BGC0001800: theonellamide biosynthetic gene cluster from Candidatus Entotheonella serta
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Location: 1 - 55,291 nt. (total: 55,291 nt).
This entry is originally from NCBI GenBank MG844357.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001800
Short description theonellamide biosynthetic gene cluster from Candidatus Entotheonella serta
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: MG844357.1
Compounds
  • theonellamide
Species Candidatus Entotheonella serta [taxonomy]
References
Chemical products information
theonellamide
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C76H99Br1N16O28
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AVI26388.1
  • tnaA
 622 - 8811 (+) polyketide synthase
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  • AVI26389.1
  • tnaB
 8825 - 14383 (+) polyketide synthase
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  • AVI26390.1
  • tnaC
 14419 - 28872 (+) polyketide synthase / nonribosomal peptide synthase hybrid
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  • AVI26391.1
  • tnaD
 28877 - 29941 (+) putative dioxygenase
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  • AVI26392.1
  • tnaE
 29947 - 35355 (+) putative nonribosomal peptide synthase
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  • AVI26393.1
  • tnaF
 35352 - 47435 (+) nonribosomal peptide synthase
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  • AVI26394.1
  • tnaG
 47425 - 48444 (+) putative monooxygenase
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  • AVI26395.1
  • tnaE_rename1
 48492 - 50999 (+) nonribosomal peptide synthase-like protein
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  • AVI26396.1
  • tnaI
 51115 - 52440 (+) glycosyltransferase
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  • AVI26397.1
 52567 - 53190 (-) DUF2063-containing hypothetical protein
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  • AVI26398.1
 53299 - 53436 (-) hypothetical protein
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  • AVI26399.1
 53672 - 53992 (+) putative dehydrogenase
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  • AVI26400.1
 54264 - 54827 (-) transport protein
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  • AVI26401.1
 54835 - >55290 (-) transport protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tnaC
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
tnaF
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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Modifications to original record
  • renamed CDS with name tnaE at [48491:50999](+) to tnaE_rename1 to avoid duplicates