BGC0001794 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001794 (Alternaria oxytropis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	23,916	swainsonine	Polyketide	71%

BGC0001794 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 23,916 nt. (total: 23,916 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 23,917
Label		BGC0001794

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001794.1	1.66	Polyketide	swainsonine	Alternaria oxytropis
BGC0000979.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.57	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001068.1	0.48	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001909.1	0.46	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.45	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001793.1	0.44	Polyketide	swainsonine	Chaetothyriaceae sp.
BGC0001280.1	0.44	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.44	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000003.1	0.41	Polyketide	AF-toxin	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001794.1	0.94	Polyketide	swainsonine	Alternaria oxytropis
BGC0000979.1	0.62	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.62	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001068.1	0.57	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0001909.1	0.56	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001793.1	0.55	Polyketide	swainsonine	Chaetothyriaceae sp.
BGC0001280.1	0.55	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.55	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000003.1	0.53	Polyketide	AF-toxin	Alternaria alternata

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 23916:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

swnK

Search NORINE for peptide: strict or relaxed

AMP-binding (47..439): X

NRPSPredictor2: asp, asn, glu, gln, aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: dmlqigvygk
Nearest Stachelhaus code:: N, A
Stachelhaus code match:: 0% (weak)

PKS_AT (1167..1455): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Propionyl-CoA: 62.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.9
inactive: 110.6
Methoxymalonyl-CoA: 74.0
Methylmalonyl-CoA: 70.8
Propionyl-CoA: 43.2
Isobutyryl-CoA: 33.4
Ethylmalonyl-CoA: 29.0
Benzoyl-CoA: 25.4
fatty_acid: 21.7
CHC-CoA: 21.2
2-Methylbutyryl-CoA: 20.4
3-Methylbutyryl-CoA: 20.0
trans-1,2-CPDA: 19.7
Acetyl-CoA: 19.4