LOCUS       BGC0001811             27272 bp    DNA     linear   PLN 18-MAR-2017
DEFINITION  Fusarium asiaticum DNA, tri gene cluster.
ACCESSION   BGC0001811
VERSION     BGC0001811
KEYWORDS    .
SOURCE      Fusarium asiaticum
  ORGANISM  Fusarium asiaticum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae;
            Fusarium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 04:36:46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 27272
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..27272
                     /culture_collection="MAFF:111233"
                     /db_xref="taxon:282267"
                     /mol_type="genomic DNA"
                     /organism="Fusarium asiaticum"
                     /strain="MAFF 111233"
     subregion       1..27272
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0001811"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..27272
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(33..1367)
                     /gene="tri8"
     CDS             complement(33..1367)
                     /codon_start=1
                     /gene="tri8"
                     /product="trichothecene 3-O-esterase"
                     /protein_id="BAX01957.1"
                     /transl_table=1
                     /translation="MALDRLLFLLSLWLGFVGAAQAALSEPLPPSKDPWYTAPPGFENA
                     EPGTVLRVRPAPGNLTSVTGNCSASYNILYRTTDSHFKPTWAVTTLLVPELGPESNAHQ
                     KYQQSALMSLQVAYDSPDVDASPSNTMYTASAISSIYYEAALAEGIFVSVPDYEGPSAA
                     FTAGIISGYATLDSIRAVLSLGLGFNMTNTPSVALWGYSGGAFATEWASELAVQYAPEL
                     VAGPVVGAAMGAPLANITSIMYDVNGGPTSGLTPNMLLGLTVQYPDVRKHLVSKLNNDS
                     QYNKTDFLAAEGYTITEAGVAFSKIDINKYFQKGTDIFSDPEITALVNREGVMGYHGTP
                     RWPMYIYQAIPDEVTPIAATDAVVKRYCAVGADILFERNTLGSHYVEANSGYDVAFQWL
                     LNVFAGQHDTKGCVIKDVTRNVNGTALKTRGDADKSAVDFWTSAW"
     gene            2065..3441
                     /gene="tri7"
     CDS             join(2065..2870,2922..3441)
                     /codon_start=1
                     /gene="tri7"
                     /product="trichothecene 4-O-acetyltransferase"
                     /protein_id="BAX01958.1"
                     /transl_table=1
                     /translation="MDTASKVEGFQTFNILYYLSTLLAVCTYSALIIISTSKAGPTSLV
                     RYASPAIVLPVGKKLFQEAYGLSSSIGHRGFILGITAQLIIQCCNFLVLERLDANDLAK
                     KKVFRSSDGIVYKVYGVACLIFNLRGIGTPWQAKHLCDHPRFYQHDQGREPTRAWFILR
                     QSLIVAWQYLLLDIVYTTTMSTPKEDTQRLFAEGTEYMYLDANAEQWTVRFITGVVAWA
                     IPGRVSIDLPGRVLSIFSVLLGFTTPQQWPPVFGSILDAYTIRGFWGTFWHQYFRRALT
                     GVSNFICRDFLRLPRPSIVERYLNLSLVFLGSALVHIPVDWFSLPPPSKPPVLALAFFG
                     SFIVGIIIEDTVQALWRRITGATKQDGDEGVPLWHKLVGYIWVAFWLMVVSPWYLYHNS
                     RLPPGDTWFVPVSFMDTIGVDTAKKLLLASGVILRFAVGIEI"
     protocluster    3672..24851
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[13671:14851]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13672..14851
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    3672..24851
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     gene            4241..6003
                     /gene="tri3"
     CDS             join(4241..5020,5076..5554,5604..5640,5699..5823,
                     5889..6003)
                     /codon_start=1
                     /gene="tri3"
                     /product="trichothecene 15-O-acetyltransferase"
                     /protein_id="BAX01959.1"
                     /transl_table=1
                     /translation="MSASSSALPPLVPTLYRWESTGPRQVQRRCVGAEAIVGLEEKNRR
                     SLYDLFIATSLRNVAPASTSLTLRNLKDMFELALVEGRFEHPESACTVSWDDQVAAIIS
                     YESPESDESARDWARGCVHVQPTAKSAIDLWTEMEEGRAAAKDNTPSKPIELFLLSDVP
                     TDSTPIPQGATVYILFHSNHLFWDGIGCRKFIGDLFRLVGNHIGLSDSADTPKMQWGQE
                     IKNLSPPVVDSLKLDVSTLGTEFDDKCTEYTSALVANYKSRGMKFQPGLALPRCAIYKL
                     SAEDSIAIVKAVKTRLGPGYTISQLTQAAIILALLDHLKPTDLSDDEFFLSPTSVDGRK
                     WLREDIASNYYAMCQTAAVVRVENLKSIAVSHEDEKELQVRALEKACRDIKKCYDQWLG
                     NPFLEALGLRVHNFEAGYLHDKPNPFEGTEANPLFISDGINERFIPREIKRTATGEDVL
                     SVESIDFVVNQSLPYLWRDASTLNIIYNDANYNEEEVQTYLKSIVEFMLAFKL"
     gene            complement(7169..8910)
                     /gene="tri4"
     CDS             complement(join(7169..7355,7425..7591,7644..8608,
                     8667..8910))
                     /codon_start=1
                     /gene="tri4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 300.6; E-value: 3.4e-91)"
                     /gene_kind="biosynthetic-additional"
                     /product="trichodiene oxygenase"
                     /protein_id="BAX01960.1"
                     /sec_met_domain="p450 (E-value: 2.4e-58, bitscore: 187.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MIDQDWIKSLLNIPVSHVAGIFAASTVIYFVSSCFYNLYLHPLRK
                     IPGPKLAAIGPYLEFYHEVLRDGQYLWEISKMHDKYGPIVRVNAREVHIRDSSYYTTIY
                     TAGSRKTNKDPATVGAFDVPSATAATVDHDHHRSRRGYLNPYFSKRTITNLEPFIHERV
                     TKLLTRFQQHLDDGQVLSLDGAFCALTADVITNRFYGKHNDYLSLPDFHFVVRDGFLGL
                     TKIYHLARFLPALVTVLKRLPYSCIRMIAPSVCDLLQMRDEIQDRGGEEFLSNKSHEAK
                     SSILFGALADSHIPSHERTVERMLDEGTVILFAGTETTSRTLAITVFYLLTHPECLKKL
                     REELNSLPPVNDDQHSLATLENLPYLNGVIHEGFRLAFGPISRSGRVATQENLKYKEHV
                     IPAGTPISQSTYFMHTDPKNFPEPEKFKPERWIEAQQKGIPLKKYITNFSQGSRQCIGY
                     TMAFAEMYLALSRIARAYEVELYDTTKADIDMTHARIVGYPKAIPGKKEHLGEVRVKVL
                     KAL"
     gene            10081..10737
                     /gene="tri6"
     CDS             10081..10737
                     /codon_start=1
                     /gene="tri6"
                     /product="trichothecene biosynthesis positive transcription
                     factor"
                     /protein_id="BAX01961.1"
                     /transl_table=1
                     /translation="MIYMEDESHYESWSALPLFDRVASPDPAKDFVPDLNDYESPTFEV
                     DLLSETYDFENFPTYSLPTVDSTKTLFPEEPLVCFDFDFANPAIENYITTSSGLLDAVP
                     SQLIALPSFTRPSKCPYPSCKSTTTFESGRDFRRHYRQHFKRFFCRYSECPQSAQDLQE
                     VGTKGFATRKDRARHESKHKPTVRCPWHDQEGQQCLRVFSRVDNMRDHYRRIHKG"
     gene            13672..14851
                     /gene="tri5"
     CDS             join(13672..14140,14193..14851)
                     /codon_start=1
                     /gene="tri5"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: trichodiene_synth"
                     /gene_kind="biosynthetic"
                     /product="trichodiene synthase"
                     /protein_id="BAX01962.1"
                     /sec_met_domain="trichodiene_synth (E-value: 3.1e-246,
                     bitscore: 805.3, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAH
                     HFAQPRQQKMLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSD
                     DPHPAMVNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTMDFFEGCWI
                     EQYNFGGFPGSDDYPQFLRRMNGLGHCVGASLWPKDLFDERKNFLEITTAVAQMENWMV
                     WVNDLMSFYKEFDDERDQISLVKNFVTCHEITLDEALEKLTQETLHSSKQMVAVFADKD
                     PQVMDTIECFMHGYVTWHLCDARYRLHEIYEKVKDQDTEDAKKFCKFFEQAANVGAVAA
                     SEWAYPPVAQLANVRAKSDVKEAQKPFLSSIELVE"
     gene            15523..16869
                     /gene="tri10"
     CDS             join(15523..15900,15985..16869)
                     /codon_start=1
                     /gene="tri10"
                     /product="regulatory protein"
                     /protein_id="BAX01963.1"
                     /transl_table=1
                     /translation="MDFPKPRQVRETSLLMYYLDVVFPLQCINPNNSCVGKREWLLTIL
                     TSARPTYYATLCLSLLYKESLSSPCRTEQAMVWKREKTYYYILALQESQKLLGGLDKTF
                     GITRLKGTVVALACMLQLIGFESSHLSRGDWRVHLHAANTLIPVLVEGWSTALQSGPPA
                     TSIWCELDESDFGSTEDQTSLSFEYLGALRFLSNSLATVGILSCISIGPSAPFEDYGHL
                     LDQPGLIQLDEVLGCRNWTMLTILEVGKLDRWKRQEQEHNRLSLKTLARRAMMIEDMLA
                     DELQRLPTNETLPDLITQIYASSIMTYLHTVVSGLNPNLSEVQDSVAGTLLLLERLPNL
                     EAVASVTWPLAITGCMASESHKDFFRNTLRSYEATFSYLRKYDGTLEVLENAWKRREIE
                     TESPMRWEDLMDHHGLPVLLW"
     gene            complement(17468..17599)
                     /gene="tri9"
     CDS             complement(17468..17599)
                     /codon_start=1
                     /gene="tri9"
                     /product="hypothetical protein"
                     /protein_id="BAX01964.1"
                     /transl_table=1
                     /translation="MLAAAKLIDSYEMDPDVSWLEVFAYSGVSAALCATIWVAAKAC"
     gene            complement(18842..20582)
                     /gene="tri11"
     CDS             complement(join(18842..18995,19069..19235,19314..19632,
                     19687..20478,20536..20582))
                     /codon_start=1
                     /gene="tri11"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 347.7; E-value:
                     1.8e-105)"
                     /gene_kind="biosynthetic-additional"
                     /product="isotrichodermin C-15 hydroxylase"
                     /protein_id="BAX01965.1"
                     /sec_met_domain="p450 (E-value: 3.2e-71, bitscore: 229.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MFQYSLWPLLALSGGTAVAYFVIMLMYNLFFHPLRNYPGPWLNTM
                     TQIPHTLLMLCGLPHKRHLALHMKYGPVVRIGPNMLSFNHPDAMKDVRGHRKSGEAEHG
                     KDPIIVLSNGDNIVGSDRENHTRFRRALAYGFSAQAMLEQEPTFKAYVNQLFQRLHEQS
                     SNGTKTVDISKWYTFTTFDMIGDLAFGESFGCLDNSTYHPWVALAFESLKSLAFMAEMG
                     RYPRIAPYIGFLLPRGLLNKFAENKELASMKVRKRLDTETDRPDFVGKITQGLKAKGSS
                     MEFNELASNASVLIVAGSETTATLLSAAVYFLCSNPRTLELLTEEVRSTYTQADAIDLV
                     STQGLRYMQAVLDEALRMYPPVAGGGSPRKIAKGGSFVAGYFVPENTLVENDMWAMHYD
                     PKYFTQPHDFIPERWLGDARFNSDRLDAVKPFSIGPRNCIGMNLAYAEMRMMLARTVWE
                     FDIRLAESSRNWYQDSRVYLAWNKPPLNVYLDPR"
     gene            complement(21232..23136)
                     /gene="tri12"
     CDS             complement(join(21232..21634,21711..22461,22518..23136))
                     /codon_start=1
                     /gene="tri12"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 117.3; E-value:
                     9.6e-36)"
                     /gene_kind="transport"
                     /product="trichothecene efflux pump"
                     /protein_id="BAX01966.1"
                     /transl_table=1
                     /translation="MTATVPQEGVVDLESQPDDRLRAEALATTAAELPEGYYTSARVMA
                     SFAAFSLNVCATYFVLQASASALPNILQDIGQSENESLFSTLWTTGQAVSILVMGRLTD
                     RFGRRPFVIATHILGLVGAIVGCTANKFNTLLAAMTMLGVAAGPAGASPLFIGELMSNK
                     TKFLGLLVVSGPNIVANMGPYFGQRLSIEGDWRWIFYIYIIISAIATVLIVVWYHPPSF
                     TQLHGKKARKRDELAKLDWIGIFLVTAGVSLFLLGVSWGGKPNSAWDSGKIIGLMTSGL
                     GSLLVFALYEVYGKPERPMVPPALFKDFRGFVCILLISSIMGAMNLCLTIIYPQQVINI
                     FGSSLKNWQETAWMTATASFGTWTGVMILGNVFHLIRHIRWQILVGAMWLTAFLGAMSS
                     VNRHNKNAAIALSFFSGFVVAWAQDITMLMVQFIPTDEDLGVAFCMYSYFYCWDVSNNN
                     QYPKEIGSHLTSALRGTDIPQSSFPSLLEAAKTGRIDAVKALPGMTNSTAAVVSGAMAD
                     SYTASYANVYYFAMALGVIPIIASLCMKNFDQYLTDHVPHQLYDRKKADKDVLEGDSDS
                     QSSPTIHSIVEDKK"
     gene            complement(23871..25672)
                     /gene="tri13"
     CDS             complement(join(23871..24608,24671..25672))
                     /codon_start=1
                     /gene="tri13"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 88.6; E-value: 7.4e-27)"
                     /gene_kind="biosynthetic-additional"
                     /product="trichothecene C-4-hydroxylase"
                     /protein_id="BAX01967.1"
                     /transl_table=1
                     /translation="MFLSIGLVAVALYLLYRWALPKPISSIPYNPLALQSLFGDIPAMM
                     KWTNASKQSHMEWIIQQMKNHESPIIQLFLKPLGNPVVILADFRETQDIMLRRKEFDRA
                     TNARALLEDVIPDHHLYEQTNSIFRTHRKLVQDVMLPSFIQKVAGPCFHSNIMRLVRVW
                     ELKAEIANGSPFLATQDIQGAVLDAVYTFAFGEYYKSSTTLPNIEILEKLNNNQNPKSD
                     KPVDFPDVAFDDLITATIDLAKAPQGVQSSPIAKVQSKVLMNMPYFRRVRKIRDDFLRG
                     SLRSAVSKLQSESGLSDSPPVTSALEQMVLRETLLAKAENRSPNYLSTMMQGELFGLIL
                     GGYDTTSTTTLWGLKFLTGNAGAQKRLRQALQSAFPKAKSENRSPTFQELAAARIPYLE
                     AVIEESLRCGGATSALQRLAMVDTQILGHHIPKGTEILFLTHGPSVFTPGLEIDERKRS
                     QTCQVAGEKKDSAWDDHDIGAFKPERWLRQKESSTGTDATEAAEEFDGLAGPTLAFGLG
                     TRGCFGRRLGHQQLRTSLAILIWNFELLPCPKELSSYRAIEGLTSMPEHSYISLAKVDL
                     TRA"
     misc_feature    26481..>27272
                     /gene="tri14"
                     /note="putative trichothecene biosynthesis gene, partial"
     gene            26481..>27272
                     /gene="tri14"
ORIGIN
        1 tcaggctatg gccagagagg tcaagagatg aattaccagg cagatgtcca gaagtcgact
       61 gcactcttgt cagcatcccc acgtgttttc agggcagttc cattaacgtt tctcgtcacg
      121 tccttgataa cacaaccctt tgtgtcatgc tgaccagcga agacgttcaa aagccactgg
      181 aaagccacgt catagccact gttggcttct acgtagtgcg aaccgagggt gttcctttcg
      241 aagagaatgt cggcccccac ggcacaatat ctcttgacta cagcatcggt agcagctatc
      301 ggcgtgacct cgtcggggat agcttggtag atatacatgg gccatctggg ggtgccatga
      361 tatcccataa cgccctcccg attgacaaga gctgtgatct ccgggtcgct gaaaatgtca
      421 gtccccttct ggaagtactt gttgatatca attttagaaa aggcgacgcc agcttcagtg
      481 atagtatagc cctcagcagc gagaaagtca gtcttgttgt actggctgtc attgttgagt
      541 ttggatacaa ggtgcttgcg gacatcagga tattggaccg tgagacccaa cagcatgttt
      601 ggtgtcagac cggacgtagg cccgccattg acatcgtaca tgattgaagt gatattggcc
      661 aacggggctc ccatagcagc accaacaacg ggtcctgcta ccagttcggg tgcatactgt
      721 actgcaagtt ctgatgccca ttcagtggca aacgcaccgc ccgaatagcc ccaaagggca
      781 acactgggcg tattggtcat gttgaagccc agaccaagcg acagaacagc gcgaattgag
      841 tccaaagtag cgtatccaga gatgatacca gcggtgaaag cagccgaggg tccctcataa
      901 tccggaacag aaacgaagat accttcagct agagcagctt catagtagat agaagaaata
      961 gcgctcgcgg tgtacatagt gttgctaggg ctagcatcga catcgggaga gtcataggca
     1021 acttggagtg acatgagcgc gctttgttgg tacttttgat gcgcattact ttcagggccc
     1081 agttcgggga ccaaaagagt ggtgacggcc caagtaggct tgaaatggct gtcggtcgta
     1141 cggtagagga tgttgtaaga agccgagcaa ttgccggtaa cactggtcaa gtttccaggc
     1201 gcaggtcgca ctctcaagac tgttccaggc tcggcattct cgaatccagg aggtgcagta
     1261 taccacgggt ctttgctagg cggaagcggt tctgataacg cagcttgagc ggcgccaaca
     1321 aagcccagcc acaagctgag aagaaacaac agacgatcga gagccatact gagtggatga
     1381 atgaatggat gaagaacttg ggttgtcgtc tcaaagtact aaacgcggcg catcatttta
     1441 tctagtattt cagtggattc aagtcttggt attgtttgtc agtgaagggg tcaaagacct
     1501 caacacgtac tgcgattcgc aattggctac atagtatccg tagaacgaga tgagtcattt
     1561 agagccatag gagtgcgcgt gcttacaggg ggctcctaac tatctccgag tctcgcaaga
     1621 attctccgta gaatatgaga aaggactgaa gacgtggaca cagcgtggac acagcaaacc
     1681 ttactttgcg gaatggacct cgctttataa atggatcttg aacggaatct tcggaataaa
     1741 ttatgagatc agaaagtgca gttacctata attggaacag ccatcaaatt gaccccatat
     1801 cgggccctgg cccttttatc aggccttcca tttgatactt tatcactggc tcgcttcaag
     1861 attgaacttt aaactaggcc caccggcgag gcctgagaaa agaaaagaaa ggtaaggctt
     1921 aatcagtctt gtatagctct ttctcttaca tgcttggacc tctggttttt gtatatcaag
     1981 cggttcattt tcacggcctt cgtgatagct ctagtcaaga acccaaagtc agacggaacc
     2041 ttttccagca ccagcgacaa cacgatggac accgcatcga aggtcgaagg tttccagact
     2101 ttcaacatat tatattacct ttcaaccttg cttgccgttt gcacgtattc tgcgctgatc
     2161 atcatttcaa cctccaaggc tggccctacc tctctggtgc gatatgcctc tcctgccatc
     2221 gtccttccag tagggaaaaa gctattccaa gaagcatatg gacttagcag cagtatcggt
     2281 catcgcggtt tcattctggg gatcacggca cagcttataa tacaatgctg caacttcttg
     2341 gtccttgaaa ggttggatgc gaacgacctg gcaaagaaaa aagtattccg gtcctctgat
     2401 ggtatcgtgt acaaggttta cggagtggct tgtctcatct tcaacctgcg aggtattgga
     2461 acgccatggc aagcgaagca tctttgtgac catccccggt tctaccagca tgaccaagga
     2521 cgagaaccaa ctcgcgcctg gtttatactt cgtcagtcac tcattgttgc gtggcaatat
     2581 cttcttctag atattgttta cacgaccacg atgagcacgc caaaggagga cacacagagg
     2641 cttttcgccg aaggaacaga atacatgtac ttggacgcca atgccgagca atggacggtt
     2701 cgttttatca ctggggttgt tgcatgggct ataccaggta gggtatcaat cgatttacca
     2761 ggtcgtgtct tgtcgatatt ctcggtcctg cttggcttta cgactcctca acaatggccg
     2821 ccggtgtttg ggagcatttt ggatgcatac accatccgag gtttctgggg gtaagttccg
     2881 atactctcct catctacgaa cgttttctga cacaagatta gtacattttg gcaccagtac
     2941 tttcgcaggg ctcttacagg agtcagcaat ttcatatgtc gagactttct gcggcttcca
     3001 cggccgtcta ttgtcgaacg ttacttgaac ctctcgctcg tcttcttggg atcagctctt
     3061 gtgcacatac ctgttgattg gttttctttg ccgccgcctt caaaaccacc tgtactggca
     3121 ctggcattct tcggctcttt tattgtcggc attattatcg aagacacggt tcaagctcta
     3181 tggcgccgca tcaccggtgc cacaaagcaa gacggagacg aaggagtccc tctatggcac
     3241 aagcttgtag gctacatttg ggtagcgttt tggttgatgg tggtatcgcc ctggtatctt
     3301 taccacaaca gccgattgcc cccgggtgat acatggtttg tgccggtgag ctttatggac
     3361 acgattggtg tcgacacagc caagaagttg ctgcttgcca gcggggtgat cttgaggttt
     3421 gcagtcggca ttgagattta aataccttgt gtgggggtag cgatatttaa tttgcatttg
     3481 gttggataga taccatccat agatatctag taatgcaggt ggtcattgtc tccattataa
     3541 caaggctgca tgatacttca acgagagttt cggcgatgtg atggatcaag cacatggggc
     3601 cacaggtgga tttatctgac ccttcatgcg tcgtatatta tttaatcacg agcattatat
     3661 tatacctctt ttattcgtag gttgattcat ggtactgaga tacaaaaatg atcccttccc
     3721 tgccttgtag tggtgccact ggaaactaaa ggaatgaaga atcgacattt acaactaacg
     3781 ttgcattttc gccattttgc ccgcctagat gcttcaactc aagtctgtaa cgtattgaca
     3841 tgaaccaatg tgtgccacta aactgaatcc ttggcgaaaa acttgaatac atgatggaat
     3901 ggtaaaagga ggtaagagat gcaaggataa atgtttgatc cgtccgctta tgccagccag
     3961 actagactaa gaatccgtca aactttgaac aagttaaggc gtgtcgtgtc ggtgggggct
     4021 gtgtaaggcc caacagtgca ttgtaagcta agactctcag cgcctcaact ccctgtaagt
     4081 ctacaacatt tgttggctcg gattgcaaga aggcttgtat ttattatctt aactaccaac
     4141 cgactacttt ctgagctgtt ctactaacat ctggttccga atcatcttta aattttacaa
     4201 acaagaaaac aagcaactta tttattctac aactatcaag atgagcgctt catcctccgc
     4261 cttgccgccc ttagtaccaa cactttacag atgggagtcg actggtccac gtcaggtcca
     4321 gcgtcggtgt gttggtgctg aggcaatcgt tggactggaa gagaagaaca gaagatcttt
     4381 atacgatctc ttcatcgcta cttctcttcg gaatgttgca ccagcctcaa catcgctgac
     4441 tttgcgaaac ctcaaagata tgttcgagct ggccttggtt gaaggacggt tcgagcaccc
     4501 cgaaagtgct tgtacagtat cttgggatga tcaagtagct gccatcatct cctacgaatc
     4561 accagagagc gacgaatctg ctcgtgattg ggctaggggt tgcgttcatg ttcagcccac
     4621 cgcaaagagt gctatcgacc tttggaccga gatggaggaa ggaagagcgg cagccaagga
     4681 taacacacca tccaagccga ttgagctctt cctgctttca gatgtcccta cagactcgac
     4741 gccaatccct caaggcgcga ctgtctatat cttgtttcac agcaatcatt tgttctggga
     4801 cggaattggt tgtcgaaagt ttatcgggga cctctttcgc cttgtgggca atcacattgg
     4861 cctcagcgac agcgctgaca cacccaagat gcaatggggc caagagatca agaacctgag
     4921 ccctccagtc gttgactcgt tgaagttgga cgtgagtact cttggcactg agttcgacga
     4981 caagtgcaca gaatatacga gcgctcttgt ggccaattat gtaagttgac gttcagtttc
     5041 ctatctgcca atacatactg accttctcac aacagaaaag ccgaggtatg aaatttcaac
     5101 cagggcttgc tttgcctcgc tgtgctattt acaaactcag cgccgaggac tccattgcta
     5161 tagtcaaggc tgtcaagact cgacttggcc ctggctatac catcagtcag ctaacccaag
     5221 ctgcgattat actcgctctg ctagaccacc tcaagcctac tgatctttca gacgacgagt
     5281 tcttcttatc gccaacatca gtggatggtc gcaagtggtt gcgtgaggat atagccagca
     5341 actactacgc tatgtgtcag actgctgccg ttgttcgcgt cgagaacctg aagtctattg
     5401 cagtgagcca cgaagatgaa aaagagcttc aagtccgagc tctggagaag gcctgcaggg
     5461 atatcaagaa atgttacgat caatggcttg gaaatccctt cttagaggct ctgggcctca
     5521 gagttcataa ctttgaggcc ggttatttgc acgagtaagt aaaaccagtt cctctctcat
     5581 cgcatcagct aacaccgctc cagcaaacca aatccgttcg aaggtacaga agcaaacccg
     5641 gtatggctac tgaatctcgt gtaattaagt ccctgaaatg ctgacaatcg ttcaacagtt
     5701 gttcatcagt gacggtatca acgaacgctt catcccgcgc gaaatcaagc gaactgcaac
     5761 aggcgaggac gtgttatccg ttgaaagcat agactttgtt gtgaaccagt ctttgccata
     5821 tctgtgagtc cgataagtgt atatcgaagc tatgactaac aagataacag ggcaatccga
     5881 ctggacagtt ggagagacgc ttccaccctc aacatcatct ataatgatgc aaactataac
     5941 gaggaagagg tacagacgta tctgaagagt attgtagagt tcatgctggc attcaaattg
     6001 taatttactg tttattctga atggtacatg ggctccttga ggagcgatgt tgtccaggca
     6061 atacttgggg tggtttttga gttcggttgt attccaacgc caggaagacg ttacatatgt
     6121 gctagaattg gatgattaaa tgtagtttga aaatgaattt atttgcaaat ttgatcatta
     6181 gttccctttt cacaattcaa ttttgcactt cccaaactgc gacccatgtg gcctgatatc
     6241 agatcttgga gaggtcagag ccgagtttct accattaaaa ctgccttcag attctaccag
     6301 gccatttgca cctgtaatgc tagctcttgt aatatcggtt ctatttaaag ttgttcgata
     6361 ctgtgttgca ggaggacgag acagctactg tgcgtatatc ccggaagaag cttcttctat
     6421 tatgtacgtg ttcttgttaa gaatgttagt cgttagcaga accttgattc aatatgtcaa
     6481 atttttgatc caggttgatc ctttattgac aatttgtaaa aatattgaga aggttagggc
     6541 tgcagctgac agaccaaaat tagttaaata aaaggaatat taatttccag cagtacaaga
     6601 taaaaatgag gaaaactcag agggacagct ttccagctgg agaagggaat aaatacttat
     6661 taggtgaagt cacatcgcta ccggaaactt gtagttgact gtttatatac aaaactacga
     6721 catgaaaccc agctcaatag ataaccatca tgttcatatg tgaggttgat ggcttgcata
     6781 taccaaaaac ttaatgaatc gctttcattg agctatctca atattactgg cttttacaag
     6841 ttacctctat gtccagagac gttgatttat gtaaaagata ctcaagctca tcccaagata
     6901 tattattacc aatgtataag tcttctacca ggagcaagtt ttgtagtgca tgcacaatct
     6961 ctttttcatc ccataatgca ttgactgaaa tgaataatgt ttatatggac gagcgtataa
     7021 atagagtaca atttatttta cgttcaggtg ttactacaat gaacttccat tcctgcatac
     7081 caaaaatgga ctgaacaaaa gaaacaggat tcgatgccga tatagtgagt tatctagtaa
     7141 gatattgaga cagtttgtca gatgcgcctt acaaagcctt gagaaccttg actcgaactt
     7201 cgccaaggtg ttccttcttg cctggaattg ccttggggta gccaacaata cgggcgtgag
     7261 tcatgtcaat gtcggccttt gtggtgtcat aaagctcaac ttcgtaagct cgcgcaatgc
     7321 gagaaagggc gaggtacatc tcagcaaagg ccatgctatt aaaatgttag caagtgttct
     7381 cctccaatca gagagtgcca ataggcaaaa gggaatcgac ttacgtgtat ccgatgcact
     7441 gtctagaacc ctgagagaag ttggtgatgt acttcttgag agggataccc ttctgttgtg
     7501 cctcgatcca tcgctcaggc ttgaactttt cgggctcggg gaaattcttg ggatcggtgt
     7561 gcatgaaata ggtggactga gaaatgggag tctgtgacaa ttgttagcat gcatagatat
     7621 agagagatag aaaatgaacc tactccggca gggatgacat gttccttgta cttcaagttc
     7681 tcctgagtag ccacacgtcc cgagcgagaa atgggaccaa aagcgagacg gaatccctcg
     7741 tggatgacac cgttcaggta agggaggttc tctagggtag cgagagaatg ctggtcgtca
     7801 ttgacaggtg ggaggctgtt caactcctct cggagcttct tcaagcattc tggatgggtc
     7861 aagaggtaga atacagtgat ggccagtgtc cttgaagtag tctcagtacc agcgaacagg
     7921 ataacggtgc cctcatcgag cattcgctcc acggttcgtt catgagaggg gatgtgtgag
     7981 tctgcaaggg caccgaaaag gatggatgac ttggcctcat gagatttgtt ggacaggaac
     8041 tcctcaccac cgcggtcctg aatctcatct cgcatctgga gaagatcaca cacagaaggt
     8101 gcgatcatgc ggatacaaga gtaagggagg cgcttcagaa cggtgaccag agcagggagg
     8161 aagcgtgcaa gatggtagat cttggtaaga cccaagaatc cgtcgcgaac gacaaagtgg
     8221 aagtcgggaa gactgagata gtcgttatgc ttgccataga atcgattagt gatgacatcg
     8281 gcggtcaagg cacaaaaagc accatcaaga ctgagaacct ggccgtcgtc cagatgctgt
     8341 tggaatcgag tcaaaagctt ggtaacacgc tcatggatga aaggctcgag gttggtgatg
     8401 gttcgcttcg agaagtaagg gttcaggtag ccgcgacgag aacgatgatg gtcatgatcg
     8461 acagtggcgg cagtggcgga gggaacgtca aaagcaccga cagtggcggg gtccttgttg
     8521 gtcttgcgag aaccagcagt atagatagta gtgtagtagg atgaatccct gatgtgaact
     8581 tcgcgggcgt ttactcgaac gatggggcct tgaagatgcg gtggtcagta tttgtgtcgt
     8641 acaaggcgca tctctgcata tcttaccata tttgtcgtgc atcttggaga tctcccagag
     8701 atattggcca tcccggagga cttcatggta gaactcaagg tagggcccaa tggcagcgag
     8761 ctttggtccc gggatctttc gcagtgggtg caagtacagg ttgtaaaaac aggaagagac
     8821 aaagtagata acagtcgatg ctgcgaaaat ccccgcaaca tggctgacgg ggatgttgag
     8881 taggctcttg atccagtctt ggtcaatcat cttttcaaag ttcaagtctt tgatagacct
     8941 gtaaaagaag ctgatggttg tgaagataga atattgagaa aacctgtggt gattgaggat
     9001 actatatagt gttgttgttg aatagaagca gtcggatagt ttctctgatc tcccaacccc
     9061 gcctcacgga ctctgccctc actccgatga cgaaaaatga agcattaggt acctagtctg
     9121 tcacgtctct agagtgcttt gcattcgttg tggccgcaaa ggctcacaac tctgaagctg
     9181 tcctcagtat caccatgtcc gatgaggttc gcaagagtgt ccggtcgaaa actcaccaat
     9241 caactcaaca ggacgaacaa ggggtctgaa aggcctggca ggcctgacag gagcgataaa
     9301 aaatgagaag agatatgccg atacaaccgt gtaacttgtg aaacggggca tggaatccca
     9361 tggcaagttc cggggtcagc actcagcagc aactgaattg cccacgactc aagaagtgca
     9421 ttctttcacc ggcggcttat ccgaagttgc tgccgatcag atgcagacac atgcagaatg
     9481 gtacgactgc acagaagaat aagaagcatc agtgcgccgc aatgttaaaa actgatgtgc
     9541 ggaagcaaga ttaagctttg gagacatgcc agggtcttgt ctcaaaatat ctttgtctcc
     9601 cccgagaccc atgcataatc aaaaagtatg tacatggatg gtcttgcaca gaagccagcc
     9661 tcgagtgtta tgcaaactgt caaggctgca gtaagttggc acactcccac tgacttgaat
     9721 cgattatcat tgaccgttcg gaagcgttct ctgtttggaa tctttccaga ccacaactgc
     9781 cactttggca tctgcatgcc agcactagta gccacatagt gaaccttcaa ctgccgccgc
     9841 atcaaactgt aaataggtac cggccgacgc gtctcggata agataccttt taaactgccg
     9901 tagcaaactg taattgtcgg tacttgtcgg acaatatttt tgtagctttg agaagctttc
     9961 actcttaata aaacttgatc tgaataagaa actttaccaa tcgtgtcccc tcccatcaag
    10021 ccatcttttt ttcctcatca ccaaccaata cattgaacgt ctattttaac tacactcgag
    10081 atgatttaca tggaggacga atctcactac gaatcttgga gcgccttgcc cctctttgat
    10141 cgtgttgcgt ctcccgatcc cgccaaggac tttgtcccag atctaaacga ctatgaatca
    10201 ccaacattcg aagtcgatct tctatcagaa acttatgact ttgaaaactt ccccacatac
    10261 tctctaccaa cggtggattc aaccaagact ttgttccctg aggaaccact tgtttgcttc
    10321 gactttgact tcgcgaaccc ggctatcgag aattatataa ccacatcgtc gggactgttg
    10381 gatgcagtgc caagccagct catcgccctc cccagcttca cacggccaag caaatgcccg
    10441 tatcccagtt gcaagtcaac tacaaccttt gagagcggac gggatttcag gcggcattac
    10501 cgacaacact tcaagcgctt tttctgtcgc tactcagaat gccctcagtc agctcaagac
    10561 ctacaagaag tcggtaccaa aggatttgcg actcgcaagg accgtgctcg gcatgagtct
    10621 aagcacaaac caacagtgcg gtgcccttgg cacgaccagg aaggacaaca atgtctgagg
    10681 gtctttagca gggtggataa catgcgagat cactataggc ggatacacaa gggttgacga
    10741 ggagggatcg gtgtgcaaaa ctgcagatag ttactcataa aaggcaacat ttgcgaaaat
    10801 caataacaat atctccataa atattccatt gtacttttga gtttcgtaaa tgatgacgag
    10861 tttggcgccg atcgatgctg tttctagcac caattcataa tgtactccat atagtaaccg
    10921 agaccctgcg gctcattggt accagccctg tttttattgc acaattaatg atactctatt
    10981 ctgcacgcga ctcaacggct ttcaacacat acatacagag tacagtgcct ctacgcgtgg
    11041 ctatgtctaa gcgagattag cacagccatt gatattgttg cgttgctttg gccccgtaag
    11101 ttccacaaca atctggatac tgcaaggtat cagcagccga tgtttaaatt ctctcagtcg
    11161 tctgcctcat ctggcaggtg ccaataatat attttaaccg cgtttggctg gccatgctac
    11221 cctaaaggct tcatatctgg accgtaccta tcgtgtactc gcttcgacag ctatgcgcat
    11281 acgcctctcg tatcaatgtc gcaaacaaac aaacgtacgt cattgtttac tatgcctggt
    11341 ttccgtgaac cattgctgtg ccgcaaaaga atgcatcggt actctgtaga ttgcgatcct
    11401 atgttggagg gtggctcgag tcaagacgta acgtcgcaat tgagatgttg aggtcactca
    11461 cccaaaggca atttaaggtt tcaaactccg aggaaagtca tttgccatgg acgataacct
    11521 gcaatagggt aggctttgtt ttttcgtagc attggtgatt gttttggatt gagttttcgg
    11581 ggtccttttg ctgtcaagac tggtgacttt gcaggggatg agtcattagc gacaggcatc
    11641 gagtcaaaca ccgtttcgta ataactatcc atttgttaca aaattcttac aaagctttgt
    11701 gcggtcagtc aaattcgcac atgtcgatac ttcttgctgg cattagctca gtattcatct
    11761 atgagtggct aaagcgtagt cgattctcaa atccaagcct aacaactccc cggcgggatg
    11821 agaccttgtc ggatatctct agccgagatg cggatagtaa cgatacccta gtcaaatgag
    11881 acgggggcag ggttcatggt tgttgaacct tgcttattgt aatgttgatg ccgttgacct
    11941 acggcataat actatccttt acatgccttt gtttctagcc cacgtggcta tcctgacatc
    12001 cgctgtatat tgattggttg gcttcgcata ttgatacaaa caaattcaag atcgtgagag
    12061 ggaatttcct tgtcaaatca gaggcgtgtt ctatgccgtg gggataaaag tcaaagtcaa
    12121 atcagataag tacgtagcaa ccggaaaggc tccgtggctt cagtacggta gcgagataaa
    12181 tcaccttgat gtggttgccg cttcctccat atcactcaca tatccatagt tattccaaac
    12241 aattcgagtt ctgcagatag tggatacatc gtccaggatg tagtctagca gtcggtagtt
    12301 gaaacaccta ctatgtagag gcgaggagcc cgctttacct tgagcctggc agcatcgcca
    12361 gtactatgta tgcactaaaa gtgatgatct caatcgtgct tccccctgtt gcgactttcc
    12421 tagtgctaaa ttgctagtgc gaccggactt gtcacatttg ctgtattccc aaattgtgtc
    12481 agcttctgac agcgatgaca gacatgatag ataaccgttt tcgtcatcat cagattagat
    12541 agacaagggc agcgtagcct caaactatga aaacggttgc atgcatgctg catgtgtaac
    12601 ttcccggtag gggtgttcac gccatgggaa caccctgata acttcgcata gataaggatc
    12661 tgtcaagagg caagacagcg gctatacgga ccatatccta gaactcaggc aagggttaat
    12721 caagaacagg attcatgatt ccgtactctg tcctacgtca acatggggga ataatcactg
    12781 ttcttagccc cttgttaagc taagtatttc ggcatgtaaa cggagttcat ccacggtaga
    12841 gttgacaaga tctgcactct catcggtact taatgtcgtt ctagctacgc gaccttcagg
    12901 tactggtaat ggagatcttg gccaatattc caacacacag gaaatgggtt gtagatcata
    12961 cagctaaatt cagaaccgct tgctaaaccc aaaatggata agtaacttga accttattca
    13021 acgcagttgc attgcattcg ggagccaact ccgcgggata tatgtaacgg ccggcagttt
    13081 cgtggtgttg atgataaaag tggtcatcct taaggcctgt cacccaggta agcttttgcc
    13141 agggcagaat aaaacaccgc ggctacctag tcaagtgagg ctttcttctg tgttgataga
    13201 cggctgtttc accagtccaa acacagccca cggacaacaa ccgaacccaa catgccaact
    13261 caaggattga tccctagatt taggcctact ccctgtcctt tgacactagc atctagcacc
    13321 aatcgcttgt gtaggtctac caagtgtatt gagctaaaga caaaaatgaa ccaagagttt
    13381 gctccaagag ccggatgttt tctaatatct gtagccttgc agggaatgag aaagcacgtc
    13441 catacggcac ggtcttgaag agagaccatc tggttgggga cgctattcgc attgacttga
    13501 gatcagtctt taggcctaac aagacaatat tgactaacaa ctgtgtacgg gtcgagatgc
    13561 ttgccatcta atgatatata gctaatagca acagcacttt gtagcaatag aatgataacg
    13621 acttgacttg ttgattcatt gaataactgt taccaataca cctttgccat catggagaac
    13681 tttcccaccg agtatttcct caacactagc gtgcgccttc tcgagtacat tcgataccga
    13741 gacagcaatt acaccagaga ggagcgtatc gagaatttgc actatgctta caacaaagct
    13801 gcccaccact ttgctcagcc tcgccagcag aagatgctca aggtagaccc taaacgacta
    13861 caggcttccc tccaaacaat cgttggcatg gtcgtataca gttgggcaaa ggtctccaaa
    13921 gagtgcatgg cggatctatc tattcactac acctatactc ttgttttgga tgacagcagc
    13981 gatgatcctc atcctgccat ggtgaactat tttgatgacc ttcaagccgg acgagagcag
    14041 gcccacccat ggtgggcact tgtcaacgag cactttccca acgtcctccg ccattttgga
    14101 cccttctgct cgttgaacct catccgtagc actatggact gtaagtttac cgattgtatt
    14161 atttacctgt atgaagaagc taacagcggc agtttttgag ggatgctgga ttgagcagta
    14221 caactttgga ggattcccgg gatctgatga ctacccccaa ttccttcgtc gtatgaacgg
    14281 tttgggtcac tgtgttgggg cttctctatg gcccaaggac ctgttcgacg agcgaaagaa
    14341 tttcctcgaa atcacgacag ccgttgccca gatggagaac tggatggttt gggtcaatga
    14401 tctcatgtcg ttctacaagg aattcgacga tgagcgtgat caaatcagtc tggtcaagaa
    14461 ctttgtcacc tgtcatgaga tcactctgga tgaagctttg gagaagctca cccaggagac
    14521 tctgcactcg tccaagcaga tggttgctgt cttcgcggac aaggaccctc aggtgatgga
    14581 cacgattgag tgttttatgc acggctacgt cacgtggcac ttgtgcgacg ctagataccg
    14641 ccttcatgag atttatgaaa aggtcaagga tcaggataca gaggacgcca agaagttctg
    14701 caagttcttt gagcaagcag ccaatgtcgg cgccgttgcg gcctcggagt gggcttaccc
    14761 accagttgca cagctggcaa acgttcgggc caagagcgat gtgaaggagg ctcagaaacc
    14821 cttcctaagt tcgattgagc tagtggagtg accgaatgcg agtttagaag tatgatttgc
    14881 gggtactcgt cacataggag aaatactggt ctgttataat gattacaaat agcttgcttg
    14941 gttgtgtttt tgttacatag aatgtacggt tgaacaagga taattaccac ggaataggca
    15001 gctgaaactg attgtctgta acctgagcct gtaaccattt cccactcgag tgcaggcttt
    15061 tgcgcaacca agttacgccc gtcggtgcga caaggctacc cccgaaccct gcaactgcag
    15121 ctgcagctgg cagaatggta tgtagactgg tagactggcg ctacgaacta tagtgcgatg
    15181 cgggaatctt gtacccgctc ggaggttgga gggagctggc acattcttta gacccgcgaa
    15241 ttgatcttca aagcgcttgc gtcctgtcca gatcagtgac cacacccttg ttttttcgca
    15301 ccacccaacg tccactgaat gaggcgtaca gaaaccacac aagataaagt ttaatgcctg
    15361 cttgagcact gttgacggac acgacaatcc tgcaaaactc tatccttgca ttatattgta
    15421 acatcgttta acttctccac gcccattcct tcccgttttc ccccaacctg aattgtatgc
    15481 caaccaacaa tcatcaaatt attattattg ccgttagtca tcatggattt cccaaagcct
    15541 agacaggtca gagagacgag cctgttgatg tactacctag acgtcgtgtt tcctctgcaa
    15601 tgcatcaacc caaacaacag ttgtgtggga aagagagagt ggctgttgac tatactgacc
    15661 tctgcgcggc ctacgtacta cgccacattg tgcctgtcac tcctctataa agaatcacta
    15721 tcaagccctt gcagaactga acaggcgatg gtatggaaga gggagaagac ctactactac
    15781 attctcgcac tccaggagtc tcagaagctg ttgggtgggc tcgacaaaac ctttggcatc
    15841 acaaggctga aaggtaccgt cgttgccctt gcttgcatgc tacagcttat cgggtttgag
    15901 gtaagacaaa tccaccttga tttcggtgct cgatgctcga tacccgatct acgattatcg
    15961 ttggtcacta acaaattaaa atagtcttcg catctgagca ggggagattg gcgcgttcat
    16021 ctccatgcgg ccaacacact cattcctgtc ttggttgagg gatggtccac agctttgcaa
    16081 tcaggccccc cagccacctc catatggtgc gagctggatg aatcagactt tggctcgact
    16141 gaagatcaaa cctctttgag cttcgaatat ctcggagctt tgagattcct gtcaaactca
    16201 ctcgccacag tcggcatcct ttcgtgcata tccattggtc catcagcacc atttgaagat
    16261 tacggccatc tcctggacca gccaggcctt atacagctgg atgaggtgct ggggtgcagg
    16321 aattggacca tgctgactat tctcgaagtg ggtaagctgg atcgttggaa gcgacaggag
    16381 caagaacata atcgcttgag cctaaagacg ctcgccaggc gcgccatgat gattgaggat
    16441 atgttggcag acgagctaca aaggctgccg acaaacgaga cgcttccgga tctcatcact
    16501 caaatttacg cctcttctat tatgacgtat ctgcatacag tcgtttccgg actcaacccc
    16561 aacctttcag aggtccagga tagtgtggct ggaacgcttc tgttgttgga gaggctccca
    16621 aatcttgaag ctgtcgcgag cgttacttgg cctctggcta ttacagggtg catggcctca
    16681 gaaagtcata aggacttttt cagaaatact ctgaggtctt atgaagcgac attcagctac
    16741 ttaagaaagt acgacggaac gcttgaggtc ctagaaaacg cttggaagag aagagagata
    16801 gagacagagt ctccaatgag atgggaggac ttgatggatc accatgggct tccagtgctc
    16861 ctttggtagg gatgatatca gcgcagagac tacggatacc gatacccgaa gtctttcttc
    16921 tgcatcatct acccgataca tgtaagtttg gtgctcactt acagatgaca catgcaggga
    16981 agttttatta gagcttacgg gttcgactca ttttggcgtt tgggacaggg attgtcatga
    17041 agcatgattt aaatggaata gaagagcgaa aacgtttgtc atgtaattta aatgatagac
    17101 tttgaacata tattcctagt ataatctttt aaccataaac cacaccttat ccatctatcc
    17161 aaccagtcgt gctgaaagta gtctagaacc atggtgggct aatcagtgct gtgtcccttg
    17221 attgtcttga catggcttga cgttgttcaa cccgtacgac aaacgatgtt gatcatagtg
    17281 atgaaggagt gttggcttcg agcgagggga tttgtcgcag ttccttgtga agatccccgg
    17341 aacgaaaccc agttgggaaa tgattcattc gtggggccga agtgggagaa tgctgagatt
    17401 tgcgacaggc aattcttcct ctgttgggct gggtagatga tagaggtgct gacctggcac
    17461 tgcagtctca gcatgctttg gctgcgaccc atatggtagc gcataaagca gcgctaactc
    17521 ccgagtatgc gaaaacctcg agccacgaga catcagggtc catctcatat gagtcgatca
    17581 atttagcggc tgcgagcatc ttggagattt gggggtgagt ctttgagtgg atagtagtag
    17641 tggtagtagt gtgatgtgat gtattgtgat gcaattgatg tcgtgttcgt gtttgtttga
    17701 tgggaagaaa ttgttgagat gtttctaatc ggttctaacc gatggttaat atcttaattg
    17761 tcttaatgtc tatgctctat ctaccgacca aaaatatcgc aaatatgcga gaaaaaggcc
    17821 tgaatgatgc ttgagttggt gtgaagctga aacgtcagta gtaaaaggcc tgaatatgca
    17881 agcgacgaac cgaacatccg gcctgaactg cgtctcgtct ggcattgcca ttgccgattc
    17941 catcgccatt gaggctcagc atagagtgcc attgagcttc acgatctctc ttctctcgtc
    18001 ggcaacatgg caacggactt gtcggcaccg acaacccatg cacaactgat ggtgggttac
    18061 atccaagggt ctgttctttt taagctttca tgacaggccg gcggaggagt taaatctgcc
    18121 gtcggtgtgt gtgagtgaac ccttgaatag gtcccttctt tttaaattaa tgcatggcat
    18181 ttgttgccct acggcaacag cgcgaaaagc aaaaattaat gaaagcatat ctatgttatg
    18241 acggagtggc ttgatacccc agctgaagtt accaccctgc tggtcggtat acacacacgc
    18301 cttgctgttc accaatatat ttcgtgcgac ccttaatatc gttactgctg tataaacttt
    18361 aacactctga ctcgccccgt ctctgtatct gtctctgtct cctgtcttgg tgggcctact
    18421 ggcctggcct ggcctcactg cgctcatccc actttgcacc cacacacaca tgcctgtgca
    18481 acgtattaca gggcttgcaa gtttggttac gcagcatgtt tgaccattgg cggaattacg
    18541 aatgcaacat tcacccattt tgaggcaccg attctcgaga cctatccact taatcaacat
    18601 acgtgtttca ttccattgat acccatccaa gaggcctgac ccctcaaaaa caagctagat
    18661 acatacaaca catccattat acaacagcgc gagacagaac aacaatcatg gagcttaggc
    18721 catccatgcc tccacgcccc caccaaccaa caaaatacga aaatccacca tctacagata
    18781 tcatcgctgg ctttgaggcc ggcaattatt ttcctcctag acaagggtag tccagccggc
    18841 ttcaccttgg gtcaaggtac acattcagcg gaggtttgtt ccatgcaaga tatactctgc
    18901 tatcctggta ccaattgcgg ctactttcgg caaggcgaat gtcaaactcc caaactgttc
    18961 ttgccagcat catgcgcatc tctgcgtagg caaggctaat agacgtgtta gttgggtcat
    19021 ctatctttga gcagggacat gattgagctg gctagtttag taacttactt cataccaatg
    19081 caattccgcg gtccaattga gaatggcttg accgcatcca gtcggtcact gttgaaacgc
    19141 gcatctccga gccagcgctc tgggataaag tcgtgtggtt gggtgaaata cttggggtcg
    19201 tagtgcattg cccacatgtc gttctcaacc aaggtctgtt cggcaagagc ggataatgtc
    19261 agtgtcaggt ctcccaccgt ctgcagtact caatgactcg ctatcacact tacattctcc
    19321 ggaacaaagt atccggcaac aaaactgccg cctttcgcga tcttccgtgg tgaacctcca
    19381 cctgctacag gtgggtacat acgtagagcc tcatctagca ctgcctgcat gtaccgcagt
    19441 ccctgtgtag atacaaggtc aatagcatcc gcttgtgtgt atgtagaccg gacctcttct
    19501 gtcaaaagtt ccaaagtgcg tggattggag cataggaagt agacggctgc agagagcaag
    19561 gtagcagttg tctcagaacc agctacaatc aaaaccgagg cgttggatgc aagctcgttg
    19621 aactccatac tctgaaagaa aacgttagac aaatacaatt accaaaacgt ataaaaagaa
    19681 cctacagatc ctttcgcttt cagcccttgc gtgatcttgc ccacgaaatc tggtctgtct
    19741 gtttccgtgt caagtcgctt gcgcactttc atgctggcga gctctttgtt ctctgcaaac
    19801 ttgttgagaa gacctcgagg aagcaaaaaa ccaatgtacg gggcaattct gggatagcga
    19861 cccatctcag ccataaacgc aagactcttt agactctcaa aggccagagc aacccaggga
    19921 tggtaggtag agttatcaag acatccgaaa gactctccaa acgccaaatc accgatcatg
    19981 tcaaatgtcg taaaggtata ccatttagaa atgtcaacag tctttgtacc attagacgac
    20041 tgctcatgga gacgctggaa taactgattg acatatgctt taaaggtagg ctcttgttca
    20101 agcatggctt gggcagagaa accatatgct agagcacggc ggaaacgagt atgattctct
    20161 cgatcgctac cgacaatgtt gtcgccattg gacagtacta tgattggatc cttaccatgt
    20221 tcagcctcac cagacttgcg atggccacga acatccttca tggcgtccgg gtggttgaac
    20281 gagagcatgt taggccctat tcgcaccact ggaccatact tcatgtgaag tgcaagatgt
    20341 ctcttgtgag gaagtccaca gagcatgagc agagtatggg ggatttgtgt catggtattc
    20401 agccaaggcc ctgggtaatt ccgcagggga tggaaaaaga ggttgtacat cagcataatc
    20461 acaaaatatg caaccgccta taaaatccag tgttagacgt atccagacct ctgcgaacaa
    20521 gcaatggaac ctactgtgcc gcctgacaag gccaacaaag gccacaggga gtattgaaac
    20581 atggcgtctg agtgttcgaa gagtgcatac agaaagaaga ttgtgattca cgtcttagtc
    20641 ttaacgcagt attaaatagg acgttggtaa gtttgtaggc ctatgctatt gaactagtga
    20701 cgccctcagg cgacgctctt tagtttaggc cttgaagttg taatgtaatc cctgaaaacc
    20761 ttaactccca ttcgacactg gcttgttggg ctaagtcatc atgcaatcct aaactaggcc
    20821 ttccaaacgc ttgcaccttt aacgtgccca aatcatctta gctccctcca gactcaccgt
    20881 aagaaccaca accctggtca attccttcgt ccgtagtatt cccatctaca ctacactggt
    20941 cctttgcccc cgttccagtt tttactgaca acaccaagtc tgcccaattt ctaatttcta
    21001 gatcgtaata cttttcaaat tggaaagctg caatgctggg caacttcagg cgatacctat
    21061 ttatttacat agttactgac ttgccagtct cgaggaggag gcaataagca agcttgagta
    21121 ttcatacttt tacgatctgc atgctgggca gttatggtgt ctgaaatgta gtgtgttagt
    21181 cttgtttttt ttttatacct gtgatgctaa tcgaggaatg aaaaaatacc tttacttctt
    21241 atcttcaaca attgaatgga tagttggaga tgactgtgaa tcggaatctc cctcaagtac
    21301 atccttatcc gctttctttc tatcataaag ctgatgcggg acatgatcag tgaggtattg
    21361 gtcaaagttc ttcatgcaaa gactggcgat gataggaatg actcccagtg ccatggcgaa
    21421 gtagtataca ttagcatatg aagctgtgta actatccgcc atagctccgc taaccaccgc
    21481 agcagtgctg ttcgtcatcc cagggagagc cttgacagca tctattcgtc ccgtcttggc
    21541 agcctcaaga agactgggga atgatgattg cggaatatcc gtaccacgca gggctgaagt
    21601 cagatggctt ccgatttctt ttgggtactg gttgctgtag agggatataa agacggcggt
    21661 gaaaatggac ccaaaaaagg gacgggaagc agcaacaaca gctagacaac ttgttagaaa
    21721 catcccaaca ataaaagtag gaatacatac agaaagctac acccaaatct tcatctgtcg
    21781 ggataaactg aaccatgagc atggtgatgt cctgagccca ggcgacgaca aagccggaaa
    21841 agaacgacaa agcgatggct gcgttcttgt tatgccgatt gacagatgac atggctccta
    21901 ggaaagccgt gagccacata gccccgacaa gtatttgcca acggatgtgc ctgatgagat
    21961 ggaacacgtt gcccagaatc atcacaccag tccatgtacc gaatgaggca gtcgctgtca
    22021 tccatgcagt ctcttgccag ttcttcaaac tggacccgaa tatattaatg acttgctgag
    22081 ggtaaatgat agtgaggcaa agattcatcg cgcccatgat ggagctgatg agaaggatgc
    22141 agacaaagcc gcgaaaatcc ttgaataggg caggcgggac cataggtcgc tcgggtttgc
    22201 catagacctc gtacaaggcg aacacaagga gagagccaag accagatgtc atgagtccga
    22261 tgatcttgcc agagtcccaa gcgctgttcg gtttgcctcc ccaggagaca ccaaggagaa
    22321 agagggatac tccagcagtg acaaggaaga tacctatcca gtcgagcttt gccagttcgt
    22381 ccctcttgcg agccttttta ccatgaagct gcgtaaatga cggagggtgg taccaaacaa
    22441 cgataagtac agttgcaatc gctgcataca tgtcaatatc attaccatgc attcgatgca
    22501 agaagaagac aacttaccac taatgataat atagatgtaa aagatccaac gccaatcccc
    22561 ttctatactg agacgctgac caaagtaggg gcccatattc gcgacaatgt tggggccaga
    22621 tacaacgagg agaccaagga atttggtttt gttactcatc agttcgccaa tgaatagagg
    22681 gctcgcacct gctggaccag cagcaacgcc aagcattgtc atggcagcca gaagggtatt
    22741 gaatttatta gctgtacacc caacgatagc accaacaagg ccgaggatat gggtagctat
    22801 gacaaatggt cgtcgcccaa atctatccgt aagacgaccc atcaccagga tactgacagc
    22861 ctgaccagtc gtccatagag ttgagaagag actttcgttc tcgctctggc caatgtcctg
    22921 gagaatgttg ggaagagcag aggctgatgc ttgaagaaca aagtaggtag cgcagacatt
    22981 gagagagaat gctgcgaagg aagccatcac acgagctgag gtgtaatatc cttctggaag
    23041 ctcagcggct gtagtggcga gagcttcggc tcgcaacctg tcgtctggct gagactcaag
    23101 gtcaacaaca ccttcctggg gaactgtagc agtcatcttg gaacgaatag gccggctgat
    23161 agggcggtct tgaaaatgaa ctggcacgtt cgtatgctgt atctagcact ctcaatggtc
    23221 gtgagagggg taacaggcca atggacttgg atccgtcata tatatatcct cgccatggat
    23281 ataaccttat tcagacgttc tttttcgact gtcaccctac atctcgtagg tgtaatatgg
    23341 tagacggcaa ctgtaacact ccagggttgt agatttctga tgggccgaag taacacggaa
    23401 tcctcggagc gacagttaaa gtgagatacg ggaggcatta agtcgggccc ccccggattg
    23461 tgattgggtg ataaggtggc gcaagccctg aaagtccagc tggaaggcct gacgtaaagt
    23521 ctagaacgtg cgactagaca tggtttcgtc ggctaactaa tcttggttgg gaatagaccc
    23581 cttgcttcga tatctcagga agcaggggac ggacttgaag gaacactgaa actaactgga
    23641 caatagacga cacaagacga ggacggtata tcaacaaatg gagaggagct ttgtagtaaa
    23701 ttgagagtta atagtcaaca cataagaacg ccattttcca tcgacataga gtttgggggc
    23761 aataaaagaa acgaatcagt gccaagtaca ggcggatgtt tctgccaaga cgaaggatgg
    23821 tcaaaagcaa atagcacgga tatatcggct cgaattaaat ataaagtcta ctatgccctt
    23881 gtcaagtcga cctttgccag gctaatatag gaatgctctg gcatactagt cagaccttct
    23941 atggcgcgat aactagagag ttccttagga caaggcaaca gctcaaagtt ccatatcaag
    24001 atcgctaagg atgtcctcag ctgttgatga cccagtcttc tgccaaaaca gccacgggta
    24061 cccaagccga aggccaatgt tgggccagcc aatccatcaa attcctctgc cgcctcggtc
    24121 gcatcggttc cagtcgatga ctccttctgt ctgagccatc tttcgggctt gaaagctcca
    24181 atgtcgtggt catcccaagc tgagtccttc ttctctccgg caacttggca agtttgactc
    24241 cgtttacgct cgtcgatctc aaggccgggg gtaaaaacac tgggtccatg ggtgagaaac
    24301 aggatttccg tccccttggg tatgtggtgt cccaggatct gcgtgtcaac catggccaag
    24361 cgttgaagtg ccgatgtagc tccaccgcat cgaagactct cttcaatgac tgcttcaagg
    24421 taggggattc gagcagctgc tagctcttgg aaagtgggac tgcggttttc ggatttggcc
    24481 ttggggaacg ctgactgcaa agcctgtcgg agtcgcttct gggcgccagc attgcctgta
    24541 aggaacttca agccccacag agtggtggtg ctcgttgtgt cataacctcc gaggatcagt
    24601 ccgaatagct agaataaccc aacgtatcag cttccatcat cttaatatgt cattgagtcg
    24661 ttgtgcttac ctctccttgc atcattgttg acaaatagtt tggactccga ttttccgctt
    24721 tggccaacaa tgtttcacgt agcaccatct gttccaaagc agaagtgaca ggcgggctat
    24781 ctgatagacc actctcgctt tgaagtttag aaacagcaga tcgaagacta ccacgcagga
    24841 aatcatctcg gatcttccta accctcctga aatatggcat attcattaat acctttgact
    24901 ggactttggc tattggtgaa ctttgcacgc cttgtggggc tttggctaga tcaattgttg
    24961 ccgtgataag atcatcgaaa gcaacatcag gaaagtcaac gggcttgtcg cttttcgggt
    25021 tctggttgtt gtttaacttt tctagtatct cgatgttggg aagcgtcgta ctagacttgt
    25081 agtattctcc gaaggcaaaa gtgtacacag catccaacac ggcaccttga atatcttggg
    25141 ttgcaaggaa tggagaccca ttcgcaattt cggctttcaa ttcccaaact cgaacaagtc
    25201 tcatgatgtt ggaatggaaa caaggtcctg cgaccttctg aataaaggaa ggcagcatga
    25261 catcttgtac cagtttgcgg tgtgttcgaa atatcgaatt tgtttgctcg tataaatgat
    25321 gatcggggat cacgtcttcc agaagagctc gggcgttggt ggctcgatcg aactccttgc
    25381 gtcgcagcat aatatcttgg gtctcgcgaa agtcggcaag gataacgacg ggattgccca
    25441 agggtttgag aaacaattga atgatgggag attcatgatt cttcatttgt tgaatgatcc
    25501 attccatatg cgattgtttg ctggcatttg tccacttcat catagctgga atgtcgccaa
    25561 aaagactctg caaagcgagc ggattgtaag ggatgctcga tattggctta ggaagagccc
    25621 acctgtacaa caagtacagg gccacagcca ccagaccgat agagagaaac atgatgactg
    25681 tttcttctat gtgagctgga agctatcgct gccatagaag acaaaagagt gtagttaagt
    25741 tatcgaatag aaatacgacg agagactgaa tcatcaaata gtaaatgacg ggatggtcaa
    25801 ttatttaaaa caatcacatg tcaatcatta catgaattag ctttcccaga aactatcgaa
    25861 tcagaatgct gacaatcaat catataactt tctcatcaag gtcgacagcc ttaaagcgtg
    25921 gttagatagc tcagtcaatc gatcctaatg ggacacttta actgccaacg catttttagc
    25981 tttctcgccg tccataagga tggcctaagg cttgttgaga cacgcagtgc catggctgcg
    26041 taatgctgtt aatccactct cagttagaaa cgaccatccc aaggcctact gtcgcgtcgt
    26101 tccagaatcc tagtaaatag ttatccacct gtggtaggcc taatccaaac tcaattcaag
    26161 aggcctgggt ccctggtctg gccgacaatg tgatccacaa taccgagtat cagtctccaa
    26221 tcggtcaatg cgaaggggcc gagtcatact taagtctctc tttggcggat gaggcggtgg
    26281 aagtcatctt tgacacggcc ttccaagtcg tcggtgtgtt ttgaactttc ctgtgagtac
    26341 agagtagtgc gtgttttata tcaagtagaa ataaaaatta tttaggcata tctctgccct
    26401 ctacatatct atctattgct tcttatccat tacaacaagc acaaacaagt atactcatca
    26461 gctattgaat agtatacacg atgttgccac aagttatttt gagccatctt ggttccattg
    26521 gcgaagttgc ctcaacatgg ctctctgaaa acggttatct cagcacacaa tgcccaccat
    26581 tgcctaaagg caacatcaac tatgacattt atatgggcta tcccgagatg ttcgcttggg
    26641 acaagaaacg ttgcgttgcc tacgtcaggt atgtgatcct tggctatgaa aatatccccc
    26701 gctaatctca tcatcttgaa gcaacctata caacgccact gtcagtactt gggatcctta
    26761 caagggtgtt gttcttgaca ccattgaatt cccaggtctc agtcacgctg gtgattcagc
    26821 cagcccgaac ccgctacatg ctagcggaat catcctgaga cctgatgcgt ataatcctca
    26881 cactctcgaa gtcgtgattg acaatggaga cgctttctac agtgatggtt tcaacgtgtc
    26941 gggacccgac cacttgatga ctattgatct caagacgaag gaggttacaa ataagttgcg
    27001 tctcaacaac ggcctttatg ccggctatgc ggatgccagt cttggacctg atgggaacac
    27061 atatgtcctg ggaacttacg catcaaacat tctacgagta acacctgaga aggaaatctc
    27121 gacattttac gttgctgata agcttgaacc acctcgtctc tacggcttca ccggcattgc
    27181 tcacgttgga aacgccatga ttgttcccga caacatcatt gggcagctca ttcgcttcga
    27241 cgtccgcgac aaggttggaa ctcccgttgt ga
//
