BGC0001812 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001812 (Micromonospora chalcea subsp. izumensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	73,895	tylactone	PKS	100%

BGC0001812 - Region 1 - T1PKS

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Location: 1 - 73,895 nt. (total: 73,895 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 73,896
Label		BGC0001812

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001812	1.00	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086	0.79	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000018	0.44	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.42	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000113	0.40	Polyketide	niddamycin	Streptomyces caelestis
BGC0000166	0.39	Polyketide	tylactone	Streptomyces fradiae
BGC0000016	0.38	Other	amphotericin B	Streptomyces nodosus
BGC0001276	0.34	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001830	0.33	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0002347	0.33	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001812	1.00	Polyketide	tylactone	Micromonospora chalcea subsp. izumensis
BGC0002086	0.92	Polyketide	rosamicin	Micromonospora carbonacea
BGC0000018	0.75	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000113	0.72	Polyketide	niddamycin	Streptomyces caelestis
BGC0000166	0.71	Polyketide	tylactone	Streptomyces fradiae
BGC0000016	0.70	Other	amphotericin B	Streptomyces nodosus
BGC0001276	0.67	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001830	0.66	Polyketide	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0002347	0.66	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 72907:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - Me-ccmal) + (ccmal) + (Me-ohmal - redemal) + (Me-ohmal) + (ohmal)
Non-colinear ordering:: juvEI + juvEII + juvEIII + juvEIV + juvEV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

juvEI

PKS_AT (532..835): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.3
Ethylmalonyl-CoA: 169.8
Methoxymalonyl-CoA: 152.2
2-Methylbutyryl-CoA: 120.8
trans-1,2-CPDA: 103.0
Propionyl-CoA: 91.4
Malonyl-CoA: 81.9
Isobutyryl-CoA: 77.9
CHC-CoA: 74.8
Benzoyl-CoA: 70.0
Acetyl-CoA: 36.7
inactive: 27.0
fatty_acid: 25.4
3-Methylbutyryl-CoA: 12.7

PKS_AT (1575..1878): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.6
Ethylmalonyl-CoA: 169.8
Methoxymalonyl-CoA: 149.4
2-Methylbutyryl-CoA: 117.9
trans-1,2-CPDA: 106.3
Propionyl-CoA: 91.8
Malonyl-CoA: 81.5
Isobutyryl-CoA: 71.9
CHC-CoA: 68.2
Benzoyl-CoA: 66.7
Acetyl-CoA: 35.8
inactive: 27.0
fatty_acid: 23.7
3-Methylbutyryl-CoA: 15.1

PKS_AT (3090..3390): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.3
Ethylmalonyl-CoA: 166.5
Methoxymalonyl-CoA: 147.0
2-Methylbutyryl-CoA: 114.8
trans-1,2-CPDA: 102.2
Propionyl-CoA: 92.2
Malonyl-CoA: 81.2
Isobutyryl-CoA: 71.8
CHC-CoA: 69.0
Benzoyl-CoA: 66.8
Acetyl-CoA: 36.6
inactive: 26.4
fatty_acid: 23.3
3-Methylbutyryl-CoA: 14.4

juvEII

PKS_AT (601..900): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.1
inactive: 107.5
Methylmalonyl-CoA: 73.8
Methoxymalonyl-CoA: 73.0
Ethylmalonyl-CoA: 44.2
Isobutyryl-CoA: 44.0
Propionyl-CoA: 30.6
Benzoyl-CoA: 23.7
CHC-CoA: 21.7
trans-1,2-CPDA: 14.7
2-Methylbutyryl-CoA: 12.9
Acetyl-CoA: 12.7
fatty_acid: 9.6
3-Methylbutyryl-CoA: 0.0

juvEIII

PKS_AT (595..898): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.8
Ethylmalonyl-CoA: 171.1
Methoxymalonyl-CoA: 151.0
2-Methylbutyryl-CoA: 119.6
trans-1,2-CPDA: 104.9
Propionyl-CoA: 90.6
Malonyl-CoA: 79.0
Isobutyryl-CoA: 76.0
Benzoyl-CoA: 68.2
CHC-CoA: 68.1
Acetyl-CoA: 36.1
inactive: 27.0
fatty_acid: 25.4
3-Methylbutyryl-CoA: 12.8

PKS_AT (2113..2411): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 235.2
Methylmalonyl-CoA: 202.9
Methoxymalonyl-CoA: 180.1
trans-1,2-CPDA: 166.5
2-Methylbutyryl-CoA: 159.8
Propionyl-CoA: 121.3
CHC-CoA: 98.1
Malonyl-CoA: 83.6
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.4
Acetyl-CoA: 59.5
fatty_acid: 48.6
3-Methylbutyryl-CoA: 34.9
inactive: 16.4

juvEIV

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.3
Ethylmalonyl-CoA: 190.5
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 138.5
trans-1,2-CPDA: 128.2
Propionyl-CoA: 97.8
Malonyl-CoA: 85.8
CHC-CoA: 85.1
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 56.3
3-Methylbutyryl-CoA: 38.3
fatty_acid: 38.2
Acetyl-CoA: 29.8
inactive: 17.5

juvEV

PKS_AT (568..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.3
inactive: 114.1
Methoxymalonyl-CoA: 64.7
Methylmalonyl-CoA: 52.3
Propionyl-CoA: 28.3
Isobutyryl-CoA: 22.1
Benzoyl-CoA: 20.0
Acetyl-CoA: 17.8
fatty_acid: 14.0
CHC-CoA: 12.6
Ethylmalonyl-CoA: 12.2
2-Methylbutyryl-CoA: 11.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0