BGC0001801: thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
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Location: 555,257 - 584,067 nt. (total: 28,811 nt).
This entry is originally from NCBI GenBank FR845719.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001801
Short description thiazostatin biosynthetic gene cluster from Streptomyces venezuelae ATCC 10712
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FR845719.1
Compounds
  • thiazostatin
  • watasemycin A
  • watasemycin B
  • 2-hydroxyphenylthiazoline enantiopyochelin
  • isopyochelin
Species Streptomyces venezuelae ATCC 10712 [taxonomy]
References
Chemical products information
thiazostatin
(no structure information available)
watasemycin A
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C16H20N2O3S2
Chemical database entries
NPAtlas
watasemycin B
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C16H20N2O3S2
Chemical database entries
NPAtlas
2-hydroxyphenylthiazoline enantiopyochelin
(no structure information available)
isopyochelin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SVEN_0503
  • CCA53790.1
555257 - 556507 (-) non-ribosomal peptide synthetase
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  • SVEN_0504
  • CCA53791.1
556563 - 557837 (-) Na+ or H+ antiporter
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  • SVEN_0505
  • CCA53792.1
557988 - 559934 (-) hypothetical protein
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  • SVEN_0506
  • CCA53793.1
559994 - 561358 (-) Anthranilate synthase, aminase component
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  • SVEN_0507
  • CCA53794.1
562062 - 562751 (+) putative transcriptional regulator
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  • SVEN_0508
  • CCA53795.1
562748 - 563959 (+) putative reductoisomerase
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  • SVEN_0509
  • CCA53796.1
564071 - 564757 (+) putative transcriptional regulator
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  • SVEN_0510
  • CCA53797.1
564822 - 566423 (-) Long-chain-fatty-acid--CoA ligase
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  • SVEN_0511
  • CCA53798.1
566493 - 567293 (-) thioesterase
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  • SVEN_0512
  • CCA53799.1
567290 - 571834 (-) iron aquisition yersiniabactin synthesis enzyme
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  • SVEN_0513
  • CCA53800.1
571891 - 573600 (-) putative ABC transporter
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  • SVEN_0514
  • CCA53801.1
573597 - 575438 (-) Transport ATP-binding protein CydC
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  • SVEN_0515
  • CCA53802.1
575754 - >577328 (+) radical SAM domain protein
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  • SVEN_0516
  • CCA53803.1
577364 - 578590 (-) putative reductoisomerase in siderophore biosynthesis
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  • SVEN_0517
  • CCA53804.1
578587 - 584067 (-) pyochelin synthetase F
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
SVEN_0510
Module ?
Specificity: salicylic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
SVEN_0512
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Homology
SVEN_0517
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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