LOCUS       BGC0001797             22234 bp    DNA     linear   BCT 06-SEP-2017
DEFINITION  Streptomyces anulatus genes for telomestatin biosynthetic gene
            cluster, complete sequence, strain: 3533-SV4.
ACCESSION   BGC0001797
VERSION     BGC0001797
KEYWORDS    .
SOURCE      Streptomyces anulatus
  ORGANISM  Streptomyces anulatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:19:00
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..2274
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:MMPL domain-containing transport protein (Score:
                     617.6; E-value: 4.7e-187)"
                     /gene_kind="biosynthetic-additional"
                     /note="tlsA"
                     /product="MMPL family transporter"
                     /protein_id="BBA31803.1"
                     /transl_table=11
                     /translation="MIIAGPGQLGESLSVQELDRTAVPERTFLVRVAEFTLRRRRAVLA
                     VTGLLVVVAGWFGVGVVERLSNGGYAAATGNLRVAQSELRERFGVDRTHLILVLRAGTD
                     VGSPRTAAAGAAYTERVAGTPAVASADSFWTTGDPLLRSDDRRSAVVMVRLDGDDDQAQ
                     RTAKRIVPELIGEQGPFQVGVTGEAQTNGELQRQSDQDLVRAELFAAPVILLILLLVFR
                     TVVAALLPFLVGVIGVVLTLAILRAVSEFTDVSIFALNLTTALGLGLAIDYSLFILMRF
                     REETEGGKPVHEAAVTAVRTAGRTVFFSALTVALCLSALLVFPLYFLRSLAYAAIPAVL
                     TVGVAAVLVLPAALLVFGRWLDAGDITPLLHRLGRAVGHRRKEHAEPWWSRVAARIARR
                     PVAVALPVVVLLLLLGLPFTQAKFGLTDERVLPADAESYRTARVVERDFDAHALNPVQV
                     IVRDASREERDAYAQRVSRIDGVAYAVGATGRFERGRPAGPPAEPPRAYTSGTVSRVHA
                     VPVDSAFSPRSEQVVKDIRALSGPGDVFVAGDSALFTDTKTVIAERLPYALGIILVLMF
                     LLLLLFTGSLLVPLKAIIFNTLSLTASFGAMVYIFQDGHLKWLVGDFVTTGYLDVTVPV
                     LMFCAAFGLSMDYEIFLMSRIREQYSVHGDNTRAVIEGVGRTGSLITAAAVLIGGVLLA
                     LASSDISVLKLLGLGMFLAVLMDAVLIRGVLVPAFMLVMGRANWWAPRWLSRLHARIGI
                     KGDG"
     source          1..22234
                     /db_xref="taxon:1892"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces anulatus"
                     /strain="3533-SV4"
     subregion       1..22234
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001797"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22234
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             2337..2996
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 56.4; E-value:
                     4e-17)"
                     /gene_kind="regulatory"
                     /note="tlsB"
                     /product="transcriptional regulator"
                     /protein_id="BBA31804.1"
                     /transl_table=11
                     /translation="MHTFPTECTSTHEDGDTGECRVILVGTWPALRGEGTVPDGAAQIT
                     RCAERDELGSIVYATGAGWILAGQDLDDGDVQRTIAKARAVREGIRLAILGQSRDWRRC
                     ERWMRRGCRVYLEDTINLRRGVAAIRASQTLEVNVMDRIFFEVLRERATGPAPHLTRRE
                     RDVLELLRRGMRNREIAGALFVTENTVEYHMRHLLSKFSARNRLEVVERATALGLA"
     CDS             3093..3221
                     /codon_start=1
                     /note="tlsC"
                     /product="precursor peptide"
                     /protein_id="BBA31805.1"
                     /transl_table=11
                     /translation="MADITFDIVDEQISSLESIGVEEGCTTSSSSSSLDISDVDFE"
     CDS             3341..4264
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 76.8; E-value: 3e-23)"
                     /gene_kind="biosynthetic-additional"
                     /note="tlsD"
                     /product="SAM-dependent methytransferase"
                     /protein_id="BBA31806.1"
                     /transl_table=11
                     /translation="MSAPTGGAQQDLQGDYHRRLFHALHDWERSWAGALDVAGDRSRAH
                     ALGLDQLGHFGAQGCELVADAIVAAVPTGAPMTLAELGCGFGGALRAVVDRLSRRDVTV
                     RTAVGLDFVADHVRLFATIEAQRAADTGARTRVGAAPWTARPVQADVRALPLRTASLDV
                     AVCTGSLSHFARTDSVFAEAARVLRPGGLLVMTDEAGLLGPGGEPSETFRRLHPPGIFF
                     LTGVETRVAQLRAAGFTDVRLRELTDWACALLHDRLKVMRLFFGDLAAIYGSDEARTLL
                     DTLTVARDEYRRGAIVPALVTARLPV"
     protocluster    4343..22234
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[14342:18325]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      14343..18325
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    4343..22234
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     gene            4371..5168
                     /gene="tlsE"
     CDS             4371..5168
                     /codon_start=1
                     /gene="tlsE"
                     /product="MaoC dehydratase"
                     /protein_id="BBA31807.1"
                     /transl_table=11
                     /translation="MTRIREPFLFATGPVETGEFTDALRIPYAPVPAFFAARALPAAVR
                     SALADFLPVPDPAHIRHAAQETTLHRWPGAREELTVTPILEAEGDYGFQRAVTLRTRMT
                     GAAGDEVADLLTTLTVGPARGGGRLPRPPAPTNGTGPVLLTWRERIPDDLPHRYAEASG
                     DHNPVHLSEAAAHRAGLPGVIVHGMATLLLAVAGLTARMFDGDGAAVAAVRTRFVRPVR
                     PGDELDLAVRAAGAPGSYALHVSVAGRPVLKDTRVTRATAAVG"
     gene            5170..6153
                     /gene="tlsF"
     CDS             5170..6153
                     /NRPS_PKS="Domain: PKS_AT (4-285). E-value: 9.9e-57. Score:
                     184.4. Matches aSDomain: nrpspksdomains_tlsF_PKS_AT.1"
                     /codon_start=1
                     /gene="tlsF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 217.7; E-value: 5.7e-66)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyltransferase"
                     /protein_id="BBA31808.1"
                     /sec_met_domain="PKS_AT (E-value: 3.7e-57, bitscore: 184.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVWVFPGQGSQRPDMTAGLAAAPALLREARELIGAVPGGGHGDA
                     EDPEFVQPALFVVGVAAATALLRHEPAPAAVIGHSFGEFAALTAAGALPFETGLRLAVL
                     RARAMARRADTRTGMLAVLGLAPAEVRAVCADITQVTGDDGDFVQISNINSPSQTVVAG
                     TTAALADAAELCRARGAFRVRPLRIPYAAHTPLMAPAAAELGAALSDADIRVPAAKLYS
                     CLTGEATADPDRIRELLVQGMTRPVDFHAAVTAAAHDGHRSFVELGPGSPARLLGLVGE
                     TLAAEVPSPRLRLVSSDAEAKTPRPFQAGRSGPRPNPVRQAVDDAR"
     CDS_motif       5176..5229
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsF_0001"
                     /evalue="9.20E-07"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="tlsF"
                     /protein_end="20"
                     /protein_start="2"
                     /score="21.0"
                     /tool="antismash"
                     /translation="VWVFPGQGSQRPDMTAGL"
     aSDomain        5182..6024
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsF_PKS_AT.1"
                     /evalue="9.90E-57"
                     /label="tlsF_PKS_AT.1"
                     /locus_tag="tlsF"
                     /protein_end="285"
                     /protein_start="4"
                     /score="184.4"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VFPGQGSQRPDMTAGLAAAPALLREARELIGAVPGGGHGDAEDPE
                     FVQPALFVVGVAAATALLRHEPAPAAVIGHSFGEFAALTAAGALPFETGLRLAVLRARA
                     MARRADTRTGMLAVLGLAPAEVRAVCADITQVTGDDGDFVQISNINSPSQTVVAGTTAA
                     LADAAELCRARGAFRVRPLRIPYAAHTPLMAPAAAELGAALSDADIRVPAAKLYSCLTG
                     EATADPDRIRELLVQGMTRPVDFHAAVTAAAHDGHRSFVELGPGSPARLLGLVGETLAA
                     "
     CDS_motif       5314..5361
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsF_0002"
                     /evalue="2.30E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="tlsF"
                     /protein_end="64"
                     /protein_start="48"
                     /score="11.3"
                     /tool="antismash"
                     /translation="EFVQPALFVVGVAAAT"
     CDS_motif       5386..5499
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsF_0003"
                     /evalue="8.70E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="tlsF"
                     /protein_end="110"
                     /protein_start="72"
                     /score="50.0"
                     /tool="antismash"
                     /translation="PAAVIGHSFGEFAALTAAGALPFETGLRLAVLRARAMA"
     CDS_motif       5626..5658
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsF_0004"
                     /evalue="3.10E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="tlsF"
                     /protein_end="163"
                     /protein_start="152"
                     /score="10.9"
                     /tool="antismash"
                     /translation="INSPSQTVVAG"
     gene            6143..6922
                     /gene="tlsG"
     CDS             6143..6922
                     /NRPS_PKS="Domain: PKS_KR (25-194). E-value: 1.1e-21.
                     Score: 69.4. Matches aSDomain:
                     nrpspksdomains_tlsG_PKS_KR.1"
                     /codon_start=1
                     /gene="tlsG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     208.7; E-value: 1.6e-63)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="BBA31809.1"
                     /sec_met_domain="adh_short (E-value: 6.7e-42, bitscore:
                     133.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.8e-07,
                     bitscore: 21.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDDRTVNGRAAAVPDDPTARRAPRVALVTGATGAIGSAVARALA
                     ARGTRVAVGFRRDEAAGRALAAELPGALPVRVDVADPESVRACFREVTEAAGLVSVLVG
                     AAGALRDRPVVRMRDEDWDDVLRTNLTGMFHCVRHALPSMIAQRFGRIVCVGSVSGALG
                     LPGQANYAAAKAGLLGLTRSVARENGRYGITANVVAPGLVESPLTAGLGVPARERFLGL
                     SATGRYVTPEDVAGAVRFCVDSPAVTGQLINVDGGLY"
     aSDomain        6218..6724
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsG_PKS_KR.1"
                     /evalue="1.10E-21"
                     /label="tlsG_PKS_KR.1"
                     /locus_tag="tlsG"
                     /protein_end="194"
                     /protein_start="25"
                     /score="69.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGATGAIGSAVARALAARGTRVAVGFRRDEAAGRALAAELP
                     GALPVRVDVADPESVRACFREVTEAAGLVSVLVGAAGALRDRPVVRMRDEDWDDVLRTN
                     LTGMFHCVRHALPSMIAQRFGRIVCVGSVSGALGLPGQANYAAAKAGLLGLTRSVAREN
                     GRYGIT"
     CDS_motif       6224..6292
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsG_0001"
                     /evalue="5.20E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="tlsG"
                     /protein_end="50"
                     /protein_start="27"
                     /score="19.1"
                     /tool="antismash"
                     /translation="LVTGATGAIGSAVARALAARGTR"
     CDS_motif       6599..6661
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsG_0002"
                     /evalue="2.00E-08"
                     /label="PKSI-KR_m4"
                     /locus_tag="tlsG"
                     /protein_end="173"
                     /protein_start="152"
                     /score="26.7"
                     /tool="antismash"
                     /translation="VCVGSVSGALGLPGQANYAAA"
     gene            6947..7207
                     /gene="tlsH"
     CDS             6947..7207
                     /NRPS_PKS="Domain: PP-binding (12-78). E-value: 9.6e-12.
                     Score: 37.2. Matches aSDomain:
                     nrpspksdomains_tlsH_PP-binding.1"
                     /codon_start=1
                     /gene="tlsH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl carrier protein"
                     /protein_id="BBA31810.1"
                     /sec_met_domain="PP-binding (E-value: 3.6e-12, bitscore:
                     37.2, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTDTTRDKVESELRALLTERFEVPAELITPQAHVFGDLGLDSVD
                     LMSAVAIMEERHQLTVSDKDLENLLVIGGIIDHFTELLERT"
     aSDomain        6983..7180
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsH_PP-binding.1"
                     /evalue="9.60E-12"
                     /label="tlsH_PP-binding.1"
                     /locus_tag="tlsH"
                     /protein_end="78"
                     /protein_start="12"
                     /score="37.2"
                     /tool="antismash"
                     /translation="ELRALLTERFEVPAELITPQAHVFGDLGLDSVDLMSAVAIMEERH
                     QLTVSDKDLENLLVIGGIIDH"
     gene            7204..8436
                     /gene="tlsI"
     CDS             7204..8436
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (84-408). E-value:
                     3e-46. Score: 150.0. Matches aSDomain:
                     nrpspksdomains_tlsI_PKS_KS.1"
                     /codon_start=1
                     /gene="tlsI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 335; E-value:
                     1.1e-101)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-oxoacyl-ACP synthase"
                     /protein_id="BBA31811.1"
                     /sec_met_domain="t2fas (E-value: 6.6e-126, bitscore: 410.7,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPRRVAITGIGPVTPIGTGVKAFEESLWEGRSGIGPLTRFTLDG
                     FPVRAAGEVNGFRAEDHLDRRKLGRLERFAHFGVAAARLAVRDAGPVESGLDPLRAGVV
                     IATAYAGMERIAAEGLVLRERGWRATAPTTSMAMMPTVAAAMVSMEYGFMGAVECPATG
                     CAASGHALSRGADLIREGSADVVLAGGCDAPLNANALAIFATARVLSTRDGDPSRACRP
                     FDAGRDGIVMSEGATVLVLEELGRARARGARIYAELAGHGHTADAYNLSRPRPDGRGAL
                     AAMTLALARAGRPPGDVGYVNAHAAGTRAGDAAEVSALRQLFGDDLPPVSSTKSGHGHL
                     MGATAATEAAATALALHRGVLPPTLHRERTDPDIDIDIVADHAREADVDLALSNSFALG
                     GVNCSLALAKV"
     aSDomain        7456..8427
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsI_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.00E-46"
                     /label="tlsI_PKS_KS.1"
                     /locus_tag="tlsI"
                     /protein_end="408"
                     /protein_start="84"
                     /score="150.0"
                     /tool="antismash"
                     /translation="AVRDAGPVESGLDPLRAGVVIATAYAGMERIAAEGLVLRERGWRA
                     TAPTTSMAMMPTVAAAMVSMEYGFMGAVECPATGCAASGHALSRGADLIREGSADVVLA
                     GGCDAPLNANALAIFATARVLSTRDGDPSRACRPFDAGRDGIVMSEGATVLVLEELGRA
                     RARGARIYAELAGHGHTADAYNLSRPRPDGRGALAAMTLALARAGRPPGDVGYVNAHAA
                     GTRAGDAAEVSALRQLFGDDLPPVSSTKSGHGHLMGATAATEAAATALALHRGVLPPTL
                     HRERTDPDIDIDIVADHAREADVDLALSNSFALGGVNCSLALA"
     CDS_motif       7672..7701
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsI_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m5"
                     /locus_tag="tlsI"
                     /protein_end="166"
                     /protein_start="156"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="VECPATGCAA"
     CDS_motif       8101..8148
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsI_0002"
                     /evalue="1.20E-02"
                     /label="PKSI-KS_m5"
                     /locus_tag="tlsI"
                     /protein_end="315"
                     /protein_start="299"
                     /score="8.7"
                     /tool="antismash"
                     /translation="YVNAHAAGTRAGDAAE"
     gene            8433..9209
                     /gene="tlsJ"
     CDS             8433..9209
                     /NRPS_PKS="Domain: PKS_KR (17-174). E-value: 2.2e-07.
                     Score: 22.8. Matches aSDomain:
                     nrpspksdomains_tlsJ_PKS_KR.1"
                     /codon_start=1
                     /gene="tlsJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     151.6; E-value: 4.5e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="BBA31812.1"
                     /sec_met_domain="adh_short_C2 (E-value: 6.4e-37, bitscore:
                     118.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPANGRDADPRPFAGRTALVTGGGKGIGGGIARRLAARGADVAV
                     TYLRDRDAAERMVEELTGLGVRSCARRAFFGDPRDDVPAKVMEWVTGELGPPTLLVSNA
                     GTGVPLSLVDTRRSHWDWAVETHARSMLRLVQAGPELRSVLAVSSIGASRVLPHAYGLL
                     AASKAAQESLVRYLAVELAPRCRVNAVTPGLVDTAAARGFEWHKKLFDAALPRTPAGRL
                     TNPQDVGALAAFLLSDEAEMITGQTIVIDGGYSILM"
     aSDomain        8484..8954
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsJ_PKS_KR.1"
                     /evalue="2.20E-07"
                     /label="tlsJ_PKS_KR.1"
                     /locus_tag="tlsJ"
                     /protein_end="174"
                     /protein_start="17"
                     /score="22.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGGGKGIGGGIARRLAARGADVAVTYLRDRDAAERMVEELT
                     GLGVRSCARRAFFGDPRDDVPAKVMEWVTGELGPPTLLVSNAGTGVPLSLVDTRRSHWD
                     WAVETHARSMLRLVQAGPELRSVLAVSSIGASRVLPHAYGLLAASKAAQESLV"
     CDS_motif       8490..8555
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_tlsJ_0001"
                     /evalue="1.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="tlsJ"
                     /protein_end="41"
                     /protein_start="19"
                     /score="14.7"
                     /tool="antismash"
                     /translation="LVTGGGKGIGGGIARRLAARGA"
     gene            9221..10231
                     /gene="tlsK"
     CDS             9221..10231
                     /NRPS_PKS="Domain: NAD_binding_4 (42-207). E-value:
                     2.2e-31. Score: 100.7. Matches aSDomain:
                     nrpspksdomains_tlsK_NAD_binding_4.1"
                     /codon_start=1
                     /gene="tlsK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 74.6;
                     E-value: 1.5e-22)"
                     /gene_kind="biosynthetic-additional"
                     /product="epimerase"
                     /protein_id="BBA31813.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-10, bitscore:
                     30.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 8.1e-32, bitscore:
                     100.7, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHPLLVTGAGGVVGQSLVECFGPGRVIGLVRPAGNRPDGAAELI
                     AGDVTRPRLGLDVPAYAALAGRIGGVLHSAALTSFTRAAADIHDVNATGTAHALRLAED
                     AGVPFHLISTIYVRRRDGSHEDGRARPYRESKRAAEDTVRAARVPWSILRMSLVIGDSA
                     TGSTPRFQGVYAAMKSLITGGAPVVPVAAGSYVDFLPRDHVARSVRALVDSGALGEHWI
                     TAGERALTIEEFVERCLGYARRQGRTVPRPRLVDSEMVHRLIIPAFGDSIGADLRKRLE
                     LFTDILGPLATDRTLPRLPDDLPGLGAPPDLGACLDTSLEFFGTRARLAATGTPA"
     aSDomain        9347..9841
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsK_NAD_binding_4.1"
                     /evalue="2.20E-31"
                     /label="tlsK_NAD_binding_4.1"
                     /locus_tag="tlsK"
                     /protein_end="207"
                     /protein_start="42"
                     /score="100.7"
                     /tool="antismash"
                     /translation="ELIAGDVTRPRLGLDVPAYAALAGRIGGVLHSAALTSFTRAAADI
                     HDVNATGTAHALRLAEDAGVPFHLISTIYVRRRDGSHEDGRARPYRESKRAAEDTVRAA
                     RVPWSILRMSLVIGDSATGSTPRFQGVYAAMKSLITGGAPVVPVAAGSYVDFLPRDHVA
                     RS"
     gene            10228..11514
                     /gene="tlsL"
     CDS             10228..11514
                     /NRPS_PKS="Domain: Aminotran_3 (46-363). E-value: 7.5e-83.
                     Score: 270.2. Matches aSDomain:
                     nrpspksdomains_tlsL_Aminotran_3.1"
                     /codon_start=1
                     /gene="tlsL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 353.6;
                     E-value: 2.3e-107)"
                     /gene_kind="biosynthetic-additional"
                     /product="PLP-dependent aminotransferase"
                     /protein_id="BBA31814.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.1e-84, bitscore:
                     273.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSADAEPYTVRADTARHTARDDVIGLYRRHVNSGLARLAELTGAP
                     VVVRAEGDHLYTAEGEQLLNCGGFSVFLLGHGYPPVVDAVCQQLRTMSITGPMIFHEQL
                     AQAARTLADACPDGLEYVYLTNSGAEAVETALKLARMNGRRHVVSTDGGFHGKTMGALS
                     VTGREVFRTPCEPLPGPVDFVPYGDSDALAARLTAATCVIVEPVQGEGGVRIPPPGYLR
                     RVADACRSAGALLVVDEIQTGLGRTGPLWAVEEEGVTPDMLLSGKALGGGVVPVGAVVA
                     TPEVFAPLNRDPVLHTSTYGGSPLASVALRHTVEAVLREEVPRRTRELEVRLRQLLEER
                     LAGCRHLVREVRGRGALFGVEFHQPSLAGEFVLGLQERFVVVCPTANALSTVRLTPSAF
                     FGEPELEWLGRAVGESADALGKRYPPSGI"
     aSDomain        10366..11316
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsL_Aminotran_3.1"
                     /evalue="7.50E-83"
                     /label="tlsL_Aminotran_3.1"
                     /locus_tag="tlsL"
                     /protein_end="363"
                     /protein_start="46"
                     /score="270.2"
                     /tool="antismash"
                     /translation="VVRAEGDHLYTAEGEQLLNCGGFSVFLLGHGYPPVVDAVCQQLRT
                     MSITGPMIFHEQLAQAARTLADACPDGLEYVYLTNSGAEAVETALKLARMNGRRHVVST
                     DGGFHGKTMGALSVTGREVFRTPCEPLPGPVDFVPYGDSDALAARLTAATCVIVEPVQG
                     EGGVRIPPPGYLRRVADACRSAGALLVVDEIQTGLGRTGPLWAVEEEGVTPDMLLSGKA
                     LGGGVVPVGAVVATPEVFAPLNRDPVLHTSTYGGSPLASVALRHTVEAVLREEVPRRTR
                     ELEVRLRQLLEERLAGCRHLVREVRGRGALFGVEFH"
     gene            11574..12152
                     /gene="tlsM"
     CDS             11574..12152
                     /NRPS_PKS="Domain: Polyketide_cyc (13-130). E-value: 4e-16.
                     Score: 51.3. Matches aSDomain:
                     nrpspksdomains_tlsM_Polyketide_cyc.1"
                     /codon_start=1
                     /gene="tlsM"
                     /product="polyketide cyclase"
                     /protein_id="BBA31815.1"
                     /transl_table=11
                     /translation="MRYVRVSARAPGRTAAEIYPVISDFARYPELTDAVRSVDIEDLGS
                     GRTGCSWEVTFRRGILKWTEEDHYDPENHRVDFSLVTGDLDHLVGHWWMRDEGPDCRID
                     FACDFDMGIPTLADVIEPIAAQTLGEYITVILRALVGEIVMIENEPEDTHRPQETHEPP
                     AVGAPAGGAPAVGAPAVGAPAGGVRRRPS"
     aSDomain        11613..11963
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tlsM_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="4.00E-16"
                     /label="tlsM_Polyketide_cyc.1"
                     /locus_tag="tlsM"
                     /protein_end="130"
                     /protein_start="13"
                     /score="51.3"
                     /tool="antismash"
                     /translation="TAAEIYPVISDFARYPELTDAVRSVDIEDLGSGRTGCSWEVTFRR
                     GILKWTEEDHYDPENHRVDFSLVTGDLDHLVGHWWMRDEGPDCRIDFACDFDMGIPTLA
                     DVIEPIAAQTLGE"
     gene            12149..13339
                     /gene="tlsN"
     CDS             12149..13339
                     /codon_start=1
                     /gene="tlsN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 97.9; E-value:
                     1.1e-29)"
                     /gene_kind="biosynthetic-additional"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="BBA31816.1"
                     /transl_table=11
                     /translation="MSRAGERAAASLTAAFLAPDRALLEHHLPGLDGQLAAVDLRTLER
                     PGSPAVDLFRGSGAPALFVPEEYSGLGVGLRDGVRIQRAIGSRAPSLAVASTMHHFSVA
                     SLTGWDSQEGGMEWLIAEAVARHSMLVASGAAEARPGSGILNPAMSARPVAGGVLVSGS
                     KKPCSLSRSMDLLFATLRVGTPDGERCAVAVIPADSPGLSCRPFWRSDILAGAQSDELV
                     LDDVFVPGRLVSDVGPVGTTTDALRRSMVWFELLIAASYVGMAAALVERAVRAPRTDTR
                     RLADLAVGLEAATYALEGVAARSDADEEPATLLGPALTVRFAAQDAVLDVAATAADALG
                     GGAFITSPDVAYLCAAVRCLAFHPPSRTAATDALVAHLRGESVGMDPVERPGDGKP"
     gene            13422..14339
                     /gene="tlsO"
     CDS             13422..14339
                     /codon_start=1
                     /gene="tlsO"
                     /product="hypothetical protein"
                     /protein_id="BBA31817.1"
                     /transl_table=11
                     /translation="MVAVGAADVELRTLGEGRFELLTGARKFVLRITDEQEKALSEIVT
                     EILPKLFRTVPVREQVTAADIELLAPYVKQLASMGVLLFPRQSIETVADLRLYSFIARR
                     TAEPDKVFGSVKAKRVTLTGPDRLTTVFAGLLRDQGLTVDGAGAHPRTETETETDTDAA
                     LTVAVSLGDEAGLDAINRRLCGEGRSWLPVLVTPDQLRLGPWTMPGESACPRCYGPPRP
                     VADDLPATGSWLTLQPGFLGWAGGVLAHMTMRGFVPMGAEHPWGRITTIDAARCEQTSV
                     RAWRDPYCAVCAPHAPARQEWAEV"
     gene            14343..16145
                     /gene="tlsP"
     CDS             14343..16145
                     /codon_start=1
                     /gene="tlsP"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /product="FMN-dependent nitroreductase"
                     /protein_id="BBA31818.1"
                     /sec_met_domain="PF00881 (E-value: 3.7e-16, bitscore: 50.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDEDMLRCVTEQGFAARTLPLPLYVRAHAEVLVPAADAGERLDLR
                     AADIPLLDVAVAADRGGALRQLVERAAVLRILRSGHGSLRDSLPDSDGDARAGARDGSP
                     PAVGVGDGHDEAVARAIYQELARRRAESGIEKGTLITGRDQAGGPSGVALRGVDGRIDC
                     YLLGETAGVPAVGAVLRLDRLERPLCAVVCDLWERRGVERAVQAVLREFVVTTLPRRDD
                     TDRAPFPYGDFHDVVAVGETDFETLAPRPPRDETGELRDRLRLHGHRASVRVLGPADRA
                     ALVACRLEPTAKSEPSAESESEPVRRPTTGIEDDWRPRDVAALGLRAPRQLSLTYERDD
                     VRIGRVYHENSKMRTAYGTLPVVDIAEMSPPARRLLGQAYRDFGHARRQYPMRPSGQPR
                     LLTLDQVVRRRRSWAAMGDGELTRAELAHLLTLSYGTTGAAVAGQDLRLPLRATPSAGG
                     LYSSDLFVLVDRVTDVEPGLYYFHPGKRLLQLVDDERTLAEVAEYTGYRERAGEAAAMV
                     VYVGAFRRNQWKYRERGYRTVLLDCGHLAQSVVTTATSLGLVAHPMIAFVDDYFNAYVG
                     VDGVEDAVLYLTLLGPRRTGDEAA"
     gene            16142..18325
                     /gene="tlsQ"
     CDS             16142..18325
                     /codon_start=1
                     /gene="tlsQ"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     TIGR03604"
                     /gene_kind="biosynthetic"
                     /product="YcaO protein"
                     /protein_id="BBA31819.1"
                     /sec_met_domain="TIGR03604 (E-value: 1.3e-88, bitscore:
                     287.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 4.2e-74, bitscore: 240.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETQRVRVSVHVLDDENGFVETAHEIHRVKGKGLSGLTDELPPE
                     LLDKLRIAPPAAADATEPDGPRVRRLAVAGPKSLTRQFFAVAEHTSGLDAHELPAGEDE
                     LDEGPGRCDLVVIATASLFDPRAARTAARCVRAGLPHLVYGAARDGVTFVGPLWSPQGE
                     GACYECLRVRVASNSVHGQTWRAYMTFLAETGAETGPPFQHEVPPWAAAQLAGAVGRRA
                     EAWLTDAADEATAELLWNDESSPAKTGRTLLPVPTCAVCADLHRTRATSTTEPNDDGKA
                     NGDGKVNGDGKANGDGGPDALRAAEDDRVGIVHATSVRRAESGPPVYLSGSTSADLSLI
                     KRTMGVTVNGGAGFSKGEAVAATIGESLERYAAGLYRPADLHLATWDELEAAGRSAVPP
                     AEFGLFSPEQHAEPGFPFTPFDGGTPVRWTEATDLLSGAPVQVPASQVYMHYRRVRGEA
                     AIGQSISTGLAAGPSYRAAVLSGLYEVIERDALAISWLHRLPPRPLPPEVVAASSRVSY
                     LIDRATTWRVRFYDLSLDLTPSTVVAVMEHHSGAEQIMSFGSACRWSPVKAVEKAFLEA
                     AQGLTYVRRLLRQHEDWEAAEDFGNVDDFNKHAILYSKYPRLRERAGYLVHPSAPVPPG
                     RPERPAPAATDDPVGRIAAELAAAGHRVCVVDLTTPDVRRSGAHVVRVLVPGLQHLSGV
                     HGCRMLGNRRLYDIVAALGCDTRPDNPYPHPLP"
     gene            18344..19126
                     /gene="tlsR"
     CDS             18344..19126
                     /codon_start=1
                     /gene="tlsR"
                     /product="hypothetical protein"
                     /protein_id="BBA31820.1"
                     /transl_table=11
                     /translation="MASSFLAYPSLSVVRNDDFADTADIAEAFARHVTSRQLPGDVAPV
                     RCSVESEAVPGGVRLRFTSTARKLAAPATVTHKFFFIDRDESRERRHLLTPVRTAATTE
                     LLVLFEEGQERDYFHGSVFDSDNLLLASSAVVFDREGRHVPYPFTQKYVCPQRLAAADF
                     EVTRDADGRRVARFSLACRDLTETLRLSVAWETIGVVHQRDLVCTPERPATYLDMPLDD
                     NDELAPGDWVVIAVDDRQRLLAQTVVTLVSTEAGRCPS"
     gene            19114..20295
                     /gene="tlsS"
     CDS             19114..20295
                     /codon_start=1
                     /gene="tlsS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /product="peptidase M16"
                     /protein_id="BBA31821.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 3.1e-11, bitscore:
                     34.0, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTTGPRDPTGPRHLTLDNGLHLVGVRRPGSPLAALRLRIDIG
                     SADEAPGEHGLAHVLEHLVVRCSMGGGRVADGALVEAATGRPHTSYDALVRTGDIATAG
                     DVLGAAFRQLRPDTRDLADELAAIRRERAQRTADVRWRVQEAMFAALCPDTPYAHPVLG
                     DPRTVDALTPEAVHRLHSRWYHPSRATLVIGSDRVDEELAALAERARLWAPGHPRTETR
                     AAAPPPDGHAVVSEAVGAGRRAVAVGFTEPGAPCGADAGFALARRSVRAARGIDVLRLR
                     LRSHTCTWVMLAATDETAAVRSVAAALRAIRELLLGPDGAALLRTEALIPELRAAEDIQ
                     RSVADATDAFDASDRIPASRPTTATATGVGEVADVIARWRQGFAAALPEGPAT"
     gene            20292..21362
                     /gene="tlsT"
     CDS             20292..21362
                     /codon_start=1
                     /gene="tlsT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /product="peptidase M16C"
                     /protein_id="BBA31822.1"
                     /sec_met_domain="Peptidase_M16_C (E-value: 3.7e-12,
                     bitscore: 37.1, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPGAPVLANSVPGEHAVAAATLAVPLTGADRASVLAAPLVAAA
                     WACAVAAEARRGGTPVRTEPVVTADYAGITAEAAPGDHEALRRLADWFAAVAEHPLEEW
                     EFGTVRRSFLSRTPSSARWSDAVRRALFGDRHRYGVGHDERVAHVTGCGPADVTAAARE
                     LLAARPAGPAPLVPRTVRVRLPAEGGAACHLLGTPGVSLGSDDKYALHVAWALLGGRDG
                     MLDRRLRGEHALTYSLAAFSREFADGGYGACFAACAPGARDEVAERTGEVLRALERGAF
                     PRSLVDSAKERLIIANHRSLRNGRSVTERLCGYQIAGTDPGGITQYARHVGGVTPEQVA
                     DVARRHIGSDQPGGDL"
     gene            21359..22234
                     /gene="tlsU"
     CDS             21359..22234
                     /codon_start=1
                     /gene="tlsU"
                     /product="MOSC domain containing protein"
                     /protein_id="BBA31823.1"
                     /transl_table=11
                     /translation="MNRFAIREIWRYPVKSMAGERLDGCAVTADGLLGDRCWALRDEER
                     ACIADARKLPAMLDIHVRYARQPEPTVAGGRSAGVELRLPGTESGPVASDDPAVHDVLS
                     AHLGRKVTLWPLLSAQEDRAHYVRAWPEDVERYLKDLFGVADLAEMPDLSALPPEVAEY
                     QTMPGTYFDAYPVHLVTTGELEALARAEPPPPDVDSRRFRPNLLLEGPAAPDWVGRRVR
                     IGSAVLRVEADCPRCVMVSQPQQGLPAARGLLRTVHRDFGHQVGLYASVERPGRVECTD
                     VAEVEDAEEE"
ORIGIN
        1 gtgatcatcg ccggaccagg tcagctgggg gagtcgttga gcgttcaaga gctcgatcgc
       61 accgcggtac cggagcgcac ctttctcgta cgggtcgcgg agttcaccct gcgccgccgg
      121 cgggccgtgc tcgccgtcac cggtctgctg gtcgtcgtcg cgggctggtt cggggtcggc
      181 gtggtcgagc gtctgtcgaa cggcgggtac gcggcggcga ccgggaatct gcgcgtcgcc
      241 cagagcgaac tgcgcgagcg cttcggggtg gaccggaccc atctgatcct cgtgctcagg
      301 gccggcaccg acgtcggctc cccgcgcacg gccgccgcgg gcgccgcgta caccgagcgg
      361 gtcgccggca ctcccgccgt ggcctccgcg gactccttct ggaccaccgg cgacccgctg
      421 ctgcgctcgg acgaccggcg ctcggccgtc gtgatggtgc gactcgacgg ggacgacgac
      481 caggcgcagc gtacggcgaa gcgcatcgtc ccggaactga tcggcgaaca gggcccgttc
      541 caggtcggag tcaccggcga ggcccagacc aacggcgagt tgcagcggca gagcgaccag
      601 gacctggtca gggccgagct gttcgcggcg cccgtcatcc tgctcatcct gctgctggtg
      661 ttccgcaccg tcgtggccgc gctgctcccc ttcctcgtcg gcgtcatcgg ggtcgtactg
      721 acactcgcga tcctgcgcgc cgtcagcgag ttcaccgatg tgtcgatctt cgccctcaat
      781 ctgacgacgg cgctcggact cggcctggcg atcgactaca gcctgttcat cctgatgcgg
      841 ttccgggagg agaccgaggg cgggaagccg gtgcacgaag cggcggtcac cgccgtgcgg
      901 acggccggac gcacggtgtt cttctccgcc ctgacggtgg ccctgtgcct gagtgcgctg
      961 ctggtcttcc ccctctactt cctgcgctca ctggcgtacg cggccatccc cgccgtcctc
     1021 acggtcggcg tcgcggccgt gctcgtgctt cccgccgcgc tgctcgtctt cggccgctgg
     1081 ctggacgccg gggacatcac accgctcctg caccggctgg gccgcgctgt cggacaccgc
     1141 cgcaaggagc acgccgagcc ctggtggtcc cgcgtcgcgg cccgtatcgc ccgccgcccg
     1201 gtcgcggtgg cgctgcccgt cgtggtgctg ctgcttctgc tcggactgcc cttcacccag
     1261 gccaagttcg gcctcaccga cgagcgtgta ctgcccgcgg acgcggagtc gtaccgtacg
     1321 gcgcgggtcg tcgagcgcga cttcgacgcg cacgcgctca accccgtcca ggtgatcgtg
     1381 cgggacgcct cgcgcgagga gcgggacgcg tacgcccaac gggtctcgcg catcgacggt
     1441 gtcgcgtacg ccgtgggcgc gacggggcgc ttcgagcggg ggaggccggc cggaccgccg
     1501 gccgagccac cgcgggcgta caccagcggg acggtgagcc gtgtccacgc cgtgcccgtc
     1561 gacagcgcct tctcgccccg cagcgaacag gtcgtcaagg acatccgcgc gctgtccggc
     1621 cccggtgacg tcttcgtcgc gggcgactcc gccctcttca ccgacaccaa gacggtcatc
     1681 gccgagcggc tgccctacgc gctcggcatc atcctcgtcc tcatgttcct cctgctgctg
     1741 ctgttcaccg gcagcctgct cgttccgctg aaagccatca tcttcaacac actcagtctc
     1801 accgcatcct tcggcgcgat ggtctacatc tttcaggacg gccatctcaa gtggctcgtg
     1861 ggagacttcg tcaccaccgg atacctcgat gtgaccgtgc ccgtactgat gttctgtgcg
     1921 gcattcggcc tgtccatgga ctacgagatc tttctgatgt cgcggatccg tgagcagtac
     1981 tccgtacacg gtgacaacac cagggcggtg atcgagggcg tcggcagaac cggctcactc
     2041 atcaccgcgg cggccgtcct catcggagga gtgctgctcg cactcgccag ctccgacatc
     2101 tcggtcctga agctgctggg cctcggcatg ttccttgctg tgctcatgga cgccgtgctg
     2161 atccgcggcg ttctcgtacc ggccttcatg ctcgtcatgg gccgggcgaa ctggtgggca
     2221 ccgcgctggc tcagccggct ccacgcgcgc atcgggatca agggggacgg gtgaaaggga
     2281 agtgaacggc actacgtaat cgaccacatg cgagtcaaat cgggggccct gctgtgatgc
     2341 acacctttcc caccgaatgt acgagcacgc acgaagacgg tgacacgggg gagtgtcgcg
     2401 tcattctcgt cggcacctgg cccgccctgc gcggcgaagg gaccgtcccg gacggcgcgg
     2461 cgcagatcac ccgctgcgcc gaacgggacg agctgggttc gatcgtctac gccaccgggg
     2521 ccggctggat cctcgccgga caggatctcg acgacgggga cgtccagcgc acgatcgcca
     2581 aggccagggc cgtcagggag ggcatcaggc tggccatcct cggtcagagc cgcgactggc
     2641 gccgctgcga acggtggatg cgccgcggct gccgggtgta tctggaggac accatcaatc
     2701 tgcgccgggg cgtcgcggcg atccgcgcgt cacagaccct cgaagtgaac gtcatggacc
     2761 gcatcttctt cgaagtcctg cgcgaacggg ccaccggacc cgccccccat ctcacccggc
     2821 gtgagcgcga cgtactggaa ctgctccggc gcgggatgcg caaccgtgag atcgccggcg
     2881 cgctcttcgt cacggagaac acggtcgaat atcacatgcg acatctgctc tcgaagttca
     2941 gcgcccgtaa ccgacttgag gtggtagagc gtgcgaccgc ccttgggctc gcgtgaatgc
     3001 gttcactcct acggcaatcc gtgatgtatg cgaacggccc tcttcctaag ctggatacgc
     3061 aagttcgggt aagtccgaga ggagcatggg aaatggcaga catcacgttc gacattgtcg
     3121 acgagcagat ctccagcctg gagtcgatcg gcgtcgagga aggctgcacg acctcttcgt
     3181 cgagcagctc tctcgacatc tccgacgtcg acttcgagta attccggcgc ggaaaatctc
     3241 agggcgtgcg cccgcggtct gcccatcggc cgcgggcgca cggccgtttc cgcggcgcca
     3301 ctgtccgcgt caccgcgtga ggccgggacg gagcgaacac atgtcagcac ccacaggcgg
     3361 cgcccaacag gacctccagg gcgactacca ccggcggctg ttccacgccc tgcacgactg
     3421 ggaacggtcc tgggccggcg cgctcgacgt ggcgggcgac cgctcccgcg cccatgcgct
     3481 gggcctcgac cagctcggcc acttcggcgc ccagggctgc gagttggtcg ccgacgcgat
     3541 cgtcgccgcc gtgccgacgg gtgcccccat gaccctggcc gagctgggct gcggattcgg
     3601 cggcgcgctg cgcgccgtcg tcgaccggct gagcaggcgc gatgtcaccg tacggaccgc
     3661 cgtcgggctc gacttcgtcg ccgaccacgt ccggctgttc gcgaccatcg aggcgcagag
     3721 agcggccgat acgggggcac ggacccgggt tggggcggct ccctggacgg cgcgccccgt
     3781 ccaggccgac gtacgggccc tgccgctgcg tacggcctcg ctggacgtcg ccgtgtgcac
     3841 cggctcgctc tcccacttcg cccggaccga ctcggtgttc gccgaggcgg cccgggtgct
     3901 gcgccccggt ggcctgctgg tcatgacgga cgaggccggg ctgctcggcc ccggcggcga
     3961 gccctccgag accttccggc gactgcaccc gccgggcatc ttcttcctca ccggcgtcga
     4021 gacacgcgtg gcgcagttgc gcgccgccgg gttcaccgac gtgcggctgc gtgaactcac
     4081 cgactgggcc tgcgcgttgc tgcacgaccg gctgaaggtc atgcggctgt tcttcggcga
     4141 cctcgcggcg atctacggct ccgacgaggc gcggacgctc ctcgacacgc tcaccgtcgc
     4201 gcgcgacgag taccggcgcg gcgccatcgt gcccgcactc gtcaccgcgc ggctaccggt
     4261 ctgattcacc cgggtttttc cccggaatca gactacggaa ttccgggtgg agacccgggg
     4321 ctccggctct ctaggatcgc aatgccggaa gtcatcacgg gggacaggcc atgacacgta
     4381 tacgtgagcc atttctgttc gcgacaggtc cggtcgagac cggggaattc accgacgcgc
     4441 tgcggattcc gtacgcgccc gttcccgcat tcttcgcggc ccgcgccctt cccgcagccg
     4501 tacggtccgc gctggccgac ttccttcccg tacccgaccc ggcgcacatt cgccacgcgg
     4561 cgcaggagac gacgctgcac cgatggcccg gcgcgcgtga ggaactcacc gtcaccccga
     4621 ttcttgaggc cgagggcgac tacggattcc agcgggccgt cacgctgcgc acccgcatga
     4681 cgggcgccgc cggggacgag gtcgccgacc tgctgaccac actcaccgtc ggccccgcgc
     4741 ggggcggcgg ccggctgccc cggcccccgg cgccgacgaa cggcaccgga cccgtactcc
     4801 tgacctggcg cgagcggata cctgacgacc tgccacaccg ctacgccgag gcgagcggcg
     4861 accacaaccc ggtccacctc agcgaggccg cggcgcaccg ggccggactg cccggcgtca
     4921 tcgtgcacgg catggccacg ctcctgctgg ccgtcgccgg actcacggcc aggatgttcg
     4981 acggggacgg cgcggccgtc gcggcggtcc gcacccgttt cgtacggccg gtgcgccccg
     5041 gcgacgaact cgacctcgcc gtacgcgccg ccggggcgcc cggctcgtac gcgctgcacg
     5101 tgagcgtcgc cgggcggccc gtgctgaagg acacccgggt cacacgcgcc acagcggcgg
     5161 tggggtgaca tggccgtatg ggtgttcccc gggcagggtt cccagcgccc ggacatgaca
     5221 gcgggcctgg ccgcggcccc ggcgctgctg cgcgaggcac gggagctgat cggggccgta
     5281 ccgggcggcg gacacggtga cgccgaggac ccggagttcg tccagcccgc cctcttcgtc
     5341 gtcggcgtcg ccgcggccac cgccctgctg cgccacgagc cggccccggc ggcggtcatc
     5401 ggccacagct tcggcgagtt cgccgccctg acggcggccg gcgcgctccc gttcgagacc
     5461 gggctgcggc tggccgtgct gcgcgcccgc gccatggccc gccgcgccga cacccgcacc
     5521 ggcatgctcg ccgtactcgg cctcgccccg gccgaggtgc gggccgtctg cgcggacatc
     5581 acccaagtca ccggggacga cggcgacttc gtccagatct ccaacatcaa cagcccctcc
     5641 cagaccgtcg tcgcgggcac gacggccgcg ctcgccgacg ccgcagaact ctgccgcgcg
     5701 cgtggcgcct tccgcgtccg gccgctgcgc atcccctacg ccgcccacac ccccctgatg
     5761 gcccccgccg cagccgagtt gggggccgcg ctcagcgacg ccgacatccg ggtccccgcc
     5821 gcgaagctgt actcctgcct caccggggag gccaccgccg acccggaccg catcagggaa
     5881 ctcctcgtcc agggcatgac ccggccggtc gacttccacg cggccgtgac cgccgccgcc
     5941 cacgacggcc accggtcctt cgtcgaactg ggccccggct cccccgcgcg gctgctcggg
     6001 ctcgtagggg agaccctggc cgccgaagtg ccgtccccgc gcctgcgcct ggtgtccagc
     6061 gacgccgagg ccaagacgcc gcgcccgttc caggccggcc ggagcgggcc gcgtccgaac
     6121 ccggtccgtc aggcggtgga cgatgcccga tgaccgcacg gtgaacggcc gggcagccgc
     6181 cgtacccgac gaccccacgg cccgccgcgc tcccagggtc gcgctggtga ccggggcgac
     6241 gggagccatc ggatccgccg tggccagggc cctggcggcc cggggcaccc gggtcgccgt
     6301 cggtttccgc cgcgacgagg cggcgggacg cgcgctggcg gccgaactcc ccggcgcgct
     6361 gcccgtacgc gtggacgtcg ccgacccgga gtccgtacgc gcctgcttcc gcgaggtgac
     6421 cgaggccgcc gggctcgtct ccgtactggt cggcgccgcg ggcgcgctcc gcgaccggcc
     6481 cgtggtgcgg atgcgcgacg aggactggga cgacgtactg cggaccaacc tgaccggcat
     6541 gttccactgc gtccgccacg cgctgccctc gatgatcgcg cagcgcttcg gacggatcgt
     6601 ctgcgtcggc tcggtcagcg gcgccctcgg cctgccggga caggccaact acgcggcggc
     6661 caaggccgga ctcctcggcc tcacccggtc ggtggcccgc gagaacgggc ggtacggcat
     6721 caccgccaac gtggtggccc cgggcctcgt ggagtccccg ctcacggccg gactcggcgt
     6781 ccccgcccgt gaacgcttcc tcggactgtc ggcgaccggt cgctacgtga cccccgagga
     6841 cgtggccgga gcggtccggt tctgcgtcga ctcaccagcc gtcaccggac agctgatcaa
     6901 tgtggacggc gggctctact gagcggccac aacggaggga agaaccatga acaccgacac
     6961 caccagggac aaggtcgaga gcgagctgcg cgcactgctc accgaacgct tcgaggtgcc
     7021 cgccgaactc atcacaccgc aggcccatgt cttcggcgac ctcgggctcg actccgtgga
     7081 cctcatgagc gccgtcgcca tcatggagga acgccaccaa ctcaccgttt ccgacaagga
     7141 cttggagaac ctcctcgtca tcgggggcat catcgaccac ttcaccgaac tgctggagcg
     7201 gacatgaccc cccgcagggt cgcgatcacc ggcatcgggc ccgtcacccc gatcggcacc
     7261 ggggtgaagg ccttcgagga atccctgtgg gagggccgct ccggcatcgg cccgctgacc
     7321 cggttcaccc tcgacggctt ccccgtacgg gccgcgggag aggtgaacgg cttccgcgcc
     7381 gaggaccatc tcgaccgccg caaactgggc cgcctggagc ggttcgcgca cttcggcgtc
     7441 gccgccgccc ggctggccgt gcgggacgcc ggaccggtgg agagcggcct cgaccccctg
     7501 cgcgcgggag tcgtgatcgc caccgcctac gccggcatgg aacgcatcgc cgccgagggc
     7561 ctggtcctgc gcgagcgggg ctggcgggcc acggcgccca ccaccagcat ggcgatgatg
     7621 ccgacggtcg ccgccgcgat ggtgtccatg gagtacgggt tcatgggcgc cgtcgaatgc
     7681 cccgccaccg gctgcgccgc ctccggccac gccctctccc gtggcgccga cctgatccgc
     7741 gagggcagcg ccgacgtcgt cctcgcgggc ggctgcgatg ccccgctcaa cgcgaacgcg
     7801 ctcgccatct tcgccaccgc ccgcgtcctg tccacccgcg acggcgaccc ctcacgggcc
     7861 tgccgcccct tcgacgccgg acgcgacggc atcgtgatga gcgagggggc gaccgtactg
     7921 gtcctggagg agctggggcg ggcccgcgcc cgcggcgccc ggatctacgc cgaactcgcc
     7981 ggacacggcc acaccgcgga cgcctacaac ctctcccggc cccggccgga cgggcgtggc
     8041 gcgctcgccg ccatgaccct cgccctcgcc agggccggac gccctcccgg cgatgtgggg
     8101 tacgtcaacg cgcacgccgc cggtacgagg gccggcgacg ccgccgaagt gagcgccctg
     8161 cggcagctgt tcggcgacga cctgccgccg gtctcctcca ccaagtcggg gcacggacat
     8221 ctgatgggcg ccacggcggc caccgaggcg gcggcgaccg cgctcgcact gcaccgggga
     8281 gtgctgccgc cgacgctcca ccgcgagaga accgacccgg acatcgacat cgacatcgtc
     8341 gccgaccacg cccgggaggc cgatgtggac ctcgcgctga gcaactcctt cgccctggga
     8401 ggtgtcaatt gttcgctggc cctggcgaag gtgtgacccc cgcgaacggg cgggacgccg
     8461 atccccgccc gttcgcgggc cggaccgccc tggtcaccgg cggcggcaag ggcatcggcg
     8521 gcggcatcgc ccgccggctg gcggcccgcg gcgccgacgt ggccgtgaca tacctgcgcg
     8581 accgggacgc ggcggagcgc atggtcgagg agctgacggg gctcggcgta cgctcctgcg
     8641 cccgcagggc cttcttcggc gacccgcgcg acgacgtacc ggccaaggtg atggagtggg
     8701 tcaccggcga actcggcccg ccgacactgc tggtctccaa cgccggtacg ggagtgcccc
     8761 tttcactcgt ggacacccgg cgcagtcact gggactgggc cgtggagacc cacgcccgct
     8821 cgatgctgcg actggtgcag gccgggcccg agctgcggtc ggtcctcgcc gtctccagca
     8881 tcggcgcctc ccgggtgctg ccccacgcgt acggactcct cgcggcgtcc aaggcggcgc
     8941 aggagtccct cgtccgctat ctggccgtcg aactcgcgcc gcgctgccgg gtcaacgcgg
     9001 tcacgccggg gctcgtcgac accgccgccg cccgcggctt cgaatggcac aagaagctct
     9061 tcgacgcggc actgcccaga acgcccgcag gccggctgac gaacccgcag gacgtgggcg
     9121 cgctcgccgc gttcctgctc tccgacgagg ccgagatgat caccggccag acgatcgtga
     9181 tcgacggcgg ctactcgatc ctgatgtgag gacgtgtccc atggcccatc cccttctcgt
     9241 gaccggagcc ggcggcgtcg tcgggcagag cctcgtcgag tgcttcggac ccggccgcgt
     9301 catcgggctc gtacgcccgg cggggaaccg gccggacggc gccgccgagc tgatcgccgg
     9361 cgacgtgacc cgaccccgcc tcggcctcga cgtcccggcg tacgcggcgc tggcgggccg
     9421 gatcggcggc gtcctgcaca gcgccgccct cacctccttc acccgcgcgg cggccgacat
     9481 ccacgacgtc aacgccaccg gcaccgcgca cgcgctgcgg ctcgccgagg acgcgggcgt
     9541 ccccttccac ctgatcagca ccatctatgt gcgccgccgc gacggcagcc acgaagacgg
     9601 gcgcgcccgc ccctaccggg agtcgaagcg ggccgccgag gacaccgtca gggccgcccg
     9661 cgtgccgtgg agcatcctgc ggatgtcgct ggtgatcggc gacagcgcga ccggctccac
     9721 cccccgcttc cagggcgtgt acgccgcgat gaagtctctg atcaccggcg gcgccccggt
     9781 cgtgccggtg gccgcgggca gttacgtgga cttcctgccc cgtgaccatg tcgccaggag
     9841 cgtacgggcc ctcgtcgact ccggcgcgct cggcgagcac tggatcaccg cgggcgaacg
     9901 cgccctgacc atcgaggagt tcgtcgagcg ctgcctcggc tacgcgcgac gacagggacg
     9961 caccgtgccc cgcccccgcc tggtggactc cgagatggtc caccggctga tcatcccggc
    10021 gttcggcgac agcatcggcg ccgacctgcg caaacgtctt gagctgttca ccgacatcct
    10081 cggaccgctg gcgaccgacc gcacactgcc gcgcctgccg gacgatctgc ccggactcgg
    10141 cgccccgccc gacctcggag cctgtctgga cacctcgctg gagttcttcg ggacacgggc
    10201 caggctcgcc gcgaccggga cgcccgcgtg agcgccgacg ccgagccgta caccgtccgt
    10261 gccgacaccg cgcggcacac cgcccgcgac gacgtcatcg gcctctaccg ccgccatgtg
    10321 aactccggcc tcgcccggct ggccgaactg accggcgccc ccgtggtcgt acgggcggag
    10381 ggcgaccacc tctacaccgc cgagggcgaa cagctcctca actgcggcgg gttcagcgtc
    10441 ttcctgctgg gccacggcta cccgccggtc gtcgacgccg tgtgccaaca gctccgtacg
    10501 atgtcgatca ccggcccgat gatcttccac gagcagctgg cgcaggctgc ccggacactc
    10561 gccgacgcct gccccgacgg cctcgaatac gtctacctca ccaactccgg cgccgaggcg
    10621 gtcgaaacgg cgctcaagct cgcccggatg aacggacggc gccacgtcgt gtcgaccgac
    10681 ggcggcttcc acggcaagac catgggcgcg ctgagcgtca ccggccgcga ggtgttccgg
    10741 accccgtgcg aaccgctgcc ggggccggtg gacttcgtcc cgtacggaga ctccgacgcc
    10801 ctcgccgcca ggctcacggc cgccacgtgc gtgatcgtcg aacccgtcca gggcgagggc
    10861 ggcgtacgga tcccgccccc cggctatctg cggcgggtgg ccgacgcctg ccgaagtgcg
    10921 ggcgccctgc tggtcgttga cgagatccag acgggcctcg gccgtaccgg accgctgtgg
    10981 gccgtcgagg aggagggtgt cacccccgac atgctgctca gcggcaaggc gctcggcggg
    11041 ggagtggtgc cggtcggcgc ggtcgtcgcc acacccgagg tgttcgcccc gctcaaccgg
    11101 gacccggtcc tgcacacgtc gacgtacggc ggcagcccgc tcgcgtccgt ggctctgcgg
    11161 cacacggtcg aggcggtact gcgcgaggaa gtgccacgcc gcacgaggga gttggaggtc
    11221 aggctccgcc aactcctcga agagcgcctc gcgggctgcc ggcatctcgt acgcgaggtc
    11281 agagggcgcg gggccctctt cggcgtcgag ttccaccagc cgtccctcgc gggcgagttc
    11341 gtgctcggac tccaggagcg cttcgtcgtc gtctgcccca ccgccaacgc cctgtcgacc
    11401 gtccgcctca ccccgtcggc gttcttcggc gagccggaac tcgaatggct cgggcgggcg
    11461 gtcggagaat ccgccgacgc tctgggaaaa cgctatccac cgtccggcat ctgaacgcct
    11521 ggaatctgac cgctcggctc agcaccaact ctccctcagc tcaggaggaa cacatgcgat
    11581 acgtcagggt gtcggccagg gcgcccggcc ggacggccgc cgaaatctat ccggtcatca
    11641 gtgacttcgc ccgctatccg gaactcaccg atgccgtccg cagcgtggac atcgaggatc
    11701 tgggctcggg acgcaccgga tgctcatggg aagtgacatt ccgccggggc atcctgaaat
    11761 ggacggagga ggaccactac gaccccgaga accaccgggt ggatttctct ctggtcaccg
    11821 gcgacctgga ccatctcgtg ggccattggt ggatgcgcga cgaagggccc gactgccgaa
    11881 tcgatttcgc gtgcgacttc gacatgggaa tcccgacgct cgccgacgtc atcgagccca
    11941 tcgccgccca gaccctcggt gagtacatca ccgtcatcct gcgcgccctt gtgggagaga
    12001 tcgtgatgat cgagaacgag ccggaggaca cgcatcggcc gcaggagacg cacgagcccc
    12061 cggccgtcgg cgccccggcc ggcggcgccc cggccgtcgg cgccccggcc gtcggcgccc
    12121 cggccggcgg cgtacggcgg aggccgtcgt gagccgggcc ggggaacgtg ccgccgcatc
    12181 cctgacggcc gcgttcctgg caccggaccg cgcactgctc gaacaccatc tgccgggact
    12241 cgacgggcag ctcgccgccg tggacctccg cacgctcgaa cggccgggct cccctgccgt
    12301 ggacctcttc cgcggctccg gcgcgcccgc gctgttcgtc cccgaggagt actccggcct
    12361 cggggtgggc ctgcgcgacg gggtacgcat ccagcgcgcg atcggcagcc gcgcgccctc
    12421 cctggcggtc gcctccacga tgcaccactt ctccgtggcg agcctgaccg gctgggacag
    12481 ccaggaaggc ggtatggagt ggctgatcgc ggaagctgtc gcccgtcact cgatgttggt
    12541 ggcctccggc gccgccgagg cccggccggg ctccggcatc ctcaaccccg ccatgtcggc
    12601 ccggccggtc gcgggcggcg tcctggtcag cggatccaag aagccgtgca gcctgagcag
    12661 gtcgatggac ctgctgttcg ccacactgcg cgtcggaacc cccgacggcg agcgatgcgc
    12721 ggtcgccgtg atcccggccg actcaccggg tctgtcctgc cggccgttct ggcgcagcga
    12781 catcctcgcc ggtgcccaga gcgacgaact ggtcctggac gacgtcttcg tgcccgggcg
    12841 gctggtctcg gacgtgggtc ccgtcggtac gacgaccgac gcgctgcgcc gctccatggt
    12901 ctggttcgaa ctgctgatcg ccgcctcgta cgtcggcatg gcggcggccc tcgtggagcg
    12961 ggccgtccgc gcaccgcgta cggacacccg gcggctggcc gacctggccg tggggctgga
    13021 ggcggcgacc tacgccctgg agggtgtcgc ggcacggtcg gacgccgacg aggaacccgc
    13081 cacgctgctc ggtccggcgc tgacggtccg cttcgcggcg caggacgccg tcctggacgt
    13141 cgcggcgacc gcggccgacg cgctgggcgg cggggccttc atcacctcgc ccgacgtcgc
    13201 ctatctctgt gcggccgtac gctgtctggc cttccatcca ccgtcgcgta cggcggcgac
    13261 cgacgcactg gtggcccatt tgcgcggtga atcggtcggc atggacccag tggagcgacc
    13321 gggagacgga aaaccgtagt tccgtactac ggaaagacgt atcggatcac gggcggcccg
    13381 gcgctagatt cgaagacgtg aatacttctg agccagcgga aatggttgcc gtcggcgccg
    13441 ccgatgtcga attgaggacc ctgggagaag gacgcttcga actcctcacc ggcgcgcgca
    13501 agttcgttct cagaattacg gacgagcagg agaaggcgct gagcgaaatc gtcaccgaaa
    13561 tcctgccgaa gctcttccgc accgtgcccg tccgggaaca agtaacggcg gccgacatcg
    13621 agttgctggc gccgtacgtc aaacagctcg cgtctatggg ggtgttgctc tttccccgcc
    13681 agagcatcga gacggtggcg gatctgcggc tctactcgtt catcgcgcgc cggaccgccg
    13741 agcccgacaa ggtcttcggt tcggtgaagg ccaagcgcgt caccctgacc ggccccgacc
    13801 ggctcaccac ggtgttcgcg ggcctgctga gggaccaggg gctgacggtc gacggcgcgg
    13861 gtgcccaccc tcgtacggag acggagacgg agacggacac ggacgcggcg ctcaccgtcg
    13921 cggtgtccct cggggacgag gccgggctgg acgccatcaa ccgccggctg tgcggcgagg
    13981 gccgctcgtg gctgcccgtc ctggtcaccc ccgaccaact gcgcctgggg ccctggacga
    14041 tgcccggcga atccgcctgc ccgcgctgtt acggaccgcc ccgccccgtg gccgacgacc
    14101 tgcccgcgac cggcagctgg ctcaccctgc aacccggctt cctcggctgg gcgggcggcg
    14161 tactcgccca tatgacgatg cgcggcttcg tcccgatggg cgccgagcac ccctggggcc
    14221 ggatcacgac gatcgacgcg gcgcgctgcg agcagacgtc ggtgcgcgcc tggcgggacc
    14281 cgtactgcgc ggtgtgcgca ccgcacgccc ccgcacgcca ggaatgggcg gaggtctgag
    14341 cggtggacga ggacatgctg cgctgcgtga cggagcaggg cttcgcggcc cgtacgctcc
    14401 ccctgcccct gtacgtacgg gcgcacgccg aggtgctggt accggccgcc gacgccgggg
    14461 agaggcttga tctgcgggcc gccgacattc cgctgctcga cgtcgccgtg gcggccgacc
    14521 ggggcggcgc gctgcgccaa ctggtcgagc gggcggcggt gttgaggatc ctccgctccg
    14581 gccatggctc tctccgtgac tcgctccctg actccgacgg tgatgccagg gctggtgccc
    14641 gcgacggcag cccgcccgcc gtgggcgtgg gcgacggcca cgacgaagcc gtggcgcgcg
    14701 cgatctacca ggaactggcg cgccgccggg cggagtcggg catcgagaag ggcaccctga
    14761 tcaccggccg cgaccaggcc gggggaccct cgggcgtcgc cctgcgcggc gtggacggcc
    14821 ggatcgactg ctatctgctg ggcgagacgg ccggagtgcc cgccgtcgga gcggtcctgc
    14881 gactcgaccg cctggaacgg ccgttgtgcg cggtcgtctg cgacctgtgg gagcggcggg
    14941 gcgtggagcg ggccgtccag gcggtcctgc gtgagttcgt cgtcaccaca ctgccccggc
    15001 gcgacgacac cgaccgggcg ccgttcccgt acggcgactt ccacgacgtg gtggccgtcg
    15061 gcgagaccga cttcgaaaca ctggcccccc ggccgccgcg ggacgagacc ggcgaactcc
    15121 gcgacagact gcgtctgcac ggccaccgcg cgagcgtgcg cgtactcggc ccggccgacc
    15181 gcgccgcgct ggtggcctgc cgtctggagc cgacggccaa gtccgagccg tcggccgagt
    15241 ccgagtccga gcccgtgagg cggccgacga ctggtatcga ggacgactgg aggccccgtg
    15301 acgtcgcggc cctcgggctg cgcgcgcccc gccaactgtc gctcacctac gagcgcgacg
    15361 acgtacgcat cggccgcgtc taccacgaga actccaagat gcgcacggcc tacggcacgc
    15421 tgcccgtggt cgacatcgcc gagatgagcc cgccggcccg ccgcctcctc ggccaggcct
    15481 accgggactt cggccacgcc cgcaggcagt acccgatgcg tccgtcgggc cagccgcgac
    15541 tcctcacact cgaccaggtc gtacgccgca ggcgctcctg ggccgcgatg ggcgacggcg
    15601 agctgacccg cgccgagctg gcgcatctgc tgaccctgtc ctacgggacc accggagccg
    15661 ccgtcgcggg ccaggacctg cgcctgccgc tgcgcgccac tccgtcggcg ggcggcctct
    15721 actccagcga cctgttcgtc ctcgtggacc gtgtcaccga cgtggagccc ggcctgtact
    15781 acttccaccc cggcaagcga ctcctgcaac tggtcgacga cgagcggacg ttggcggaag
    15841 tcgccgagta caccggctac cgggagcggg cgggggaggc cgcggcgatg gtggtctacg
    15901 tcggcgcgtt ccggcgcaac cagtggaaat accgcgagcg cggctaccgc accgtactgc
    15961 tcgactgcgg ccacctcgcg cagagcgtgg tgaccacggc gacctcgctc ggtctggtcg
    16021 cacacccgat gatcgcgttc gtcgacgact acttcaacgc ctacgtcggc gtcgacggcg
    16081 tcgaggacgc ggtgctctat ctgacactgc tcggcccgcg acgcacaggg gatgaggccg
    16141 catgacggag acacagcgcg tacgtgtgag cgttcacgta ctggacgacg agaacggctt
    16201 cgtcgagacc gcgcacgaga tccaccgggt caagggcaag gggctcagcg ggctcacgga
    16261 cgaactgccc ccggaactcc tggacaagct gcgcatcgca ccgcccgccg ccgccgacgc
    16321 gaccgagccg gacggtccgc gcgtacgccg actggccgtc gccggaccga agtcgctgac
    16381 ccggcagttc ttcgccgtgg ccgaacacac ctcaggtctg gacgcacacg aactgccggc
    16441 cggcgaggac gagttggacg aggggccggg ccggtgcgac ctggtcgtca tcgccacggc
    16501 gtcgctgttc gacccacggg ccgcgcggac ggccgcccgg tgcgtacggg cgggcctgcc
    16561 gcacctggtg tacggagccg cgcgcgacgg cgtgaccttc gtgggaccac tctggtcgcc
    16621 gcagggggag ggtgcctgtt acgagtgcct gcgcgtccgg gtcgcctcca actcggtgca
    16681 cggccagacc tggcgcgcgt acatgacgtt cctcgccgag accggggccg agaccgggcc
    16741 cccgttccag cacgaggtgc ccccgtgggc ggcggcgcaa ctggccggag ccgtcggccg
    16801 gagagccgag gcctggctga ccgacgcggc cgacgaggcc accgccgagc tgctgtggaa
    16861 cgacgagagc agccccgcca agacgggccg caccctcctc cccgtaccca cctgcgcggt
    16921 ctgcgccgat ctgcaccgca cccgcgccac gagcacgacc gagccgaacg acgacgggaa
    16981 ggccaacggc gacgggaagg tcaacggcga cgggaaggcc aacggcgacg gcggcccgga
    17041 cgcactgcgc gccgccgagg acgacagggt cggcatcgtg cacgccacca gcgtgcgccg
    17101 cgccgagagc ggcccgcccg tgtacctcag cggcagcacc tccgccgacc tctcactgat
    17161 caaacggacg atgggcgtca ccgtcaacgg cggcgccgga ttctccaagg gcgaggccgt
    17221 cgccgccacc atcggcgaat ccctcgaacg ctacgccgcc ggcctctacc gccccgccga
    17281 cctgcacctc gccacctggg acgaactcga agcggccggc cgatcggcgg tcccgcccgc
    17341 cgagttcggc ctgttctccc cggagcagca cgccgagccc ggcttcccct tcaccccctt
    17401 cgacggcggc accccggtcc gctggactga ggccacggac ctgctgagcg gtgcgcccgt
    17461 ccaagtcccc gcgtcccagg tgtacatgca ctaccggcgc gtccggggcg aggccgcgat
    17521 cgggcagtcc atctccaccg gcctcgccgc gggcccctcc taccgggcgg cggtcctcag
    17581 cggcctgtac gaggtcatcg agcgcgacgc cctggccatc tcctggctgc accgactgcc
    17641 gccccgcccc ctcccgcccg aggttgtcgc cgcctcgtca cgtgtctcgt acctcatcga
    17701 ccgcgcgacg acctggcgcg tgcggttcta cgacctctca ctcgatctga cgccgtcgac
    17761 ggtggtggcc gtcatggagc accacagcgg cgccgaacag atcatgtcct tcggcagcgc
    17821 ctgccgctgg tcgccggtca aggcggtgga gaaggcgttc ctggaggccg cgcaagggct
    17881 cacctatgtc cgaaggctgc tgagacagca cgaggactgg gaggcggccg aggacttcgg
    17941 caacgtcgac gacttcaaca agcacgccat cctctactcg aagtaccccc gactgcgcga
    18001 gcgggcgggc tatctcgtcc acccctcggc cccggtgccg cccggccgcc ccgaacgccc
    18061 cgccccggcc gccaccgacg accccgtcgg ccggatcgcc gccgaactgg ccgccgccgg
    18121 ccaccgggtg tgcgtcgtgg acctgaccac ccccgacgtc cgccgcagcg gcgcacacgt
    18181 cgtacgcgtc ctggtccccg gcctccagca cctgtccggg gtgcacggct gccggatgct
    18241 cggcaaccgc cggctgtacg acatcgtggc cgccctcggc tgcgacaccc ggcccgacaa
    18301 cccgtatccg cacccgttgc cctgaacgtg gcaaggagct ccgatggcgt cctcattcct
    18361 cgcgtacccc tccctgtccg tcgtccgcaa cgacgatttc gcggacaccg ccgacatcgc
    18421 cgaggcgttc gcccggcatg tcaccagccg ccaactgccc ggcgacgtcg cgcctgtccg
    18481 gtgctccgtc gagagcgagg cggtccccgg cggggtgcgg ctgcgcttca ccagtacggc
    18541 gcggaagctc gccgccccgg ccaccgtgac gcacaagttc ttcttcatcg accgcgacga
    18601 gtcccgcgaa cgccgccatc tgctcacccc ggtgaggacc gcggccacca ccgaactgct
    18661 ggtgctcttc gaggagggcc aggagcggga ctacttccac gggtccgtgt tcgacagcga
    18721 caacctgctg ctggccagct ccgccgtggt gttcgaccgc gagggccggc acgtcccgta
    18781 tccgttcacc cagaagtacg tctgtccgca gcgcctcgcc gccgccgact tcgaggtgac
    18841 gcgcgacgcc gacggccgcc gggtggcacg gttctcgctg gcctgccggg acctcaccga
    18901 gacactgcgg ctgtcggtcg cctgggagac gatcggcgtg gtccaccagc gggacctggt
    18961 gtgcacgccc gagcggcccg cgacctacct ggacatgccg ctggacgaca acgacgaact
    19021 cgcccccggc gactgggtcg tcatcgccgt cgacgaccgg cagcggctgc tggcacagac
    19081 cgtggtgacc ctggtctcca ccgaggccgg ccggtgcccg tcctgaccac cgggccccgc
    19141 gacccgaccg ggccccgcca cctcacgctc gacaacggac tccacctcgt cggagtgcgc
    19201 cggccgggct cgccactggc cgccctgcgg ctgcgaatcg acatcggcag cgccgacgag
    19261 gcgcccggcg agcacggcct ggcccatgtc ctggaacacc tggtcgtacg gtgctcgatg
    19321 ggcggcggcc gggtcgcgga cggggcgctg gtcgaggccg ccaccggtcg gccgcacacc
    19381 tcgtacgacg ccttggtgcg gaccggcgac atcgcgacgg ccggggacgt cctgggcgcc
    19441 gccttccggc agttgaggcc ggacacccgg gatctcgccg acgagctggc cgcgatccgg
    19501 cgggagcgcg cgcagcgcac cgccgatgtg cggtggcggg tgcaggaggc gatgttcgcc
    19561 gcgctctgcc cggacacccc gtacgcccat ccggtgctcg gcgacccccg gacggtcgac
    19621 gcgctgaccc ccgaggccgt gcaccgcctc cactcccgct ggtaccaccc ttcgcgcgcc
    19681 acgctcgtca tcggctcgga ccgggtggac gaggaactgg ccgcgctcgc cgagcgggcg
    19741 cgactctggg cgccgggcca cccccgtacg gagactcgcg ccgccgcgcc gccgccggac
    19801 gggcacgccg tggtgtcgga ggcggtgggc gccgggagac gggccgtcgc cgtcgggttc
    19861 accgagcccg gcgccccctg cggcgccgac gccgggttcg ctctggcccg gcggtccgta
    19921 cgcgcggccc gaggcatcga cgtgctgcgg ctccggctgc ggagccacac ctgcacctgg
    19981 gtcatgctgg cggccaccga cgagacggcg gcggtccgct cggtcgccgc cgcgttgcgg
    20041 gccatacgtg aactgctgct cggtccggac ggggcggccc tgctgcgtac cgaggcgctc
    20101 atccccgaac tgcgcgccgc cgaggacatc cagcggtccg tcgccgacgc caccgacgcc
    20161 ttcgacgcct ccgaccgcat cccggcctcc cggccgacga cggcgacggc gacgggcgtc
    20221 ggggaggtgg ccgacgtgat cgcgcggtgg cggcaggggt tcgccgccgc cctgcccgaa
    20281 ggcccggcga catgacggcc cccggcgcac cggtcctcgc caacagcgtt cccggcgaac
    20341 acgccgtcgc cgccgccacc ctcgccgtgc cgctgaccgg ggcggaccgc gcgagcgtac
    20401 tcgccgcacc tctcgtcgcg gcggcgtggg cgtgcgccgt cgccgccgag gcacggcgcg
    20461 gcggaacgcc cgtcaggacc gaaccggtcg tgacggcgga ctacgcgggc atcacggccg
    20521 aagccgcgcc cggcgaccac gaagcgctgc gccgcctcgc cgactggttc gccgccgtgg
    20581 cggaacaccc gctggaggaa tgggagttcg gcacggtacg gcggtccttc ctgtcccgta
    20641 caccgtcgtc cgcccgctgg tccgacgccg tacgacgcgc cctcttcggc gaccggcacc
    20701 gttacggcgt cggccacgac gaacgcgtcg cccatgtcac cggctgcgga ccggccgacg
    20761 tgaccgcggc ggcgcgcgaa ctgctcgcgg cgcgccccgc cggacccgcg ccgctcgtgc
    20821 ctcgtacggt ccgcgtccgg ctcccggccg aaggcggcgc ggcctgccat ctgctcggta
    20881 caccgggcgt cagtctcggc tccgacgaca agtacgccct gcatgtcgcc tgggcgctgc
    20941 tcggcggtcg cgacgggatg ctcgaccggc ggctgcgcgg cgagcacgcc ctcacctact
    21001 cgctcgccgc cttcagccgg gagttcgccg acggcggcta cggcgcctgc ttcgccgcct
    21061 gcgcgcccgg cgcgcgggac gaggtggccg agcggaccgg ggaggtgctg cgcgcgctgg
    21121 agcgcggcgc gtttccccgc tcgctcgtcg actccgcgaa ggagcgcctc atcatcgcca
    21181 accaccgctc cctgcggaac ggccgcagtg tgacggagcg gctgtgcggc taccagatcg
    21241 cggggaccga ccccggcggc atcacccagt acgcccgtca cgtcggcggc gtcacacccg
    21301 aacaggtcgc ggacgtcgca cggcgccata tcggctcgga ccaaccggga ggggacttgt
    21361 gaacaggttc gcgatacgag agatctggcg ctaccccgtc aagagcatgg cgggcgagcg
    21421 cctggacggc tgcgcggtca cggcggacgg gctgctgggc gaccgctgct gggcgctgcg
    21481 tgacgaggaa cgcgcgtgca tcgcggacgc ccgcaagctc cccgcgatgc tcgacatcca
    21541 cgtccgctac gcccggcagc cggagcccac cgtggccggg ggccggtccg ccggtgtcga
    21601 actgcgcctg cccggcacgg agtcggggcc cgtcgcctcc gacgacccgg ccgtccacga
    21661 cgtactgtcc gcgcatctcg gcaggaaggt caccctgtgg cccctgctgt ccgcgcagga
    21721 ggaccgggcg cactacgtac gcgcctggcc cgaggacgtc gagcgctatc tcaaggatct
    21781 cttcggggtg gcggacctgg ccgagatgcc ggacctgtcg gcgctcccgc cggaggtggc
    21841 cgagtaccag acgatgcccg gcacgtactt cgacgcgtac cccgtgcacc tcgtcaccac
    21901 cggcgagctg gaggcgctgg cacgggccga gccgcctccg cccgatgtgg actcccgccg
    21961 cttcaggccc aacctccttc tggagggccc ggccgcaccg gactgggtgg ggcgccgggt
    22021 acggatcggc tcggcggtgc tgcgcgtcga ggcggactgc ccgcgctgcg tcatggtctc
    22081 ccagccccag cagggactgc ccgcggcgcg gggcctgctc cgtacggtgc accgcgactt
    22141 cggccaccag gtcggcctct acgcgtcggt ggagcgaccg ggccgggtgg agtgcaccga
    22201 cgtggccgag gtcgaggacg cggaagagga gtga
//
