BGC0001785 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001785 (Streptomyces spectabilis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	95,304	streptovaricin	PKS	100%

BGC0001785 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 95,304 nt. (total: 95,304 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 95,305
Label		BGC0001785

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001785	1.48	Polyketide	streptovaricin	Streptomyces spectabilis
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002229	0.61	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0001068	0.60	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000122	0.59	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0002138	0.59	Polyketide	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0000129	0.59	Polyketide	pyripyropene A	Aspergillus fumigatus Af293

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001785	1.00	Polyketide	streptovaricin	Streptomyces spectabilis
BGC0000122	0.67	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002406	0.66	Other	hydroxycinnamoyltyramine	Oryza sativa Japonica Group
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001163	0.64	Polyketide	1-heptadecene	Moorea producens 3L
BGC0002229	0.64	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 414 - 95304:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - mal - Me-ohmal) + (Me-ccmal - Me-ccmal) + (Me-ccmal - Me-ccmal) + (Me-ccmal) + (ccmal - Me-ccmal)
Non-colinear ordering:: stvA + stvB + stvC + stvD + stvE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

stvA

CAL_domain (1..303): pk

minowa: AHBA

Prediction, score:

AHBA: 347.9
shikimic_acid: 200.7
Acetyl-CoA: 12.9
fatty_acid: 0.0
NH2: 0.0

PKS_AT (1467..1766): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.0
Ethylmalonyl-CoA: 207.1
Methoxymalonyl-CoA: 167.2
2-Methylbutyryl-CoA: 140.9
trans-1,2-CPDA: 118.0
Propionyl-CoA: 104.5
CHC-CoA: 100.6
Malonyl-CoA: 99.2
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 53.7
Acetyl-CoA: 37.0
fatty_acid: 32.7
inactive: 17.5
3-Methylbutyryl-CoA: 16.2

PKS_AT (3148..3450): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.1
inactive: 102.5
Methoxymalonyl-CoA: 72.5
Methylmalonyl-CoA: 53.9
Propionyl-CoA: 37.3
Isobutyryl-CoA: 30.0
Acetyl-CoA: 17.5
Benzoyl-CoA: 17.0
CHC-CoA: 16.0
Ethylmalonyl-CoA: 12.2
2-Methylbutyryl-CoA: 7.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4470..4768): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 203.8
Ethylmalonyl-CoA: 192.3
Methoxymalonyl-CoA: 164.0
2-Methylbutyryl-CoA: 122.1
trans-1,2-CPDA: 108.5
Propionyl-CoA: 100.7
Malonyl-CoA: 86.3
CHC-CoA: 82.8
Isobutyryl-CoA: 75.2
Benzoyl-CoA: 54.5
Acetyl-CoA: 38.2
fatty_acid: 35.3
inactive: 19.2
3-Methylbutyryl-CoA: 14.9

stvB

PKS_AT (564..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.4
Ethylmalonyl-CoA: 198.8
Methoxymalonyl-CoA: 173.1
2-Methylbutyryl-CoA: 130.3
trans-1,2-CPDA: 124.8
Propionyl-CoA: 102.2
Malonyl-CoA: 101.0
CHC-CoA: 92.1
Isobutyryl-CoA: 84.5
Benzoyl-CoA: 60.1
Acetyl-CoA: 40.3
fatty_acid: 33.0
inactive: 16.2
3-Methylbutyryl-CoA: 12.3

PKS_AT (2295..2594): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.8
Ethylmalonyl-CoA: 208.2
Methoxymalonyl-CoA: 162.0
2-Methylbutyryl-CoA: 124.8
trans-1,2-CPDA: 118.8
Propionyl-CoA: 98.7
Malonyl-CoA: 97.4
CHC-CoA: 85.9
Isobutyryl-CoA: 80.2
Benzoyl-CoA: 60.7
fatty_acid: 32.9
Acetyl-CoA: 32.9
inactive: 19.4
3-Methylbutyryl-CoA: 14.4

stvC

PKS_AT (512..811): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.3
Ethylmalonyl-CoA: 206.5
Methoxymalonyl-CoA: 162.9
2-Methylbutyryl-CoA: 123.4
trans-1,2-CPDA: 121.9
Propionyl-CoA: 98.3
Malonyl-CoA: 96.0
CHC-CoA: 91.4
Isobutyryl-CoA: 77.3
Benzoyl-CoA: 56.9
fatty_acid: 40.5
Acetyl-CoA: 34.1
inactive: 18.7
3-Methylbutyryl-CoA: 17.4

PKS_AT (2269..2567): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.4
Ethylmalonyl-CoA: 208.3
Methoxymalonyl-CoA: 171.3
2-Methylbutyryl-CoA: 127.2
trans-1,2-CPDA: 119.3
Malonyl-CoA: 101.6
Propionyl-CoA: 100.4
CHC-CoA: 90.0
Isobutyryl-CoA: 89.1
Benzoyl-CoA: 66.8
fatty_acid: 48.5
Acetyl-CoA: 41.7
inactive: 23.1
3-Methylbutyryl-CoA: 19.8

stvD

PKS_AT (571..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.3
Ethylmalonyl-CoA: 198.1
Methoxymalonyl-CoA: 160.3
2-Methylbutyryl-CoA: 120.9
trans-1,2-CPDA: 114.3
Malonyl-CoA: 101.4
Propionyl-CoA: 94.0
CHC-CoA: 83.3
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 62.4
Acetyl-CoA: 33.4
fatty_acid: 33.1
inactive: 22.9
3-Methylbutyryl-CoA: 19.1

stvE

PKS_AT (569..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.1
inactive: 110.2
Methoxymalonyl-CoA: 80.2
Methylmalonyl-CoA: 63.7
Ethylmalonyl-CoA: 44.2
Propionyl-CoA: 42.1
fatty_acid: 30.6
Isobutyryl-CoA: 28.2
CHC-CoA: 26.9
trans-1,2-CPDA: 24.5
Acetyl-CoA: 22.0
Benzoyl-CoA: 19.7
2-Methylbutyryl-CoA: 18.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (2321..2619): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.9
Ethylmalonyl-CoA: 207.1
Methoxymalonyl-CoA: 163.5
2-Methylbutyryl-CoA: 132.2
trans-1,2-CPDA: 118.1
Propionyl-CoA: 102.3
Malonyl-CoA: 94.1
CHC-CoA: 91.7
Isobutyryl-CoA: 70.3
Benzoyl-CoA: 51.8
Acetyl-CoA: 35.0
fatty_acid: 31.5
inactive: 17.5
3-Methylbutyryl-CoA: 13.8