LOCUS       BGC0001775             30001 bp    DNA     linear   PLN 19-JUN-2018
DEFINITION  Cordana terrestris FKA-25 DNA, sespendole biosynthetic gene cluster.
ACCESSION   BGC0001775
VERSION     BGC0001775
KEYWORDS    .
SOURCE      Cordana terrestris
  ORGANISM  Cordana terrestris
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Sordariomycetidae; Sordariomycetidae incertae
            sedis; Cordana.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 04:21:11
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..30001
                     /db_xref="taxon:1293529"
                     /mol_type="genomic DNA"
                     /note="synonym: Pseudobotrytis terrestris"
                     /organism="Cordana terrestris"
                     /strain="FKA-25"
     subregion       1..30001
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001775"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..30001
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /product="indole"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..20791
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[8177:10791]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8178..10791
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     protocluster    1..20791
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[8177:10791]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      8178..10791
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="2"
     cand_cluster    1..20791
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="chemical_hybrid"
                     /product="terpene"
                     /product="indole"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(2712..4638)
                     /gene="spdQ"
     CDS             complement(join(2712..3124,3180..3357,3409..3643,
                     3701..4131,4189..4317,4375..4485,4531..4638))
                     /codon_start=1
                     /gene="spdQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 112.1; E-value: 5.4e-34)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="BBD84642.1"
                     /sec_met_domain="p450 (E-value: 1.6e-38, bitscore: 121.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MYLDHFLDPLSAWLSPPMIAGLAVALGIALNNLLRKQNIDAPFIG
                     PAVWLSKWPAAIRNLRFARESIHEGYAKHGKTFFQIPTMRRSEIYICNPLMIKEYRDAP
                     DEHLSMFAVMSDEFQFKWTAPGGQYDAHRLGTPVMAKALGWQRLRTNNPKDPFFEDFAA
                     TCLDGLDHGIRMLQETRPSPISSSNAGDTESISNADWVSVPCFKLALDVVSRMTTKSLF
                     GQSDFWDEPDFLNMCRQYADAVPRDAMILHLIPTFLRPYFSELLPVRKLHWKLTAVICN
                     EIGSRSRKTTTEDPPGDLLDFGIKWIEDPKYVGMYNDRHVANLLSFTVFAALHTTSQLI
                     TLTIYELATRPEYIQLLRDEIDKCMLEYGSWTKASIDAMHNLDSFMKETQRCNVLNASS
                     LERIALKPFTFSNGLHIPKGSWMGTPHSPLFQDERYYSDPERFDGLRFARMRNSEDPQI
                     RRECLLTATSEHSMHFGHGRHTCPGRWMAADEAKLVMARLVSSYDIALFSPRPANIKLL
                     KFNVPSMTANIWLRKRS"
     misc_feature    2712..20673
                     /note="sespendole biosynthetic gene cluster"
     gene            complement(4888..6431)
                     /gene="spdM"
     CDS             complement(join(4888..4932,4985..5347,5434..6076,
                     6142..6431))
                     /codon_start=1
                     /gene="spdM"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 242.1; E-value: 1.9e-73)"
                     /gene_kind="other"
                     /product="putative monooxygenase"
                     /protein_id="BBD84643.1"
                     /transl_table=1
                     /translation="MSEDFRVIIVGGSVAGLTLAHSLERLGISFQVLEKNDDISPQIGA
                     SIGILPNGARILDQLGLFGAIEKEVEPMKTARISYPDGFTFQSDFPSSWEKSFGYPAAF
                     LERQKFLEILYSKLQHKERVHTGQKVVSICYEKSTVIVKTASGDEYSADLVVGADGVHS
                     TVRSEMWKHMAGVKPGISTASNSSALKLEYACIYGISSQVPEIEAGVWYNLLDKQLTLH
                     FIGVAGGRVFWFLIVKPEKEHWHADRQYLTEDETRRICERLGSKRLSPTLTFGDIWSRC
                     DIFKMTPLEEGWFKTWHFHRLVIMGDAVRKMAPSIGQGANMAIEDAAVLANAIWKAGLG
                     SSKFDTSAMELKIEGVLRHYSTSLRTRTRQMCDRSEFLVRLQTHDGLIKRILARYVIPL
                     LGDVPASLSAKSIQAAPLLEFIDIPARSCQDTRVFSPAQRRWFPCSS"
     gene            complement(7108..7898)
                     /gene="spdB"
     CDS             complement(join(7108..7315,7381..7898))
                     /codon_start=1
                     /gene="spdB"
                     /product="putative membrane protein"
                     /protein_id="BBD84644.1"
                     /transl_table=1
                     /translation="MDGFNNLQPPKEYQQIQWIADIFVTLMGVGWIVNYATMIWHAYTE
                     STYSMALLPLCSNIGWELTFVLVYPSPNPYEFGVFASLLTLNLGIMITAARAAPAEWAH
                     SPLVANYAVPIFLIGILICFGGHVCLAAQIGPGLAYSWGAFICQLGLSVGAICQLLQRN
                     STRGTSWIMWLGRFLGSCCTVVFAALRWKYWPEVFSWLGSPLMLWGVGVFFASELAYGL
                     CFYLVQKSEVETKKSIKAQ"
     gene            order(8178..8213,8279..8928,9003..10079,10132..10602,
                     10656..10791)
                     /gene="spdE"
     CDS             join(8178..8213,8279..8928,9003..10079,10132..10602,
                     10656..10791)
                     /codon_start=1
                     /gene="spdE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 91.3; E-value:
                     9.1e-28)"
                     /gene_kind="biosynthetic"
                     /product="putative prenyltransferase"
                     /protein_id="BBD84645.1"
                     /sec_met_domain="fung_ggpps2 (E-value: 2.3e-100, bitscore:
                     323.4, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="dmat (E-value: 6.1e-112, bitscore: 363.3,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRRKGSLKHRTLSTERLPLYIASCATTRNNDQHQPISKSTNSHTH
                     ILISKHPMATAECPYEYLLSQYGQHHFGPFVDKLRPSLSMEDPDKYTLVLDIMDAVHFC
                     AILVDDIADRSPLRKNKAAAHVVFGETETSSRAYLVLTRVVNRAMRERPVLAAELLKSL
                     EEIHQGQDQSLVWRRYGLNSFPLGDNERLVAYKRMARLKTGSLFVLLGRLLNDGGAELD
                     DKLARFGWYAQLQNDCKNIYSAEYARNKGSVAEDLRNSELSYPIVVGLITDNANGAVKR
                     ALETRSDADIEKALRVLESPTVRNACLQALKEASCGVEELVASWGRRETMSSNTSIKAT
                     TQKDGRGFTEIAAAPCNTSKLLEADLAYWTRRCIPMVSNLLKSCGVYSLTDQEEQLRFL
                     KEHVLPNLGPRPCGPESQVFSMATFSGFPLQPSINISNSGRAKVRYTFEPLDAISGTPA
                     DPFALGPAQRMLFALAKNLGVWPGWIEALVSAYHPTPQEVQRIKPKLRQYLEQTLKKTT
                     GQTDIEIPEMQRMWVCFIAFDLDGPSQAMKAYFDPKVKEAATGIPSCKYGFQVFRSMEK
                     FGNATAIDMLEQFLDERQSVGAVELIAIDCVPESMLPSARIKVYVHTMSNSFKTVRDYV
                     TLGGRRADLATLQGLSKLRDIWHLLLGEPNGIDEDFNKPLTGFSPMQHRLYFSYEMKPG
                     NSDPAVKVYIPVQNYAPNDDAIVQNYEANFRQCGWPWGKDGAYRNVIESSLGPVTHRHA
                     SFLHGGSSFIYSKGKGVYQSIYLEPSFEEEKDRNIE"
     gene            order(11720..11962,12021..12146,12217..12285,12348..12438,
                     12499..12630,12691..13164,13223..13665)
                     /gene="spdJ"
     CDS             join(11720..11962,12021..12146,12217..12285,12348..12438,
                     12499..12630,12691..13164,13223..13665)
                     /codon_start=1
                     /gene="spdJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 101.2; E-value: 1.1e-30)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="BBD84646.1"
                     /sec_met_domain="p450 (E-value: 1.4e-35, bitscore: 111.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MAIEQFLHRSWLHGLDHLDQLSWGQLILALVIIWSISSWMSGLDG
                     PKVPMVGYRWPFEPKFLVRMRFVTQGLGMMSEGYSKFKDSIFKITTHDADWLIIPKRYL
                     DDLQSLPVERLSVTDALVTMWGSDHGPFALLKKSDLGTRALRDVVVPNYARDLDGLADE
                     LRYTLEHDITLEQDWTTVDTLQLCSKMILRISQRILVGWPMSRDQELIDCTQAYTNAVT
                     IVQFGLKPLPRLLRPIVYPLIPAGWTAKACVRQANKLLAKEMQRREHLEKTDPTYEKPK
                     DLLQGMVDLDPSRPLNELGSDFLVQVQISRTAPVVTMARALMDLALHPQDLDELRNEIE
                     QVMGRNGEGLRNLRQTLNKLEKMDSFLRESARWTPLSMVTVHRVVQDAAGITLHDGVHL
                     PRGTHLAFPAYNIGRDPAMVPDAHIFNGMRWYQQRLSKSFDSDRAKCQFATPDSNYLTF
                     GSGKYVCPGRFIASHMMKLMMVAVLLRYDFKWIPGTAKPSQKYVHVFAFPDKTTLLMKQ
                     RPGGEHAF"
     gene            order(18681..19005,19066..19681,19739..20373,20465..20673)
                     /gene="spdH"
     CDS             join(18681..19005,19066..19681,19739..20373,20465..20673)
                     /codon_start=1
                     /gene="spdH"
                     /product="putative GMC oxidoreductase"
                     /protein_id="BBD84647.1"
                     /transl_table=1
                     /translation="MKLFILLSLTLSAGRTGAEIFDYVIVGAGTAGLVIANRLSEDPSN
                     TVAVIEPGTDQRTNPNVTDWSRFTQAFGTSIDWQYQTVKQSGADGRVLDLHQGKAWGGT
                     STINGMAYIRGDLAQFDAWEGLGNPGWNWESLFPYYKKSEMYTVPSDTQLAAGATYEPQ
                     YHGFNGHVHTGYPSALMNGSFASPIIQTWEGLSLPHNPDLNSGSVRGFSMGPQTLDRAL
                     DVRWDSARAYYYPVGTRSNLRIIKGTVKRINWSSKEHKRSGCSNSLLVADEVEFLDDNG
                     DSQIVGVRKEVIVSAGAVRTPLVLEYSGIGNPRILEGLGIQTRVDLPGVGENLQEQPNH
                     VLAYIGSTELGSSASAYHTFISLRDLFGDDIDQLQESTGAKLSSWAQAAVEASGNGALN
                     VTAVTKLLRVQHNLLFKQNVTAAEIITAVAPTGGGLLASNFWILLPFSRGSVHLGSIDQ
                     INKPVIDPRFFLAEFDLDATIALGKYAQKFWFSEPIASSVIGPLIPGADILPNNATSAQ
                     WETYIRSTVGVNSHPLGTAAMMSRELGGVVDPQLKVYGTANVRVVDASVFPTQFSGHLT
                     ATIYAVAERAADIIKQAI"
ORIGIN
        1 ttcagggcca atctgagcta acagcgcctc agaaaccagg ttgttataag agtcgtcacc
       61 tgtcagggac cagtaatcga gcatggcctc ccatatcgct cctgacgacc accagtagta
      121 gggcattccg tagacaccga tgggctctcc tggctgtgta ccattataat acgaaacaag
      181 gactttggca agtgactttg aggcactttt gacagagtct acatcagtaa gcatggggat
      241 agcgctcaat tgacttgctt catatgacga gaatctcacc tggactgccg acatcgagag
      301 aaagcgcatt cacaatgggc gctgtgaaga gcgcaaacga cgtgagctga acaaaagaaa
      361 agcgcatttt gactgtcggg aagagaagga cttattataa aacgaacgaa ataacgaatg
      421 agatgataga aacaaaatgc agttccagag cagtcaactg cagaggtttc atgattctat
      481 gtaaactaat tttccagatt acctaatcta tgacaggggt agtatgttgt tgcctggaac
      541 gaacccctta ttttagtctt cctacgctgg cagtagcctg aatacgagag tcatttttgt
      601 gatcttcaaa taaataatca ggagaaattg gccgatctta tatttctatt atattcgtaa
      661 gtagaacatc atttaggctg acacctagca tgtaagcctt agagccttaa tttcgtggcc
      721 aattgttaca ccacgacctc gttccttgat ttcatgagat atgtgcggat taggaggcag
      781 ccacttttct ccttgcaccg ccacacaata tttctgactg gggtgcatgt tacgaaaaca
      841 gcaaagaggg tagccgccca gatttcctcc cctcccattc atgttcaggt ctcgctattg
      901 tgtatttttt tttttttctc aaatcattca taccggcgat tacatatata ctgtgatcta
      961 agcatttagt ttggttactg cttaacctcc tgcggtaaac cagaaagtgc gattatcaat
     1021 agaactgagt tgctagattt caccacattg gctcacaggg cccgtcgatg ggacgcaaaa
     1081 gtgccatgat aatgatttca accatttttg atgtaaaatg tggatgaatg tggtgactgc
     1141 agccataaag catggtctct tggcgggtgg ctaccaacgt ccgcattttg tcacaacact
     1201 ggatcctttg atgatcttaa tgcttgcccc ctctcaaatt agtagtgtat ctaatcagta
     1261 cagcttgtgt caggctgatt cctgctggag gtgatgtcgg tagggcagat acagcattgt
     1321 ggcggtgtga ttggtggaca tacggtcatg gattaagctg acgcggacag taacgtgtgc
     1381 gaagatgggg ctgaaaatta agggaacagc tagaacatgc tctcacttct cgggaagggg
     1441 ttttttatcc aagtgcaacc caattatttt cttgattgat tgattgattt gggttgacat
     1501 ttggtagcaa caagcatcct ctccttactt ctagcaaggg acacatcatt agcaatgttt
     1561 gaccgcaatt ccactgacaa ggaggatgag aggcatttgc tgggacagga agcgacacgg
     1621 gacgatgagg ttatttggga ccattctggg aggaatatgg cagcttctcc agacctctgg
     1681 gcccaggatc ctctttcaga ggagacacat gagctacaag cggtgtcaaa ttcagtgact
     1741 ggagcgaatc aacagagcgc tcggaagtta agggttagga cgccctcgcc atatcaaatt
     1801 gaagcagctt caaatctgga aacggaattt gagaggatat ttagcccggt aacacaatat
     1861 ggtgtccatg cccggcttta tgacttgtac taattgattg taggtgaaga aagacgaaga
     1921 gcaaaagaga cgatttcata atgagctcga cgctgcttgt gaagcatact ccatccgcct
     1981 agaagatatg caagatcaac agcgtgaaaa ggaggaagca atcgagaaac cttggctaat
     2041 tgctcgacga cggcagacat tgtatcgtac catgggggta gttcggaata tcggtgttat
     2101 cttgacatgc tattgtggtg gtagcgtcgc acgtcttgct gaactacccc ccgaaattcc
     2161 gtggccacca ccgcatctta caaggatgag agagcaccac agtctagaaa gaaaggcact
     2221 tcgcgaagca cactttgcac ttgtccatga attgcgggca aagtatatgc ttgaggatca
     2281 ggaagaggga gaacaagaaa gtcatgtctg cgttcagaga aagctactga aacaggtact
     2341 gggagatgtg ccagcaacac cgatcggcga ctcagaacaa tagcctgctc cacagcatta
     2401 tacaaaggtg attaatcttg ggcgattaca ggagtaatta tgcgtatatg aacagcacac
     2461 acaatattgg tcggtcttgc agcaacaaaa cttggcacag cagccgcaca aacgagagat
     2521 aatgaccttc acaaagtgat ttccatccca gtctagtcat tgaataaggg cttgtgcaat
     2581 aattttagaa tctacctact tggatgcaaa tcccttgtat ataattcagt cttggctcaa
     2641 cgtgaaactg aaaatgagta gaaggcacgg gaagaccgga ctttccatgt caatttttca
     2701 tggctgctat cctacgaccg ttttctcaac cagatatttg cggtcatact tggcacattg
     2761 aactttagca acttgatgtt agccggcctt gggctgaaga gagcaatgtc gtagcttgaa
     2821 acaaggcgcg ccatgaccaa cttcgcttca tctgctgcca tccacctacc aggacacgtg
     2881 tggcggccat gaccgaagtg catactatgc tcgctcgtag ccgtcagaag acattcacgc
     2941 ctgatttgag gatcttcaga gttgcgcatt cgtgcgaaac gaaggccatc aaaccgctct
     3001 gggtcactgt aataacgctc atcttggaac aaaggcgaat gcggggtacc catccaagat
     3061 cctttcggta tgtgaagccc gttggagaat gtgaaaggtt tcagagcgat acgttcaaga
     3121 gatgctgtaa tcatgcgtaa gagtaagata aatcaaaata catttacatt tcaacctaca
     3181 ggcgttgagg acattacacc gctgtgtctc cttcatgaag ctgtctagat tgtgcatggc
     3241 gtcaatcgaa gctttggtcc acgatccgta ctctagcatg catttatcga tttcgtctcg
     3301 taacagttga atgtactcag ggcgagtcgc cagttcgtaa atggtaagag tgattagctg
     3361 atggatttgc tgttagaggt cattctgaaa ttgtttcaag aatcttactt ggctggtggt
     3421 atgtagagca gcaaatactg taaatgataa caagttggca acgtgtctat cattatacat
     3481 cccaacatat tttggatctt ctatccactt tatgccaaaa tcaagtagat cgcctggagg
     3541 gtcctcggtc gtcgtctttc gcgatctgga tccaatttca ttgcaaatga ctgctgttaa
     3601 tttccagtgc aattttcgaa ctggtagaag ctccgagaag tatctaagat tatcaggaat
     3661 aactcttgta cagaacaatc agaagaagcg ggatacgtac ggcctcagga atgtagggat
     3721 gagatgcaat atcatagcat ctcgaggtac cgcgtccgcg tactgacgac acatgttcaa
     3781 gaaatctggc tcatcccaga aatctgactg cccgaaaaga gacttggtag tcatccgaga
     3841 gacaacatct aatgccagct tgaaacatgg caccgacacc cagtctgcgt tgcttataga
     3901 ctccgtatct cctgcgttgg agcttgagat aggggacggt ctagtctctt ggagcatacg
     3961 aataccgtga tcaagaccat caaggcaggt agcagcgaag tcctcgaaaa agggatcctt
     4021 tggattgttg gttcggagcc gttgccaacc caaggctttt gccataacag gtgtcccaag
     4081 tctatgagcg tcatattggc caccgggagc agtccacttg aattggaact cctatagaac
     4141 tgtcagtcta gtccctacat ttggttatgt cattgttgat agcctaacat cagacatgac
     4201 tgcaaacata gacagatgct catccggtgc gtcgcggtat tccttgatca tgagagggtt
     4261 acaaatatag atctcagatc ttcgcatagt agggatttgg aagaacgttt tgccatgctt
     4321 gtttttaccg ttagcttaga ttcttcttcg tcagtgatcg atcagaatgt ctaccttagc
     4381 atagccctcg tgtatggatt cacgcgcgaa ccgcaagttt cgtatcgcag ctggccattt
     4441 actaagccat acagctggac caatgaatgg tgcatcgatg ttctgctaca gataagccaa
     4501 acagcctcgc caaagaatgt ggtgaaagac cttgcgcaac aaattgttca gcgcgatgcc
     4561 caaagcaacc gccaaaccag cgatcatggg gggagatagc catgctgaca atggatcgag
     4621 aaaatggtca agatacatag gaacaatctg gaaagaattc ctaaacgacg aattggagtg
     4681 gaggagggga atggcaccaa gggaaagtca agtgtattgc agctacggat acaaatttat
     4741 taaagcatct acagtaggca ataactttag aaagagacga aaaaaaactt tcgggggata
     4801 tctgatctat cagcgccacc aagccccctg ttgcacagca agggcattaa gggagagatt
     4861 tctcgggtct atcaacaccg ctcgacatta gcttgaacaa gggaaccacc gccgctgtgc
     4921 aggcgagaaa acctgatagt agccacccat tccctgaaaa ccaatttgac tcatagcttg
     4981 gtacccgagt gtcctgacat gatcgtgcag gtatgtcgat aaactcaagc aacggcgctg
     5041 cttgaatcga ttttgccgac agactggctg gaacatctcc caagagaggg ataacgtatc
     5101 gggcaaggat acgcttgatt agaccatcat gggtctgcag acgtaccaag aactcagacc
     5161 ggtcgcacat ctgtcttgtg cgcgtccgta gacttgtgct gtagtgtcgc agtacgcctt
     5221 caatttttag ctccatggcc gacgtgtcaa atttggagct gcctagtccg gctttccaaa
     5281 tcgcattagc aaggacagcg gcgtcttcaa tggccatgtt agcaccttgc cctatgctcg
     5341 gtgccatctg cggattggtg tcagccatca atctgtgtat ctcggtgtct taaacaacgt
     5401 gggtggcaag cagcattgag acaacagact tactttgcgc actgcgtctc ccataatgac
     5461 taggcggtga aaatgccacg tcttgaacca tccctcttcg agaggggtca ttttgaaaat
     5521 gtcgcacctg gaccagatgt cgccgaaagt aagggttggg ctgagtctct tagatcctaa
     5581 tcgctcgcag attcggcgcg tctcatcttc cgtaagatac tgcctatctg cgtgccagtg
     5641 ctccttctct ggcttgacta tgagaaacca gaatactctt ccgcctgcaa caccaataaa
     5701 atggagtgtc agttgcttat ccaacaaatt gtaccaaaca ccggcctcaa tctcgggaac
     5761 ctggcttgaa attccgtaaa tgcaagcgta ttcgagcttc aaggccgaac tgttgctagc
     5821 cgtcgaaatt ccgggcttga ctcctgccat atgtttccac atctcagagc gaacagtgct
     5881 gtgtactcca tcagctccta caactaaatc ggctgagtac tcgtcaccag aagctgtctt
     5941 cacaatgaca gtggatttct cgtaacagat tgacactact ttttgtcctg tgtgaactcg
     6001 ctccttgtgc tgcagcttgc tgtagagaat ttctagaaat ttttgacgct ccaaaaatgc
     6061 cgcgggatac ccgaaactgt tcaagagtaa atattagcac agcatcagac gagagcattt
     6121 gataaacatt tgaatacgaa cgatttttcc cacgatgacg gaaagtcact ttggaaagtg
     6181 aagccatcag ggtaagagat acgagccgtt ttcattggct caacctcttt ctcaattgcc
     6241 ccaaacaggc ccagttggtc gaggatacga gctccattgg gaagaatacc aattgatgca
     6301 ccaatctgag ggctgatatc gtcgttcttt tccagtacct ggaaagaaat acccagtctc
     6361 tcaagtgaat gcgcaagtgt gaggccggca actgagccgc cgacgatgat gactctgaaa
     6421 tcttccgaca tggcaagggg atattttgtc attgaagggc aggatatctg gatgaacgga
     6481 cgaaatgttt gcagtatgca atttcttcgt aaggaccacg aacaaattgt tcttaggaga
     6541 attttaatac tactaacacg agcgacgaga accgaacgct cgatactaca aagctctgag
     6601 gtgcgtcgtt caaaatttca cctctttgtc catgatgaga attgagtcac attttcttat
     6661 cgtcactgtt tcttttgagt gaataagaca tgaaatagcg caaactgtcg tcccgaaccg
     6721 acgcgcccag agtggctttc cacaccagat gtcttaagca caaagttcaa ctccgataga
     6781 ctctgactac aacatttccg atctcattac cgcagtttca gtcaagtgaa acatggaagg
     6841 tggggatgtc cgttagacac ttccgcaact gattatgacc ttgccttatt cagttaaact
     6901 ggggcggcaa tcgtgtatca gatcgggtga aaaatggctt tgcgatgttg tttcatggac
     6961 tgtatacatc aataaatgaa cactggggtg ttgcgctgac gtctaaaaga aatcaagctt
     7021 gattttgggt gcaaaaatat aacatatgat ataaggttct ataggattca tgggagacat
     7081 ttactcaatg agtaagactc atttgtttca ctgcgcctta atagatttct ttgtttccac
     7141 ctcagacttt tggacaaggt agaaacacag cccatacgca agctctgaag caaaaaagac
     7201 ccccactccc caaagcatga gaggacttcc cagccacgag aagacctctg gccaatactt
     7261 ccacctcagg gcagcaaaga caacagtaca gcaagatccg aggaatcgac ctaacctacg
     7321 atcaaattta gttattgtgc tttattagta agagggattg aaggattgaa gtttacttac
     7381 cacattatcc acgatgtgcc tctcgtgctg tttcgctgta gaagctggca gatcgccccc
     7441 acgctcagtc ccagttggca gataaaagcc ccccacgagt acgcgagccc aggtccgatc
     7501 tgggctgcaa ggcatacatg acctccgaag catatgagga tgccaataag aaaaatgggc
     7561 acggcataat tggccactag gggagaatgt gcccattctg ctggagcagc acgggcggcg
     7621 gttatcatga tccccaaatt aagcgtcaag agagaggcga atactccaaa ctcgtatggg
     7681 ttaggagatg ggtacaccag aacaaatgtt agctcccatc caatgttgct gcacaatggt
     7741 agcagagcca tgctgtacgt cgattctgtg tatgcatgcc agatcatggt tgcgtagttg
     7801 acgatccagc cgacacccat gagggtgaca aaaatatctg caatccattg gatttgctga
     7861 tactcttttg gtggttgcag attattgaag ccgtccattg ttcaagatga gtgatggaat
     7921 gaagtgattg ggggtgaata gtctgaagtc gagaaacgaa gacgagagga gtgatcattg
     7981 aattaagagc tgctgtgaaa atgagtccag agaagagaaa tgtcccttcg gtatttcacc
     8041 aactaaatga ggctgggtgt ttcgcggtct gtctgacaag tcagttcagg accaacatgg
     8101 tccgacatat catgtacgac ggtctcaggc gcttgcataa atactgtaaa aggttgatta
     8161 gcgacctgat cttagacatg cgaaggaagg gcagtcttaa acaccgaact ctcgttcttc
     8221 actaggggtt atagcacgac atacgacagc tggatgtagg gagatctctt gttgatagtc
     8281 aaccgagcga cttcctttat acatcgcttc ttgtgccacc accagaaata acgaccagca
     8341 tcaaccaatt tccaaatcca ctaattcaca tactcatatt ctgataagca agcatccaat
     8401 ggcgaccgct gagtgtccgt acgaatatct gttgagtcag tatggccagc atcattttgg
     8461 acctttcgtc gacaaactcc ggccgtcact cagcatggaa gatccagata agtacactct
     8521 ggtgcttgat ataatggatg ccgtgcactt ttgcgcaata cttgtcgacg acattgctga
     8581 tcgcagccca ttacgcaaga acaaagccgc tgcacatgtt gtgtttggtg aaaccgaaac
     8641 atcgagcagg gcataccttg tgctgacgcg ggttgttaat cgggccatgc gagaacgccc
     8701 agttcttgcg gctgaattgc tcaaaagctt ggaggaaatt caccaaggac aggaccagtc
     8761 gctagtgtgg cgccgctacg ggctaaatag ctttccgctt ggtgataacg agcgtctggt
     8821 agcttacaag cgtatggcac gactcaaaac tggttcactc ttcgtgctcc tgggcaggct
     8881 tctgaatgac ggtggtgccg aactcgatga caagttagca agatttgggt aagacatacc
     8941 tattctggtt ttccctcctg ttttgagatt gggcaacatc taacgtctac ttctgcccgc
     9001 agctggtacg cccagctgca gaatgactgt aaaaacatct actcggccga atatgcccgc
     9061 aacaaggggt ccgtggctga ggatttgcgt aacagtgagc tgtcgtatcc catcgtggtt
     9121 ggtttgatca ccgataatgc caatggcgcc gtgaagaggg ccctggagac gcgatccgac
     9181 gcagatatcg aaaaggcgtt gagagttctg gagagtccga cggtgagaaa tgcttgtctt
     9241 caagcactaa aagaggcaag ctgcggcgtt gaggagctcg ttgcttcctg gggccgtcgg
     9301 gaaacaatgt ctagcaacac atcgataaag gccacgacgc agaaagacgg tcgtggattt
     9361 accgagatcg ctgcggcccc ttgtaacacc tctaagctat tagaagcgga cttggcctac
     9421 tggacccgga gatgcattcc tatggtgtct aatcttctca agtcatgtgg agtatattcg
     9481 ctcacggacc aggaagaaca actccgtttc ttgaaagaac acgtcctacc taatcttgga
     9541 ccacgcccct gtggccctga gtctcaagtt ttctccatgg cgactttcag tggtttccca
     9601 ctgcaaccaa gcatcaacat cagcaactct ggccgcgcca aagtccgata cacatttgag
     9661 cccctcgatg ctattagtgg cacccctgct gatcctttcg ctctcggccc agctcaacgg
     9721 atgctgtttg cactagcaaa gaatctaggt gtttggcctg gatggatcga ggctctggtc
     9781 tctgcttacc atccaacccc acaagaagtc cagcgaatta aaccgaagct tcgtcaatat
     9841 cttgaacaaa ctctgaagaa gacgaccggg caaaccgaca tagaaattcc tgaaatgcaa
     9901 cgcatgtggg tgtgcttcat cgcctttgac ctggatggcc catcacaggc catgaaagct
     9961 tactttgatc ccaaagtaaa ggaagccgcc accggaattc catcttgcaa atatggcttt
    10021 caggtttttc gtagcatgga aaagttcgga aatgccacgg ccatcgacat gcttgaacag
    10081 tgggctttcc catctcatct aaggcgcatt tcactgacta ctactcgaca gattcctcga
    10141 cgaacgccag agtgttggcg ctgttgaatt gattgccata gactgtgttc ctgagagcat
    10201 gctgccttct gcacgaatca aagtttacgt ccacacaatg agcaactcgt tcaagaccgt
    10261 gcgcgattac gtgactctgg gcggccgccg agcagacctg gcaactcttc agggcctgtc
    10321 gaagttgcgg gacatttggc atcttctgct gggggagcct aatggcatcg acgaggactt
    10381 taacaaaccc ctgactgggt ttagcccaat gcagcaccgt ctgtacttca gctatgaaat
    10441 gaaaccggga aatagcgatc ccgctgttaa ggtctacatt ccagtccaaa actatgctcc
    10501 aaatgacgat gcaattgtgc agaattacga ggccaatttc cgacagtgtg gttggccttg
    10561 ggggaaagac ggggcttaca gaaatgttat cgagagttct ctgtaggtca gatctaagta
    10621 tagacagcaa cacgcttact aatgtttagt cttaggggac cagtaactca tcgtcatgcg
    10681 tcttttcttc acggtggctc ctccttcatt tacagcaaag gaaagggcgt ataccaatca
    10741 atctaccttg agccatcatt tgaggaagaa aaagaccgca atattgagta ataaatatcg
    10801 tgtacttatt tgtatcagtc atacaaatta tcctttaaat gatagccaca tgaatagata
    10861 taattatcct gcaaatattt gcaaaagtgt agttgacata tacaaatgag aatgaaggta
    10921 gacttggttc attgtgtgtt ttctaacgta accgagaaga cagcggcaaa acgaaacata
    10981 agttaattag aacaaagatt aaaaaagaat tgtgaaatgt tgatagttct ttgatacctt
    11041 gtttgagaat ctgcactaac ttttccaggc aacaaaagga aagaagccag aaaagacgat
    11101 cagtagctta gtaaccctaa gtaactcaga gaatcatacc cctccgcatc ttggagatgc
    11161 ataccgggat ctgtgctcga cataacatgc acttatctga atagataaag atgtatgcat
    11221 tttcctttcg atttcacgag tgtaattcat gacttatcat gtctatcaat cttgataatt
    11281 tgaaggtgac gtggcactta gctccgaata tttatgcttt taaaaaagac tgacggcatg
    11341 tctaagacct cagctgtcgg gtggttcagc tgtagatact ttgaaaaagc aatacttgta
    11401 gataaggata cctgctaccg aattatattg agttgttttt catccggcgg ggggtgaatg
    11461 tgtctgatac gttgtaaacc attgaaccac gtatgtctcg cgctctgtct agcgcgctgc
    11521 aacatctcct atcctctccg gggtggccaa aggtcaccgc ctaatgtcgc catcacactc
    11581 tgaacacacc actaccaact ccaagcacgt ccatttgaag gataaagacc atagatccca
    11641 gtgccaattt gtccgtctga gcagcctttg caccctacac gttatctcta atattctatt
    11701 aggaagcagc gttaatacca tggctattga acagttctta cacagaagct ggctccatgg
    11761 gctggatcac ctggaccagc tgtcatgggg tcagttaatt ctggctctgg tgatcatatg
    11821 gtcaatttcc tcttggatgt caggtctgga cggaccaaaa gtccccatgg taggatatcg
    11881 ctggccgttt gagcccaaat ttctggttcg catgcgtttt gtgacacaag gcttgggaat
    11941 gatgagtgaa ggatactcca aggtgtgcat cttgaaagat agaatatcat gactttctac
    12001 taataccgta cgcattctag ttcaaagact ctatattcaa gatcactact catgatgctg
    12061 actggctgat tatccccaaa cggtatcttg atgatttaca atcgctcccc gtcgagcgac
    12121 tgagtgttac agatgcttta gtcacggtat ggagtcatat aattaagtcc cattcactct
    12181 ggttggaaac ttacaagaag gcatggttta tctcagatgt ggggcagcga ccacggacca
    12241 tttgcactgc ttaagaaaag cgatctcggc accagagctc tccgcgtatg agttcccctc
    12301 cattacccat gtgaaagatc tatagggagg ttttaacaaa ttttcaggat gtggttgtcc
    12361 caaattatgc cagagacctc gatggacttg ctgacgaact ccgatacact ctcgaacatg
    12421 acataactct cgagcaaggt gactatattg cacaattttt cgcagaacac gttcatgact
    12481 gatgaaaaac atccccagac tggactacag tcgatactct acagctttgt tccaagatga
    12541 tacttaggat ctcgcagcga atcttagttg gctggcccat gtctcgggac caagaactca
    12601 ttgactgtac ccaggcttac acgaacgcag gttagattcc gactcacaca tctaattggt
    12661 aaacaagtgg atgctaaatt tcatctacag taacgattgt ccagtttggt ctcaaaccac
    12721 tccctcgtct gctacgaccc attgtttatc ctttgatccc ggccgggtgg acggcgaaag
    12781 cgtgtgtacg acaagccaac aaacttctag ccaaagaaat gcaacgcagg gagcacctcg
    12841 agaagacaga tcctacctat gagaaaccca aggatttgtt gcagggaatg gtggatttgg
    12901 acccctcaag accgttaaac gaacttggaa gtgacttcct tgtacaagtg cagatttcaa
    12961 gaacggctcc tgtcgtcact atggcacgtg ccttaatgga tctagcactc cacccgcaag
    13021 atctagatga gttacgaaat gagatcgagc aggtcatggg acgtaatggg gagggcttaa
    13081 ggaatctgag gcaaacattg aacaagctag agaaaatgga cagctttctc agagaatcgg
    13141 cgagatggac tccactttca atgggtaagt gcgctgctgc agcttgaccg cccatcaaat
    13201 tatctcacaa cacgttctgc agtaactgtt catcgtgtcg ttcaagacgc cgccggcatc
    13261 acgcttcatg atggcgttca tctccctcgg ggaactcact tggcatttcc agcatacaac
    13321 atcggcagag accccgccat ggtccccgat gctcacatct ttaacggaat gcggtggtat
    13381 cagcagcgcc tttctaaatc cttcgatagt gatcgtgcca aatgtcaatt tgccacgcct
    13441 gacagcaact acctgacatt cgggtctggc aaatatgtct gccctggtcg gttcatcgca
    13501 tctcatatga tgaaactaat gatggttgct gtgctgcttc gatatgactt taaatggata
    13561 ccgggaacag ccaagccatc gcagaaatat gtccatgtct tcgcgttccc ggataagaca
    13621 acgctcctaa tgaagcagcg ccccggagga gagcatgcct tttaatacca tctctgaaga
    13681 gtgatgtatg gcattaggaa gcaatgtgaa attgtgtttc aagtcggtga gtctttgcca
    13741 cgcaactgag tgtgttatgc aaagaaaagt gcaaaacaag gaagtggatg caaggataga
    13801 aagtgagtct catatcaagt taggctaggc taagataaaa ttcccttaac aaaaatgacg
    13861 gggagatata aacctgagaa gatcatatgt gatatgtggg gcaaatttct tatgacttgg
    13921 acagagatct ttgtcatctt ctggtcgaca gctgttgata tcactatagc cttggcttat
    13981 cgaatagcag tatgacaata ctgagaagtg cagattttgt gcgttcgtat ttcgccaaac
    14041 tcaaaggagt atttagggtt attgaagtat gaagacaatg ctattttgtg ctctttgctt
    14101 gtctacccat agatacatag cttggcattg gaaatttagc acgcagtcaa acgtgggaaa
    14161 gttgcacatg attagtttgg cacatgcggc ggcagcccct ggtcctgaac cgattgatac
    14221 agacaagggt cttgaagcct atcttagagg agatacctgc acacaaccac tactcaactg
    14281 ggtcatttgg ctataccgcc ctgcatacta tctttcacag tgggcaatct agactaatac
    14341 aatagttttc tctttgttat catggcaaca agtcctatat tttacgtatt tgcagtacaa
    14401 tcttttggta gatctctctt cttagaagtt atatatctgg tacagtagat atgtgcgaaa
    14461 gccaggtatc caactgtaaa tccacataaa tatctgaacg attaacggaa gagtttccac
    14521 tccaggaagt tcccggatac ttttcacttt atccaatttc aatttgggat gtactctctc
    14581 cagctcatgc gcatcatcca ttccaaagta cgcgattgct cccgtacctg cgactggacc
    14641 gtgatacgct tggagtcgaa cgaatagctt tccaaccgtg tcaagcataa tttgtccacc
    14701 tgtgaatcga tcacagagtc ggcgcatgag tcgatttact tgagccggtc taatataagg
    14761 aagtaaccct tccattatca ccagcgttgg ccgatcagca ggaatgtctt caagccattt
    14821 atgatcggtt acagatgcct ccagtaagtg ataatcaccc accggtcgtg gaagtagcgt
    14881 tttacggagt ttaataactt ccggtaaatc tagatcgatc caccgcacct ggggtcccca
    14941 tgatagtcgc agggatcgac tgtcgaggcc acagcctagg tggagaactg tggcttcgga
    15001 atttttattt aggaactcag tcgtccatat gtccatcaat cttgaccgca atattataga
    15061 aataacgaat ccgtcatggt gaacaggctg gtaatcgagg cgatcaagag tcttgcgtgc
    15121 ccaagtatct cccaagattg gtttgggttg cgtggcatcg aaagctcgag ctcccagcgt
    15181 taggagcata gtttcctcca cgccgcgcag tccaactttg actttcccgg agtcagactg
    15241 actagccatg ataagcggag gaataagttg tcctgttgcg agtgatattc gtgtcagata
    15301 aaactcgcct tgccttatag gatggagaaa aaacaatagt gatctcctac caggacagcg
    15361 atttggagac caaagcgaat agagggtatt tatatgtgac acatcagcag gtttttactt
    15421 cgagataccg tctgaaggta ccgtggagcg gggagaacat caagcgaatt tattacagaa
    15481 ttctatttct ttagccgtgc aagattctag tttggcaact gtaacaccct cttccttcgg
    15541 cgggcgtagg gttatcagta acgataatat ataccctatc atgctgttca gatataggat
    15601 tgatagacag gtaatataag caaggggcta tatcatcagc catatgccga agtctaatac
    15661 agcggaaata ttaacaggct atgtcattga aatggcaccg tttatttagt tatacctgat
    15721 aaacaaatat ataggaaaca cttccccatt ccttctgaca ctatggtaga atgttgctta
    15781 ttcttgttga tcggctgcca gaatgtaaat agagctgtga gtgctgataa tattgaacga
    15841 gcattttaaa tgaattagtc acaacagctg agatttattt cctaccactg tacgttgagt
    15901 tcatcgtata cgcatagatg acttcgggga tttgcttcat agcaggagtc tggaattgat
    15961 tgccggaatt atggtggctt gtcgatctga agggcgttcg ttacgtttaa gagaaatatt
    16021 tctatttaaa taacgaatct ctcagaccta catcaactct gtccattatt catgtgtcga
    16081 cacatagttt gataagtcgt accctatgta acggcagtaa gaaagatcat ttcaacacaa
    16141 acgccgcatg tgagcgtttc ccgacattct aatgtactga tgcactgtgc caagtgttcg
    16201 ccgcaacgtc gtatctagcc gtggaaaggg agtagaaaag ggaaattata ggaattcaaa
    16261 tgtataacaa taaacgtgag ggttggaggt ttgacgtact ctgactggat gcatcagata
    16321 aatacatcaa tctggttctt ttgagctgac caccgcgata ccaatctcag aagtgacgac
    16381 gtccccccgt acggcgatga attccaacga tcttagatat gtatatcgag gtaagaaaac
    16441 caagcgcata ggtacatata ggacgactca ttaggccatc cgcaagccga tctgatatgt
    16501 atctagctta tttaaaattc gtagagatta ccgactatat actgcaacga gtaagtttct
    16561 atcaaatttg cgacaaaaac gcacaagcgc cgagattaat accgcttagg ctgattcgcc
    16621 cccagtggac cgcgtcaggc tttgaagatg cggagtttcg aactcggcta ccaaggcacc
    16681 gacgcaaccc tcactacaat ggattcgtgg ctttaggttg gtgcatcttc tcagtaggta
    16741 gcccaatgcg gctagcaaat tagttttcct tcgtataact ggtcgcggct aatctgggga
    16801 ttgtggtata ttccccacga ttgctagatg ctggtatatt gccgcgtacc tctccacatc
    16861 tgtccttttt cttctactcc tcgtctcctg tttctgtcgc tcttataatt tttgaaagaa
    16921 tatttgatga tagacccgga ggggagttca tgcaaactag cgacttccac tgaatgtcgg
    16981 actgttgaaa ggttttagtc aaatgcgtca cctacacaac gacatcgacc aaatcttagc
    17041 gacaagaaat ataatccaag cttctgatat ggagatcttg aactgacata gatggattat
    17101 cctgcgaggc ttgatgctaa tgcgttgaat gcactcaatt ttcaacagct ctctaactta
    17161 tcatcgcgaa ctggactatt aagagatagt gataaatacg cggccacgcc aatgaataac
    17221 caagaaactc tagcctcata tatctctgga gaattatcag agacgaagaa aggaacgatg
    17281 tattgatacc aaccggaaag gaatacactc taccattgtc cgtcttcgac aagtttgtgc
    17341 agattagact tccaatctta ggctacggga tacaatttta cacacacttt atgtattatc
    17401 gtagcgaagc agataatggc tttaacttga ttgcgaaaag taggttacca atcataccga
    17461 aactttcaag cagaaattga accgtcgtat gtttcatccc gtgcagcagc ccgaactaaa
    17521 tccttcgcaa gttttatgat aataagtgtc tcgaagtgcc gttctaatca cctgcaagac
    17581 agcttcttta tgtgttattc tgatctcatg atcggattcc gtcgggttca tgagtatagg
    17641 tgatgagaat agttgacata acaatcacca agtcatgaga aatcgttcgt agagtacaaa
    17701 cgtccatgta tgtcgtcttt atcttctata ctgtacctat atgcctgtca ccaccctaag
    17761 atgaagatac gaacacccgc taggtctata cgactgagcc atagattggg cgaatgacga
    17821 ttttttattt gagtcaggcc agcagtgtgt tctatgtcat cggcagccta caatctccac
    17881 ggtctagctg actgcgatca tgacagtagc gctctagtta taatgagctc gtttaaccat
    17941 ctgttatctg ttagtgaagc gtctcagagt gcactggtgt cccaaagctt ggcacataga
    18001 ttgtaagatt gcggttgggc ttggccctat tttttgttta caggcagtta aaggttgctt
    18061 gctaacttag tcctggctcg gggtttcaat gcccagtttt tttttcacac tattgatcac
    18121 ctcgaggagc ggttactgcg gggcgctaga agctagcact gtggggttcg agtggaagga
    18181 accatcggac cgtcaacagc aaggttttca gtgcaacata cgtggcgtgt gagaaagaca
    18241 atatggagaa ctcgttggaa tcagtaagat caccgagaat cgaccgtcta acgatttctg
    18301 cgcgcaaaat ccagattttc tggataaaat ggccccttcc agccatggcg agtgtaaggc
    18361 agaacgtaag gcagagaagt ccgccaatgt ttttagctca gtaatgccag ggtccgcatc
    18421 ctgataacgt ggggcagcct caggaacagc cctccccgca tggcgctaaa cttgtacagt
    18481 ggaaaaacgg ccctgaactt gtgaaagatc gatgatttgg agccctgtgg cgtaggatgg
    18541 agcggtccgc gctaccgaaa ctacggcgcc atctctggta tttaatgcct tataaactcc
    18601 gctggtaatg aatgacattt acctttgttg gtagtcacta cgaagagctt tcttgttaac
    18661 ctgccatccg gagtagcaca atgaaattat ttatattgct ttctctgacg ctctccgcag
    18721 gaaggactgg agcagaaatc ttcgactatg ttatcgttgg tgccggtact gcggggcttg
    18781 tcattgccaa tcggctttcg gaggaccctt ctaataccgt tgccgttatc gagccaggaa
    18841 cggatcaaag aacaaacccc aatgttactg attggtctag gtttactcag gcgtttggca
    18901 cttccatcga ctggcaatac cagacagtta aacagtcagg ggcagatggc agagtgctcg
    18961 acttacacca aggcaaagcg tggggtggaa ctagtactat caatggtagg cgccacgtcc
    19021 ttaacttcca cactgaaaag aagaattaat gtaacttcta ccaaggcatg gcttatatcc
    19081 gcggcgatct ggcacagttt gatgcttggg aaggtcttgg aaatccgggt tggaattggg
    19141 agtctctgtt tccttattac aaaaaatcgg aaatgtacac cgtgccgagt gatacacagc
    19201 tggcggcagg tgctacatat gagccacagt accatggttt caacggccac gttcacacgg
    19261 gatacccttc ggccctgatg aatggttctt tcgcgtctcc aattatccag acttgggaag
    19321 ggctgtctct gccacataat cccgatctga acagtggcag tgtccgcggg ttttcaatgg
    19381 gcccacagac tctagaccgc gcattagatg ttcggtggga ctcagccaga gcatattact
    19441 atccagttgg tacccgctcc aacttgagaa tcatcaaggg tacggtaaag aggatcaact
    19501 ggtcatctaa agagcacaag cggtctggat gcagtaacag tcttctagtt gctgatgagg
    19561 tggaattcct cgatgacaat ggggattcgc aaatcgtcgg tgttagaaaa gaagtaattg
    19621 tttcagcggg cgccgtgaga acaccacttg ttttggaata ttccggtatt gggaatccta
    19681 ggtaccattt gcgatcccac gcgttaagag tttagatatt gaagctcata tttcatagga
    19741 tacttgaggg cctcggaatc cagacccgcg tcgatctccc tggtgtagga gagaatctac
    19801 aggaacaacc caatcatgta ctcgcatata ttggctcaac cgaattgggt tcttcggcga
    19861 gcgcatacca tacatttatc tcactcagag acctcttcgg agatgatatt gatcagctac
    19921 aggagtctac tggggctaag ctgtcgtcat gggcccaagc tgccgttgag gcttccggaa
    19981 acggtgccct caatgtcacc gctgtaacaa aactactccg cgttcagcac aatcttctct
    20041 ttaagcagaa tgtcaccgca gcggaaatta ttaccgctgt agccccgacg ggaggaggct
    20101 tgctcgcatc taatttttgg atactcctgc cgttttcaag aggcagcgta catcttggct
    20161 ctatcgacca gattaacaag ccagtcattg atccaaggtt tttccttgca gaatttgatc
    20221 tggatgcgac tattgctctt ggaaaatatg ctcagaaatt ctggttctca gagccaattg
    20281 cttcatcggt gattgggccg ctcataccag gcgcggatat tcttccaaac aacgcaacca
    20341 gcgcgcaatg ggaaacttac attcgctcga caggtaagtc gacatataat ttttggctga
    20401 aagtgttgca gtcggtgtat aactatcaat cagaatatcg ctaacattcc atttcgccct
    20461 ttagtcggtg taaactccca tcccctgggc acggccgcta tgatgtccag ggagctcgga
    20521 ggtgttgttg atccacaatt aaaggtctac ggaacagcca atgtgcgagt tgtagatgca
    20581 tctgtttttc ctacacaatt tagtggccat ttaacggcta ctatatatgc tgttgctgag
    20641 cgagctgctg atatcatcaa gcaagctata tgatgcaggt cgttatgtga atcctcatct
    20701 aaactagaat ggtgtgtctg attgcgtcta agttttatta cctaatagcg ttgaatagaa
    20761 aataaataca ttggatcata attatttcaa gattttatga actcattaaa cgataactgt
    20821 tcaggccaca ggttgtttgg gtagtggtta gaaaatcgcg aaaaaaaacc gcctagatcg
    20881 agcgagtctc aaccaggcta ctttcacaaa cattagaatt tataaaaaat acttctaagc
    20941 cgaagaaact tggtgcatcc ggtactgaaa atgacctgtt ggcatgattg ctgtctttag
    21001 ttgtatcgaa ggatccatgc tgactcccgc gtaaacggaa tcggttcatt tagtatggaa
    21061 agttatgccc atttgccaag taacgccatt atgccagccc ctaaaaagag acagaagatc
    21121 atgaaggata tccgaatccg gtctcgagtt ctattgggat taaacagaaa gtctctcgcg
    21181 aggagttcga ctaatccggt gtagattagt attcctgctg agatggaatc aaggacacca
    21241 gacacaacgt ttgcggtgaa agatccactg tcgtacgatg tcgacagccc aataccaatg
    21301 gcgatagcaa taggagttgt cagtccgtaa gcaaggcaaa gaagccacgg caatgagttc
    21361 cagcgagtag ggaatgggat gacggagagt cgtgccccaa taccgagccc ctcaaaggcc
    21421 tgatgaaaga caacgacggg gtagagagtg gaaaattctt caccaacaac accgagatta
    21481 agaccgatga ttacagaatg aaaaatgaca ccaaactcga gaatgagaaa ggcggcaatt
    21541 tgttctgtga aggctctttc ggtggcggtc gaagtgccgg atagaatctc aagttcctcg
    21601 agatccatat acttctttgt cgatttgtac gaaccagctc ctctaagact cgcatgctca
    21661 acagattctg tctcctggct cggtacattc tcgcggctgt taatattgga aggctgtgac
    21721 ggtgcctcga tcgggccggt gccctgagtg acccgtctcg tggtttcacc tccatattta
    21781 gactcaacat accaatctgc gaggaagtcc agcagaaaga tgagcataac agaggtcatc
    21841 gctatcgctg gaggccagga gtattcagcc caggcaccgg tcattccgac acaggaagct
    21901 ggtccgatct catcgtaggc aggatcgagg agatgtatga acgcagtggc aataattaca
    21961 cctgcgccga agtaccttgc gaaaaggtag acgtataatg gtattttgat tgacttgact
    22021 cgtgtagcga taactgggaa tacagttgta gcggtcgaga caacaagaat gacaaacagg
    22081 gctgagatac gcgcccccag acggccgtcg taatcatttc caccggccgt taggtagcat
    22141 atgacttggg ttgggtcaac gtcgtcaaga ttgacatttg taggatcaaa gggctcgtcc
    22201 atggctgcaa tggcgaggaa atgaatagca cgacgctcgg taataggact ggcagaaggt
    22261 gctcaccaac caacgaagat attggtttga ggcgagttgg tggccgacga aatgttatgg
    22321 gataatatct tccatcctct taatcaacat cacagtgggc tttggtacat acttatatta
    22381 tactggagat ctcgtagatt agtcctgtgg ctaatgaatg aagaaaattt tccgcacctg
    22441 actcttaact atcccgtcat agcctaccga atcctcaatc tcacctgcag gaaagttttt
    22501 actggttaat acccatcaag tgagagaagc tgtattgaga cattaaggtt ggtcatcggt
    22561 taagtcggcc tattttcgaa tgtcatcatc ccaatatatg gagaaatatt cagtaagaga
    22621 ttgagccatc aaggttctcg ttgtcgtcag aggaaggggg atttgggatc tctcacacaa
    22681 tactcgagaa ccttgatggc tgtttgtttt gacatcatcc attcgcttgt tgactagatc
    22741 aaaactaagc gttagtttcc ttccattcct agttggtgtt cctagcgatt ggccggattc
    22801 ttatctttag gtaactcatg gctcgcccaa gagcgaatac aaccaatggc aaaacaagtt
    22861 cttcagcatt tcagtgggtt caggtagcag agacaggccc gtttaagatt acactgttct
    22921 ttaaaacaga acgagactct acacaaggat gagctggccg tagaggttct cattactgca
    22981 ttggtcaacg aattgagcta ggcattcttg gagccacagg aattattagg agataccaaa
    23041 tatattaaat tccaaaagaa gacggatgaa taattctaag agcaaataat actaactact
    23101 gttacgcaat ttcaccaaag ccttcttatc ttagatatcc gcgttttcct ccaccatacc
    23161 atcatttctc ttcacaatat catctatgac ctcttctccg tctgcccatt taaagggccc
    23221 aaaaaagttc gtttctacct tcagatcctc tttcaatccc agtactggga acaatctacc
    23281 acgcacgttc tcaaaagcaa aatcccattt cttaccgttt tgggtaaacc acaaaatatt
    23341 ctttgccaga tcaactccac aacccaccgt atcccctggc cagtatcgct ggtgattacc
    23401 agatttgata gcttgactgg ttcggttaga agacgcaaac atgccaccat cgtcggaatg
    23461 atacccccaa gatctgactc cagcggcgct ggaaggaggt gcccagcccg ggaaaacgat
    23521 gctactccca ccgaccgtag aaaagccaat agcaatgaga ggaggtgtgg cattcgccgt
    23581 ttgtttcgca gtggacggag attcatttcc aggagtagtc gatcccttga tggtgatttc
    23641 gaaatagtat ctttccagcc ctgaaggcag aggcttatca gtagtgatac acattctctc
    23701 gcgagacgta tgtgtcactg tgaggccatt ttccgaaatg cctgtgtttt gcgatgcagt
    23761 cttttcccat ctggatggaa gcataccggt ccaggcaaaa tattgcttaa gatacacctc
    23821 tgtatctgct tgcccgaacc tcatggccag atcaagtggt gtccaaccat atttgtcagg
    23881 cctattaagg tctacgccat gccttcgaag ctgcacaaga agttttttac tgccattcgc
    23941 agcacatatg gctgtgagct ctgcgtcatt ttttgctgca tcggggtcct tgtctataag
    24001 aattgacagg atttcctcga gttcatcagt agggtttagt gaccatctgt catatgcaag
    24061 cattagagct gttctacctt ccgcttcttt gagcttggta tctgctccgg cgtcaagaag
    24121 aagcttgaca acctctaggt gaccattcca tgcggcgcga tgcagagcgg ccatgcattt
    24181 cctcgtatct tggagatcaa gtgcgaggct ggaaagatct ggctcagatt tagcagcctc
    24241 aatcagccct ttcacaacat ctgtaaagcc gtgtgaagcg gcctggcgta gtggcgttcg
    24301 cttccggagc gtcggtttgt taatttccgc caaaggtaac ttaagttcaa gtagcttttc
    24361 aagcaggaag tttgctgtat cttctgaatc accgagacaa gcaaagaaaa acggtgttct
    24421 gtcgtgctta tcaacagcat ttgactgtgc actaatttcg atcagacatt ggacggtctc
    24481 cttgtaccca aaccaggcag cagagtgcat ggcagtgcga tttcgtttgt tagggtggcc
    24541 aggatttgcg cctgactgtg ccaaaaatct tacgacttcg gcatgtccct ccatcgctgc
    24601 ttgatgtaaa gctgtgtcac catcgccgtc ctcgtcgtcc atagcgtcaa tacccgcttc
    24661 tacaagcgtc tccacgagct tcatgtcgcc ccataggctt gctagttgta gagggcgagt
    24721 ggagtgacca ctttcctcgg cattgacatc tgctccatga gtgataaatg cctgcagaag
    24781 atcctgcggc acttctgagc ggcgaagaag atttaagagt ggcgtgcaac cctcattatt
    24841 tacagtgtta gtgtctccgc cctttgagac tagcaattct aatgcagcag tgtctgaccc
    24901 tctgctggca aagtgatgca gcgctgtcca accgaaactt ttgcttttga tggtgggatc
    24961 tgctccatgt tcgatcatta actgaacgat ctcaacacta ggatcttcaa tgagccaacg
    25021 gtggaatgcg ggatcgacct cgtccgtctc agcattaata tctccaccct tctcaagtag
    25081 caacttgagc atatcgaaat tgttcctcgc agccaacgaa gagtcccctg cgccaagagc
    25141 tgccacttgt agggcattga accggccaga caccacattg acatcctctc ctcgcttggt
    25201 gatgagatgt tctgcccagc tcacaagccc aaagtacgcc gcgacatgga ttggatgcct
    25261 tggctcgctt aggtaaaagt cgtagtaaga tggatcacca ataggtgtct ggaacttctt
    25321 ttgccaagca tcgaatatgc tccggttacc gtacacaaac ttgtctagtt cttcaaagag
    25381 agtggcccag gatttgctgt tagctctctc ttctggcgtc cacaagtcct cagctatccg
    25441 gatatggtat ggccaatatt gaatctcgta tcgaggattt tggtccacgg attgagcttg
    25501 gtcggaccag tcatcatcaa cattgttagt aaggcttctg tcttcgtcat ctctagaatc
    25561 gtctgagtca tatccatcat catctgtctt ttcctccaca acttctggcc cagtctcaac
    25621 aatagtatct ttagcattgt catcttgcat gtcagttgtc tcggctgcga ctgctccatt
    25681 ggtattagcc agattatcat cttcagcctc ctcattttgt ttcccaatat ttgtcacttg
    25741 gttcggtaca tcctcaggtt tggtttcctc tgttttgata tcctccggtt tggtaacttg
    25801 tataaggccg gcacgctgct ggaacagggg attatttaga tgctgtatgc atgtgattgc
    25861 aagctccaaa tggccttctc tctctgatat gtggagtgac tttttctcca gaatttccga
    25921 tttgcatcgg gcacacagta ccccctcacc atcttgatgc tcggtgttga acgactcgga
    25981 atcttggaag caatactctc tgacttgaat aagatcttct atatataagc acttgccgtc
    26041 tccaatccct agaagagaga aaaatggacc actagcttct ttgagctgct caatatccag
    26101 ctgtgaagga ggttgaaagt ccggcgtggg tacttcgatg ctgttggcgc cttgcaagat
    26161 gtcatatatt ccgttgaagt cttccatgac aacttctact ctaggccaca caacgcctag
    26221 aatcgcccaa gtcaatgctc ggtggagaag tctggcgtaa ttaggtccca ttttcctcaa
    26281 ttcctcgcta tacttgtctt tggtccccac ttcggggaga cttttaagat ggttctcaat
    26341 gggtcgttgg aaaggttctc gcatgaattt gatggccttg tctacatagg cgaaattgtt
    26401 acctgctttg tgttttatgg cctctcttgc gatttcttgt tcgtcagctg acaaccctgg
    26461 aacttcttta agctgaacag aaagctttat gtcgatatcg gagctgttcc aagagggcat
    26521 atcgatagta agtgaagatt gctcttcagg gtttccaatc tcaatgaatc tagaggaccc
    26581 aataatcatc ttcagcttgg cttttatatc ctttgaagag ccgaaaacct ctagaagctt
    26641 ggaaaggttt ttgattatcg cctcttggtc cttatttatg agtttgtcta tggcgtcgac
    26701 cacgacaagg gtgttaactt tgagcagatc agtgagcttt ttgaacgcgg ttgcaaagtc
    26761 tggtatgtaa tcttccttat ggccgggatg cggtgtctgt ctcatgctct tttccgtcgg
    26821 cttggtagtg ctcgctttcg gattctggaa gactttatta cacaactcca ggagattcgt
    26881 atcttgctgg tcctcatcgc gagccaggct atataactgg tatagaatcg tattccagat
    26941 gctgctagca ttgcgactgg cagtcccatc gggttctgta gcttccactg cggagaggtc
    27001 ttcccaggag acatataaca aaaccggttt ggttgcttct tcaagaacct tgtttgccac
    27061 aaccgacatc aatgttgtct tacccgttcc tatgacgata caaagataag tatcccaaga
    27121 ttaatataaa tctagaatat caaggatttg gacatacctt ctcctccggt aatgaacatg
    27181 aggctagcat tctgggtgtg ctgctgccaa gttgaataat agacgtcgaa cacccactga
    27241 tacgttccct ccagtctgcc ttcccctgat gctaaggtaa gaaattcttc accagaatct
    27301 ttcagtggtt tcagaacgcc cttattcttc acaaattctt gcacggcaat atcccatggg
    27361 gtctttggct tggcccacgc cttgatatcg tcgcgcaaac catcgaactt ctcatcgagc
    27421 tttgcctcca gctcgtctaa tttgtttaac tgctctttgt gcatacgctc cagctccggt
    27481 tgaaattcct tgatctgagc aactgtagat tggatatcac caataacatt ccgcatacct
    27541 tcaataccgt caagggctct ttcctgaaaa gcagcctcac agtccacaat aatcttttgc
    27601 ttgagtactg cgatagctgc aagttttgat tggaatttgt ctttttgtag cccaaaaaaa
    27661 tccttgattc catgccggat cttatctcga aaccccccac tcagatgccg cttgatggag
    27721 agggaaaagt caagcacagc gaagtacgcg tctttgatct caccaaaaag tttatcgacc
    27781 aaagcatttg gcttccatga ctgttgccta tcccgctcat catacaagcg gtcatagtgt
    27841 gggattatga tcatgatttc gctgatgtcg cttaatcctg acccaaaaaa gttatacaag
    27901 tcataattgt tttgaatcgc actcaaagtc aaccgcactg cataccatgc tagcccaaca
    27961 gattccggtg cgcctttggt ggcatagtca ccgagcttga tgaaattgcc gatattgcca
    28021 aggatattgt caatccagtt ctctgggatc tctgtatcac caacttttcg agatccatac
    28081 ttcttccccg cttcgccctt caaagccaat gcttgttgct gcgcatcttc aggagttccc
    28141 ttctctgcta ggaattcctt caggatctgg cggtctttag cgtccttgta gatctcttct
    28201 ttcttctgtg taaatttcgc gagagcctcg cgatatagat ttgactgggg cgccatggaa
    28261 aatatcgatc gtacagaacc agccagccaa gcaacatgac ccagagaatg ttcaagggct
    28321 ttatatttgg cctaggccgg gagctggaca taatgatcct tgcacgactt ggggtaattc
    28381 ggctattacg aaatcttctt ttggatgact gatcgagaaa catccaattc ttctccttca
    28441 gacccatgtc aatcaccctg gacaagtgtc aggattggcc ctcgtactct tatccaacct
    28501 cagctcgctt aatttgaccc cacccttctg cctgcctttg aaattgctgc ctggatgcac
    28561 cgtcgtaggg ctggcgatag tcaaatatat tagttgtcag atcttagcgt gcggcagctg
    28621 aagcggaaat ttattcaaga tggtgtgtga cccgaatatg tgagagcgca gaagttccat
    28681 catctcctgg caatgcttca taagaggttc ggcgctactc gaatcaaacc agtcggctta
    28741 tcgaagtgtc ccggggtggc atctgtgtct aactgcgaga atacttcttc acgtccgaca
    28801 taatagtaat attggaccga tctgaatggg ttttgtaggc agctcacctc agctggatgg
    28861 cccatcaact ccactgtgcc agagtgggtt cgcaaagcag atcaccgaat aactaaccga
    28921 ataacaattt aaaaaaaaaa ataaaaaaag ggacatttct ccatttctcc gttatatttt
    28981 attgtctgac accgttcaaa tagcagcatc atgctcccta gagctagccg cgcttcagga
    29041 gtatgaagca gccttaatct aatcttgctt catgtggcag aagtctgata tgcccgaagt
    29101 ccagggcggt ctgctagatc ttgttttcgt atagggagct actcttcact tcagctaccc
    29161 acagcggcca tggtttcgct gctcccgcta tagtagattt gccagaatca ctcgcctcgc
    29221 gatcgctaaa aaaatgcaat cccgcgcctg cactagctcc aagcatagtt gcctctcttt
    29281 gcacacgagc attttgagct gtataaatgc ccttagatat taccatttcg atagattcgc
    29341 cggtacatac gaagccgtgg ccacgcataa gagccacggg gtgcttggga agtccatttg
    29401 aaccaatttc aagtgcttcg gccagtgacg cgcccagctt ggtgcttcga accagcatgt
    29461 tgtgcgaaat gtcggggtca agatcttctc tatacacatt ggctgcatcc catactggta
    29521 cagctgtgcc aagaaatcca gccatgtgga aacaagcacg gagaggtgtc gctggggaaa
    29581 ttgagaaagg taccacatca agggaatgcg aatgaataac cgacataaca tttgggtatg
    29641 ccttatagat ctctgagtga atataccgct cagagaagcc tagttaagaa tttattagtc
    29701 aatagtgaat aatacaggac gaccttgaac tataaaagaa cgggtgatga gatgtaagat
    29761 tgaacggtga ggcatagcaa atcgtcttct cagcgtacct ctcggggcgt ttttttggat
    29821 tgcctctcca tccttgacat tatataatac aatatcatct ttcgatgaaa ctagcgcagg
    29881 agccatgtat cggcacatca ggaacgcaga atcagaaact cggaaggaga gatgcccgta
    29941 ggcatctaca atcccatgat agtgcaaaat atggcaccca tacacgtatt tccgaagcaa
    30001 c
//
