N1C=C(C2=CC=CC=C21)C[C@@H](C(=O)O)N","proteinogenic":false}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}},{"type":"nrps-type1","name":"Unk02","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"leucine","structure":"CC(C)C[C@@H](C(=O)O)N","proteinogenic":true}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}},{"type":"nrps-type1","name":"Unk03","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"substrates":[{"name":"3-nitrotyrosine","structure":"C1=CC(=C(C=C1C[C@@H](C(=O)O)N)[N+](=O)[O-])O","proteinogenic":false}],"evidence":[{"method":"Sequence-based prediction"},{"method":"Knock-out studies"},{"method":"Mass spectrometry"}]}},{"type":"nrps-type1","name":"Unk04","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"alanine","structure":"C[C@@H](C(=O)O)N","proteinogenic":true}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}},{"type":"nrps-type1","name":"Unk05","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"leucine","structure":"CC(C)C[C@@H](C(=O)O)N","proteinogenic":true}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}},{"type":"nrps-type1","name":"Unk06","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"leucine","structure":"CC(C)C[C@@H](C(=O)O)N","proteinogenic":true}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}},{"type":"nrps-type1","name":"Unk07","genes":["BBA20967.1"],"active":null,"carriers":[],"a_domain":{"type":"adenylation","gene":"BBA20967.1","location":{"from":-1,"to":-1},"references":["pubmed:28774961"],"substrates":[{"name":"trans-2-crotylglycine","structure":"C/C=C/C[C@@H](C(=O)O)N","proteinogenic":false}],"evidence":[{"method":"Sequence-based prediction","references":["pubmed:28774961"]}]}}]},"compounds":[{"name":"rufomycin","evidence":[],"bioactivities":[{"name":"antibacterial","observed":true,"references":[]}],"structure":"C/C=C/C[C@H]1C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)NC(C(=O)N1)CC(C)C)CC(C)C)C)C)CC2=CC(=C(C=C2)O)[N+](=O)[O-])CC(C)C)C)CC3=CN(C4=CC=CC=C43)C(C)(C)C=C","mass":1011.579339664,"formula":"C54H77N9O10"}],"taxonomy":{"name":"Streptomyces atratus","ncbiTaxId":1893},"genes":{"annotations":[{"id":"BBA20962.1","name":"RufO","product":"Other","tailoring":[{"function":"Other","references":["doi:10.1074/jbc.M117.791269","doi:10.1038/s41467-017-00419-5","doi:10.1016/j.chempr.2025.102438"],"db_reference":"mite:MITE0000184","details":"Other"}]}]},"legacy_references":["pubmed:28774961"]}