BGC0001763: rufomycin biosynthetic gene cluster from Streptomyces atratus
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Location: 1 - 55,642 nt. (total: 55,642 nt).
This entry is originally from NCBI GenBank LC257593.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001763
Short description rufomycin biosynthetic gene cluster from Streptomyces atratus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LC257593.1
Compounds
  • rufomycin
Species Streptomyces atratus [taxonomy]
References
Chemical products information
rufomycin
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C54H77N9O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BBA20948.1
  • rufA
 543 - 1310 (+) LacI-like regulatory protein
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  • BBA20949.1
  • rufB
 1384 - 2148 (-) alpha/beta hydrolase
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  • BBA20950.1
  • rufC
 2470 - 3531 (+) cytochrome P450
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  • BBA20951.1
  • rufD
 3536 - 3682 (-) hypothetical protein
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  • BBA20952.1
  • rufE
 3671 - 18142 (+) type I polyketide synthase
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  • BBA20953.1
  • rufF
 18159 - 18875 (+) thioesterase
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  • BBA20954.1
  • rufG
 19152 - 19253 (+) hypothetical protein
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  • BBA20955.1
  • rufH
 19488 - 19649 (+) MbtH-like protein
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  • BBA20956.1
  • rufI
 19646 - 20791 (+) aminotransferase
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  • BBA20957.1
  • rufJ
 20947 - 21354 (+) hypothetical protein
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  • BBA20958.1
  • rufK
 21362 - 22417 (+) ABC-transporter
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  • BBA20959.1
  • rufL
 22414 - 23247 (+) ABC-transporter
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  • BBA20960.1
  • rufM
 23505 - 24590 (+) cytochrome P450
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  • BBA20961.1
  • rufN
 25015 - 26151 (+) nitric oxide synthase
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  • BBA20962.1
  • rufO
 26129 - 27313 (+) cytochrome P450
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  • BBA20963.1
  • rufP
 27335 - 28456 (+) tryptophan N-dimethylallyltransferase
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  • BBA20964.1
  • rufQ
 28637 - 29011 (+) hypothetical protein
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  • BBA20965.1
  • rufR
 29042 - 29770 (-) luciferase-like monooxygenase
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  • BBA20966.1
  • rufS
 30144 - 31343 (+) cytochrome P450
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  • BBA20967.1
  • rufT
 31567 - 55542 (+) nonribosomal peptide synthetase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
rufT
Module ?
Specificity: 1-(1,1-dimethylallyl)-tryptophan
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: 3-nitrotyrosine
Evidence for specificity:
  • Sequence-based prediction
  • Knock-out studies
  • Mass spectrometry
Module ?
Specificity: alanine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: leucine
Evidence for specificity:
  • Sequence-based prediction
Module ?
Specificity: trans-2-crotylglycine
Evidence for specificity:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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