BGC0001780: siphonazole biosynthetic gene cluster from Herpetosiphon sp. B060
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Location: 1 - 52,640 nt. (total: 52,640 nt).
This entry is originally from NCBI GenBank KX765816.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001780
Short description siphonazole biosynthetic gene cluster from Herpetosiphon sp. B060
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KX765816.1
via
Compounds
  • siphonazole
Species Herpetosiphon sp. B060 [taxonomy]
References
Chemical products information
siphonazole Evidence:
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C25H25N3O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ARR97034.1
 1420 - 3708 (+) SphA
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    • ARR97035.1
    		 3717 - 4382 (+) SphB
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      • ARR97036.1
      		 4997 - 21352 (+) SphC
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        • ARR97037.1
        		 21288 - 27557 (+) SphD
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          • ARR97038.1
          		 27909 - 35990 (+) SphE
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            • ARR97039.1
            		 35875 - 42054 (+) SphF
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              • ARR97040.1
              		 42247 - 45807 (+) SphG
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                • ARR97041.1
                		 46127 - 49813 (+) SphH
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                  • ARR97042.1
                  		 49832 - 50878 (+) SphI
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                    • ARR97043.1
                    		 50889 - 51620 (+) SphJ
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      ARR97036.1
                      Substrates
                      3,4-dihydroxybenzoic acid (evidence: ATP-PPi exchange assay, Structure-based inference)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk02
                      Type
                      nrps-type1
                      Genes
                      ARR97036.1
                      Substrates
                      threonine (evidence: Sequence-based prediction, Structure-based inference)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk03
                      Type
                      nrps-type1
                      Genes
                      ARR97038.1
                      Substrates
                      threonine (evidence: Sequence-based prediction, Structure-based inference)
                      Integrated Monomers
                      Domains
                      adenylation
                      Name
                      Unk04
                      Type
                      nrps-type1
                      Genes
                      ARR97039.1
                      Substrates
                      glycine (evidence: Sequence-based prediction, Structure-based inference)
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2018-08-06
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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