BGC0001796: tauramamide biosynthetic gene cluster from Brevibacillus laterosporus DSM 25
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Location: 4,751,365 - 4,791,946 nt. (total: 40,582 nt).
This entry is originally from NCBI GenBank CP017705.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001796
Short description tauramamide biosynthetic gene cluster from Brevibacillus laterosporus DSM 25
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CP017705.1
4751365 - 4791946
via
Compounds
  • tauramamide
Species Brevibacillus laterosporus DSM 25 [taxonomy]
References
Chemical products information
tauramamide Evidence:
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C44H65N9O9
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BrL25_22140
  • ATO51555.1
  • arsM
 4751365 - 4752156 (-) arsenite S-adenosylmethyltransferase
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    • BrL25_22145
    • ATO52181.1
    		 4752198 - 4752563 (-) arsenate reductase (thioredoxin)
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      • BrL25_22150
      • ATO51556.1
      		 4752642 - 4753700 (-) arsenical-resistance protein
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        • BrL25_22155
        • ATO51557.1
        		 4753736 - 4754059 (-) transcriptional regulator
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          • BrL25_22160
          • ATO51558.1
          		 4754231 - 4754713 (-) GNAT family N-acetyltransferase
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            • BrL25_22165
            • ATO51559.1
            		 4755133 - 4755609 (-) hypothetical protein
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              • BrL25_22170
              • ATO51560.1
              		 4755739 - 4756194 (-) hypothetical protein
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                • BrL25_22175
                • ATO51561.1
                		 4756590 - 4757354 (-) endospore coat-associated protein YheC
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                  • BrL25_22180
                  • ATO51562.1
                  		 4757712 - 4759013 (-) MFS transporter
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                    • BrL25_22185
                    • ATO51563.1
                    		 4759101 - 4778273 (-) non-ribosomal peptide synthetase
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                      • BrL25_22190
                      • ATO51564.1
                      		 4779030 - 4780565 (-) (2Fe-2S)-binding protein
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                        • BrL25_22195
                        • ATO51565.1
                        		 4780869 - 4781246 (-) Replication termination protein
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                          • BrL25_22200
                          • ATO51566.1
                          		 4781633 - 4782307 (-) transcriptional regulator
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                            • BrL25_22205
                            • ATO51567.1
                            		 4782506 - 4783102 (+) hypothetical protein
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                              • BrL25_22210
                              • ATO51568.1
                              		 4783222 - 4783470 (-) hypothetical protein
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                                • BrL25_22215
                                • ATO51569.1
                                		 4783743 - 4784150 (+) DUF3221 domain-containing protein
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                                  • BrL25_22220
                                  • ATO51570.1
                                  		 4784252 - 4785754 (-) hypothetical protein
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                                    • BrL25_22225
                                    • ATO51571.1
                                    		 4785984 - 4788449 (-) peptidase
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                                      • BrL25_22230
                                      		 4788799 - 4789610 (-) transposase
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                                        • BrL25_22235
                                        • ATO51572.1
                                        		 4789670 - 4789945 (-) transposase
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                                          • BrL25_22240
                                          • ATO51573.1
                                          		 4790141 - 4790335 (-) hypothetical protein
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                                            • BrL25_22245
                                            • ATO51574.1
                                            		 4790570 - 4791946 (-) branched-chain amino acid transport system II carrier protein
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                                              Biosynthesis information

                                              Biosynthetic modules

                                              Name
                                              Unk01
                                              Type
                                              nrps-type1
                                              Genes
                                              BrL25_22185
                                              Substrates
                                              tyrosine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk02
                                              Type
                                              nrps-type1
                                              Genes
                                              BrL25_22185
                                              Substrates
                                              serine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk03
                                              Type
                                              nrps-type1
                                              Genes
                                              BrL25_22185
                                              Substrates
                                              leucine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk04
                                              Type
                                              nrps-type1
                                              Genes
                                              BrL25_22185
                                              Substrates
                                              tryptophan (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Name
                                              Unk05
                                              Type
                                              nrps-type1
                                              Genes
                                              BrL25_22185
                                              Substrates
                                              arginine (evidence: Structure-based inference [1])
                                              Integrated Monomers
                                              Domains
                                              adenylation
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2022-09-15
                                              Added NRP substrate specificities
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2018-08-06
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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                                              Modifications to original record
                                              • BrL25_00005 crossed the origin and was split into two features