BGC0001811

BGC0001811: trichodiene-11-one biosynthetic gene cluster from Fusarium asiaticum

View antiSMASH-generated output

Download Cluster GenBank file

Download region SVG

Location: 1 - 27,272 nt. (total: 27,272 nt).
This entry is originally from NCBI GenBank LC222739.1.

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

General

Compounds

Genes

History

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0001811
Short description	trichodiene-11-one biosynthetic gene cluster from Fusarium asiaticum
Status	Minimal annotation: yes A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s) Completeness: Unknown Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	Terpene
Loci	NCBI GenBank: LC222739.1
Compounds	trichodiene-11-one
Species	Fusarium asiaticum [taxonomy]
References	Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis. Tokai T et al., FEMS Microbiol Lett (2005) PMID:16125338 Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis. Tokai T et al., Biochem Biophys Res Commun (2007) PMID:17188234 Genetically engineered Fusarium as a tool to evaluate the effects of environmental factors on initiation of trichothecene biosynthesis. Ochiai N et al., FEMS Microbiol Lett (2007) PMID:17711459 Involvement of the osmosensor histidine kinase and osmotic stress-activated protein kinases in the regulation of secondary metabolism in Fusarium graminearum. Ochiai N et al., Biochem Biophys Res Commun (2007) PMID:17897620 4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3. Tokai T et al., Biosci Biotechnol Biochem (2008) PMID:18776660 Effect of disrupting the trichothecene efflux pump encoded by FgTri12 in the nivalenol chemotype of Fusarium graminearum. Nakajima Y et al., J Gen Appl Microbiol (2015) PMID:26227913 Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype. Maeda K et al., Environ Microbiol (2016) PMID:27120196 Acetyltransferase activity in Pseudomonas sp. capable of acetylating the C-4 hydroxyl group of nivalenol-type trichothecenes. Tanaka A et al., J Gen Appl Microbiol (2017) PMID:27773916

Chemical products information

trichodiene-11-one

(no structure information available)

List of genes involved in compound(s) production

Identifiers	Position	Product	Extra
BAX01957.1 tri8	33 - 1367 (-)	trichothecene 3-O-esterase	copy AA seq copy Nt seq
BAX01958.1 tri7	2065 - 3441 (+)	trichothecene 4-O-acetyltransferase	copy AA seq copy Nt seq
BAX01959.1 tri3	4241 - 6003 (+)	trichothecene 15-O-acetyltransferase	copy AA seq copy Nt seq
BAX01960.1 tri4	7169 - 8910 (-)	trichodiene oxygenase	copy AA seq copy Nt seq
BAX01961.1 tri6	10081 - 10737 (+)	trichothecene biosynthesis positive transcription factor	copy AA seq copy Nt seq
BAX01962.1 tri5	13672 - 14851 (+)	trichodiene synthase	copy AA seq copy Nt seq
BAX01963.1 tri10	15523 - 16869 (+)	regulatory protein	copy AA seq copy Nt seq
BAX01964.1 tri9	17468 - 17599 (-)	hypothetical protein	copy AA seq copy Nt seq
BAX01965.1 tri11	18842 - 20582 (-)	isotrichodermin C-15 hydroxylase	copy AA seq copy Nt seq
BAX01966.1 tri12	21232 - 23136 (-)	trichothecene efflux pump	copy AA seq copy Nt seq
BAX01967.1 tri13	23871 - 25672 (-)	trichothecene C-4-hydroxylase	copy AA seq copy Nt seq

Annotation changelog

MIBiG version	Submitter	Notes
1.4	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Submitted
2.0	Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).	Migrated from v1.4

Similar known gene clusters