BGC0001807: totopotensamide A biosynthetic gene cluster from Streptomyces pactum
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Location: 1 - 98,792 nt. (total: 98,792 nt).
This entry is originally from NCBI GenBank MG012231.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001807
Short description totopotensamide A biosynthetic gene cluster from Streptomyces pactum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MG012231.1
via
Compounds
  • totopotensamide A
  • totopotensamide B
Species Streptomyces pactum [taxonomy]
References
Chemical products information
totopotensamide A Evidence:
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C52H84Cl1N7O19
Chemical database entries
PubCHEM
totopotensamide B Evidence:
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C45H72Cl1N7O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATL73023.1
 1 - 873 (-) ABC-type transport protein
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    • ATL73024.1
    		 1108 - 1953 (-) transcriptional regulator
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      • ATL73025.1
      		 2008 - 3147 (-) oxidoreductase
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        • ATL73026.1
        		 3331 - 4230 (-) virginiamycin B lyase
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          • ATL73027.1
          		 4417 - 4992 (-) secreted extracellular small neutral protease
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            • ATL73028.1
            		 5217 - 5504 (-) hypothetical protein
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              • ATL73029.1
              		 5684 - 6721 (-) luciferase-like monooxygenase
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                • ATL73030.1
                		 6822 - 7022 (-) ferredoxin
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                  • ATL73031.1
                  		 7052 - 8257 (-) cytochrome P450 hydroxylase
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                    • ATL73032.1
                    		 8688 - 9839 (+) scyllo-inosamine-4-phosphate amidinotransferase
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                      • ATL73033.1
                      		 10147 - 29712 (+) type I modular polyketide synthase
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                        • ATL73034.1
                        		 29798 - 41014 (+) type I modular polyketide synthase
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                          • ATL73035.1
                          		 41075 - 42142 (-) O-methyltransferase family protein
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                            • ATL73036.1
                            		 42445 - 61209 (+) amino acid adenylation protein
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                              • ATL73037.1
                              		 61255 - 62466 (+) cytochrome P450 hydroxylase
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                                • ATL73038.1
                                		 62565 - 63476 (+) glycolipid sulfotransferase
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                                  • ATL73039.1
                                  		 63544 - 64455 (+) taurine dioxygenase
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                                    • ATL73040.1
                                    		 64510 - 65631 (+) dihydroxyphenylacetic acid synthase
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                                      • ATL73041.1
                                      		 65652 - 66368 (+) enoyl-CoA hydratase/isomerase
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                                        • ATL73042.1
                                        		 66365 - 67744 (+) enoyl-CoA hydratase/isomerase
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                                          • ATL73043.1
                                          		 67741 - 69045 (+) aminotransferase
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                                            • ATL73044.1
                                            		 69104 - 70252 (+) scyllo-inosamine-4-phosphate amidinotransferase
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                                              • ATL73045.1
                                              		 70302 - 73532 (+) amino acid adenylation domain protein
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                                                • ATL73046.1
                                                		 73529 - 75181 (+) TetR family transcriptional regulator
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                                                  • ATL73047.1
                                                  		 75178 - 76659 (+) putative argininosuccinate lyase
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                                                    • ATL73048.1
                                                    		 76656 - 77573 (+) hypothetical protein
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                                                      • ATL73049.1
                                                      		 77592 - 79034 (-) halogenase
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                                                        • ATL73050.1
                                                        		 79177 - 79548 (-) ketosteroid isomerase-like protein
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                                                          • ATL73051.1
                                                          		 79818 - 82484 (-) LuxR family transcriptional regulator
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                                                            • ATL73052.1
                                                            		 82872 - 85613 (-) LuxR family transcriptional regulator
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                                                              • ATL73053.1
                                                              		 85771 - 86370 (-) TetR family transcriptional regulator
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                                                                • ATL73054.1
                                                                		 86653 - 86868 (+) MbtH-like protein
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                                                                  • ATL73055.1
                                                                  		 86894 - 89128 (+) TotD2
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                                                                    • ATL73056.1
                                                                    		 89650 - 92049 (-) LuxR family transcriptional regulator
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                                                                      • ATL73057.1
                                                                      		 92962 - 94158 (-) macrolide glycosyltransferase
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                                                                        • ATL73058.1
                                                                        		 94319 - 95044 (+) hypothetical protein
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                                                                          • ATL73059.1
                                                                          		 95276 - 95890 (+) TetR family transcriptional regulator
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                                                                            • ATL73060.1
                                                                            		 95915 - 97408 (-) efflux permease
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                                                                              • ATL73061.1
                                                                              		 97614 - 98792 (+) hypothetical protein
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                                                                                Biosynthesis information

                                                                                Biosynthetic modules

                                                                                Name
                                                                                Unk01
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73036.1
                                                                                Substrates
                                                                                threonine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk02
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73036.1
                                                                                Substrates
                                                                                alanine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk03
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73036.1
                                                                                Substrates
                                                                                2,4-diaminobutyric acid (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk04
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73036.1
                                                                                Substrates
                                                                                2-chloro-3,5-dihydroxy-4-methylphenylglycine, 3,5-dihydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk05
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73036.1
                                                                                Substrates
                                                                                isoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Name
                                                                                Unk06
                                                                                Type
                                                                                nrps-type1
                                                                                Genes
                                                                                ATL73045.1
                                                                                Substrates
                                                                                glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                                                Integrated Monomers
                                                                                Domains
                                                                                adenylation
                                                                                Annotation changelog

                                                                                Entry version: 3

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2022-09-15
                                                                                Added NRP substrate specificities
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 2

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2019-10-16
                                                                                Migrated from v1.4
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                2019-10-16
                                                                                Updated compound(s) information (MIBiG Annotathon)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 1

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2018-08-06
                                                                                Submitted
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                Detailed domain annotation
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