BGC0001792: surugamide A biosynthetic gene cluster from Streptomyces albidoflavus
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Location: 3,888,752 - 3,971,215 nt. (total: 82,464 nt).
This entry is originally from NCBI GenBank CP004370.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001792
Short description surugamide A biosynthetic gene cluster from Streptomyces albidoflavus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP004370.1
3888752 - 3971215
via
Compounds
  • surugamide A
  • surugamide D
Species Streptomyces albidoflavus [taxonomy]
References
Chemical products information
surugamide A Evidence:
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C48H81N9O8
Chemical database entries
NPAtlas
surugamide D Evidence:
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C47H79N9O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • XNR_3438
  • AGI89780.1
 3888752 - 3889462 (+) ABC transporter permease
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    • XNR_3439
    • AGI89781.1
    		 3889459 - 3890220 (+) ABC transporter permease
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      • XNR_3440
      • AGI89782.1
      		 3890301 - 3891290 (+) Amino acid ABC transporter amino acid-binding protein
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        • XNR_3441
        • AGI89783.1
        		 3891563 - 3892783 (+) Secreted protein
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          • XNR_3442
          • AGI89784.1
          		 3893050 - 3894624 (+) major facilitator superfamily permease
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            • XNR_3443
            • AGI89785.1
            		 3894724 - 3895032 (+) Hypothetical protein
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              • XNR_3444
              • AGI89786.1
              		 3895094 - 3895705 (+) TetR family transcriptional regulator
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                • XNR_3445
                • AGI89787.1
                		 3895714 - 3897060 (+) Drug resistance transporter EmrB/QacA subfamily protein
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                  • XNR_3446
                  • AGI89788.1
                  		 3897105 - 3909449 (-) Nonribosomal peptide synthetase
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                    • XNR_3447
                    • AGI89789.1
                    		 3909503 - 3932578 (-) Nonribosomal peptide synthetase
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                      • XNR_3448
                      • AGI89790.1
                      		 3932743 - 3945540 (-) ATP-dependent valine adenylase
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                        • XNR_3449
                        • AGI89791.1
                        		 3945597 - 3962798 (-) Nonribosomal peptide synthetase
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                          • XNR_3450
                          • AGI89792.1
                          		 3962919 - 3964274 (-) Alpha/beta hydrolase MppK
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                            • XNR_3451
                            • AGI89793.1
                            		 3964523 - 3965620 (-) putative membrane protein
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                              • XNR_3452
                              • AGI89794.1
                              		 3965830 - 3966246 (-) Transcriptional regulator, GntR family
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                                • XNR_3453
                                • AGI89795.1
                                		 3966342 - 3966713 (+) Hypothetical protein
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                                  • XNR_3454
                                  • AGI89796.1
                                  		 3966710 - 3967651 (+) ABC transporter ATP-binding protein
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                                    • XNR_3455
                                    • AGI89797.1
                                    		 3967648 - 3968445 (+) ABC transport system membrane protein
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                                      • XNR_3456
                                      • AGI89798.1
                                      		 3968509 - 3968766 (-) MbtH domain-containing protein
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                                        • XNR_3457
                                        • AGI89799.1
                                        		 3968942 - 3969751 (-) LipE
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                                          • XNR_3458
                                          • AGI89800.1
                                          		 3969788 - 3971215 (-) Succinate-semialdehyde dehydrogenase
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            Unk01
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3446
                                            Substrates
                                            isoleucine, valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk02
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3446
                                            Substrates
                                            phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk03
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3446
                                            Substrates
                                            leucine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk04
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk05
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            leucine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk06
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk07
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            alanine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk08
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk09
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3447
                                            Substrates
                                            alanine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk10
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3448
                                            Substrates
                                            tryptophan (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk11
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3448
                                            Substrates
                                            leucine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk12
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3448
                                            Substrates
                                            valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk13
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3448
                                            Substrates
                                            threonine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk14
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3449
                                            Substrates
                                            isoleucine, valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk15
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3449
                                            Substrates
                                            alanine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk16
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3449
                                            Substrates
                                            isoleucine, valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk17
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3449
                                            Substrates
                                            allo-isoleucine, valine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            Unk18
                                            Type
                                            nrps-type1
                                            Genes
                                            XNR_3449
                                            Substrates
                                            lysine (evidence: Structure-based inference, Sequence-based prediction)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Annotation changelog

                                            Entry version: 4

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 3

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Updated bioactivity data
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added NRP substrate specificities
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Switch to GenBank accessions
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2019-10-16
                                            Migrated from v1.4
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2019-10-16
                                            Updated compound(s) information (NPAtlas curation)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2018-08-06
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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