LOCUS       BGC0001777             25112 bp    DNA     linear   PLN 18-MAY-2018
DEFINITION  TPA_exp: Escovopsis weberi shearinine biosynthesis gene cluster,
            complete sequence.
ACCESSION   BGC0001777
VERSION     BGC0001777
KEYWORDS    .
SOURCE      Escovopsis weberi
  ORGANISM  Escovopsis weberi
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
            Escovopsis.
COMMENT     THIRD PARTY DATABASE: This TPA record uses data from
            DDBJ/EMBL/GenBank entry LGSR01000019.1.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 04:21:34
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..25112
                     /db_xref="taxon:150374"
                     /mol_type="genomic DNA"
                     /organism="Escovopsis weberi"
     misc_feature    1..25112
                     /note="shearinine biosynthesis gene cluster"
     cand_cluster    1..25112
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="terpene"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..25112
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001777"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25112
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="True"
                     /product="terpene"
                     /product="indole"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..18230
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[7239:8230]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7240..8230
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..18230
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     misc_feature    complement(join(101..111,198..764,842..1160))
                     /note="hypothetical protein 1"
     mRNA            complement(join(<2791..2797,3182..3420,3522..3889,
                     3957..4228,4310..>4596))
                     /gene="JanM"
                     /product="FAD-dependent monooxygenase"
     gene            complement(<2791..>4596)
                     /gene="JanM"
     CDS             complement(join(2791..2797,3182..3420,3522..3889,
                     3957..4228,4310..4596))
                     /codon_start=1
                     /gene="JanM"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 232.9; E-value: 1.2e-70)"
                     /gene_kind="other"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="DAB41644.1"
                     /transl_table=1
                     /translation="MATSFKVIIVGGSVAGLTLAHCLDRLGIAYEILEQGEIAPQLGAS
                     VGILPNGGRILDQLGIFETVESEIEPLQYAKIRYPDGFSFNSQYPSVLNTNFGYPLSFL
                     ERRRFLQILHEKLSGKHRIHTNKKVCRIDDDGCRAVVSTTDGTKYEADLVVGADGVHSV
                     VRSEIWRLANIKSPGAVTEKETSSLLLQYACVYGISHGVPFVEAGVQQSLLDSDLTIHL
                     FVGTESKVFWFLIVRIPDERWAQSRRFSSDEARQLCEGYASKSLGPDLVFGDLWSRQTI
                     FKMTPLEEGVFNYWNHGRLVCMGDAIRKMAPNIGQGANMAIEDAAILSSILSKANLRGN
                     DPTMKPELEDLLQEYVKMQHPRTKEVCDQSEFVVRMQSNSDMAKTILGRR"
     misc_feature    complement(join(5612..5828,6010..6530))
                     /note="integral membrane protein"
     protocluster    6963..25112
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[16962:18357]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16963..18357
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    6963..25112
                     /candidate_cluster_number="3"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     mRNA            join(<7240..7838,7912..>8230)
                     /gene="JanC"
                     /product="prenyl transferase"
     gene            <7240..>8230
                     /gene="JanC"
     CDS             join(7240..7838,7912..8230)
                     /codon_start=1
                     /gene="JanC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: fung_ggpps2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 93.5; E-value:
                     2.1e-28)"
                     /gene_kind="biosynthetic"
                     /product="prenyl transferase"
                     /protein_id="DAB41645.1"
                     /sec_met_domain="fung_ggpps2 (E-value: 1e-102, bitscore:
                     331.1, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MRMPSKPVDQYGYLKKRASGRAERDGFECPFEYVLNIYGKHHFAP
                     FVKAFQPSLASEDPAKYTLILDIMDAVHFALILVDDISDDSYQRKNHPTAHLIWGASET
                     ANRAYLVLTGVINRALHDQPVLGAELMKALEDILQGQDLSLVWRRDGLRSFPVDGEERL
                     AAYKKMAQLKTGTLFTLLGRLLNDGRDDMDDKLLRFGWYAQLQNDCKNIYSSEYAQHKG
                     AVAEDLRNGELSYPIVVALNDKSGRPIMEKALETRAEADIEAAMGALQTQPVRDACLKA
                     MQDAGVGLEKLVALWGRREKMQSS"
     misc_feature    complement(join(9261..9879,10063..10400))
                     /note="hypothetical protein 2"
     mRNA            complement(join(<10820..11247,11315..11492,11552..11780,
                     11836..12260,12323..12451,12515..12619,12688..>12798))
                     /gene="JanQ"
                     /product="cytochrome P450 monooxygenase"
     gene            complement(<10820..>12798)
                     /gene="JanQ"
     CDS             complement(join(10820..11247,11315..11492,11552..11780,
                     11836..12260,12323..12451,12515..12619,12688..12798))
                     /codon_start=1
                     /gene="JanQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 109; E-value: 4.6e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="DAB41646.1"
                     /sec_met_domain="p450 (E-value: 6.4e-37, bitscore: 115.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MALNGLVLDERSWPVIKFVGGALLFLMIYRYLDYRKVVDVPVVGP
                     GVRFTKWVAALRNVWCARKAIHEGYYKHRNFAFQIPTLTRMDIFLCDRQMTKEYYLQDE
                     EKMSFQSIINEEFQFDLLLPGLHPTAHKLPITVMSKALSFTKTRSSKPEDPFFSEFASE
                     SLFAFNEALKEYSKRVKTPNVKMPAAGTPYAKGDWISIPCFPLVLSVMTSLTIKALCGN
                     ILCRDKKFLKTSSTFGNAVPRDGMILRCFPAFTRKFFMKFLTAPRTIGSLRAMIHDEIV
                     MRRSCRDKNPLSDCLDYSLGWIDDHAAEGYNDWNVVDMMANTIFGALHSSSQLITHLVY
                     ELALRPEYVQPLRDEMEACFVEHGDRTKKALDSMLLMDSFMKETQRLYPLDSSALGRLV
                     LKPYTFSNGLHVPTGSVIYTPNSPLFEDERFYPDPQVFDGYRFSKMRDDPEKKTLAPFT
                     TASENSMHFGLGRHACPGRYMVADEIKLLLIYFLRNFDIAFADHGKRPGNVWFGKFMLP
                     DMTARVWLRQRNDTLEA"
     mRNA            join(<14641..14835,14894..15104,15179..15850,15915..16168,
                     16222..>16377)
                     /gene="JanP"
                     /product="cytochrome P450 monooxygenase"
     gene            <14641..>16377
                     /gene="JanP"
     CDS             join(14641..14835,14894..15104,15179..15850,15915..16168,
                     16222..16377)
                     /codon_start=1
                     /gene="JanP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 118; E-value: 8.8e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="cytochrome P450 monooxygenase"
                     /protein_id="DAB41647.1"
                     /sec_met_domain="p450 (E-value: 2.3e-39, bitscore: 124.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MILTAFSLQAPVILIGLLISYVVNRNRKKLSIPTMRVWPSFFPEF
                     LDRLSYASNAARLVDEGCAKHQDKPFRLLKPDMDLIVIPLRYATELRAVTNDKLDPLVA
                     AFDDNAGKLTNILLDSELHSDAIHRRLTPGLPKIIPQVVDELSWAWNSVIPNADDTWVP
                     LNSYGVVLDLATRAGARVFVSDPICRDEAFLQTCAGYSRNIFNTIETFRYIGQSLYGAI
                     LGTWSPTVRKALEQLAYVQKLLGEEVHRRRAHPEEKFDDFLQWCIDLARNEHESTPEAL
                     AQRTVGILAMAVVHTTAMAANHLLFDLIANPVLCEALRKEQQEILPGGWETISQKAMLE
                     MNLLDSLMRESQRFNPVGEFTFRRIVRKPIVLSDGYELKPGQQIGMAAKNLGMDRELLG
                     ATAETFEPTRWASEKLASGSFSHSSSSNLNFGLGRYACPGRFFASYMIKAIISRFLIEY
                     DFKLESGETTRPANMVQGDKIFPNRDAVILFRRRKVA"
     mRNA            join(<16963..17636,17725..18174,18240..>18357)
                     /gene="JanD"
                     /product="aromatic prenyl transferase"
     gene            <16963..>18357
                     /gene="JanD"
     CDS             join(16963..17636,17725..18174,18240..18357)
                     /codon_start=1
                     /gene="JanD"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /product="aromatic prenyl transferase"
                     /protein_id="DAB41648.1"
                     /sec_met_domain="dmat (E-value: 1.8e-99, bitscore: 322.3,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MADYDAERDSRDIEYWTKHTVPPIASLLRTAGYSPSDQEAQLATL
                     TQHVIPHLGPRPSKANSSSFMVAKGSPFQPQINVSAGKPMVRFSWEPMGLHGGSDRDPW
                     SVETTRHVVRYLSDKIGFSTAWLDAIIAAYAPDPAQYEAMSAILPGWMAGQLGVPEPPP
                     LKRIPFSFLAFDLKGSKAAVKVYLNPQVMELASGVPSTKIALDVLRTLKPAFDTSALDL
                     IDEFLTGRPGIGMTAFDCVEEGNLSSARVKIYLTTPTNSFNTAREYITLGGRINNATTK
                     KYLILLQRVWHLLLQDPEDRDDEYETPVLDNLKLYFSIELKPGMKVPEVKSYVPTWKYV
                     KSDKETVQNYQRIFREIGHPWGAEGRYQDIYEDAFGPADVKHAMSVHTDTSFIYSEDKG
                     CYQTLYFGADLDPE"
     mRNA            complement(join(<18854..18933,19029..19249,19315..>19724))
                     /product="endoglucanase-1"
     CDS             complement(join(18854..18933,19029..19249,19315..19724))
                     /codon_start=1
                     /product="endoglucanase-1"
                     /protein_id="DAB41649.1"
                     /transl_table=1
                     /translation="MKSSTVLAGLLPAALAQNTSCDQWASFSNEQYILSNDLWGQDAGE
                     GWGCITNDGLTSTSAAFHADWNWSGGQSNVKAFPSVQRVIPLGRRISSISSMPTEATWD
                     YTGSDIRADVAYDVFSSSVPTNPTWDGDFEIMLLGKFGDVGPLGSSQGTVTVAGRSWEL
                     FWGYNGAMQVYSFVAPTNINQFSGDFKNFFDFLSESKGVNFDDQYLLSYQFGSEPFTGD
                     CSKFTTSHWSAEVV"
     misc_feature    complement(join(20548..20568,20872..21849))
                     /note="hypothetical protein 4"
     misc_feature    complement(23015..25012)
                     /note="hypothetical protein 5"
ORIGIN
        1 ctcgtgacag atcttgcctc ctttcattgt gacgatgctg acgacgagga cttgcactcg
       61 cttgtttgtt ggtgggacgc tgggaagaat ccaaggcatc tcatgcgtat gcttgaagcg
      121 cacatggatc tcgtcgacta cccgagttgc accaatggtt cgagacagca atgtgagccg
      181 cagagacggg ggcgtaccga agaaatcggc gtagaacttc tccagctcgt cctcgccgat
      241 ccctcccgtc agcgtcggca gatacgtgac gtgaggattc tcccgcgtcg tgaaggagtc
      301 cattgttgcc gtcaggttgc ggctccagaa cttgccacgc aggctgtgct caacggcgag
      361 ctccaggttc tcgtggcggt tgaaggcctg cctggcagag gccagactgc ggctccaggc
      421 cagatctgcc gccacccggt catactcttc gagatcgtgc tctgaaaagc cggccttggc
      481 gtggtaggcg tagctcgagt aggccatgtt gagcaggcca cccgtgccga tgccgctatc
      541 gaccgtccct cggctgacgg tcagctttcc cttcatgccg tgcatctggc tcctctgtgt
      601 gatgttgatc ggttctccgg caatcagatg aaccaggacg ttgaggctgc tcggaaaccg
      661 gccttccgga tgggggatgg acgagggata gtaggcaatg agaaacgcaa gctgaaatcc
      721 cggattattg tcccagatgt ggtagtgctc gaggcaaagc gtagctgcat ctccgaatgc
      781 ttcaagacat tagcaaggcc tttgcgaaag gaaaaaaaaa gaatgaggag caagttcata
      841 ccgacgatgc cgaatgtctc gcaaggcccc ctctcgacct tgctcaggtc gcggagagca
      901 cggttgtagg cctctgtgtc gttgcccatg ggaaaatact cgacgtcgaa gccctcattg
      961 cgccagtctg ccaaggtctc gggatcgaag tcgtcatcct cggctgtcag gtaaatcttg
     1021 ggagccgccc gaggaaagtc gctcgccaga aagtgatgat cgcggtaatt gacattgcga
     1081 tcggagatga tcctcgctgt tctcccttcg gagtcccccg ggaccatgct tttaatcagc
     1141 tcgggcacgt cgacgttcat gatggcagtg atgtatcaga tagctgattg caaagaggac
     1201 agaagccata taccgtcact gtctgataga aaatacggtt ttttccaaaa gattgatgag
     1261 atttgctaaa attatcgaca gcgtgcgcgc gttaacgatc agtggcttcg tgcctgcggt
     1321 caatcaagct ccatggcctc gtgatatcga cgtcattcgc cacaaccatc gccagaatca
     1381 aggacagcta tagcaattag gccacgccct cctcttcatg gatggcattg aatcctcgat
     1441 tcaatctttg atgggtatta ccagaaatgc atgcatcagt acgcgttgat cttgcgatac
     1501 tttattgacg tccgctttaa tgaagctctt gggcactgac gatgcttcac ttgaaattgt
     1561 tgacattgaa atttcagatt gccatccaga ggtgacttgg tagctccttc caagttcaga
     1621 aaaaaaagtt gaaggaaaag tggtcaagaa tcatcagaga taacgacgta gggaaggcgc
     1681 ggccactgaa tccgagaatc aggaggtgct gccttcccaa aagatatctc gcctccaagt
     1741 aagggcggct ccttccagag caacggaacc attcgcgtgc aagtgctgca tcaggcaatt
     1801 gcttccttcc caacttgaaa gcacgcctgc ttccttccat aacagaaatc tctcacttcc
     1861 aggcacgatg actccttcca tcaaatgcca tgatgtccgg agagagggga aaataaaatc
     1921 gatcaattcc tctcctcctt ggactgtcct cggtctgaaa tctcccaaga tccccttctc
     1981 catgcacgac aatcgatcgc gatagacctc aagcgatctc tttcttccca ccgtcttttc
     2041 agtctcctga acattgcctg agcacaagac atccgcccaa aattcctagg tcgtcagctt
     2101 cttcttcgga aagcagctcc aatagggggt atgcatcttt ggcatccatc aagacttggt
     2161 cttacaacga aatcatgagg aaactgtttg aggaccccca cgtggaattt gagggggaaa
     2221 tctacagact ggtcctagac atgaggagtg gaccccaatt cccggaaaca cttgaagagc
     2281 tcaaggttag ttcagccctc gcctgcagcg aatctggcag tccacaacca actgagctgt
     2341 caccaacgga ccatcccaga gtcgtctttt tctcgtgcaa cgagctcagg gccacaatag
     2401 tcgcccaagg aggttatctc atgacccagg ggcatcgcag aatgatcata gattcgcgtg
     2461 gattgagtga gcctctgcgg ccgcgtttgg tgcgttgtgg caatagcaca tcgccgacat
     2521 gtgcccatgt cgtcgtttca ttcaagaggc aagtcttaac ccgccattgt ctcttattcg
     2581 acctccaaac tctttacctc ctgacctcaa gacacagtaa aagaactcga tttcgaccgc
     2641 ctgttcgacg gagatgacgc aactcaccaa agaaaatgtc tcaatccgat cacaaataaa
     2701 gagggaacgt gggaggcaga tccgtggagt cccacaaata tttagggagg ttaatttgtg
     2761 agaaaaagaa aattgaagaa agttgctgca tcaccgtctg gatggaacca cagttgcact
     2821 ggtattttgc cccggccagg aaactctgct gtttcaactc tgattcgaga aaataataac
     2881 cgccttttga accgattttg attgctggac tcgcgaagct tgagacgtct acttaaacat
     2941 cacaaacatg ttttccaaaa cacccatcca agccaagatc atcgcaagca ggcacgcata
     3001 tccactcatg ctcaccctcg gttgaaagca atccagatcc ttgaagaagc tcttccagga
     3061 accttgccat cctcctgtga gggatcggct tggcagctca agaaagtcga ggcggggcgc
     3121 ggacttgatg gaaaggccgg aaaggcctgc gggaacatcc ctaagaaaag gaaccaagta
     3181 ccgaccgagg atcgtcttgg ccatgtctga gttcgattgc atgcgcacca cgaactcgga
     3241 ctgatcgcag acctccttgg tccgcggatg ctgcatcttg acatactctt gcaagaggtc
     3301 ctcgagctcg ggtttcatgg tcggatcgtt gccgcgcagg ttcgccttcg aaaggatgct
     3361 agagagaatc gcagcgtctt caatggccat gttggcgcct tgcccaatgt tgggagccat
     3421 cttcagagta gggatcaatg gtcagtcacg tcggcatttg ggggtttgaa aaatctgaca
     3481 agcaaaacag gtacaaggcc ggtgccggta ggagcacata ccttgcggat cgcatcgccc
     3541 atgcatacca gccggccgtg attccagtag ttgaagactc cttcctccag cggcgtcatc
     3601 ttgaagatgg tctgtcgcga ccacagatcg ccgaacacga gatctgggcc gagcgatttt
     3661 gatgcgtatc cctcgcatag ctggcgcgct tcgtccgagg aaaatcgccg gctctgcgcc
     3721 catcgctcgt ccgggatcct cacaatgaga aaccagaaca ccttggactc ggtgccgacg
     3781 aagagatgga tcgtcaggtc cgaatccagc aggctttgtt ggacgccagc ctcgacaaaa
     3841 ggcactccgt gggatatgcc gtacacgcac gcatactgaa gtaagaggcc tgagaatcat
     3901 gcattgcatt agcatcgcgc tctcttgcgc ccctgacacg aatatgtagt actgactgga
     3961 cgtctccttc tccgtcacag cgccaggaga tttgatgttg gccagcctcc agatctcaga
     4021 tcgcacgacg ctatggacgc cgtctgcgcc gacgacaaga tctgcctcgt actttgtgcc
     4081 atctgtcgtg ctcaccaccg cgcgacagcc gtcgtcgtct atcctgcaca ccttcttgtt
     4141 ggtgtggata cggtgtttcc cactgagctt ttcgtggaga atctgcagaa accgccgcct
     4201 ctcgagaaac gatagagggt atccaaagct ttccgacagt caaatagtca gcctgcccga
     4261 caaagtcact ccctgaatcg gcacggacga acccatcatg gcaactcact tggtattaag
     4321 aacgcttggg tattggctgt tgaaggagaa gccatccgga tatctgatct tggcgtattg
     4381 caacggctcg atttcgctct caacagtctc gaatatgccc agctggtcga gaatccgccc
     4441 cccatttggc aatataccga ccgatgcacc cagctgggga gcaatctcgc cctgctctag
     4501 gatttcatac gcgatcccga gtctgtcgag gcaatgcgcc agcgtgagac ctgctactga
     4561 tcctcccacg atgatgactt tgaagctggt cgccatcact gacgatgagg tctgggcctc
     4621 aaggatttcc tcagcttgct tttctcgaat gggccacttt cttggtgtcg aatagtctgc
     4681 ttctactctg cctcttgctc agaacgcagg gtcgatcagg ataactcacc atgcggcaga
     4741 aggattcaga atcagcagag tacatctgac cgaagcatca tattcttgtc agggaagagg
     4801 gagaaggatt tgcggatctg cgccatcagc gccatctgct gattcctcgc ctgggcgcat
     4861 cccatgggaa gcctgaaagg cgctcgatac acacaaccaa ttacgtgaga ggcattcatt
     4921 gatgcatacg cctggatggc agctgaagaa accatggcat catcaggagg gaagacgaca
     4981 ccagcctcac tctcatcctt caggtctcga catgtgctcg tctaccgcac gataggggag
     5041 gccgatgagt tacattgatg gaagatggaa tatgcagccg tggacgcata gctgtgccca
     5101 gcagagaaac acaaggtttc gacatggttc acctcagagg cttcgcattg gcaagtatgg
     5161 tctcccgtgg tgatgatagt aatatgtaag agtcggagaa tattactcac atctgcatgc
     5221 acagaccaaa aaaaaccctg tcagacctgc atcgatgtcc tcaattctct tcaggtatga
     5281 tcgaaaagtc aatgccactg ccgcgctacc tggtcactct gtctcaagga gatcacacca
     5341 tgtctcagcc cagtgtgttc cctcctggtt attggtatcg agcgacacac tcagccagtc
     5401 catctatcct gaaatggaag agtcatccaa gcaatacata caatgtccag ggacagccca
     5461 ccaatgtccc gggatcacgg cagggcacgc ggcagatcaa tgcaagcgat gagtggacca
     5521 aacgagagat gattgggcgc acacaggcct tgcattgcat gatgccccct tcttgatgaa
     5581 gcgcctgcga gcgtccgccg tctccctcta ttcacatctt tttctgacgc ttttgctccg
     5641 aggccgctgc cgcctcattc caagacacgg catagagaca gatgccgtaa gtggtgtcga
     5701 gcaggacaaa ggtccccaag ctccagagaa caaggggcct ggacagccag ccaaacgcct
     5761 cgggccagta cttccatctc agatacgcga agcccaccgt gcagcaggac ccgacgaatc
     5821 gactcgacct ggaggcggta ttatctcagt gacaggtttt cgcccagcgg atcatccaat
     5881 gacgagctca cgtaatgtga gacgaccggc cttccagact ccctttcggc gtagggaagg
     5941 cacacaatgc tgggaaagcc ggaacgatga aagagagaga aagggggggg gggggcgaaa
     6001 tcaacatacc acagactcca cgacgtgccc ctggtgctgt tcctctgcag cagctggcac
     6061 aaccctccgc cgctgagcgt gagctggcag atgacagctc cccagttgta agcaaggccg
     6121 gggccgatct cctgggccag gcagacatgg cccaggaagc agacgagcgt cgtgatggac
     6181 aggatgaggg ccgtgtggtc cgccacgatg ggcgagtgag cccactccgt cttggccgcc
     6241 ctggtggcgg caaccatgat gaagacattg agcagggcgc cggcggcgaa gacaaagagc
     6301 tcgaccgggt tgacagacgg gtacacgagt gtgtacgcca gctcccacgc gatgttgcag
     6361 cagagcggca agatggccat gctgtatgtc ttgccctggt acgagtgcca gatcatggcg
     6421 acgtagttga tgatccagcc ggcgcccatc agcccgacga gggtgtctgc aatccatcgg
     6481 acctcgacgt actcgggcgg aggtggcggt agcttgacaa atccttccat tgtgctggaa
     6541 aggaaggggg ggggttcaag agagggcgaa aagggtggct gaggctctga ggattgccaa
     6601 ggcgtggaca atcgatccgt ctagatgctg cgtctgcaga gacgtcgagg gcaaggatct
     6661 ggatgacgac gacggcgata ctggtcccgg ggcggcctgt gggatcgggg tcgagagagc
     6721 cgaggataag cagcataaca cgagctgtgc agggagatgg aaaagtcacg acaaaacgtc
     6781 agccttttat atctggagag agcgcatgga ttggacccac gaccaattag tagtcatatc
     6841 ctgcagcgag gaccctacaa aaaccaatcc agtctcctgt cctgaaactt ttcgaacatt
     6901 ctcttcccca gtcctcgtcc tcagcctgac acagacgcct tcacacgcac acaccaacat
     6961 attatatcgg ggttgatcca acagacagac ctccaccgaa caggtagtag catctgcctc
     7021 cgcctctgcc tccgcctccg cctctgcctc tgcttccttt tcgatacttt gttcagacct
     7081 ctcaaagttc tcggtgaatg attggtcaaa atgatcattc cggttgtaca cctggttcaa
     7141 tggttctctg aacggctcgc cgtcagtgcc agcgcggtcc ttgtcctcgc cttctcgata
     7201 ggcttcctgt ccagggggtc gacctcatcc agaccaaaga tgcgcatgcc ctccaagccc
     7261 gtcgaccagt acggctatct caagaagagg gccagcggcc gcgccgagcg cgacggcttc
     7321 gagtgcccct ttgagtacgt cctcaacatc tacggcaagc accacttcgc ccccttcgtc
     7381 aaggcattcc agcccagcct cgcctcggag gacccggcca agtacactct catcctcgac
     7441 atcatggacg cggtgcactt tgcgctcatc ctcgtcgacg acatctcgga cgacagctac
     7501 cagcgcaaga accacccgac ggcgcacctc atctggggcg cgagcgagac ggccaatagg
     7561 gcgtacctgg tgctcacggg cgtcatcaac cgcgcgctcc acgaccagcc tgtgctcggc
     7621 gcggagctca tgaaggcgct cgaggatatc ctgcagggcc aggacctgtc gctcgtgtgg
     7681 cgccgcgacg ggctcaggtc gttcccggtc gatggcgagg agcggctcgc ggcgtacaag
     7741 aagatggcgc agctcaagac gggcacgctc ttcacgctcc tcgggcggct gctcaacgac
     7801 ggacgggacg acatggacga caagctgctc cggtttgggt aaatcccctt ctgcgccttg
     7861 atctgttgac cctgagatgc gacgcgcaag aatgctgacc cgtcttttta ggtggtacgc
     7921 ccagctccag aacgactgca agaacatcta ctcctccgag tacgcacagc ataagggcgc
     7981 cgtcgcggag gacctgcgca acggggagct gtcgtacccc atcgtcgtgg ccctcaacga
     8041 caagagtggc cgcccgatca tggagaaggc gctcgagacg cgggccgagg cggacatcga
     8101 ggcggccatg ggcgcgctgc agacgcagcc cgtgagggac gcgtgcttga aggcgatgca
     8161 ggatgcgggc gttgggctgg agaaactggt ggcgctctgg ggccggcggg agaagatgca
     8221 gagctcttga ggctgttggc tcccttttgg cttggtgatg gatatatctg tttcaacagc
     8281 atttcacatc atttctcttc cctttttttt ttcattctca tgagtgtaga gcaagactat
     8341 gaggaatcaa tggctacgac aatctgtgtc tgtgtttctc ttctgcttga gcagcattct
     8401 gcctccgact tcttgttcag atgggatgat cttcaagctc tgcaatgatc attcgagatt
     8461 ccgacatgtg attcatgtcg gcgtaaattg caagcttgga aacaaggggc tgagattggg
     8521 tcgttccgca tagacgtctc cctgctttga tacgacgttg cggacttgac gctgttgttg
     8581 aggcgcaaaa ctcctgcaac ctccactctg ttttttgcca gcgggcagct cccagattca
     8641 cccataatat ggacaatact catcttcttg tttaccgtct tgacaaagaa aagagaacga
     8701 atgcaagccg ttgtccactg ttgatgaatg aaatattcga tcgaatgcat cagttacatt
     8761 gatccgtgtg aacagactcc agggtagcca caacaagggg ggtgtaatgt tgacattctc
     8821 aggggtacgt ggaggagcca ggggttgtgc atcacgctta tgtatgtaca tgcactcatg
     8881 cattagacga ggcatgattc aggaacagtc agaagtaatt ttagacttct tttctagctc
     8941 tattgcttga ctgaagcctg aaaggtgtgg atatagccag acttactaca gatgcagatt
     9001 cagctagcac ggatgacgag gaagtggtag tggagtcaac acagacccaa cccatcacct
     9061 cattactttt gtatatgcat acgctgcaaa ttgcggagag taatgcacgg tggattctca
     9121 atgagatact ggagtagcga aaggctcgga tcagctgtct gtaatcagga gggcaagcat
     9181 atctattcgt acgggcataa tcatccttct cacccgacga gactgattca gatactgagc
     9241 ccccctcgct ctatgcctcc ctactcggcc tcaagcagcc agtcccgggc gagcagtaga
     9301 gacgcgcagc cggcggccgg accggcaacc agactgatca agaacatcca cagcaccgcc
     9361 tccaggctca cacgccggcc ctttgccgcc agcgcgtcgc agaacagccc cacggccgcg
     9421 aagaagccgc tcgacgtccc aaccatctcg tttatctgcc tgagccgggc gacccgcagc
     9481 atcgatgccc acggctcggc ccacggatcc gacgacccga tgcgggggct cggcggtact
     9541 ccggccaggc tgttcatgac gtggagggcg ttggcggcat gggggttgaa gagggtcggc
     9601 tcgacggtcg ccgagatggc gaggatccag agtccgatgt gtgcggcggt cgagccaagc
     9661 aggataaggc cgaggagcag cctgcggcct gcggagccgc ggggcactcc gcctccggga
     9721 actgtgctgg tttgtttcgc cttcttcgtg ttgtctggtg gcggtgcttc ttgtcgagat
     9781 gacggcaacc gatgcaaggc gaagaagatg atggatgtga ggggcatggc tgacgagagg
     9841 ccgatgacgg ggttcgcgag cacgagcaga gtgaccgttc taaacgggtg agcatgatca
     9901 gcgacccgtt gcagcgcccc tcgcgtgaga tcaaacacgg catgatgcaa gctgcagatc
     9961 ggaatttctc cgccaaggaa aggaagaaag ggaggcttcc aaagaaagaa gaaagaaaga
    10021 aaataagaaa gaacggaata tcaaggaacg gggtcgactt acacgagcgc cgcccatgcc
    10081 tttctctgat gcatcgactc catgaccatc atcgccacga ggggcgtgaa ctggctcacg
    10141 tacattgccc agtgcagggc gaccagcggc caggtgctca ccagggcggc tggcacgatg
    10201 ccctggacgt ccagggtcct gaccaaggcg gatgcccagg tccagtctcc cttctgtagt
    10261 ttttccgata gcatcctgta ctccgaggcg aggccgtggt ccgggaggtc gtacgccggg
    10321 aagttctcgt tgagcttcca ggcgatgccg gcgagggcga ggcccgcctg tatcaggggg
    10381 acgatgacgc ggtggaccat tgctgccgac tgccctcagc ttaacttagg ttgaatggaa
    10441 ggtaaatcaa agataaagaa atcaaggcag cgcgagatat cgaggggctt gggggaagac
    10501 ggggagcttt aagatggagg atgcctgcac tgtatgtaga cagaaagatg cgcatgatgg
    10561 atcatgtgtg ctgaaggatc aggtagtttg aatcatcaag ctccctgcat gaacgcgtgt
    10621 ctctgtcata aggagccgtt ctctaatgtc tctgacagag aagacgcgat cgtgtagccg
    10681 agtatctacg atgatcgtgt cttgcgatcg tcacggttga tcctcaattt gcattatagc
    10741 aagggccgag attctcgacg agaaagagcc caaaagacct gcattcagat gaactactaa
    10801 agacaacgcg cattcacaat cacgcctcaa gcgtgtcatt cctctgcctc aaccacaccc
    10861 gggctgtcat gtccggcagc ataaacttgc caaaccatac gttgcccggc ctcttcccgt
    10921 ggtccgcaaa cgcaatgtca aagttcctca ggaagtaaat gagcagcagc ttgatctcgt
    10981 cggcgaccat gtaccgcccg gggcacgcat ggcggccgag cccgaagtgc atgctgttct
    11041 cgctggcggt ggtaaagggc gcgagcgtct tcttttcagg atcgtcgcgc atcttggaga
    11101 agcggtagcc gtcaaagact tgcgggtccg ggtagaagcg ctcgtcctcg aagagagggg
    11161 agttgggcgt gtagatgacg ctgccagtgg ggacgtgcag gccgttggaa aaggtgtatg
    11221 gcttgaggac gaggcggccc agagcggcta cacagacttg gcgttagctt ttatgagaga
    11281 cttgggaagg ggaaacatca ggatcggaac ttacaagagt ccagggggta tagcctctga
    11341 gtctccttca tgaagctgtc catgaggagc atagaatcca aggccttctt tgtgcggtct
    11401 ccgtgctcta cgaagcacgc ctccatctcg tccctcagcg gctggacgta ttcaggacgc
    11461 agcgcgagct cgtagacgag gtgagtgatg agctttagat tgtcagatta gctgtaataa
    11521 aagagaggag ggggccaggg agaacacaga cctgactcga cgagtggaga gcgccaaaga
    11581 tggtgttggc catcatgtcg accacgttcc agtcgttgta gccctcagcg gcgtggtcat
    11641 cgatccagcc gagcgaatag tcgagacagt cgctcagcgg gtttttatcg cgacaggacc
    11701 tccgcatgac gatctcgtcg tggatcatgg cccgcaggct gccaatcgtt cttggagccg
    11761 tcaagaattt cataaagaat ctggccacag atattagctc cactaatcga cccaatgtat
    11821 caatggagcg ctcacttccg ggtgaaggcg ggaaagcagc gaagaatcat gccgtcacga
    11881 ggcacggcat ttccaaaggt ggaggatgtc ttgagaaact tcttgtccct gcagagaatg
    11941 ttgccgcaga gcgccttgat cgtcaggctc gtcatgacgc tcaagaccaa ggggaagcac
    12001 gggatcgaga tccagtcgcc cttggcgtac ggggtgcccg cggccggcat cttgacgttg
    12061 ggggtcttga cccgcttgct gtactccttg agggcctcgt taaaggcgaa gagggactcg
    12121 ctggcaaact cgctgaagaa ggggtcctcg ggcttgctgg agcgggtttt ggtgaagctg
    12181 agggccttgg acatgaccgt gatgggaagc ttgtgggcgg tcgggtgcag gccggggaga
    12241 agaagatcaa attggaattc ctggtttgat catttgcctt agtgtctctc agatcaccca
    12301 ttatcctggg cgggaataat acctcgttga tgatggattg gaaggacatc ttctcctcat
    12361 cttggaggta gtactccttg gtcatctgcc tgtcgcagag gaaaatgtcc atacgcgtga
    12421 gagtcggaat ctgaaaggca aagttccggt gctggtgccc gtgtcagtct ctgccgccat
    12481 gagatgtccg gaactgaatt caatgaggcc tcaccttgta gtatccctcg tggatggcct
    12541 ttcgagcgca ccacacgttc ctcagcgcgg ccacccattt cgtgaaccgg acgccgggac
    12601 cgacgacagg aacgtcaacc tgaatagatg aatgagaaat cagcttcttg gagatcaaga
    12661 tgcggttttt gggatggtgc cactcaccac tttccggtag tccagataac ggtagatcat
    12721 gaggaatagg agagcccctc cgacgaactt gatcacgggc catgatcgct catcaaggac
    12781 aagcccgttg agggccattg tcaacgtcat ggccgagttg gtagacgggc gccggatctc
    12841 ttgggataag gatagaccac aaaaaaatcg caaaaaggat gttcaagatg atatggaaac
    12901 taccagtctt cggccattac atagagccct gccgatatca gagatggcaa agggttattg
    12961 gtcgaagcac cccaggacgg aggggggcat ttagacactc aacagccagc aacaagcatt
    13021 gatccatgta ggtcatcttg cgtgttttga ttgctgccac gccccggtgc ctcgcctgtg
    13081 tgccggcatc ttgaggcctg tgccgctcag tcaggcacgc gcatcattcg tgcgcggcgt
    13141 gggccatgac ataagaagtc tcttctcatc ctggctgctt tcccaagaat cgttttcgat
    13201 gccacatgca ttcatgattc ccgatgatgg gccatgatcg gagtctcggc agggcctgga
    13261 attcgcgctg acagtgccac ttcgacctca aatccgatgg gatgagatca atgcatgtgt
    13321 cttgactggt gaaatccaac aggagatcac gaaagatcat gtaaatcata tcggtagata
    13381 aggcctcaat caagagcact gagatgaatg aagaccaccg atcttcggcg tgcattcctg
    13441 ctgcaaaagg cgctaggtct ggtctcacat aatgagacac cactgttgac ctcaagggca
    13501 gacaggggca tgggcgccga caagaggact ctgtagaccg agcagagtga aaggctcaga
    13561 tgcatctgcc gtatcttccc aagggcacca tcgagccgga cctaaaatca cgtaatagga
    13621 cctgtaagtc ggccgacctg tcggcagggc agcgctgtgc aaggatctgg atccctgcga
    13681 ctgatccaag ccatccggat gcagagcaac cgccaggggt agggccagtt gcaaagatat
    13741 caaggcttct ccgaggcctg tcgcagtccg tagccagcca tgatgctcgt atgtaagagc
    13801 caaaagaagg gtggccaatc gactatggcg aaatcttgtc tgttcttgat cgcacatctt
    13861 gatgggatcc acgacatgtc caattcgccg atcatctcat ctgccgcatc agggtcagca
    13921 ctctcattcg cgtggatgct ttcgagctga acatgatgcg gcgtcactga ttgcccggct
    13981 gcatggctcg tgggggcccc tttgactgac ctctgccatt gctggcgccc tccttgcaaa
    14041 agtctccagt cccccacatc cgcatcatgc aagacagggc atgcacgaac gccaacttac
    14101 tcagcttgca gatcatccac gagggcgcct gagcccagcc gattcgacgc cggagaggat
    14161 ggtcccgagt ctctgatcca gatatgcaga tatgcatccg agagcagatg aacactcgtt
    14221 gactagagca tctagagcat tcgcagatgc tcgccgcttg taccatgcaa atccgcttta
    14281 tctctggtcg tgtaaagagc agcagcagca gcagctccgg atcctctgca cgagatcctc
    14341 cgcagtggtt gactcagtcg agacgttctg agccagcatt cgtgtaaaaa tcttgtggac
    14401 catgccgtga agtcgagaag gtcggcaaga atatctccat tcgaaaggcc gatgctcgta
    14461 agatgcaagt ggtgacacca atatcttgaa tcgcccatcc tgctcctctg catctctcga
    14521 ttcctaccgt cctcctagtt ttttcgagag attccaattc cttcaccccc gatctggctc
    14581 ggcctctcaa tttagtagca ggaatcagca gctgatgccc gcccgcggag aagcctcatc
    14641 atgatcctga ccgcgttttc gctccaggcg ccggtcatcc tgatcggcct cctgatctcc
    14701 tatgtcgtca acaggaaccg caagaagctg tccatcccga caatgagggt atggccaagc
    14761 ttcttcccag agttccttga tcgcctcagc tatgcgagca atgccgcccg cctcgtggac
    14821 gagggatgtg ccaaggtcag tcgtttgttg ccttttcttc gagcccattt gaatcccatc
    14881 tgaccgtccc aagcatcaag acaagccgtt ccggctgctc aagccggaca tggacctgat
    14941 tgtcatcccg ctgagatatg cgacggagct gcgcgccgtg accaacgaca agctggatcc
    15001 gctcgtcgcg gcctttgacg acaacgccgg aaagctcacc aacatcctgc tcgacagcga
    15061 gctccactcg gatgccatcc acaggcgcct gaccccagga ttgcgtgagc gagaccctga
    15121 tcgatgctgt catgactgaa tatgtccatg tcttctaaca tgacccttcg cttcccagcc
    15181 aaaatcatcc cccaggtcgt ggacgagctg tcttgggcgt ggaattcggt catccccaac
    15241 gctgacgaca cctgggtgcc cctcaactcg tacggcgtcg tccttgacct cgccacccgc
    15301 gccggcgccc gcgtcttcgt ctccgacccc atctgccgtg acgaggcctt cctccagacc
    15361 tgcgccgggt acagccgcaa catcttcaac accatcgaga ccttccgcta catcggccag
    15421 tcactctacg gcgccatcct gggaacctgg tccccgaccg tccgcaaggc cctcgagcag
    15481 ctcgcgtacg tccagaagct gctcggcgag gaggtgcacc gccggcgcgc ccacccggag
    15541 gagaagtttg acgattttct tcaatggtgc atcgacctcg cgcgaaacga gcacgagtca
    15601 acgcccgagg cgcttgcgca gcgcaccgtg ggcatcctgg ccatggccgt ggtgcacacg
    15661 accgccatgg cggccaacca cctgctgttc gacctcatcg ccaaccctgt gctttgcgag
    15721 gcgctgagaa aggagcagca ggaaattctc ccgggcggtt gggagaccat cagccaaaag
    15781 gccatgctcg agatgaacct ccttgacagc ttaatgcgag agtcgcagcg cttcaaccct
    15841 gttggcgaat gtaagtccac atcgctgttg tgattctcgt gatcagcggc aagccaaggg
    15901 ctcacgatgt ccagtcacct tccggcgcat tgtcaggaaa cccatcgtcc tctccgacgg
    15961 gtacgagctc aagccgggcc agcagatcgg catggccgcc aagaacctcg gcatggacag
    16021 ggagctcctc ggcgcgacgg ccgagacctt tgagcccaca cgctgggcct cggagaagct
    16081 cgcctcggga tctttctcgc atagcagttc gtccaaccta aacttcggcc ttggccggta
    16141 cgcctgtccg ggacgcttct tcgcatcggt atgtttatct ggcggtccaa gtcgagtaac
    16201 ggaggtattg acagattgca gtacatgatc aaagccatca tcagccgctt cttgatcgag
    16261 tacgacttca agctcgaatc tggcgagacg acgcggccgg cgaacatggt acagggtgac
    16321 aagatcttcc ccaacagaga tgccgtaatt ctcttccgtc gtcgcaaagt tgcttgagag
    16381 tcgcattctg tatcatcaag atgtcggata gaggcaagaa tatttccctt ctcaaaggag
    16441 agagaactga agtagagtta attccgggaa atgatgatag attcggtgcc gtaattcatg
    16501 aagagcctgg aggttccaga cgacgcgtct gtatggatcc cagtctcatg cattggacca
    16561 tgaaggcatt cgagccctca agctggtggc tgtatggact ctgcattcaa gattggtatc
    16621 ctatcctaac aaagtgagaa ctcggccaac agggccctcc gaatcgtgga gcatggcctg
    16681 gttcaggtct cagctgagga gctgcatctt gcgtttttcc tgttccaaac tcgggaccat
    16741 ttttggtaca aggatagtaa tatccgatgt aatgtgataa tacgtggtac gaccagcgta
    16801 gtaatgagga gaccgagtcc gacttgattg aaatattcgc aactcccgct ccgcagtgtc
    16861 ttcttgtgat tcttccttgt gccaaacaag cttcgaagac ttttcaagag aatttgtgat
    16921 caaagagggt cgaagcctgc cttcaaagcc tccaagtccg caatggccga ttatgatgct
    16981 gaacgggatt ctcgcgatat cgagtactgg acgaagcaca ccgtgccgcc cattgcctcc
    17041 ctgctgagga ccgccggata ctccccctcc gatcaggaag cccagctcgc caccctcacg
    17101 cagcatgtca tcccgcatct cggcccgcga ccctccaagg cgaactcgtc gtccttcatg
    17161 gtcgccaagg gctccccgtt tcagccgcag atcaacgtca gcgcggggaa gcccatggtg
    17221 cgcttcagct gggagccgat gggcctccac ggcggcagcg accgcgaccc gtggagcgtg
    17281 gagacgacgc gccacgtcgt gcgctacctc tccgacaaga tcggcttcag cacggcgtgg
    17341 ctcgacgcca tcatcgcggc gtacgcgcca gaccccgcgc agtacgaggc catgtcggcc
    17401 atcttgccgg gctggatggc cgggcagctc ggtgtcccgg agccccctcc tctgaagaga
    17461 attccttttt ctttcttggc tttcgatctc aagggatcca aggcggccgt caaggtgtac
    17521 ctcaaccctc aggtcatgga gctggcgagc ggcgtgcctt cgaccaagat tgccctggac
    17581 gtgctgcgga cattgaagcc tgcgttcgac acgagtgccc tggacttgat tgatgagtat
    17641 gccatggacc atttgatatc ttgccttatt ctgcgcctgt tctttgcatg tgtcgagtgt
    17701 taaagagctg acgtcgggcc acagatttct gactggccgt ccgggcatcg gcatgacggc
    17761 gtttgactgc gtggaggaag gaaatctctc gagcgcgcga gtcaagatct acctgaccac
    17821 accgacgaac tcgttcaaca cggcccgcga gtacattacc cttggggggc gcatcaacaa
    17881 cgccaccacc aagaagtacc tcatcctgct tcaacgcgtc tggcatctcc tgctgcaaga
    17941 cccggaggac cgcgacgacg agtacgagac gcccgtgctg gataacctga agctgtactt
    18001 cagcattgag ctcaagcccg gcatgaaggt gcccgaggtc aagagctacg tcccgacgtg
    18061 gaagtacgtc aagagcgaca aggagacggt gcagaactac cagcgcatct ttcgagagat
    18121 cggccatccg tggggcgcgg aggggaggta tcaggacatc tatgaagacg ctttgtgagt
    18181 gacctcagca cgcaacggac acagacaacg gatactgaca ttctgatttt ccttctcagt
    18241 ggccctgcgg acgtgaagca cgccatgtct gtccacacgg acacgtcctt catctacagc
    18301 gaggacaagg ggtgttatca gactttgtat ttcggtgcgg acttggaccc ggagtagact
    18361 ttggttgtgg tcggggagga gaagctgaat cgaggaatct cggcggcggc aggcgtcgtg
    18421 tcatcttgat gaatgggaag acgttgaatt tctttttctg ttagtttttt tcgttgtttc
    18481 ttttggtgat ccagagatat tctgaaaatc agggaaagca cgataagagc caagtccttc
    18541 cttccctgat tgcgtagtcg tttctttctg gcaagagcca gtcgagtcca tgcctcctgc
    18601 cttcggacgg gcaaaatggg aggaatttcc cgatcaggca attccactcg gtctgacttc
    18661 aatgctggat ttgacctcaa tgttgatcaa tactccaact gccgagatcc cagacccggg
    18721 gccgggccgg ccagagcttg aaaagacctc ataacattcg attgacgctc tctctgtgtt
    18781 gcaagccgat tgcttgaagc tttcagtgtg tatttacatt ggaaatgcta tgtacaatat
    18841 atgagacagt cccctaaacc acctctgccg accagtgaga cgtggtgaac ttgctgcagt
    18901 cgcccgtgaa gggctcggaa ccgaactggt agcctgtaca cgagaatcag tacatgggtt
    18961 ccacggaatt ggaaaacatc cagagctgat agagggatcg gcgaggagga aggacaccag
    19021 ggacgtactc agcaggtact ggtcgtcgaa attgacgccc ttgctctcgg acaggaagtc
    19081 gaagaagttc ttgaagtctc cgctgaactg gttgatgttg gtcggcgcca cgaagctgta
    19141 cacctgcatt gcgccgttgt agccccagaa gagctcccag cttcgccctg cgaccgtgac
    19201 cgtcccctga gaggagccga gcgggcccac gtcgccaaac ttgccgagcc tgttggcatc
    19261 aattagtatt ctcattcatg agggagagag aggacttcgg gtcacacgtc ccacaacatt
    19321 atctcgaagt ccccgtccca ggtgggattc gtggggacgc tggaggagaa aacatcgtag
    19381 gccacgtccg cccggatgtc gctcccagtg tagtcccaag tcgcctccgt cggcatgctc
    19441 gagatggagc tgatccgtct tccgagagga atgacccgct gcacgctcgg aaaggccttg
    19501 acgttggact gcccgccgga ccagttccag tcggcgtgaa aggcggccga ggtcgaggtc
    19561 aggccgtcat tggtgatgca tccccagccc tcgccggcat cctggcccca gaggtcgttg
    19621 ctgaggatgt actgctcgtt ggagaagctg gcccactggt cgcaggaggt gttctgggca
    19681 agggcggctg ggagaagccc ggcgaggacg gtggacgact tcatctttgg gggccggagc
    19741 gggaaccgag gagaggtgat ttataaggag acttgatgat ttcgaggcgt tgttgtctgt
    19801 ctggttcttc ttttctgccc ccctttgact gacgaaactc gaggctgtcg actccccttt
    19861 tatacaccgt agacgacgct tcgatcgata tactcgttgc gaaaatggtt tcaccctcag
    19921 gcccagacgg cattgaaaca tccgccaaaa cctaattatc cgcaaacagc acagagtatc
    19981 tccgtccaga aaggccctta aatagcatcg cttcggcccg ggcctggagg gcatggggac
    20041 ccatccaaag acggcgagaa gggtcctctt tagccggcac cacggcggga tgactcgcat
    20101 gttggggaca aaaactccgc cggctctcgg tccaacgcgg acgccgtcga cgagcccctg
    20161 ggatggcgga tacaggtaga ttgccagcac accatctcgg gctggcaaat gaatgccgaa
    20221 gctcaaaggg acctctagcc cctgttcttc ccatgtccgg tcgaggagtc agatcctccg
    20281 tactccgagg tattcatatc gtgagactcg gctctcggtc gtgtttcctg ttgtggtctc
    20341 ggcaggaggg gcatataaac aagtccgtgt cctgactgtc acgtaatttt cgatcgatct
    20401 tcggattttc cgtcggctcg ggtcgggagt cgtcatctcc ggtcgtgagc tcgaggtatg
    20461 cacgctggta aggatcggct cgatatctgt tggagaaaat aaggtaggat actcgtcttg
    20521 aaaatagatc cataggacct caattctcta aataccctcg tcgaaacgct ttccaggaat
    20581 tagcaagctg taccagtagc aagacgtagg cgtatcaggc atcaacggat tggggaaagg
    20641 gattgaactc acctcccggg atcagagctg ccgagtacat caccctcgag atgggtctca
    20701 gcgcggcgat tgcttgatcc tcctcccgct cctcctcctg ctcttccacc acttcctcca
    20761 tctcttcccc actcccctcc cttcctcccc cgccccccct tcctcctctg cctcctcctc
    20821 ctcctcctcc tccgtatgcc gcctccccca atagcccagc agctcgccca cccacatcct
    20881 caaccgctcg tccgcctcca cgcacccgac gcccagacac agcccgaact cgcgaaacgc
    20941 cagcctcatc cgcgcgcccg ccgggtccct ctccccgagc aggatcagct gagggaccac
    21001 ctccgcggcc tgcagcagcg cgtcgccccg gtactcgtcc gcccacgacg cgccgtcctc
    21061 gtcgtcgcag aactggctca cccacaggcc catgcccagg tccagcgggt ccgcgctcgg
    21121 cgtgaagaag cggctgcgcg ccgtcaccgc ggcgtactcc tggatctcgc cgtacagcgt
    21181 gcggtcctgg cccttgccct tgcccttgcg ctgccgatgc gccgtgtctc gcagcagctt
    21241 gaacacggcg aaacccgtcg ccgcgtcgag gtggccctcc gagggcacca gcactgtctt
    21301 catgtcggtc gagaccttcc acaccatccg cggctggctc gccaccgtcg cgcgcgtcac
    21361 gaaccgcgcg tggatcgcct ccgccagctc gatcgccagg tcgttgtagc tccgctcgcc
    21421 cgaggccacc gacacccggt tgagcgcgaa catccacagc gtcaggtagt ggtggtactg
    21481 cccgtccccg tccatccccg acgccgacat cttgccgatc cgcagcccgc ccttgagcgg
    21541 ctcctcgtcc gtcgccccgt cgagccgccc ggacccgtcc cttttggagc ccaggatgtc
    21601 gtgcacggcg gtgaccagcc gtttcgccag gtggagatag cgctcgtcgg acgtctccgt
    21661 gtatagcgtg acaaagttga ccaccccgaa cgcgtcggtc cacaggtacc gcccgcggtg
    21721 gccgccggct ccaggattgc tcggcggcat ccattcggcc gtttgctcga gggtgaggct
    21781 gtcaaagggc ccgtacaccg tctccatggc cttgatgaaa cgcttgcggg cgtcggcatc
    21841 cggatccatt gtgtcggatt gagtgctgca cgccctcgtg atatcttcag gtcggccgat
    21901 ttcgctttcg tcttcctctt tttttttctt ttttttttcg tcttctttcc tttgtctgtt
    21961 cctcgggctc gtcgtgtgtg atggcacacc tgctttggag gatcgacagt atgacacagt
    22021 gagcctgggc atcgggtgac tcgattgtga gactgttgtg aaactgctac tatccgcgag
    22081 gtcaaccgaa cgtggcgcgg gaatgatgcc gagatgacgc gcaaccccga ccgagtcgat
    22141 ttctctcaca aatatcaatg gcatcaatct atgccttcag cggactccag ccttggagct
    22201 cggaagacgc tttaaccggg aaagcccgcg aaaacaggct caaaggaaaa taatatcaat
    22261 tctgatcttc acgtagtact ccgtaatcgc atcgagctct ccttcatctg cagggcaaaa
    22321 gcaaagtgcc aattccatac atggatggat tgatttgact gcatcgatgg aaccatcaac
    22381 tgcttctttg attacaaacg tcttctgttt gagacaacgt tcaatgtcca gtcacagggg
    22441 acaaacatct tgtatgcata gaatggaata gatcaattgc atgtattcga tcatctccct
    22501 tcaaagacta ctacctacta ctagtaatag gccttgactg attcccttga aataatcaat
    22561 gcatcgtgac aaattcatta gagagaacgg taggatggat attagaaaga atcggtaggt
    22621 agtcgcaagt tctgtgtagt tttgaaaaga catcaatgaa gatcttaagg agtgaattgg
    22681 taagaggaaa ttgacaaagg aatatcggcc tcgtgcggcc agggtatctc atcgtatcca
    22741 aaaagaaaaa tggaaaaaga aaagaaaaga aaagaaaaaa gaaagaaaat cgcgagcaat
    22801 gcttgcttag tatccaaaac aaaacgacgc cgtgggtgaa tcgcgctggc gtattacaca
    22861 acaaaatcag tatgatcaaa atcttttttt tccgtcttcc cttttttttt ccctcttcct
    22921 ctctctttcg ctcgttcaat actatgcaag tcgacaatgc gcagaagctt gcctcgccgg
    22981 atgccacggg cgatgtcatc tcagatcgtg aaaattaggc attaccctcc tctgctcccg
    23041 tagtgttgtc gcagagattc tccgacagag cgtttcgatc gaccgtctcg gtgatggtcg
    23101 cagacggggc ctcgtctcgt ttctgggtct tccaatactt ggagaacccg ggaatggctc
    23161 cgggctggtt gttgccatga gctcgatgcg gatcatggac ctcgcggcgc acgaatctgg
    23221 cggcgggact cgagctcccg ccccagagtc tccagccggt ccaggctcca agacccccgg
    23281 cacccccacg gggtgtctgt gaggtgattg cctcggcaga caaggtggaa gacagcttcg
    23341 acacctggaa atgagcaaac tgattgcgca gggcggcatc gctcaggcgg gagcgagttc
    23401 gtgccaaggt cggctcggca ttcacgccgg aaacaacggc gacggcgtcg gcgctgcctt
    23461 gggacctcag cgtgatctgg ccaggggagg ccaccagcgc agacatgtcg agaccacccg
    23521 ccagcgacat cgagtattcg tgggtgttgc tgcggtggaa tgaggggcgg atcgggcccg
    23581 attccgactc gtcctccgtc tcgtcctccg tctgtgagag atccagctcg tcggcgaggg
    23641 ccatcttggc cctcaaggat gagtggtgaa tcgacctgag cgtctcggag agatggtcct
    23701 cctcatcttc ctcacggatg gtggcgctgg cccatcggcg atgggaatag tgggcatgtg
    23761 tccgagcgga ttcgctatca gccagggatt ggaggctcga agaagatgcc tctgaagcgc
    23821 gctttttgtg agaggcccgc cacgtcggag agatggggtc gtagctggtc gagggcgaaa
    23881 ctggtcgatc ggcgtctggc accacctggt cgaagtagcc gcgagagctt gactgcgggg
    23941 agccaatgac cgaagagacg gccgaggaat gggaggagta ctcggcccag catccggagg
    24001 ccacgggcat ggaagggttg caggggatct cgttgcatga gcgtgatgat gagccggcag
    24061 gggtggacac agagcgccat tcgttcgacg aggacgagac tgccggggtg gatgacgggc
    24121 gaagcggtga ggtcggggga taggatccga gcgttgaatg gcgcttcttg cccgaccctc
    24181 gggtgtcttg cttcaagtgg cagtggtggt gactgcgcat ttcctgcgag agtttcgggg
    24241 aatccatcag aggttcaagc tctgccttga tggcagagga aatagcggcc ttttcgccct
    24301 gcgagactgg ctggtggaat agaagctgtt cgcgcaagga ttggatttcg tcgttggagt
    24361 tgaagagcat ctcccgaagc tcggcgatgg cgagctgcag ggtggcgttg tcctgtagga
    24421 gatccttgac gaagttgccg acagtcttgc tgcttgcctg ccttctgtgc ttcttgtgtg
    24481 tgggcggttt ggatgcagcg gcgcccttga ggcgctgagc ggcagcattg agctgtttct
    24541 caacctcgcg ctggcggccc atcttctcga ccgtctcggc gtggcgctcg cgttcctggc
    24601 gagcctccct ctccatgcgg tccagctgat cctgcatgtc gaggatgccg cgctgcgcct
    24661 ccttgaagcg gtaagcatga gagcgcgcct cctccctaga ggactggagc tcgccctgga
    24721 gcctttcctg ttcctctaca agctccttga ggtgacgctc agcatcaacg gctcgagaag
    24781 cagtgccctc gaggtgaacg agggcttgct gggaggagag gagcgtggcc tccagtgttt
    24841 tgatctttgc gtcggcgtcg aagacggtgt tgttgagaga ctcgagctgg tcgatcaagg
    24901 cgaggttgtc ctggaccttg agggaatttt gggtctcgag ctcttccttg tccagctcga
    24961 gccgttctat acgggcgttg agtcgcatgc ggtcgcgctc ggcttcggcc atgtatgctt
    25021 catgtctcga aagaagggcc tggatgatat taattagctt gccgaaggca cagaagtcat
    25081 gtcgaggacg gaacaaaaaa ggaagacgga tc
//
