BGC0001773 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001773 (Pseudonocardia sp. HH130630-07)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	127,311	High	selvamicin	PKS

BGC0001773 - Region 1 - T1PKS

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Location: 1 - 127,311 nt. (total: 127,311 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 127,312
Label		BGC0001773

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

AFB00_29715: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AFB00_29745: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase glycosyltransferase transferase

AFB00_29670: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

AFB00_29705: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AFB00_29730: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

AFB00_29750: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AFB00_29760: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AFB00_29775: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

AFB00_29790: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

AFB00_29755: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AFB00_29785: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

AFB00_29720: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AFB00_29725: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AFB00_29735: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AFB00_29780: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001773.4	1.00	PKS	selvamicin	Pseudonocardia sp. HH130630-07
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.71	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001773.4	1.00	PKS	selvamicin	Pseudonocardia sp. HH130630-07
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.71	PKS	oronofacic acid	Pseudomonas syringae
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 2820 - 127311:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ccmal - ccmal - ccmal) + (redmal) + (ccmal - ohmal - Me-ohmal - ohmal - mal - ohmal) + (redmal) + (mal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: AFB00_29725 + AFB00_29720 + AFB00_29780 + AFB00_29775 + AFB00_29735 + AFB00_29730

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AFB00_29720: mal

PKS_AT (545..831): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.4
inactive: 101.1
Methoxymalonyl-CoA: 57.2
Methylmalonyl-CoA: 50.3
Propionyl-CoA: 32.0
Benzoyl-CoA: 25.4
Ethylmalonyl-CoA: 23.8
trans-1,2-CPDA: 21.4
CHC-CoA: 19.0
Isobutyryl-CoA: 18.6
Acetyl-CoA: 15.7
fatty_acid: 10.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AFB00_29725: mal - mal - mal - mal

PKS_AT (554..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 182.3
inactive: 76.8
Methoxymalonyl-CoA: 65.6
Methylmalonyl-CoA: 59.4
Ethylmalonyl-CoA: 30.6
fatty_acid: 30.1
Propionyl-CoA: 29.5
CHC-CoA: 24.1
Acetyl-CoA: 23.6
Isobutyryl-CoA: 21.6
Benzoyl-CoA: 20.0
trans-1,2-CPDA: 19.8
2-Methylbutyryl-CoA: 14.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2280..2557): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.5
inactive: 93.8
Methoxymalonyl-CoA: 70.0
Methylmalonyl-CoA: 59.5
Isobutyryl-CoA: 32.7
Acetyl-CoA: 23.8
Ethylmalonyl-CoA: 22.2
fatty_acid: 22.0
CHC-CoA: 20.6
Propionyl-CoA: 19.6
Benzoyl-CoA: 18.8
trans-1,2-CPDA: 17.1
2-Methylbutyryl-CoA: 11.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (3993..4269): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.0
inactive: 84.3
Methoxymalonyl-CoA: 61.1
Methylmalonyl-CoA: 54.7
Propionyl-CoA: 28.0
Isobutyryl-CoA: 26.5
fatty_acid: 22.0
Acetyl-CoA: 21.8
Ethylmalonyl-CoA: 19.9
trans-1,2-CPDA: 17.3
CHC-CoA: 16.8
Benzoyl-CoA: 15.0
2-Methylbutyryl-CoA: 4.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (5735..6016): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.4
inactive: 88.2
Methoxymalonyl-CoA: 60.4
Methylmalonyl-CoA: 53.5
Propionyl-CoA: 28.0
Acetyl-CoA: 24.5
Isobutyryl-CoA: 24.2
Ethylmalonyl-CoA: 20.8
fatty_acid: 18.9
trans-1,2-CPDA: 15.2
CHC-CoA: 15.0
Benzoyl-CoA: 11.4
2-Methylbutyryl-CoA: 2.2
3-Methylbutyryl-CoA: 0.0

AFB00_29730: mmal - mmal

PKS_AT (575..872): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.1
Ethylmalonyl-CoA: 165.4
Methoxymalonyl-CoA: 149.8
2-Methylbutyryl-CoA: 126.5
trans-1,2-CPDA: 100.0
Propionyl-CoA: 94.2
CHC-CoA: 80.1
Malonyl-CoA: 77.4
Isobutyryl-CoA: 62.6
Benzoyl-CoA: 55.1
Acetyl-CoA: 46.3
3-Methylbutyryl-CoA: 44.2
fatty_acid: 37.5
inactive: 21.1

PKS_AT (2142..2440): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.8
Ethylmalonyl-CoA: 194.8
Methoxymalonyl-CoA: 174.9
2-Methylbutyryl-CoA: 133.7
trans-1,2-CPDA: 125.6
Propionyl-CoA: 109.3
Malonyl-CoA: 102.5
CHC-CoA: 89.1
Isobutyryl-CoA: 72.9
Benzoyl-CoA: 58.4
3-Methylbutyryl-CoA: 51.6
Acetyl-CoA: 45.4
fatty_acid: 35.1
inactive: 30.7

AFB00_29735: mal

PKS_AT (559..722): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 21.0
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AFB00_29775: mal

PKS_AT (570..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.9
inactive: 88.6
Methoxymalonyl-CoA: 61.6
Methylmalonyl-CoA: 58.2
Propionyl-CoA: 30.5
Isobutyryl-CoA: 30.3
Acetyl-CoA: 22.6
fatty_acid: 21.0
Ethylmalonyl-CoA: 18.8
CHC-CoA: 17.8
Benzoyl-CoA: 16.8
trans-1,2-CPDA: 16.7
2-Methylbutyryl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0

AFB00_29780: mal - mal - mmal - mal - mal - mal

PKS_AT (553..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 186.9
inactive: 68.8
Methoxymalonyl-CoA: 54.5
Methylmalonyl-CoA: 50.4
Isobutyryl-CoA: 22.7
Propionyl-CoA: 22.0
Acetyl-CoA: 18.8
Benzoyl-CoA: 17.1
Ethylmalonyl-CoA: 13.9
CHC-CoA: 11.1
2-Methylbutyryl-CoA: 9.5
fatty_acid: 8.9
trans-1,2-CPDA: 5.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2279..2551): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.8
inactive: 96.8
Methoxymalonyl-CoA: 58.3
Methylmalonyl-CoA: 53.2
Isobutyryl-CoA: 24.9
Propionyl-CoA: 24.7
Acetyl-CoA: 21.0
Ethylmalonyl-CoA: 18.4
trans-1,2-CPDA: 12.4
Benzoyl-CoA: 10.3
fatty_acid: 9.0
2-Methylbutyryl-CoA: 7.1
CHC-CoA: 6.9
3-Methylbutyryl-CoA: 3.1

PKS_AT (3813..4114): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.1
Ethylmalonyl-CoA: 191.0
Methoxymalonyl-CoA: 178.5
2-Methylbutyryl-CoA: 144.7
Malonyl-CoA: 117.7
trans-1,2-CPDA: 116.0
Propionyl-CoA: 114.0
CHC-CoA: 102.6
Isobutyryl-CoA: 71.4
Benzoyl-CoA: 48.2
Acetyl-CoA: 41.1
inactive: 37.8
3-Methylbutyryl-CoA: 30.6
fatty_acid: 24.2

PKS_AT (5354..5654): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.6
inactive: 93.3
Methoxymalonyl-CoA: 67.7
Methylmalonyl-CoA: 54.7
Propionyl-CoA: 25.4
Acetyl-CoA: 17.3
Isobutyryl-CoA: 16.9
Ethylmalonyl-CoA: 16.7
Benzoyl-CoA: 15.6
CHC-CoA: 14.7
trans-1,2-CPDA: 12.2
fatty_acid: 11.7
2-Methylbutyryl-CoA: 4.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (6875..7163): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.7
inactive: 100.4
Methoxymalonyl-CoA: 52.1
Methylmalonyl-CoA: 47.7
Propionyl-CoA: 25.5
Acetyl-CoA: 20.4
Benzoyl-CoA: 15.8
CHC-CoA: 12.9
Isobutyryl-CoA: 11.1
fatty_acid: 11.0
trans-1,2-CPDA: 9.1
Ethylmalonyl-CoA: 7.6
2-Methylbutyryl-CoA: 4.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (8320..8613): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.7
inactive: 91.7
Methylmalonyl-CoA: 66.9
Methoxymalonyl-CoA: 65.4
Isobutyryl-CoA: 37.0
Ethylmalonyl-CoA: 30.7
Propionyl-CoA: 28.8
Benzoyl-CoA: 26.3
Acetyl-CoA: 21.8
fatty_acid: 18.8
trans-1,2-CPDA: 16.6
CHC-CoA: 13.7
2-Methylbutyryl-CoA: 10.9
3-Methylbutyryl-CoA: 6.0

Link to PARAS substrate predictor