BGC0001800: theonellamide biosynthetic gene cluster from Candidatus Entotheonella serta
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 55,291 nt. (total: 55,291 nt).
This entry is originally from NCBI GenBank MG844357.1, but has been modified (see Modifications tab for details).

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0001800
Short description theonellamide biosynthetic gene cluster from Candidatus Entotheonella serta
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MG844357.1
via
Compounds
  • theonellamide
Species Candidatus Entotheonella serta [taxonomy]
References
Chemical products information
theonellamide Evidence:
Copy SMILES
C76H99Br1N16O28
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AVI26388.1
  • tnaA
 622 - 8811 (+) polyketide synthase
    copy AA seq
    copy Nt seq
    • AVI26389.1
    • tnaB
    		 8825 - 14383 (+) polyketide synthase
      copy AA seq
      copy Nt seq
      • AVI26390.1
      • tnaC
      		 14419 - 28872 (+) polyketide synthase / nonribosomal peptide synthase hybrid
        copy AA seq
        copy Nt seq
        • AVI26391.1
        • tnaD
        		 28877 - 29941 (+) putative dioxygenase
          copy AA seq
          copy Nt seq
          • AVI26392.1
          • tnaE
          		 29947 - 35355 (+) putative nonribosomal peptide synthase
            copy AA seq
            copy Nt seq
            • AVI26393.1
            • tnaF
            		 35352 - 47435 (+) nonribosomal peptide synthase
              copy AA seq
              copy Nt seq
              • AVI26394.1
              • tnaG
              		 47425 - 48444 (+) putative monooxygenase
                copy AA seq
                copy Nt seq
                • AVI26395.1
                • tnaE_rename1
                		 48492 - 50999 (+) nonribosomal peptide synthase-like protein
                  copy AA seq
                  copy Nt seq
                  • AVI26396.1
                  • tnaI
                  		 51115 - 52440 (+) glycosyltransferase
                    copy AA seq
                    copy Nt seq
                    • AVI26397.1
                    		 52567 - 53190 (-) DUF2063-containing hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • AVI26398.1
                      		 53299 - 53436 (-) hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • AVI26399.1
                        		 53672 - 53992 (+) putative dehydrogenase
                          copy AA seq
                          copy Nt seq
                          • AVI26400.1
                          		 54264 - 54827 (-) transport protein
                            copy AA seq
                            copy Nt seq
                            • AVI26401.1
                            		 54835 - >55289 (-) transport protein
                              copy AA seq
                              copy Nt seq
                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              tnaC
                              Substrates
                              serine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk02
                              Type
                              nrps-type1
                              Genes
                              tnaC
                              Substrates
                              asparagine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk03
                              Type
                              nrps-type1
                              Genes
                              tnaF
                              Substrates
                              threonine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk04
                              Type
                              nrps-type1
                              Genes
                              tnaF
                              Substrates
                              serine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Name
                              Unk05
                              Type
                              nrps-type1
                              Genes
                              tnaF
                              Substrates
                              phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                              Integrated Monomers
                              Domains
                              adenylation
                              Annotation changelog

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2018-08-06
                              Submitted
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Similar known clusters from MIBiG 4.0
                              Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                              Detailed help and explanations are available here.

                              Click on reference genes to show details of similarities to genes within the current region.
                              Double click on a reference drawing to reverse the display of the genes.

                              Click on an accession to open that entry in the MIBiG database.


                              Location:

                              Identifier
                              Identity
                              Coverage
                              Detailed domain annotation
                              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                              A domain glossary is available here, and an explanation of the visualisation is available here.
                              Selected features only
                              Show module domains
                              Modifications to original record
                              • renamed CDS with name tnaE at [48491:50999](+) to tnaE_rename1 to avoid duplicates