LOCUS       BGC0001787             13318 bp    DNA     linear   BCT 10-OCT-2016
DEFINITION  Streptococcus suis strain 3908 lantibiotic gene cluster, complete
            sequence.
ACCESSION   BGC0001787
VERSION     BGC0001787
KEYWORDS    .
SOURCE      Streptococcus suis
  ORGANISM  Streptococcus suis
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:17:45
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13318
                     /db_xref="taxon:1307"
                     /mol_type="genomic DNA"
                     /organism="Streptococcus suis"
                     /strain="3908"
     misc_feature    1..13318
                     /note="lantibiotic gene cluster"
     protocluster    1..13318
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2665:5170]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2666..5170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..13318
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13318
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001787"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13318
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             423..602
                     /gene="allorf_00423_00602"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_00423_00602"
                     /protein_id="allorf_00423_00602"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEALRHCPEKWKAHPTGKHAPGGGYLSLYYQRELRQLSLADTGEQ
                     AQVYHSDNXLKRSC"
     CDS_motif       423..575
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MEALRHCPEKWKAHPTGKHAPGGGYLSLYYQRELRQLSLADTGEQAQVYHS"
                     /locus_tag="allorf_00423_00602_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       576..602
                     /prepeptide="core"
                     /locus_tag="allorf_00423_00602_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.30"
                     /molecular_weight="816.9"
                     /monoisotopic_mass="816.4"
                     /core_sequence="DNXLKRSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEALRHCPEKWKAHPTGKHAPGGGYLSLYYQRELRQLSLAD
                     TGEQAQVYHS"
                     /leader_location="[422:575](+)"
     gene            2409..2582
                     /gene="suiA"
     CDS             2409..2582
                     /codon_start=1
                     /gene="suiA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="suicin 3908 precursor"
                     /protein_id="AOT85879.1"
                     /sec_met_domain="L_biotic_A (E-value: 2.3e-11, bitscore:
                     32.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNIKPEIYVQTATDQEITLLIGGAGSGFVKTLTKDCPGFLSNVC
                     VNIGFISGCKNC"
     CDS_motif       2409..2480
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MNNIKPEIYVQTATDQEITLLIGG"
                     /locus_tag="suiA_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2481..2582
                     /prepeptide="core"
                     /locus_tag="suiA_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.00"
                     /molecular_weight="3290.8"
                     /monoisotopic_mass="3288.6"
                     /core_sequence="AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNIKPEIYVQTATDQEITLLIGG"
                     /leader_location="[2408:2480](+)"
                     /alternative_weights="3308.9"
     gene            2666..5170
                     /gene="suiM"
     CDS             2666..5170
                     /codon_start=1
                     /gene="suiM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     371.9; E-value: 1.1e-112)"
                     /gene_kind="biosynthetic"
                     /note="involved in lantibiotic modification"
                     /product="synthetase"
                     /protein_id="AOT85880.1"
                     /sec_met_domain="DUF4135 (E-value: 2.7e-51, bitscore:
                     164.1, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.6e-25, bitscore:
                     76.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTINITEEKSFDIVISKVIEEFSFSTSKFSEVCSFSDSIINSFKE
                     EFRKILLPVLVQEINLFRIGKGTNSKYSEYNEFCKNILNNGLYFLDKYPVLKRRLNLLK
                     ENYEISIECFLKNLTKNYNEIIENFDLRQENISVKILSMVGDNHGSNRNISFELQNKSF
                     FYKTSGYTLYPILNELNCRVFDSKYFKFPDTFIGSNFMIQEKIDNLSCHDKSQIHSFYR
                     NMGVLLAFTYVLNGNDMHNENIIACKEHPYVIDFETLINPVSQIEGRISQSIFSTGLLP
                     MKYRRNFDGIFDCSSIGQVNIVVKKVFEEINPFSSELRLELTEHQFNDIKEFLPLLHES
                     HISANKFLGDIESGFIFGYSRLRSCYKIIKTVVLRYKNALLCRLVLRNTSVYSALIDRI
                     TVPDLLMDELKTRNVLTSFLKEIPVISSHEKKYIMLEVEQLVNGEVPLFTFGNFGNVSR
                     NDTKYLMSLYDSVNFKLNCMSDEDLQYQLNLLRVCLNIDNYNFSKLRNNHLELDVKKLV
                     RESIFNVTRPYALTLQKDSSGNYIYGESNLGLYEGKLGLLLSYDELEEIFDLKVIEQEI
                     INSKDIGLINGYASLLLYKNLNNSLNKDDYLLHDIDFTEFDIIDGLGGLILQSYLIFLK
                     KPELVDVVELKKLGEVFLELTKNQEQFKVGFAHGFTGIKVIYKICSLISPDNSEFMNRF
                     EYFESQDNVSLYPSSGWCNGLTGYLVSEYILYKISNDSRYLDKVLYNIDYLMNKLCETE
                     EYCLCHGFLGGLDFLQVLNQDNLLSNEHKKRLEILEKTLIFKSNHNNILKKDISLFTGI
                     SGFLYYLKRKKTLRGSVITLGF"
     gene            5182..7251
                     /gene="suiT"
     CDS             5182..7251
                     /codon_start=1
                     /gene="suiT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 130.2; E-value:
                     1.6e-39)"
                     /gene_kind="transport"
                     /product="ABC transporter"
                     /protein_id="AOT85881.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.1e-34, bitscore:
                     106.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIREKLQSQQNDCGPCCLAMILDYLGRDVELSELYKYKNTAVG
                     WSMGDIKNVAKQFGVDATVFRIVNMKGMSSILLPAILYWDFSHFVVLEKYNELEVTILD
                     PNYGRKTLNKDTFIKFFSGYCMELRPNQSFTKRKSSLRDKVSKIRNTKIWNLKFGKVYP
                     TVLVGYNILLLIIPVLISKLINELSTRDININQVIILIGVIWLTTGLNYILEKFRNQKT
                     IILEEKSTVNIYEKLFSLTESEICRYHSGDIMSRISVNPQICRFLAVEVPNMIISIMLI
                     FFASLYLILNTGIYACMLILLLLLIAIINCIFITILMKLSKNESYKRSILRSVANDGIL
                     SYNFLIGSGITYRYLKKIKSSLSDYVQSQIDRGIVEAKSITFQQATSTFFSLLISIMSL
                     VIVLLNPERSGEIALISSMAMILYSPTMGIVSSLINMANLYPNIERLVDLVGEEQIPKT
                     FTKIQNGTVNVDGLSYRYDDASTYLFKNLSFSLKEGDTLFITGKSGTGKTSLVKILLGL
                     QSISGEGNEGNIIIGGVNLLDQNLDLRRDICYISHPSILFKGTLKSNLKLFCPNYTIEE
                     LMLAIDKANLSDIFPHALNIENLFILENGTNFSTGQRQRIGMLRLFLQEYKVIILDEPT
                     SNMDSENAKAIMAAINALESTKIIITHDNELIQPGSKQLELGVGENGYTYKSYK"
     gene            7223..8137
                     /gene="suiF"
     CDS             7223..8137
                     /codon_start=1
                     /gene="suiF"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 175.6; E-value:
                     2.2e-53)"
                     /gene_kind="transport"
                     /product="immunity protein"
                     /protein_id="AOT85882.1"
                     /transl_table=11
                     /translation="MDIHINHISKKYGNRIILNDVTIRIPSGKIYGFIGANGAGKTTTM
                     KILTGLLPATKGNIYFDGVSLNDLKNQESIIGAFISTPSYYKNLTAYENLAIIQEVLKK
                     PQEEIDRVLNLVGLSEVRNKVVSSFSFGMKQRLGLAFAFLNNPDVLVLDEPTNGLDPKG
                     IVEIRELLYRLAKEEGKTIFISSHHISEIETIADMVGIIHDGELIFEGTLSELYNKRDS
                     SYLFEVANPDVFEHILRVRDISFIRKESHFEINSYKKDIPNLIKLIVQEGIDILEVSPN
                     KNLERIFLDLTKGDKVYGHIDKK"
     gene            8115..8834
                     /gene="suiE"
     CDS             8115..8834
                     /codon_start=1
                     /gene="suiE"
                     /product="immunity protein"
                     /protein_id="AOT85883.1"
                     /transl_table=11
                     /translation="MVTLIKNEIKRFVGTPTALLLLGITFCLQMLGTVFIIKSLDVQVG
                     DIAQTPFQKSMIIFLGFSGLVSLVVNGITNFFVTSSEHNNHTWELLLLGIGKKNKILFS
                     KYFTVILSFIFYQLLSTIFFVIVTQTYLSLTIDWSTVFLVLSSTIFFSLLTITLQFCAH
                     LLEKNSLSALSSVIILILLQTLFASNAIFIYVFPINGISYLITSSILNPIIILVITLEN
                     IIWSGAVLLVVFKKFHL"
     gene            8844..9539
                     /gene="suiG"
     CDS             8844..9539
                     /codon_start=1
                     /gene="suiG"
                     /product="immunity protein"
                     /protein_id="AOT85884.1"
                     /transl_table=11
                     /translation="MWKLELLKYKRTYLAPVFIGIGMFLVIFQSYAGYTIKEIPSKVLF
                     VTGLDLYSNFLLPVMIPVFLIISLHREVENTAFQNLTIKGISSQQIKWSIVKFYWIVMP
                     ILFLCHFLIPLIFISLRGESALNVIIDNSLFLLLSILSIIALINISLLIHQSSGNYVLP
                     ILTAIVGVVVGRFPLGEITWIVNPYSYLSYLANFKSFTVTHYLAFFLVFSLSFIGIILC
                     KKKIDLSKT"
     gene            9536..11044
                     /gene="suiK"
     CDS             9536..11044
                     /codon_start=1
                     /gene="suiK"
                     /gene_functions="regulatory (smcogs) SMCOG1048:sensor
                     histidine kinase (Score: 67; E-value: 2.6e-20)"
                     /gene_kind="regulatory"
                     /product="sensor histidine kinase"
                     /protein_id="AOT85885.1"
                     /transl_table=11
                     /translation="MRRNLLSTAYYALFITGLIYLSAKCFLNNIENILFLLALNVLLLL
                     DFILHRAISTRSKISKFIIWLIRLCQCHSILFVIGDSAFPPWIQYMIGIIIYSSLISIS
                     LSLFFQKLQTSFYLFVMIVGLLSSVSLLFPRLTSIAFSLYLVVTFAMALLIVLLRNKQT
                     FYRNDSNRFYWLMLLIFYLMICFSSIGFIFFNSSALFSGFWLFYFLALITGLILILFYH
                     NDAVFKQREQLLTLIFLILLYIVLFILILKRTSLVVLETVTIILYFQYFFQLVGESYRL
                     ITGSKQSEHVGINSILKEEALKQEFANFLHDNILQDINALIQLSRLDNPSVSVKIIEER
                     LEYLNTFVRERMNQYSPQLLKGLSLYDNYRMMLKAFEKRYPKMNISLNFYSEKNIAIYP
                     PYDFLIYRWLRELVNNAYKYSNAQTVTVKLARDGRELSLSVMDNGYYQKLKPFKHGHGL
                     LVLEEQVKSVGGTITFEQADSNGLRVDIKLMMEGEKAIENFINR"
     gene            11022..11621
                     /gene="suiR"
     CDS             11022..11621
                     /codon_start=1
                     /gene="suiR"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 79.5; E-value:
                     3.5e-24)"
                     /gene_kind="regulatory"
                     /product="response regulator"
                     /protein_id="AOT85886.1"
                     /transl_table=11
                     /translation="MKILLIDDHILFAESLALTIHQYQPDIHIDILNNEDEFKSIFSKV
                     IEYQVILLDINLDNKFSTDGFGIAQDILEEYPDSKIALLTGFDLPVYEYQAQKIGVKAF
                     VPKNISSKRLIQILKDISYGKNYFPNQNYFIDELTEREKEILIHLGNGEKRKDIAKFLY
                     ISDRTLTNHIQNILEKLEVDSTLKAVIKAQKLGYIK"
     gene            11688..11843
                     /gene="suiI"
     CDS             11688..11843
                     /codon_start=1
                     /gene="suiI"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /product="immunity protein"
                     /protein_id="AOT85887.1"
                     /transl_table=11
                     /translation="MKKVIPYALLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCS
                     LKFRKQ"
     CDS_motif       11688..11711
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MKKVIPYA"
                     /locus_tag="suiI_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       11712..11843
                     /prepeptide="core"
                     /locus_tag="suiI_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.90"
                     /molecular_weight="5054.2"
                     /monoisotopic_mass="5050.9"
                     /core_sequence="LLTLSMFFLFNAIRIFLESRSLYVVDVLLFIVFLVCSLKFRKQ
                     "
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKVIPYA"
                     /leader_location="[11687:11711](+)"
                     /alternative_weights="5072.2"
                     /alternative_weights="5090.2"
                     /alternative_weights="5108.2"
                     /alternative_weights="5126.3"
     CDS             12434..12583
                     /gene="allorf_12434_12583"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="allorf_12434_12583"
                     /protein_id="allorf_12434_12583"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRFGVFRDERHFSDCHLFTGFTLKKTSLGFNIVGISLIFRIDTVD
                     LCWK"
     CDS_motif       12434..12472
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MRFGVFRDERHFS"
                     /locus_tag="allorf_12434_12583_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12473..12583
                     /prepeptide="core"
                     /locus_tag="allorf_12434_12583_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="3994.7"
                     /monoisotopic_mass="3992.2"
                     /core_sequence="DCHLFTGFTLKKTSLGFNIVGISLIFRIDTVDLCWK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRFGVFRDERHFS"
                     /leader_location="[12433:12472](+)"
                     /alternative_weights="4012.7"
                     /alternative_weights="4030.7"
                     /alternative_weights="4048.8"
                     /alternative_weights="4066.8"
ORIGIN
        1 aacatgttaa agataactgg agaagccaga aaactagcca ttgacatgcg tctcattgat
       61 cctgcttaca ccttgtctga caatcagaag attcttcaag tagtggacaa tgtggaacgc
      121 atttaccgtg agggagaaaa tgagaaagca acccagatga ttttctcaga tattggaacg
      181 cctaagagta aggaagaggg ctttgatgtt tacaatgagt tgaaaaacct tttagtagat
      241 agaggcattc caaaagaaga aattgccttt gtccatgatg ccaatactga tgagaanaaa
      301 aactctctct cacgaaaggt caatagtggg gaagtacgga ttctcatggc ttctacggaa
      361 aaaggtggaa cgggtctaaa cgtgcaatca cgtatgaaag ctgtccatca tttagatgtt
      421 ccttggaggc cctcagacat tgtccagaga aatggaaggc tcatccgaca gggaaacatg
      481 caccaggagg tggatattta tcactatatt accaaaggga gcttcgacaa ttatctctgg
      541 cagacacagg agaacaagct caagtatatc actcagataa tganctcaaa agatcctgtt
      601 agatcagctg aagacattga tgaacaaact atgacggctt ctgactttaa ggccttggcc
      661 actggtaatc cctaccttaa gctcaaaatg gaattggaaa atgaactgac agttttagaa
      721 aatcaaaaac gagcctttaa tcgctccaaa gatgagtatc gccataccat ttcctatagt
      781 gagaagcacc tccctattat ggaaaaacgg ttgagtcaat atgataaaga tattgcccaa
      841 tctttggtaa caaagtcgca agattttgtc atgcgatttg acaatcaagc aatggataat
      901 cgtgctgaag ctggggacta tctgcgaaaa ctcattacct ataaccgctc agaaaccaag
      961 gaagtcagaa cacttgccaa ctttagagga tttgatttga aaatgactac acgaggtcct
     1021 agtgagccct taccagaaac catttcttta atggttgtag gtgataacca gtatactgtc
     1081 gcccttgatt tgaaatcaga cgtgggaacc attcaacgga ttagcaatgc cattgaccat
     1141 atcatggatg accaagaaaa gacgcaagag ctggtaaaga atttaaagga taagctacga
     1201 gtagccaaag tagaagttga aaaagtcttt cccaaggaag aagattatca acttgtaaag
     1261 gctaagtatg acgttttggc tcccttggtt gaaaaagaag cagagattga agtgatagat
     1321 gcagctttgg ccaagtttag tgaagagaca acagcccaaa tgaagcaaca aatagcactc
     1381 gagatataag aaaaaaggct gacaaatatt tttgaacgcg gtaaaatgaa gtcaagaaat
     1441 cacaaaagga gaatagatca tgacccaaac actagaagaa atgcgttatc aacttgaaga
     1501 atggttggca caaggctata caagtccaga agatagggca aactaccaaa ctttaaagga
     1561 acagtatgaa gatgaaactc ttgattatag cttttcaagg cgtgaaatca ctggacagct
     1621 ggaactcatc atcacaagtc gtgagaatga ttttccaaac ttagatgagg tgacgaaggc
     1681 agaatacctt gatttggttg cccaacttga tgatttagac aagagacagg ctgactatta
     1741 tcgcaagcaa ttagcctaga aagaggtgta agatgttgga gcaatttcta caaagccttt
     1801 tgattatcgc agcaatagga ctgatgttgc tcgtccttta tcggattgtg aaagtttcag
     1861 gtgctttgtt tcttatcgga ctcatcagcg gcttagtctt tattgaaatc tatggaatct
     1921 acctcttctt tacggaaagg tatctctata cagaagattt agccaccaat ggtatttgga
     1981 gttttactgg tttttatatt gcctttaata actttctctt gtttataatt actataaaaa
     2041 tcttaaaaat agagcaacct aaatcttagg attatcagga atgtgtgaat tgatattcct
     2101 agtgattggt ttgagatatt atttgttttt ttcaatacac atagaagaaa gtcaatgtga
     2161 actgatattt caagataaag tacagttcag aatagatgaa cttgagaagc aaaaagcaaa
     2221 atttaataag aggaataaag agaactaata atttagtttg caggtttatt ttctcgtttc
     2281 gttattttta ggatttgtac catagagttt tgcctttttt actcatgttt tacatcacta
     2341 atcgatttat aataatctta tagggaaaca tagttacaaa tatttaatta ttcaaggagg
     2401 aatttataat gaataatatt aaaccagaaa tctatgttca aactgcaact gatcaagaaa
     2461 ttacattatt aattggtggt gctggtagtg ggtttgttaa gactctaact aaagactgtc
     2521 caggcttttt atcaaatgtt tgcgtaaata ttggattcat ctctggatgc aaaaattgtt
     2581 aaaataaaaa ttagtttgta actatgtatg tcctatcgcc ataattgata ggacatttcc
     2641 ttttatttta ctagaggtaa catctatgac aattaatatt acagaggaaa aaagttttga
     2701 tatagtaatt tcaaaggtaa tagaggaatt ttctttctcc acttcaaaat ttagtgaagt
     2761 gtgctctttt tctgatagca ttattaatag ttttaaggaa gagtttagaa aaatactgct
     2821 tcctgtattg gtccaagaaa taaatttatt taggataggg aaaggaacca attcaaaata
     2881 tagtgaatac aatgaatttt gtaaaaatat tcttaataac ggtttgtatt ttcttgataa
     2941 atatccagtt ttaaaaagaa gattgaatct tttaaaagaa aattatgaaa ttagcattga
     3001 atgttttttg aaaaatttaa ccaagaatta taatgaaatt atagaaaatt ttgatctaag
     3061 gcaagaaaat ataagtgtaa aaatattatc aatggtggga gacaatcacg gtagtaatag
     3121 gaatatcagc tttgaacttc aaaataaatc atttttttat aagacttcag gatacacttt
     3181 gtatccaatt ttgaatgaat taaattgtag agtattcgat tctaagtatt tcaaatttcc
     3241 tgatacattc attggtagca attttatgat ccaagagaag attgacaatt tgtcctgcca
     3301 tgataaaagt caaatccatt cattttatag aaatatggga gtacttttgg catttacgta
     3361 tgtgttgaat ggaaatgata tgcacaatga aaatattatt gcttgtaaag aacatcccta
     3421 tgtgattgat tttgaaactt taataaatcc tgtgtcacaa atagagggaa gaatttcaca
     3481 aagcatcttt tcaactggct tactcccaat gaaatataga cgaaattttg atggaatatt
     3541 tgactgtagc agtataggtc aagtaaatat agttgtaaaa aaagtttttg aagaaattaa
     3601 cccgtttagt tcggaattac gattggaatt gacagaacac caatttaatg atatcaaaga
     3661 attcttacct ttactccatg aatctcatat ttctgctaat aaatttttag gtgatattga
     3721 atctggattc atatttggtt attcaagatt gagaagttgt tataagatta taaaaacagt
     3781 ggtcttaagg tataaaaatg ccttactatg tagattggtc ttaagaaata catctgtata
     3841 ttcagcactt attgatcgaa ttactgtgcc agatttatta atggatgagc taaaaacaag
     3901 aaatgtttta acaagcttct taaaagaaat accagtaatc agtagtcatg aaaaaaagta
     3961 cattatgctt gaagttgagc aattagttaa tggtgaggtt ccattgttta catttggtaa
     4021 ttttggaaat gtttcaagaa atgatacaaa ataccttatg agtctttacg attctgtaaa
     4081 ttttaagtta aattgtatgt ccgatgaaga tttacaatat caattaaatc tccttagagt
     4141 ttgtttgaat attgataatt acaatttttc taaattgaga aataatcatc ttgaattaga
     4201 tgttaaaaaa ttagtaaggg aatcaatatt taatgtcaca cggccttatg cactgactct
     4261 tcagaaagat tctagtggta attacatata tggagagtct aatttgggac tatatgaagg
     4321 aaagttggga ttgctattat cttatgatga attggaagaa atatttgatt taaaagttat
     4381 tgaacaagaa attataaatt caaaagatat aggcttaatt aatggctatg cttcattatt
     4441 gctttataaa aatttaaata actctttaaa taaagatgat tatttacttc atgatataga
     4501 ctttactgaa tttgatataa ttgatggttt gggtggatta attttacaaa gctatttaat
     4561 atttttgaaa aaaccagaat tagtagatgt agttgaattg aagaagttag gagaagtttt
     4621 tctagaacta acaaaaaatc aggaacagtt taaagtagga tttgctcatg gatttaccgg
     4681 tataaaggtt atttataaaa tatgttctct tatttcacca gataattcag agtttatgaa
     4741 tagatttgag tactttgaga gtcaggataa tgtttcatta tatcctagct cgggatggtg
     4801 caacggattg acaggttatc ttgtttctga atatatttta tataaaataa gtaacgactc
     4861 tagatatctt gataaagtat tatataatat tgattatctt atgaataaat tatgtgagac
     4921 tgaggaatat tgtttgtgcc atggattttt aggaggattg gatttcttgc aagtattgaa
     4981 tcaggataat ttgctttcta acgagcataa gaagagactg gaaatattgg agaaaacttt
     5041 aatttttaaa tccaatcaca ataatattct aaaaaaagat atttcgctat ttacaggaat
     5101 ctcaggattt ctctattatc tcaaacgaaa aaaaacactt agagggtctg ttattactct
     5161 agggttctaa gggagatgcc aatgaaaaaa ataagagaaa agctacaatc ccaacaaaat
     5221 gattgtggac catgctgttt agcaatgatt ttggactatt taggaagaga tgttgagtta
     5281 tcagaactat ataaatataa aaataccgct gttggatgga gcatgggaga tataaagaac
     5341 gttgcaaaac aattcggtgt agacgctact gtgtttagga tagttaatat gaaagggatg
     5401 tcatcaatac tacttccagc aatactttac tgggatttct cacattttgt agtgctagaa
     5461 aagtacaacg agttagaggt aactatactt gaccctaatt atggtagaaa aactcttaac
     5521 aaagatacat ttataaaatt cttttcagga tactgtatgg agctaagacc aaatcaatcc
     5581 tttacaaagc gaaagtcatc cctaagagat aaagtatcta agatcagaaa cacaaaaatt
     5641 tggaatttga aatttggaaa agtctatcct actgttttgg tgggttacaa tatattatta
     5701 ttaattatac ctgttttaat aagtaaatta ataaatgaat tatcaacaag agacattaat
     5761 ataaatcaag taattatttt aataggtgtt atatggttaa caactggttt gaactatatt
     5821 ttagaaaaat ttcggaatca aaaaacaata attcttgaag aaaaatcaac agttaatatt
     5881 tacgagaagt tatttagtct aactgaatct gaaatatgca gataccatag tggcgacatc
     5941 atgtcacgaa tatcggttaa tcctcaaatc tgtagatttt tggcagttga agtacctaat
     6001 atgattatct caataatgct tattttcttt gcaagtttat acttaatatt aaacactgga
     6061 atctatgctt gtatgttgat tttgctactt ttactaattg ctatcattaa ctgtatattc
     6121 atcactattt taatgaaatt atccaaaaat gaaagttata aacggtctat acttcgaagt
     6181 gttgctaatg atggtattct atcttataat tttttaatag gatcaggaat tacctatcgt
     6241 tatctaaaaa aaatcaaaag tagtttatca gattatgtac agtcgcagat tgatagagga
     6301 attgtagaag ctaaatcaat aacattccag caagccactt cgacattctt ttctcttcta
     6361 atttctatta tgagcctagt tatagtgtta ttgaatcctg aaagaagtgg ggaaattgcc
     6421 ttaatcagtt ctatggctat gatattgtat tctcccacga tgggaattgt aagtagccta
     6481 attaacatgg ctaatctata tccaaatatt gaaagacttg tagacttggt aggagaagaa
     6541 caaattccta aaacctttac gaagattcaa aacggcacag ttaatgttga tgggttatca
     6601 tatagatacg acgacgcatc aacatatctt ttcaaaaatc tttcgttctc tcttaaggaa
     6661 ggagatactc tttttataac tggaaaatca ggtaccggca aaacctcctt agtaaaaatt
     6721 ttactaggtt tacaaagtat tagtggggaa ggtaatgaag gaaatataat tattggagga
     6781 gttaacttac tagaccaaaa cctagattta agaagagata tttgctatat atcacatccg
     6841 tcaattcttt ttaaaggcac tctgaaatca aatttgaaat tattctgtcc aaactatact
     6901 attgaagaac tgatgttagc aattgataaa gcaaatcttt cagatatatt tcctcatgct
     6961 ttaaatattg aaaatttatt tatattggaa aatggtacta atttttcaac tggtcaacgt
     7021 caaagaatag gaatgctaag attatttttg caagaatata aggttattat tttagatgag
     7081 ccaacaagta atatggattc tgaaaacgca aaagctatca tggcagctat taatgctctt
     7141 gaatcaacca aaattattat tacacatgat aatgaattaa ttcaacctgg atcaaaacaa
     7201 ttagaattag gagtgggaga aaatggatat acatataaat catataagta agaaatatgg
     7261 taatcgaatc attttaaacg atgtcactat taggattcct tcagggaaaa tttatgggtt
     7321 tattggtgct aatggagctg gtaaaactac aacgatgaaa atccttactg gattattacc
     7381 tgctacaaaa ggtaacatat actttgacgg tgtaagtctt aacgacttaa aaaatcagga
     7441 gtcaataata ggagctttta ttagtacacc aagttactat aaaaacttaa cagcttatga
     7501 aaacttagct attatacaag aagttctcaa aaaaccgcaa gaagaaattg atcgagtttt
     7561 gaatctggtg ggcctaagtg aggttcgcaa taaagttgtg tcttcgttct catttggtat
     7621 gaaacaacgt cttggtttag catttgcttt tttaaataat ccagatgtat tggtattaga
     7681 tgaacctacg aatggattag atccgaaagg aattgttgaa atcagagaac tcttatacag
     7741 actagctaaa gaagaaggaa aaacgatttt tatatcaagt caccatatta gtgaaataga
     7801 aacgattgca gatatggtcg gtataataca tgacggtgag cttatttttg agggaacact
     7861 ctctgaactt tataataaaa gggacagctc ttatcttttt gaagtcgcaa atccagatgt
     7921 ttttgaacat attttgagag ttcgagatat ctcttttatt cgaaaagaat cgcattttga
     7981 aataaattct tacaaaaaag atataccaaa tttaataaaa ttaattgtac aagaaggaat
     8041 cgatattttg gaggtttcac caaataaaaa cctagaaaga atcttcttag acttaacgaa
     8101 aggagataaa gtgtatggtc acattgataa aaaatgaaat aaagaggttt gtaggaaccc
     8161 caacagcctt gttattgctt ggcattactt tttgtttgca aatgctagga acggttttta
     8221 tcattaaatc attagatgtg caagttgggg acatagcaca aacacctttt cagaagtcta
     8281 tgataatttt tttaggtttt tctggattgg tgagtttagt ggtaaatggt attactaact
     8341 tttttgttac ttcaagcgag cacaataacc atacttggga attgttgctt ttggggatag
     8401 ggaagaaaaa taaaattctc ttttcaaagt attttacagt cattttatct tttatttttt
     8461 atcaattact gtcaactatt ttctttgtta tagttacaca gacctattta tcgttaacga
     8521 ttgattggtc tacggtattc ttagtgttat catcaacaat atttttcagc ttactcacga
     8581 tcacacttca gttttgtgct cacctgctag aaaaaaatag tttatctgct ctaagcagtg
     8641 ttattattct tattctgtta caaacacttt ttgcctctaa tgctatattt atttatgtat
     8701 tcccgataaa tggtatttct tatctgataa cttctagtat tctcaatcca attataattt
     8761 tagtaatcac tttagagaat attatatgga gtggtgctgt tcttttagta gtttttaaaa
     8821 agtttcatct ttaggaggga attatgtgga aattagaatt attaaagtat aagagaacct
     8881 atttagctcc cgtattcata gggataggta tgtttttagt catttttcaa agctacgctg
     8941 gatatacgat taaagaaatt ccatcgaagg ttttatttgt gacaggtcta gatttatata
     9001 gtaatttttt actaccagtg atgattcctg tatttcttat catttcattg caccgtgaag
     9061 ttgagaatac tgcttttcaa aacttaacaa taaaaggaat atctagtcaa cagataaagt
     9121 ggtctatagt gaaattttat tggatagtaa tgccaatttt atttctttgt cactttttga
     9181 ttccactgat ttttatttcc ttgagaggag aaagtgccct taatgtgatt attgataata
     9241 gcttattttt actgttatca attttaagta ttattgcact catcaatatt agtctactga
     9301 tacatcagtc aagcgggaat tatgtattac cgattttaac ggctattgta ggagtcgttg
     9361 ttggacgttt ccctctggga gaaatcacat ggattgttaa cccctactcc tatttaagtt
     9421 atttagcaaa ttttaaatca tttactgtaa cccactattt agcgtttttt ctagtctttt
     9481 ctttgtcttt tattggtata atattatgta agaaaaaaat agatttgagt aagacatgag
     9541 aagaaatttg ttaagtacag cgtattatgc tttgtttatt acaggactaa tctatttgtc
     9601 cgctaaatgc tttctaaata acatcgaaaa tatcttgttt ttgcttgctt taaatgtatt
     9661 attgttattg gattttattt tgcacagagc aatatctact aggtctaaga ttagcaaatt
     9721 tattatttgg ttaatcagac tttgtcagtg tcactcaatt ttgtttgtca taggagattc
     9781 cgcatttcct ccatggatac agtatatgat tggcattata atctattctt cgttaatatc
     9841 tatatcgctc agcttgtttt ttcaaaagtt acagacttct ttttatctat ttgtgatgat
     9901 agtaggactt ctatcgagtg taagcttact ttttccaaga ttgactagta ttgccttttc
     9961 actttatttg gtagttacgt tcgcgatggc tctcttaatt gttcttctaa ggaacaagca
    10021 aacgttttat agaaatgact ccaatagatt ttattggcta atgttattaa tcttttacct
    10081 catgatttgt ttcagttcta ttggtttcat tttttttaat tcatcagctt tattttctgg
    10141 gttctggtta ttttattttt tagctctaat tacaggatta atactcatct tgttttatca
    10201 taatgatgca gtatttaaac aaagagaaca attattaaca cttatttttc tgattttatt
    10261 atatattgtt ctgtttattc taattttaaa gagaacgagt ctagttgttc ttgaaacggt
    10321 aacaattatt ttatattttc agtacttttt ccagttagtt ggagaaagtt atagactaat
    10381 aactggaagt aagcaatctg aacatgtagg gatcaattca attttgaaag aagaagcttt
    10441 aaaacaagag tttgcgaatt tcctgcatga taatattctt caagatatca atgctttaat
    10501 tcaactatct cgtttagata atccaagtgt atcagttaaa attattgaag aaagactaga
    10561 gtatctcaat acttttgttc gtgagcgaat gaatcagtat agtcctcaat tactaaaagg
    10621 cttatctttg tatgataact atcgtatgat gctaaaagca tttgaaaaac gttaccctaa
    10681 aatgaatatt tctctgaact tttattcaga aaaaaacata gctatctatc ctccttatga
    10741 ttttttaata tatagatggt taagagagct cgttaataac gcttataagt attccaatgc
    10801 tcaaacggtt actgtaaaat tggctagaga tgggcgagaa ctctctttat cagttatgga
    10861 taatggctat tatcaaaagt taaaaccatt taaacatgga cacggattat tagtcttgga
    10921 agaacaagta aagtcagtag gggggactat tacttttgag caagcggact ctaacggatt
    10981 aagagtcgat atcaaattga tgatggaggg agagaaggca attgaaaatt ttattaatag
    11041 atgatcatat cctgtttgca gagagtttag ccttaactat acatcagtat cagccggata
    11101 tccacattga tatattgaat aatgaagatg aatttaaaag cattttttca aaagtaattg
    11161 agtaccaagt gatactatta gacattaact tagacaataa atttagtacg gatggctttg
    11221 gaatagctca agatatttta gaggagtatc ctgattccaa gatagcatta ttgacgggat
    11281 ttgatttacc tgtatatgaa tatcaagctc agaagatagg agtaaaggca tttgttccta
    11341 aaaatataag ttccaaaaga ttaattcaga ttcttaaaga tatttcctat gggaaaaatt
    11401 attttccaaa tcagaattat tttatagatg aattgacaga acgcgaaaaa gaaatactta
    11461 tacatttggg aaatggcgaa aaacgaaaag acattgctaa attcctttac atttctgata
    11521 gaacgctaac gaatcatatt caaaatatat tggaaaaact cgaagttgat tcaacgttaa
    11581 aagctgttat aaaagctcag aagttaggat atattaaata attacccttt ttactcatga
    11641 ttttgtattg taacttagat atactggtgt aaaggaggtt caaatttatg aaaaaagtaa
    11701 taccgtatgc gttattaact ctatcaatgt tttttctatt caatgctatc cgaatatttc
    11761 ttgagagtag gtctctgtat gttgtcgatg ttttgttatt catagtcttt ctagtatgta
    11821 gtttaaaatt tagaaagcaa taatgtagaa taaatacaaa gatatactat cttccagatt
    11881 gaagaaaaag tccattttgg acaattttct tcaatctttt ttcttaatgt tgaaaattaa
    11941 gaactcttag aaacaccgaa atatcaacat ttctaagagt ttaatgattt gttatctttc
    12001 gcaaactttt tctatttttt atatttttag gagtttgtct acgttctgaa agatatacta
    12061 tcttctacat ttgataagtt ttaaattatt cagatggtca taatttggtt gttaaaaaga
    12121 cccattgcca gctgtagcag aagacatata atctatagga gagaggagca aattgattct
    12181 atctttttga tgttaagtta gtttagaatt ttgtttctga agtttgtaac ttgtcgaaaa
    12241 ttgagtgact gacgtttgat atccttgatg agcttatcga ttgcgttaaa ttagtgttag
    12301 aatagggaaa ttaagtcaga tagcagttct aactgctgtt gtacgacaga ggttgagaaa
    12361 gggagtcttt aggtagtgga agtgtcggtg agtttttcgg tgtagtattg agtaatcttt
    12421 atgcagatgg gttgtgagat ttggtgtttt tcgtgatgag agacacttca gtgactgtca
    12481 tctgtttaca ggatttacac tgaagaagac atctttgggt tttaacatag ttggcatctc
    12541 tttgatattc agaatagata ctgtagattt atgttggaaa taacatctga ctaaggcagt
    12601 ttggagctgg gtaatcaagt tcacgctgaa tagtgatatg cgtgttgact tgaaaaagta
    12661 gtctcgattt gatgttctta ttttctaatt cgaagagtac tgttgtattc taaaattgtt
    12721 ccataagcac ttcctaatga tggttaggga ggtcttgtgg aacttttttg tatactcaaa
    12781 aaactatagg ctctgtatag attgttacta cagaaattat atgataagta ttttattgta
    12841 gtatatctaa aaaatattta gcttaaatta ttctacaaag tagttaatct ggtaaataaa
    12901 gttatttggc tcagttttaa agtaattgga gtgaaaattt ttaattttct taaagagtca
    12961 ttatagctat attttcttga aaagatgttt gagcaccaat ttttgaaaat tagttcagta
    13021 gaatttggaa tagagctggc tacttcaaaa cgcaacgaac tataattcaa catctttatc
    13081 tattgaatag gttctagttt gctatttttg atttttacag agtataattt gtagttaatc
    13141 atatttttct tgtgataaaa tctccaagct aatcttgata tgatgtggct atcactaata
    13201 aaggagtaag ccatgttaaa caaagtgaaa gctcgatttc tgattggagt aggaggttta
    13261 atcgcagtca gttttacgtt catgatcggc tatacgattg gctcacaatc cgtttcaa
//
