BGC0001813 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001813 (Streptomyces sp. NRRL WC-3703)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,PKS-like	1	28,112	tyrobetaine	NRPS:Type I	100%

BGC0001813 - Region 1 - NRPS,PKS-like

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Location: 1 - 28,112 nt. (total: 28,112 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,113
Label		BGC0001813

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001813	2.00	NRP	tyrobetaine	Streptomyces sp. NRRL WC-3703
BGC0002017	0.70	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002058	0.67	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287	0.67	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000396	0.63	NRP	nodularin	Nostoc sp. 73.1
BGC0000457	0.61	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000465	0.59	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0002135	0.58	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.58	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002437	0.57	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001813	1.00	NRP	tyrobetaine	Streptomyces sp. NRRL WC-3703
BGC0002017	0.68	NRP	potensibactin	Nocardiopsis potens DSM 45234
BGC0002058	0.67	Polyketide, NRP	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287	0.67	NRP	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000396	0.65	NRP	nodularin	Nostoc sp. 73.1
BGC0000457	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000465	0.63	NRP	xenortide A, xenortide B, xenortide C, xenortide D	Xenorhabdus nematophila ATCC 19061
BGC0002135	0.63	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.62	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002437	0.62	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28112:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NMe-Tyr - Tyr - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

IF71_RS0139180

Search NORINE for peptide: strict or relaxed

AMP-binding (6..381): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DAATVAAVCK
Nearest Stachelhaus code(s):: Tyr DAATVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1467..1842): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DASTVAAVCK
Nearest Stachelhaus code(s):: Tyr DASTVAAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2514..2917): X

nrpys: 3OH-Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAFLWGVMAK
Nearest Stachelhaus code(s):: 3OH-Leu DAFLWGVMAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

IF71_RS0139190

Search NORINE for peptide: strict or relaxed

AMP-binding (37..456): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DPYFCSLITK
Nearest Stachelhaus code(s):: Ala DPYFCSLITK (100% 8Å match)
Stachelhaus code match:: 100% (strong)