BGC0001801: thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
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Location: 555,257 - 584,067 nt. (total: 28,811 nt).
This entry is originally from NCBI GenBank FR845719.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001801
Short description thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
FR845719.1
555257 - 584067
via
Compounds
  • thiazostatin
  • watasemycin A
  • watasemycin B
  • 2-hydroxyphenylthiazoline enantiopyochelin
  • isopyochelin
Species Streptomyces venezuelae ATCC 10712 [taxonomy]
References
Chemical products information
thiazostatin Evidence:
(no structure information available)
watasemycin A Evidence:
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C16H20N2O3S2
Chemical database entries
NPAtlas
watasemycin B Evidence:
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C16H20N2O3S2
Chemical database entries
NPAtlas
2-hydroxyphenylthiazoline enantiopyochelin Evidence:
(no structure information available)
isopyochelin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SVEN_0503
  • CCA53790.1
 555257 - 556507 (-) non-ribosomal peptide synthetase
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    • SVEN_0504
    • CCA53791.1
    		 556563 - 557837 (-) Na+ or H+ antiporter
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      • SVEN_0505
      • CCA53792.1
      		 557988 - 559934 (-) hypothetical protein
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        • SVEN_0506
        • CCA53793.1
        		 559994 - 561358 (-) Anthranilate synthase, aminase component
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          • SVEN_0507
          • CCA53794.1
          		 562062 - 562751 (+) putative transcriptional regulator
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            • SVEN_0508
            • CCA53795.1
            		 562748 - 563959 (+) putative reductoisomerase
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              • SVEN_0509
              • CCA53796.1
              		 564071 - 564757 (+) putative transcriptional regulator
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                • SVEN_0510
                • CCA53797.1
                		 564822 - 566423 (-) Long-chain-fatty-acid--CoA ligase
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                  • SVEN_0511
                  • CCA53798.1
                  		 566493 - 567293 (-) thioesterase
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                    • SVEN_0512
                    • CCA53799.1
                    		 567290 - 571834 (-) iron aquisition yersiniabactin synthesis enzyme
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                      • SVEN_0513
                      • CCA53800.1
                      		 571891 - 573600 (-) putative ABC transporter
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                        • SVEN_0514
                        • CCA53801.1
                        		 573597 - 575438 (-) Transport ATP-binding protein CydC
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                          • SVEN_0515
                          • CCA53802.1
                          		 575754 - >577328 (+) radical SAM domain protein
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                            • SVEN_0516
                            • CCA53803.1
                            		 577364 - 578590 (-) putative reductoisomerase in siderophore biosynthesis
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                              • SVEN_0517
                              • CCA53804.1
                              		 578587 - 584067 (-) pyochelin synthetase F
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                Unk01
                                Type
                                nrps-type1
                                Genes
                                SVEN_0510
                                Substrates
                                salicylic acid (evidence: Structure-based inference, Homology)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk02
                                Type
                                nrps-type1
                                Genes
                                SVEN_0512
                                Substrates
                                cysteine (evidence: Structure-based inference, Homology)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk03
                                Type
                                nrps-type1
                                Genes
                                SVEN_0517
                                Substrates
                                cysteine (evidence: Structure-based inference, Homology)
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Added NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2018-08-06
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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