BGC0001785: streptovaricin biosynthetic gene cluster from Streptomyces spectabilis
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Location: 1 - 95,304 nt. (total: 95,304 nt).
This entry is originally from NCBI GenBank KY593296.1.

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core biosynthetic genes
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001785
Short description streptovaricin biosynthetic gene cluster from Streptomyces spectabilis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KY593296.1
via
Compounds
  • streptovaricin
Species Streptomyces spectabilis [taxonomy]
References
Chemical products information
streptovaricin Evidence:
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C40H51N1O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ASZ00129.1
  • stvA1
 348 - 707 (+) acetyltransferase
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    • ASZ00130.1
    		 740 - 1354 (+) arylsulfatase
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      • ASZ00131.1
      		 1380 - 1703 (+) hypothetical protein
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        • ASZ00132.1
        		 1722 - 3161 (-) 6-phosphogluconate dehydrogenase
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          • ASZ00133.1
          		 3335 - 4306 (+) acetyl xylan esterase
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            • ASZ00134.1
            		 4428 - 5765 (+) peptidase
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              • ASZ00135.1
              		 5854 - 7074 (-) membrane protein
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                • ASZ00136.1
                		 7347 - 8063 (+) ferric iron reductase
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                  • ASZ00137.1
                  		 8239 - 9288 (+) glycosyl transferase
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                    • ASZ00138.1
                    		 9379 - 10599 (+) glucose-1-phosphate adenylyltransferase
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                      • ASZ00139.1
                      • stvO1
                      		 10846 - 11814 (+) NADH-dependent dehydrogenase
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                        • ASZ00140.1
                        • stvO2
                        		 11823 - 12806 (+) oxidoreductase
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                          • ASZ00141.1
                          • stvO3
                          		 12889 - 13452 (+) NADPH-dependent reductase
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                            • ASZ00142.1
                            • stvP1
                            		 13481 - 14773 (+) cytochrome P450
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                              • ASZ00143.1
                              • stvM1
                              		 15159 - 15767 (+) type 11 methyltransferase
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                                • ASZ00144.1
                                • stvP2
                                		 15800 - 17005 (+) cytochrome P450
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                                  • ASZ00145.1
                                  • stvA2
                                  		 17106 - 18275 (-) acyltransferase PapA5
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                                    • ASZ00146.1
                                    • stvP3
                                    		 18765 - 19958 (+) cytochrome P450
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                                      • ASZ00147.1
                                      • stvA
                                      		 20415 - 37088 (+) polyketide synthase
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                                        • ASZ00148.1
                                        • stvB
                                        		 37120 - 47883 (+) polyketide synthase
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                                          • ASZ00149.1
                                          • stvC
                                          		 48086 - 58798 (+) polyketide synthase
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                                            • ASZ00150.1
                                            • stvD
                                            		 58958 - 64522 (+) polyketide synthase
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                                              • ASZ00151.1
                                              • stvE
                                              		 64592 - 75304 (+) polyketide synthase
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                                                • ASZ00152.1
                                                • stvF
                                                		 75408 - 76202 (+) amide synthase
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                                                  • ASZ00153.1
                                                  • stvG
                                                  		 76251 - 77324 (+) 3-dehydroquinate synthase
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                                                    • ASZ00154.1
                                                    • stvH
                                                    		 77495 - 78649 (+) NAHP synthase
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                                                      • ASZ00155.1
                                                      • stvI
                                                      		 78657 - 79469 (+) shikimate dehydrogenase
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                                                        • ASZ00156.1
                                                        • stvK
                                                        		 79685 - 80845 (+) AHBA synthase
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                                                          • ASZ00157.1
                                                          • stvL
                                                          		 81127 - 81942 (+) oxidoreductase
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                                                            • ASZ00158.1
                                                            • stvM
                                                            		 82095 - 82679 (+) phosphoglycolate phosphatase
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                                                              • ASZ00159.1
                                                              • stvN
                                                              		 82699 - 83652 (+) AHBA kinase
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                                                                • ASZ00160.1
                                                                • stvP4
                                                                		 83977 - 85221 (+) cytochrome P450
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                                                                  • ASZ00161.1
                                                                  • stvO4
                                                                  		 85273 - 86934 (-) 3-(3-hydroxyphenyl)propionate hydroxylase
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                                                                    • ASZ00162.1
                                                                    • stvP5
                                                                    		 87228 - 88481 (+) cytochrome P450
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                                                                      • ASZ00163.1
                                                                      • stvM2
                                                                      		 88593 - 89660 (-) SAM-dependent methyltransferase
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                                                                        • ASZ00164.1
                                                                        • stvM3
                                                                        		 89737 - 90540 (-) type 11 methyltransferase
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                                                                          • ASZ00165.1
                                                                          		 90785 - 90982 (-) ferredoxin
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                                                                            • ASZ00166.1
                                                                            • stvR1
                                                                            		 91314 - 92612 (-) LuxR family transcriptional regulator
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                                                                              • ASZ00167.1
                                                                              		 92941 - 93300 (+) hypothetical protein
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                                                                                • ASZ00168.1
                                                                                • stvR2
                                                                                		 93785 - 94414 (+) putative OmpR family two component response regulator
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                                                                                  • ASZ00169.1
                                                                                  • stvJ
                                                                                  		 94424 - 94975 (-) aminodehydroquinate dehydratase
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                                                                                    Biosynthesis information
                                                                                    Annotation changelog

                                                                                    Entry version: 4

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 3

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Updated bioactivity data
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Migrated from v1.4
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2018-08-06
                                                                                    Submitted
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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