BGC0001806: tolaasin A biosynthetic gene cluster from Pseudomonas tolaasii
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Location: 1 - 60,453 nt. (total: 60,453 nt).
This entry is originally from NCBI GenBank KX432141.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001806
Short description tolaasin A biosynthetic gene cluster from Pseudomonas tolaasii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KX432141.1
via
Compounds
  • tolaasin A
Species Pseudomonas tolaasii [taxonomy]
References
Chemical products information
tolaasin A Evidence:
Copy SMILES
C91H155N21O26
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • APU91750.1
 1 - 38658 (+) Non-Ribosomal Peptide Synthetase
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    • APU91751.1
    		 39316 - 58821 (+) Non-Ribosomal Peptide Synthetase
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      • APU91752.1
      		 58984 - >60453 (+) Non-Ribosomal Peptide Synthetase
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        Biosynthesis information

        Biosynthetic modules

        Name
        Unk01
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk02
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        proline (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk03
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        serine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk04
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        leucine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk05
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        valine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk06
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        serine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk07
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        leucine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk08
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        valine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk09
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        valine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk10
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        glutamine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk11
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        leucine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk12
        Type
        nrps-type1
        Genes
        APU91750.1
        Substrates
        valine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk13
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk14
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        threonine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk15
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        isoleucine, leucine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk16
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        homoserine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk17
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        2,4-diaminobutyric acid (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Name
        Unk18
        Type
        nrps-type1
        Genes
        APU91751.1
        Substrates
        lysine (evidence: Structure-based inference, Mass spectrometry, Sequence-based prediction)
        Integrated Monomers
        Domains
        adenylation
        Annotation changelog

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Added NRP substrate specificities
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Migrated from v1.4
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated reference publication(s) (MIBiG Annotathon)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2019-10-16
        Updated compound(s) information (NPAtlas curation)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2018-08-06
        Submitted
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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