LOCUS BGC0001789 13648 bp DNA linear BCT 10-OCT-2016 DEFINITION Streptococcus suis strain 90-1330 lantibiotic gene cluster, complete sequence. ACCESSION BGC0001789 VERSION BGC0001789 KEYWORDS . SOURCE Streptococcus suis ORGANISM Streptococcus suis Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. COMMENT ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-08 04:27:13 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 13648 ##antiSMASH-Data-END## FEATURES Location/Qualifiers source 1..13648 /db_xref="taxon:1307" /mol_type="genomic DNA" /organism="Streptococcus suis" /strain="90-1330" misc_feature 1..13648 /note="lantibiotic gene cluster" subregion 1..13648 /aStool="mibig" /contig_edge="True" /label="RiPP" /subregion_number="1" /tool="antismash" region 1..13648 /contig_edge="True" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene 337..1710 /gene="sslP" CDS 337..1710 /codon_start=1 /gene="sslP" /gene_functions="biosynthetic-additional (rule-based-clusters) Peptidase_S8" /gene_functions="biosynthetic-additional (smcogs) SMCOG1075:alkaline serine protease, subtilase family (Score: 229.9; E-value: 1.2e-69)" /gene_kind="biosynthetic-additional" /note="involved in proteolytic cleavage of the leader peptide" /product="protease" /protein_id="AOT85873.1" /sec_met_domain="Peptidase_S8 (E-value: 2.7e-39, bitscore: 124.7, seeds: 43, tool: rule-based-clusters)" /transl_table=11 /translation="MKKIGLLSNVFISLFIVILASGSVSSGVSANENKEISYNVLVSEN KSIEDVEDVLQSQGIKVTDKIPEINFLTISTEKSEDTIKKENSNYIDDIVIDNTMTVKP NITYLYGDKVYTNTNLDFWGNQWDMQKSISTGSKFQHKSSGKATIGVIDSGITYDNPDI YSHIISVQNFTSDLETGIVDNQNVVDKIGHGTSVVGQISSSGEYLGIAPDMKIRMYRVF DEGNAQDQWILKALIQAAKDDVDVINLSLGEYLLRDSTDEDDDTALINIYQRAINYAHN QGSVVVASVGDEGMDLQNQDELKNYLGSLRGKDYSQVDGTVQDIPAELDNVVTVGSVDD NDLVSSFSNQGNGDIDIYATGGGSQALSKVGYDKWVADKLYEKEWILVPTLEGKYTYAY GTSISTPKVSAALGLIIEKYNLKDQPDEAIRILYDNCFLSNNGNNGQIRLLNITNFVQ" gene 1751..2449 /gene="sslR" CDS 1751..2449 /codon_start=1 /gene="sslR" /gene_functions="regulatory (smcogs) SMCOG1008:response regulator (Score: 181.4; E-value: 3e-55)" /gene_kind="regulatory" /product="response regulator" /protein_id="AOT85874.1" /transl_table=11 /translation="MYKILVVDDDFEIVKLMRTILEMKNYNVTTYQEVRLPIKISDFDG FDLILLDVMMPNVDGLQICKQIRKSVSSPIIFVSAKDSEDDIVSGLNLGGDDYITKPFS VNQLVAKVAAHLKREERYRNAESNESVIRELLPLTFYLQEKLVRVNGEAISLTKREYDI LELLSSKTNKVYTREEIYECVYDDEADALFRSISEYIYQIRVKFGSYGINPIKTIRGMG YKWNDEKIFN" gene 2427..3791 /gene="sslK" CDS 2427..3791 /codon_start=1 /gene="sslK" /gene_functions="regulatory (smcogs) SMCOG1003:sensor histidine kinase (Score: 117.4; E-value: 1.6e-35)" /gene_kind="regulatory" /product="sensor histidine kinase" /protein_id="AOT85875.1" /transl_table=11 /translation="MMKRYSINKRILRTVLEIVIGTVANVIMLLVLSYVLIFTGQLNTY GTDYHISISDSKSANGIKNQMDYSVFDYVLFDSDNGELVSGKYQKQDLQHYKEVFDTGS SVSEGSILFTEYENSDFILVIRRPTVPEFVNQNFRHISYNLVSYLFFIVLELLLISISV IRLLREFTKNFRLIEKISLNMGIPGMDIGRKETEILECNNILLTLYQKDEELTKLLEME KKDKEDLSFQVAALAHDIKTPLTVLKGNIELLEMTNLDEKQLDFMSSINHSVGIFEKYF NSMVNYSRLLIEDKNYQEDIELAKFLDELSLECRDIMSSKKINFQIVNESHTRVIKGNR LNLDRALINILSNATRFCSEEGKVVLTISESSNFISFEIWNNGLPFTEESLKDGGKLFY TENKGRNDKHYGIGLSFAQKIAMRHQGQLILSNPQNGGAQVTLLIKKILRAGQKA" gene 3948..4664 /gene="sslF" CDS 3948..4664 /codon_start=1 /gene="sslF" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 181.6; E-value: 3.2e-55)" /gene_kind="transport" /product="immunity protein" /protein_id="AOT85876.1" /transl_table=11 /translation="MEAEKMEVIIQNLRKSYKDKEVLKDVSFKIEEGTICGLLGVNGAG KSTIMKILFGLERADSGEVIFNGKHKDIVEENRFDIGALIESPAIYLNLSAFDNLKTRA LLHDIPDERICEVLQLVGLSDTGKKKAGHFSLGMKQRLGLGMAIITNPDLLILDEPTNG LDPDGIKELLNLIRDLKKSGMTVLLSSHQLSEVSKIADQIVILNQGKIFYDDINKNSND LEKLFFRIVHGGDGND" gene 4642..5394 /gene="sslE" CDS 4642..5394 /codon_start=1 /gene="sslE" /product="immunity protein" /protein_id="AOT85877.1" /transl_table=11 /translation="MEVMEMTNIFKSEWLKQKSSSDKKLLILIPLLAIFIAFILAGPLN LESFSIYWWEGGFLFTLLGLLFLADYSAEENAGAFQNISLGRYTFTIYLAKILLKFKDV LISTFIFTIIFYGISFLFSGVISVDIGKDLICLLLIGVSSAWVLPLLYFLAKWINPYLL LATNSLICLLVAPLIAQTSVWFIFPYTYHYKIAYALLHLKPSGDLEAALSGVEISTILI SVSLSILVFVSFLSLLKWRIINEQNSKK" gene 5372..6058 /gene="sslG" CDS 5372..6058 /codon_start=1 /gene="sslG" /product="immunity protein" /protein_id="AOT85878.1" /transl_table=11 /translation="MNKILKSELLKLKGSLTLNLILILSIIQLFTIPLYLQFTNNSVVI ENIIFLPMLGYCILASIFSIFLHEQEEKANFFQNIKSEKNSGIIWGIKLISTDLLMVLL GVPVWIVVGVEFNRLSYFAYVGVITWLLLVLLNHFHMLLSLIMGKGGNLVISFIECLFI IFATNKVFLNIFWLPIVLPVNMILEIGKNEIFMILVYLIGFIILSYFCNLAVMNNVEIQ KICKKR" gene 6407..6574 /gene="sslA" CDS 6407..6574 /codon_start=1 /gene="sslA" /gene_functions="biosynthetic-additional (rule-based-clusters) TIGR03731" /gene_functions="biosynthetic-additional (rule-based-clusters) mature_a" /gene_kind="biosynthetic-additional" /product="suicin 90-1330 precursor" /protein_id="AOT85868.1" /sec_met_domain="TIGR03731 (E-value: 3.1e-24, bitscore: 74.4, seeds: 23, tool: rule-based-clusters)" /sec_met_domain="mature_a (E-value: 2.4e-08, bitscore: 22.8, seeds: 5, tool: rule-based-clusters)" /transl_table=11 /translation="MNNEDFNLDLVTISKENNSGASPRVTSKSLCTPGCKTGILMTCAI KTATCGCHFG" gene 6815..9790 /gene="sslB" CDS 6815..9790 /codon_start=1 /gene="sslB" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_N" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_C" /gene_functions="biosynthetic-additional (rule-based-clusters) Lanthipeptide_LanB_RRE" /gene_functions="biosynthetic-additional (smcogs) SMCOG1155:Lantibiotic dehydratase domain protein (Score: 786.9; E-value: 4.1e-238)" /gene_kind="biosynthetic" /note="involved in lantibiotic synthesis" /product="dehydratase" /protein_id="AOT85869.1" /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-92, bitscore: 299.7, seeds: 73, tool: rule-based-clusters)" /sec_met_domain="Lant_dehydr_C (E-value: 1.5e-22, bitscore: 70.0, seeds: 35, tool: rule-based-clusters)" /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 9e-09, bitscore: 25.6, seeds: 20, tool: rule-based-clusters)" /transl_table=11 /translation="MEHKYTTNNFLVRNAIIGIHELLECDYNSFLETIRENKIFQEQLF VASRSLYESLQKYYSGDSMKRKKINQLSESVYKYYKRSKERSTPFGLFSETSIGSFSST EKLNLNGKTLKKVLLDSEWLIRLVFKIEKEYSRELAYKINPANYQFGDRVVQLFSINDT KIEEVNIKFTKVYQLIDELCCDKYVYFNCIIEKLVESYGEEYRDIATSYIMSLIDSHFL ISNINSELIMNFKFEEFISKVKEIDKQNLYYFKLIAISNLIVEYSELEIGDGIEKLQEI YKLMSSLVETPNFLQIDLYNDGQIQLGNENKTQIVEFAEFLVSNSDHVKRTYLDDYKEK FLDKYGVNREVQLMELFDSNLGIGSPYGYQHPKNDFWESSPSTVYFSEKEELEYLNNFE KALETGGNIQLYNEEDFFNQDKDKINLGFELFFYVNKVDGKSVLSLTNTGCSKNLGASS GRFSILSDKLEHYHQTITQIVENNNHVSGYNSCEITFLPENLRHANVMRTTNVREKVLS LFTNMDKRSQILSDIYIGIDSKNSFYARNFKTKELLKFYSTNMYNQMMFSNELRFLCEI AQEDHFGIFPWEMVYQKFSHIPRIVFKDIIVAPERWRLSGRMLSKDIHQIILENNLPTK LYVDNSDNRILINRNNPLDNQLFEDIVRKSSNKNEELCLSECIFDSHLVEKESTTHISD IVVPVFAKDEIKEPRYIKEILPEVIPTNVRQKIPFDEWLYFKLYMSADRQEEFLSDIMP QILKLVNLDDGMSFYIRYTDPKFHIRLRIRTQNLYKSFEKIQEIFQLCIQNKLISNIDI STYDREIERYGGLERIPLVEEIFCLDTEIVINSLSLIRQKRLDLTLDDLAIIFNYFYLK SFFKDNNKEIIQFLEFACPEHLDSQNRDKNRNTALIDLYLIKGYLINLLPELSKLCQRL KKLSDSCIQLSDDYTYIIYDSIIHVHNNRLFGIKRENETKIYAIIRGLIISEEFRNGHN HG" gene 9771..11579 /gene="sslT" CDS 9771..11579 /codon_start=1 /gene="sslT" /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 166.8; E-value: 1.1e-50)" /gene_kind="transport" /product="ABC transporter" /protein_id="AOT85870.1" /transl_table=11 /translation="MGTIMDKFTLKNFFQTILTIPKTIRLIFRIERKYASYLIILNILQ SIIPLASLFIYQELINAVLKKGSNIFSVLIVYILMQMMLSILSQLNSYISEKFNMNLSY NLNLKLLKKTSSLNLIDFEQADTYNLIENIVQDSTYKPFQLFNAIIGVITGFLSLLTSI IYVSTWNVAVSTFLLIIPVISLVIFMRVGQLEFLIQWERANSEREVWYINYLLTHDFSF KEIKLNGISQYFIDKYGTLKRNFMNQDLNISKKKVLFRGSLDILLNFINGIAIFMMIQS IRSGKLLVGNFVSLIQAITRVNTYSQSMIQNTYIIYNTSLFMEQLFKFFDMEVSNISIQ NSRISRIEKRIDKIKVNNLSFIYPGSVKKTLEDINVEFNKGELVAIVGKNGSGKSTLVK LLSGLYQPSEGQIYYNNESSDVLDLSYYQNNVSVLFQDFVKFELSVRENIGLSDVNSIS DSKIKKHIDNLKLNFLTAENNFNLNQRLGTWFNDSRQISGGQWQKVALARTFFKNASIY ILDEPSSALDPVSEKEIFDEFVTRSKDKIALFVSHNLMAASRADRIIVMQDGRIIDEGK HDDLISKSKYYRELYYSEKYEEESDG" gene 11572..12849 /gene="sslC" CDS 11572..12849 /codon_start=1 /gene="sslC" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: LANC_like" /gene_functions="biosynthetic-additional (smcogs) SMCOG1140:Lanthionine synthetase C family protein (Score: 307.4; E-value: 2.3e-93)" /gene_kind="biosynthetic" /note="involved in lantibiotic synthesis" /product="cyclase" /protein_id="AOT85871.1" /sec_met_domain="LANC_like (E-value: 3.4e-59, bitscore: 189.9, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MDENKVIIDLSEKVFAKFDEQLKRYAEQPNYDLLTLSSGLPGLIL LSSELTSLTSERKYSARTGKYVNFMVKQMRNYGVLSDSLFSGVSGIGISILHLVEEHPE YHNLLISFNEYIKYYTLSKIENIDIKKISPTDYDIIEGVSGVLVYLLSQEQDENDYIIN RIINFLSEFSLKNSTLTGFYVESKNQMSKTESKLYPLGCLNFGLAHGLAGVGAMLSYSK LKGYSNEKSIAAIKKIIMLYEKYELKNYMWKEGLSDIELKKTEKSNLQYEFIRDAWCYG SPGISLLYLYSSLALEDKKLKSKACNILKASIRRSNGLEQSILCHGFSGAIEICLFFKK IYKTTDFDDCIKSLKEKLISDFREDMTYGFNTTAEFENIKTKDNLGYLDGIIGILLTMI ELNNLKVTTNWQRALLLFDDVIKEVK" gene 12851..13567 /gene="sslI" CDS 12851..13567 /codon_start=1 /gene="sslI" /product="immunity protein" /protein_id="AOT85872.1" /transl_table=11 /translation="MRKILFSLVVLIGICTLVACRLVDNKTIEFHDQSFNQFTYKGNDY TIMNQIVDENDLGTVKESFFKTLVIDRNSQKVVTKSNSDAVSLAYSGLYNFSDGLAISI NDSYYKVSLSSDVQSNNEMLSLEEFNNNSAGGELAIDPSDCRIVKFNNKKFRISSDIVS DDKLKEFLGVIADSKTFILNTGQEISKSELNKIDYSGSNSNEKREVWDYGEVYLLAEEG TIAVEINNEFRIARIE" ORIGIN 1 gatatagaga accgccgctt ggccaaatat gactatgcca agatgaatct aactgcggct 61 ataaaactgg aacaagttga gaaagaaatc gaaatctatc aaattaagtt agataagtca 121 atagatgatt atgagtattt aataaggagg ttggaaaagt ttgtcaaaat tttaaatgaa 181 atagactcaa gcaaggatga actaaaattt gaacacagtg aaaaaaatgt gaaagaatag 241 catttttcgg atttattgat accaaatatt gagtactctg aagaaattct gaaataaaat 301 tgataaaaag gaataaaaaa ctaaggagat gatattatga aaaagatagg cttattgtcg 361 aatgttttta tatcattgtt tattgttata ttagctagcg gttctgtgtc atcaggagta 421 agtgctaatg aaaataagga aattagttat aatgttttag ttagtgaaaa taaatctatt 481 gaggatgtag aagatgtttt acaaagtcaa ggaattaaag ttactgataa aatacctgaa 541 ataaattttt taactatttc taccgaaaaa agtgaagata caataaaaaa agaaaactct 601 aattatattg atgacatagt tatagataat actatgactg taaagcctaa tattacttat 661 ttgtatgggg acaaggttta tacaaatact aatttagatt tttggggaaa tcagtgggat 721 atgcaaaaga gtattagtac tggaagtaaa tttcaacata agtcttctgg taaagcaaca 781 attggtgtaa tagattctgg tattacatat gataatccag atatttattc acacattatt 841 tcagtacaaa atttcacatc agatttggaa acaggaatag ttgataacca aaatgttgta 901 gataaaattg gccatgggac ctctgttgtg ggacaaattt catcaagtgg agaatattta 961 gggatagcac ctgacatgaa aatacgaatg tatcgtgttt ttgatgaagg gaatgctcaa 1021 gaccaatgga ttctcaaagc gctcattcaa gcagcaaaag atgatgttga tgttattaac 1081 cttagtttag gagaatattt gttaagagat tccactgatg aagatgatga tacagctttg 1141 atcaatatct atcaacgggc aattaattat gctcataatc aaggttccgt tgtcgttgct 1201 tcagtaggtg atgaagggat ggatttacag aatcaagatg aattaaaaaa ctatcttggt 1261 agtttaagag gaaaagatta tagtcaagtt gatggaactg tacaagatat tccggctgaa 1321 ttagacaatg ttgttacagt tggttcagta gatgataatg atcttgtatc tagtttctca 1381 aatcaaggga atggcgacat tgatatctat gcaacaggag gtggaagtca agcgctttct 1441 aaagtaggat atgataaatg ggtagctgat aaattatatg aaaaagaatg gattcttgtt 1501 ccaacgcttg aaggaaagta tacatatgca tatgggactt caatttcgac tcctaaagtc 1561 tctgcagctt taggattgat tatagaaaag tataatttga aggaccaacc agatgaagct 1621 attcgaattt tatatgataa ttgttttctt agtaataatg gaaacaatgg acaaattagg 1681 ctactaaata ttacaaattt tgtgcaataa tagtgtaaaa tagtagtatg agataaaaga 1741 ggtacctagt atgtataaga ttttggtagt tgatgatgat tttgaaattg taaaattgat 1801 gcgaacaatt ttagaaatga aaaactataa tgtgacgact tatcaagaag ttaggcttcc 1861 tataaaaata agtgattttg atggatttga tttaatattg cttgatgtta tgatgccaaa 1921 tgttgatggt ctgcaaatct gtaaacagat tcgtaaatca gtatcctctc cgattatttt 1981 tgtcagtgca aaagattctg aagatgatat tgtatctggc ttaaatctcg gtggtgacga 2041 ttatataaca aagccattta gtgttaatca actagttgcc aaggttgcag cgcatttaaa 2101 acgagaagaa cgttatagaa atgctgaatc taatgaatct gttattcgag aattacttcc 2161 actaacattt taccttcaag aaaaactcgt gcgtgttaat ggtgaagcta tttctcttac 2221 taaaagggaa tatgatattt tagagctatt atctagtaag acaaataagg tttatacaag 2281 agaagaaatc tatgaatgtg tctatgatga tgaagcagat gcattatttc gttcaatttc 2341 ggaatacatt tatcaaatta gagtcaagtt tggttcctat ggaattaatc ccattaaaac 2401 aataaggggg atgggatata agtggaatga tgaaaagata ttcaattaat aagcggattt 2461 taaggacagt tcttgaaata gtgattggta cagttgcaaa tgttattatg ttgcttgtat 2521 tgagctacgt tcttattttt acaggtcagt tgaatacata tggaacagac tatcatattt 2581 caattagtga tagtaaatct gctaacggta ttaagaatca aatggattac tctgtctttg 2641 attatgtatt gtttgatagc gataatggcg aattggtctc tggaaaatat caaaaacagg 2701 atttacaaca ttataaagaa gtttttgata ctggaagttc ggttagcgag ggttctatat 2761 tgtttacaga atatgaaaac tcagatttta ttttggttat tagaagacca acagtgcccg 2821 aatttgtaaa tcaaaacttt cgacatattt cctataattt agtctcttat ttgtttttta 2881 tagtgctaga attactactc atctctatct ccgttatcag gctcttaaga gaatttacaa 2941 aaaattttcg tttaattgaa aaaatatctc tgaatatggg gataccagga atggatattg 3001 gacgtaaaga aactgaaatc ttagaatgta ataacatttt attgacgctt tatcaaaaag 3061 acgaagagtt gacaaagtta ttagaaatgg agaaaaaaga taaagaagat ttgtcatttc 3121 aagttgctgc attagcacat gatattaaaa caccattaac tgttttaaag gggaatatcg 3181 agttgcttga gatgactaat ctagatgaaa aacaattaga ttttatgtcc tcaataaatc 3241 atagtgttgg tatatttgaa aagtatttta attcaatggt taattactca aggttgctaa 3301 ttgaggataa gaattatcag gaagatattg aattagcaaa atttcttgat gaattatcat 3361 tagaatgtcg agatattatg tcttcaaaaa aaattaattt tcaaatagtt aatgaatccc 3421 ataccagagt gattaaagga aatcgtctca acttagatcg agctttgata aatatcttat 3481 ctaatgcgac tagattttgt tcagaagagg gcaaggtggt actgactata tctgaaagtt 3541 ctaactttat cagttttgag atttggaata atggtttacc atttacagaa gagtctctta 3601 aagatggagg aaaacttttt tacacagaga ataaaggaag aaatgataag cattacggaa 3661 taggactttc atttgctcaa aagatagcta tgagacatca aggtcaatta atactctcaa 3721 atccacaaaa tggtggtgca caggtcactt tattaattaa aaaaatttta cgggctggtc 3781 aaaaagccta atataaacaa aaacgcatga aatctttcat ttacaaacgt tgattttatg 3841 cgtttttttg tttcgaaaat ttgaaaaaat caatgagata tcgacttttt gctcaatctt 3901 tttttctgaa caaatactga aatttctttt gtattataat aaaagaaatg gaggcagaaa 3961 aaatggaagt tatcattcaa aatctaagaa aaagctataa agacaaagag gttttaaaag 4021 acgtttcatt taaaattgaa gaaggtacta tttgtggtct tctgggagta aatggggctg 4081 ggaaatccac cattatgaaa attctttttg ggttagaaag agctgatagt ggagaagtca 4141 ttttcaatgg aaagcataag gacattgtag aagaaaatag atttgatatt ggagcgttga 4201 ttgaatctcc tgctatctat ttgaatcttt ctgcatttga caatttaaaa acacgagcat 4261 tgctacatga tattccagat gaaagaattt gtgaggtact tcagttggtt ggtttatctg 4321 atactggaaa aaagaaggca gggcactttt cattaggaat gaagcaacga cttggtttag 4381 gaatggcaat tattaccaat cctgatttat taattttaga tgagccaact aatggtctag 4441 atccagatgg gataaaagaa ttgctaaatt taattaggga tctaaaaaaa tctggaatga 4501 cagtcctctt gtccagccat caactaagtg aagtcagcaa aattgcggat caaatcgtta 4561 tactgaatca gggcaagatt ttttacgatg atattaataa gaattcaaat gatttagaaa 4621 aactattctt tagaattgtc catggaggtg atggaaatga ctaatatttt taaatctgag 4681 tggctgaagc aaaaatctag ttctgataaa aaattactaa tccttattcc tttgctagca 4741 atttttatag ctttcatact agcaggacct ctcaatttag aaagtttttc aatttattgg 4801 tgggagggag gattcctttt cactctcctt gggttattgt ttttagctga ttatagcgcg 4861 gaggagaatg caggtgcgtt tcaaaatatt agcttgggta gatatacgtt tactatttat 4921 ttagcgaaga tactgttgaa gttcaaggat gttttgattt caacctttat ttttacgata 4981 atattttatg gcatctcatt tcttttttca ggtgtgatat cagtagacat tggtaaagat 5041 ttgatttgtt tattacttat tggtgtttct tctgcttggg tattaccact attatatttt 5101 ctagcaaagt ggataaatcc ctacttgttg ttggctacaa attctcttat ttgcttatta 5161 gttgctcctc taatagctca gacatcggtt tggttcatat ttccttatac ttatcactat 5221 aaaattgctt atgctctttt acatttaaaa ccctcaggtg atttagaggc agcattaagt 5281 ggagttgaaa tatcgacaat tttaatatca gtatctcttt caatcttagt ttttgtgagt 5341 ttccttagtt tgttgaagtg gaggataatt aatgaacaaa attctaaaaa gtgagttgct 5401 aaagttgaaa ggctctctta ctttaaatct tattttaatt ttatcaatta ttcaattatt 5461 cacaattcct ctttatttac agtttacaaa taattcagtt gtaattgaaa atatcatttt 5521 tttacctatg ttaggatatt gtatattagc atcaattttc tctatttttc ttcatgaaca 5581 agaggaaaaa gcaaatttct ttcaaaatat aaaaagcgaa aaaaatagtg gaattatttg 5641 gggaataaag cttatttcga cagacttact tatggtttta ttgggagttc cagtttggat 5701 agtggtagga gttgaattta atagactctc ttactttgcg tatgttggtg tgattacttg 5761 gttattatta gtcttactta accatttcca tatgttactt agtcttatca tgggaaaggg 5821 agggaatcta gtaatttctt ttatcgaatg tctgtttatt atatttgcaa ccaataaagt 5881 atttttaaat atcttctggt tgcctatcgt tttacctgtt aatatgatcc tagaaattgg 5941 gaaaaatgaa atttttatga ttctagtata cttaattggt tttatcatat tatcgtattt 6001 ttgtaattta gctgttatga ataatgttga aattcaaaaa atatgtaaaa agaggtaaat 6061 tggttagagg tcactaaaag agtagaatac aacaaaattc aatagataaa aagcgaatga 6121 cagcatattt tgaaatctaa agattgcagg tcatccgctt tttatgtcta ttttattatc 6181 ttttcaagac agtattgttc atgatatttt aaaaatatca gactttttca gcagtttcat 6241 tagtcaacta tctttttatt taattgtcca gagtatcagt ataaatattt catgcattct 6301 aaataaaaaa atttgttcat tctctataat tatgaacaaa ttctgaacta ggtatcttac 6361 aatatatttg ttcgaacaaa gaaaaaataa ttggaggaat tttattatga acaatgaaga 6421 ttttaatttg gatcttgtca caatctcaaa ggaaaacaac tcaggagctt cacctcgggt 6481 aactagtaaa tcattatgta ctcctggatg taagacgggt attttgatga cctgtgcaat 6541 caaaactgca acttgtggtt gccattttgg ataaaattta tttgtttagt aactatcttt 6601 ttgcaaatct tgactaagaa agaaagggac tctatatctt ttcgagtaag gtccctctaa 6661 atattagaat atttgtttag gatattactc tttagacgaa tatgtctatt gctaaaataa 6721 aggtagtgga tagtagtcta ctacctttat ttttataaat ttccaaaata atatttgaag 6781 atttataaaa ataatttaga agttggagct gctaatggaa cataaatata ctacaaataa 6841 ttttttggtt cgtaatgcaa tcattggaat acatgaattg ttggaatgtg attataattc 6901 atttttagaa actataagag agaataagat attccaggag caactatttg tagccagcag 6961 gagtttatat gaatcgcttc aaaaatatta tagtggtgat tcaatgaaaa ggaaaaaaat 7021 caaccaatta tcagaatctg tatataaata ttataagcgt agcaaggagc gctcaacacc 7081 atttggttta tttagtgaaa cttcaatagg ttcattttct tctacagaga aattaaactt 7141 gaatggaaaa acattaaaaa aagtactctt ggattcagag tggttaatac gtctagtttt 7201 taagattgag aaggaatatt ctcgagaatt agcctataaa ataaatccag ccaactatca 7261 atttggagat agagttgttc aattgttttc tataaatgat actaaaattg aagaagtcaa 7321 cataaagttc actaaagttt atcaacttat tgatgagctt tgttgtgata aatatgtata 7381 ttttaactgt attatagaaa aacttgttga atcctatggt gaagagtatc gagatattgc 7441 aacatcatat atcatgagtt tgattgatag tcattttcta atttcaaata ttaattcaga 7501 attaataatg aattttaagt ttgaagaatt catttctaaa gtcaaagaaa tcgataagca 7561 aaatctttat tattttaaac taatagcaat tagcaactta attgttgaat attctgaatt 7621 ggaaattggg gatgggattg aaaagcttca agaaatctac aagttaatgt catcgttagt 7681 tgaaacccct aattttcttc aaattgatct ttataatgat ggtcaaatcc aattaggtaa 7741 tgaaaataaa actcagatag tagaatttgc tgagtttcta gtaagtaatt cagatcatgt 7801 aaagcgtact tatttagatg attataaaga aaaattttta gataagtacg gagtaaatag 7861 agaagttcag ttgatggagt tgtttgattc taatttagga attggttctc catatggata 7921 tcagcacccc aaaaatgatt tctgggaatc ttcgccttct actgtatatt ttagtgaaaa 7981 agaagaatta gaatatctca ataattttga aaaagcctta gaaacaggtg gaaatattca 8041 actttataat gaagaagatt tttttaatca agacaaagat aaaatcaatc taggatttga 8101 gttgttcttt tatgttaata aagtagatgg taaaagcgta ctaagcttaa ctaatacagg 8161 atgttctaag aatttaggag ctagctcagg caggttttct attctatcag ataaattgga 8221 acattatcat caaactatca ctcaaattgt tgaaaacaat aatcacgtat cagggtataa 8281 ctcttgtgaa ataacatttt taccagagaa tcttcgtcat gctaatgtta tgcgcacaac 8341 aaatgtcaga gaaaaagtat tatcactttt tacgaatatg gataagagaa gtcaaatttt 8401 atctgatata tatattggta ttgattctaa gaatagtttt tatgctagaa atttcaaaac 8461 taaggaactc ttaaaatttt atagtacaaa tatgtataac caaatgatgt ttagcaatga 8521 attacggttt ttatgtgaga tagctcaaga agatcatttc ggaatattcc cttgggagat 8581 ggtttatcaa aaattttctc atattcctag aatagtattt aaggacatta ttgttgctcc 8641 tgaacgttgg aggcttagtg gaaggatgtt gtcgaaggat attcatcaga ttattcttga 8701 aaacaatctt ccgacaaaat tgtatgttga taacagtgat aatcgaatat taattaaccg 8761 taataatcca ctagataatc aactttttga agatattgta agaaaaagta gtaataaaaa 8821 cgaagaatta tgtctatcag agtgtatttt tgattcacac cttgtagaga aggaatctac 8881 aactcatatt tctgatatag ttgttccagt atttgctaag gatgaaatta aggaacctag 8941 gtacataaaa gaaatattac cagaggttat tccgacaaat gttagacaga aaataccatt 9001 tgatgaatgg ctctacttta aattgtatat gtcggcagat aggcaagagg aatttctttc 9061 ggatataatg cctcaaattt tgaagttagt aaatttagat gatgggatga gcttctatat 9121 cagatatact gatccaaaat ttcatatccg actaaggata agaacgcaga atttatataa 9181 aagttttgaa aaaattcaag aaatttttca actctgcata caaaacaagt taatatcaaa 9241 tatagatatt tcaacgtatg acagagaaat cgaaaggtat gggggactag aaagaattcc 9301 tttggtagaa gaaatttttt gtctagatac tgaaatagtc atcaattcat taagtttaat 9361 tcggcagaaa agattagatt taaccctaga tgatttagca ataatattta actactttta 9421 tctcaaatca ttttttaaag ataacaataa agaaataata caatttttag aatttgcttg 9481 tccagagcat ttagacagcc aaaatagaga taaaaatagg aatactgcat taattgattt 9541 gtacttaata aagggatatt taataaatct tcttccagaa ctatctaaac tatgtcaaag 9601 acttaagaaa ttatcagaca gttgtattca attatcagat gattatacat atatcattta 9661 tgatagtatc attcatgtac acaataatcg cttatttggt ataaagagag aaaatgagac 9721 taagatttat gctataattc gcggattgat aatcagtgaa gaatttagaa atgggcacaa 9781 tcatggataa atttacacta aaaaattttt ttcaaacaat tttgacaatt cctaaaacaa 9841 taagattaat ttttcgaata gaaagaaaat atgctagcta tctaataatt ttaaacatat 9901 tacaatcaat aattccttta gcaagcttat ttatctatca agaattaatc aatgctgttt 9961 taaaaaaagg aagtaacatt ttttcagtat taattgtcta tatattaatg caaatgatgc 10021 tatcaatact aagtcagtta aactcatata taagtgagaa atttaatatg aacttgtcct 10081 ataatctcaa tttgaagtta ttgaaaaaaa catcatctct aaatttaata gattttgaac 10141 aagcagatac atacaatctc attgaaaata ttgtacaaga tagtacatat aagccgttcc 10201 aacttttcaa tgctatcatt ggtgtgatta cagggtttct atctttatta acaagtatta 10261 tttatgtgtc cacttggaat gtggcagtat cgactttttt actgataatt cctgttattt 10321 ccttagtaat ttttatgcgt gttggccagc tagaattttt gattcaatgg gagcgagcaa 10381 attcggagag ggaagtttgg tacatcaatt atcttcttac tcatgatttt tcatttaaag 10441 agattaaact aaatggtatt agtcaatatt tcattgataa atatggaaca ttgaaaagaa 10501 attttatgaa tcaggatttg aatatttcga aaaagaaagt tcttttcaga ggaagtttgg 10561 atattttatt gaattttatt aatggtatag ctatttttat gatgatacag tcaattcgaa 10621 gcggtaaact tttagtaggt aattttgtaa gccttattca agcaataact cgtgtaaata 10681 cctactcaca atctatgatc caaaatactt atatcatcta taacacaagt ttattcatgg 10741 aacaattatt taaatttttt gatatggaag taagtaatat ttcaattcag aatagtagaa 10801 tctcaagaat tgaaaagcgc attgacaaaa taaaagtcaa taatctctct tttatctatc 10861 caggaagtgt caaaaaaact ttagaggata ttaatgttga gtttaataag ggtgaacttg 10921 tagcaattgt ggggaagaat ggttctggta agagtacctt agtaaaatta ctatcgggat 10981 tataccaacc ttcagagggt caaatatatt ataataacga atctagtgat gtcctagact 11041 tgagttatta tcaaaataat gtttctgttc tttttcagga ctttgtgaag tttgaattat 11101 ctgtgagaga aaatattggc ctaagtgatg taaacagtat atctgactcc aaaataaaga 11161 aacatattga taacttaaaa ttaaatttct taaccgcaga aaacaatttc aaccttaatc 11221 aacgtttagg gacctggttt aacgatagta gacaaatttc aggaggacaa tggcaaaaag 11281 tagcattggc taggactttc ttcaagaatg caagcatata cattttggat gaaccaagtt 11341 cagcgcttga tcctgtttca gagaaagaaa tatttgatga atttgtaact cgttctaaag 11401 ataagattgc tttgtttgtg tcacataatc taatggctgc gagtagagca gatcgaatta 11461 tagttatgca agatggacga attattgatg aaggaaaaca tgacgacctt ataagtaaat 11521 ctaaatatta tagggaactt tactattcag aaaagtacga ggaggagtct gatggatgaa 11581 aataaagtta ttattgattt atctgagaaa gtatttgcta aatttgatga gcagttaaaa 11641 agatatgctg aacaaccgaa ttatgattta ttgaccttgt cttctggttt acctggattg 11701 atattattat cttcagaatt gacaagttta actagtgaaa gaaaatactc cgctagaacg 11761 ggtaaatatg ttaactttat ggttaaacaa atgagaaatt atggtgtttt atcggattct 11821 ttattttcag gagtttctgg aattggaata agtatacttc atttagttga agaacaccca 11881 gaatatcata acttattgat tagttttaat gagtacatta agtattatac gttaagtaag 11941 attgaaaata tagatattaa gaaaatctct cctacagatt atgacatcat agaaggagta 12001 tctggagtat tagtttatct tttatctcag gagcaagatg aaaatgatta tataataaac 12061 agaattatca atttcttatc tgagttttca ctaaaaaatt ctactttaac aggcttctat 12121 gtggaatcaa agaatcaaat gtccaagaca gagtctaagc tttatccgtt aggatgtcta 12181 aattttggtt tagcacacgg ccttgcgggt gttggcgcaa tgttgtctta ttcaaaatta 12241 aaaggctatt ctaatgaaaa atctattgca gcaatcaaaa aaattataat gttatacgaa 12301 aaatacgagt taaaaaatta tatgtggaaa gagggattaa gcgatattga actaaagaaa 12361 acagaaaaaa gcaatttaca gtatgaattt attcgagatg cgtggtgcta cggtagccca 12421 ggaattagtt tactatatct gtattcaagt ttggctctag aagataagaa actaaaatct 12481 aaagcttgta acatcttgaa agcatccatc aggagaagta atggtttgga acaatctatt 12541 ttatgtcacg gattttctgg agcaattgag atttgcctat tttttaaaaa aatttataaa 12601 acaactgatt ttgatgactg tataaaatct cttaaggaaa agttaattag tgattttaga 12661 gaagacatga catatggttt taatactacc gcggaatttg aaaatataaa aacaaaagat 12721 aatcttggtt atttagatgg aataattgga attctgttaa caatgatcga actaaataac 12781 ttaaaggtta caacaaattg gcaaagggca ctcttattat ttgatgatgt tataaaggag 12841 gtgaagtagc atgaggaaaa ttttatttag cttagttgtt cttattggaa tttgtacttt 12901 agttgcatgt agattggtag acaataaaac aatagagttt catgatcaat catttaatca 12961 atttacatat aaaggaaatg attatacaat catgaatcaa attgttgatg aaaatgatct 13021 aggtactgtg aaggaatctt tttttaaaac attagtaatt gatagaaata gccagaaagt 13081 tgttactaaa agtaatagtg atgcagtatc attagcatat agtgggctct ataattttag 13141 tgatggttta gctatttcta taaatgattc ttattataag gtttctttga gttcggatgt 13201 gcaatccaat aatgaaatgc tgagcttgga agagttcaat aataattcag caggtgggga 13261 acttgcaatt gatccatctg attgtaggat agttaaattt aataataaaa aatttcgtat 13321 ttcatctgat attgtatctg atgataaact aaaagaattt ctaggagtaa tagcagattc 13381 aaaaacattt attttgaata cgggacaaga aatttctaaa tcggaactaa ataaaataga 13441 ttattctggt tctaattcta atgaaaaaag agaagtttgg gattacggag aagtttattt 13501 gttagcagaa gaaggaacca tagctgttga gattaataat gaatttagaa tagcgcgcat 13561 agaataaatt atagattatc taggtattac attgcttata tagcaaaata tcttgttgtt 13621 acctactaaa cagaaactta ttaaaata //