Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001811.1:
Cluster 1Terpene127272

BGC0001811, trichodiene-11-one biosynthetic gene cluster from Fusarium asiaticum. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: trichodiene-11-one

Class-specific details

Biosynthetic class(es):
Terpene

Gene cluster description

trichodiene-11-one (BGC0001811). Gene Cluster 1. Biosynthetic class = Terpene. GenBank LC222739. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

Literature references

1. Tokai T et al. (2005) Screening of putative oxygenase genes in the Fusarium graminearum genome sequence database for their role in trichothecene biosynthesis. FEMS Microbiol Lett 251(2):193-201. doi:
2. Tokai T et al. (2007) Fusarium Tri4 encodes a key multifunctional cytochrome P450 monooxygenase for four consecutive oxygenation steps in trichothecene biosynthesis. Biochem Biophys Res Commun 353(2):412-7. doi:
3. Ochiai N et al. (2007) Genetically engineered Fusarium as a tool to evaluate the effects of environmental factors on initiation of trichothecene biosynthesis. FEMS Microbiol Lett 275(1):53-61. doi:
4. Ochiai N et al. (2007) Involvement of the osmosensor histidine kinase and osmotic stress-activated protein kinases in the regulation of secondary metabolism in Fusarium graminearum. Biochem Biophys Res Commun 363(3):639-44. doi:
5. Tokai T et al. (2008) 4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3. Biosci Biotechnol Biochem 72(9):2485-9. doi: 10.1271/bbb.80501. Epub
6. Nakajima Y et al. (2015 TI) Effect of disrupting the trichothecene efflux pump encoded by FgTri12 in the nivalenol chemotype of Fusarium graminearum. J Gen Appl Microbiol 61(3):93-6. doi: 10.2323/jgam.61.93.
7. Maeda K et al. (2016) Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype. Environ Microbiol 18(11):3798-3811. doi: 10.1111/1462-2920.13338. Epub
8. Tanaka A et al. (2017) Acetyltransferase activity in Pseudomonas sp. capable of acetylating the C-4 hydroxyl group of nivalenol-type trichothecenes. J Gen Appl Microbiol 62(6):326-329. doi: 10.2323/jgam.2016.05.002.