BGC0001813: tyrobetaine biosynthetic gene cluster from Streptomyces sp. NRRL WC-3703
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Location: 1,569 - 29,680 nt. (total: 28,112 nt).
This entry is originally from NCBI GenBank NZ_JOCH01000080.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001813
Short description tyrobetaine biosynthetic gene cluster from Streptomyces sp. NRRL WC-3703
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_JOCH01000080.1
1569 - 29680
via
Compounds
  • tyrobetaine
Species Streptomyces sp. NRRL WC-3703 [taxonomy]
References
Chemical products information
tyrobetaine Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IF71_RS1000000149300
  • WP_129820953.1
 1569 - 2357 (-) hypothetical protein
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    • IF71_RS0139170
    • WP_003981341.1
    		 2546 - 4303 (+) DUF262 domain-containing protein
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      • IF71_RS0139175
      • WP_003981343.1
      		 4611 - 5087 (-) MSMEG_6728 family protein
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        • IF71_RS0139180
        • WP_003981346.1
        		 5223 - 15878 (-) non-ribosomal peptide synthetase
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          • IF71_RS1000000145670
          • WP_003981348.1
          		 16020 - 16751 (+) 4'-phosphopantetheinyl transferase superfamily protein
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            • IF71_RS0139190
            • WP_003981349.1
            		 16777 - 18420 (-) amino acid adenylation domain-containing protein
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              • IF71_RS0139195
              • WP_003981350.1
              		 18417 - 19691 (-) MFS transporter
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                • IF71_RS0139200
                • WP_100246535.1
                		 19688 - 20836 (-) HAD-IIIC family phosphatase
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                  • IF71_RS0139205
                  • WP_003981353.1
                  		 20842 - 21864 (-) 3-oxoacyl-[acyl-carrier-protein] synthase III C-terminal domain-containing protein
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                    • IF71_RS0139210
                    • WP_003981355.1
                    		 21861 - 22976 (-) acyl-CoA dehydrogenase family protein
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                      • IF71_RS0139215
                      • WP_003981357.1
                      		 22973 - 23266 (-) acyl carrier protein
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                        • IF71_RS0139220
                        • WP_030185022.1
                        		 23263 - 24129 (-) 3-hydroxyacyl-CoA dehydrogenase family protein
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                          • IF71_RS0139225
                          • WP_030185025.1
                          		 24168 - 27602 (-) thioester reductase domain-containing protein
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                            • IF71_RS1000000148350
                            • WP_003987412.1
                            		 27599 - 27970 (-) acyl carrier protein
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                              • IF71_RS0139235
                              • WP_003987413.1
                              		 27996 - 28829 (-) sugar phosphate isomerase/epimerase family protein
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                                • IF71_RS1000000150995
                                • WP_255304222.1
                                		 29095 - 29217 (-) hypothetical protein
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                                  Biosynthesis information

                                  Biosynthetic modules

                                  Name
                                  Unk01
                                  Type
                                  nrps-type1
                                  Genes
                                  IF71_RS0139180
                                  Substrates
                                  tyrosine (evidence: Structure-based inference, Mass spectrometry, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk02
                                  Type
                                  nrps-type1
                                  Genes
                                  IF71_RS0139180
                                  Substrates
                                  tyrosine (evidence: Structure-based inference, Mass spectrometry, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk03
                                  Type
                                  nrps-type1
                                  Genes
                                  IF71_RS0139180
                                  Substrates
                                  3-hydroxyleucine (evidence: Structure-based inference, Mass spectrometry, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Name
                                  Unk04
                                  Type
                                  nrps-type1
                                  Genes
                                  IF71_RS0139190
                                  Substrates
                                  alanine (evidence: Structure-based inference, Mass spectrometry, Feeding study)
                                  Integrated Monomers
                                  Domains
                                  adenylation
                                  Annotation changelog

                                  Entry version: 3

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2022-09-15
                                  Added NRP substrate specificities
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 2

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2019-10-16
                                  Migrated from v1.4
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                  Entry version: 1

                                  Date
                                  Changes
                                  Submitters
                                  Reviewers
                                  2018-08-06
                                  Submitted
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                  Detailed domain annotation
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