BGC0001807: totopotensamide A biosynthetic gene cluster from Streptomyces pactum
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 98,792 nt. (total: 98,792 nt).
This entry is originally from NCBI GenBank MG012231.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001807
Short description totopotensamide A biosynthetic gene cluster from Streptomyces pactum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: MG012231.1
Compounds
  • totopotensamide A
  • totopotensamide B
Species Streptomyces pactum [taxonomy]
References
Chemical products information
totopotensamide A
Copy SMILES
C52H84Cl1N7O19
Chemical database entries
PubCHEM
totopotensamide B
Copy SMILES
C45H72Cl1N7O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATL73023.1
 1 - 873 (-) ABC-type transport protein
copy AA seq
copy Nt seq
  • ATL73024.1
 1108 - 1953 (-) transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73025.1
 2008 - 3147 (-) oxidoreductase
copy AA seq
copy Nt seq
  • ATL73026.1
 3331 - 4230 (-) virginiamycin B lyase
copy AA seq
copy Nt seq
  • ATL73027.1
 4417 - 4992 (-) secreted extracellular small neutral protease
copy AA seq
copy Nt seq
  • ATL73028.1
 5217 - 5504 (-) hypothetical protein
copy AA seq
copy Nt seq
  • ATL73029.1
 5684 - 6721 (-) luciferase-like monooxygenase
copy AA seq
copy Nt seq
  • ATL73030.1
 6822 - 7022 (-) ferredoxin
copy AA seq
copy Nt seq
  • ATL73031.1
 7052 - 8257 (-) cytochrome P450 hydroxylase
copy AA seq
copy Nt seq
  • ATL73032.1
 8688 - 9839 (+) scyllo-inosamine-4-phosphate amidinotransferase
copy AA seq
copy Nt seq
  • ATL73033.1
 10147 - 29712 (+) type I modular polyketide synthase
copy AA seq
copy Nt seq
  • ATL73034.1
 29798 - 41014 (+) type I modular polyketide synthase
copy AA seq
copy Nt seq
  • ATL73035.1
 41075 - 42142 (-) O-methyltransferase family protein
copy AA seq
copy Nt seq
  • ATL73036.1
 42445 - 61209 (+) amino acid adenylation protein
copy AA seq
copy Nt seq
  • ATL73037.1
 61255 - 62466 (+) cytochrome P450 hydroxylase
copy AA seq
copy Nt seq
  • ATL73038.1
 62565 - 63476 (+) glycolipid sulfotransferase
copy AA seq
copy Nt seq
  • ATL73039.1
 63544 - 64455 (+) taurine dioxygenase
copy AA seq
copy Nt seq
  • ATL73040.1
 64510 - 65631 (+) dihydroxyphenylacetic acid synthase
copy AA seq
copy Nt seq
  • ATL73041.1
 65652 - 66368 (+) enoyl-CoA hydratase/isomerase
copy AA seq
copy Nt seq
  • ATL73042.1
 66365 - 67744 (+) enoyl-CoA hydratase/isomerase
copy AA seq
copy Nt seq
  • ATL73043.1
 67741 - 69045 (+) aminotransferase
copy AA seq
copy Nt seq
  • ATL73044.1
 69104 - 70252 (+) scyllo-inosamine-4-phosphate amidinotransferase
copy AA seq
copy Nt seq
  • ATL73045.1
 70302 - 73532 (+) amino acid adenylation domain protein
copy AA seq
copy Nt seq
  • ATL73046.1
 73529 - 75181 (+) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73047.1
 75178 - 76659 (+) putative argininosuccinate lyase
copy AA seq
copy Nt seq
  • ATL73048.1
 76656 - 77573 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ATL73049.1
 77592 - 79034 (-) halogenase
copy AA seq
copy Nt seq
  • ATL73050.1
 79177 - 79548 (-) ketosteroid isomerase-like protein
copy AA seq
copy Nt seq
  • ATL73051.1
 79818 - 82484 (-) LuxR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73052.1
 82872 - 85613 (-) LuxR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73053.1
 85771 - 86370 (-) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73054.1
 86653 - 86868 (+) MbtH-like protein
copy AA seq
copy Nt seq
  • ATL73055.1
 86894 - 89128 (+) TotD2
copy AA seq
copy Nt seq
  • ATL73056.1
 89650 - 92049 (-) LuxR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73057.1
 92962 - 94158 (-) macrolide glycosyltransferase
copy AA seq
copy Nt seq
  • ATL73058.1
 94319 - 95044 (+) hypothetical protein
copy AA seq
copy Nt seq
  • ATL73059.1
 95276 - 95890 (+) TetR family transcriptional regulator
copy AA seq
copy Nt seq
  • ATL73060.1
 95915 - 97408 (-) efflux permease
copy AA seq
copy Nt seq
  • ATL73061.1
 97614 - 98792 (+) hypothetical protein
copy AA seq
copy Nt seq
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ATL73036.1
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: alanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2,4-diaminobutyric acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: 2-chloro-3,5-dihydroxy-4-methylphenylglycine / 3,5-dihydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: isoleucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
ATL73045.1
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.