BGC0001814: ulleungmycin biosynthetic gene cluster from Streptomyces sp. KCB13F003
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Location: 1 - 57,737 nt. (total: 57,737 nt).
This entry is originally from NCBI GenBank MF541667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001814
Short description ulleungmycin biosynthetic gene cluster from Streptomyces sp. KCB13F003
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MF541667.1
1 - 57737
via
Compounds
  • ulleungmycin
Species Streptomyces sp. KCB13F003 [taxonomy]
References
Chemical products information
ulleungmycin Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATU31811.1
  • ulm1
 1 - 1617 (-) MFS transporter
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    • ATU31812.1
    • ulm2
    		 1927 - 2520 (-) RNA-binding protein
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      • ATU31813.1
      • ulm3
      		 2554 - 3270 (-) LysR family transcriptional regulator
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        • ATU31786.1
        • ulm4
        		 3380 - 3796 (+) hypothetical protein
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          • ATU31814.1
          • ulm5
          		 3885 - 4505 (-) threonylcarbamoyl-AMP synthase
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            • ATU31787.1
            • ulm6
            		 5382 - 5933 (+) ABC transporter
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              • ATU31815.1
              • ulm7
              		 5995 - 6756 (-) thioesterase
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                • ATU31816.1
                • ulm8
                		 6760 - 8052 (-) MFS transporter
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                  • ATU31788.1
                  • ulm9
                  		 8290 - 8493 (+) hypothetical protein
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                    • ATU31789.1
                    • ulm10
                    		 8590 - 9009 (+) hypothetical protein
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                      • ATU31817.1
                      • ulm11
                      		 9209 - 9880 (-) LuxR family transcriptional regulator
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                        • ATU31818.1
                        • ulm12
                        		 9868 - 11079 (-) sensor histidine kinase
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                          • ATU31790.1
                          • ulm13
                          		 11362 - 12171 (+) ABC transporter ATP-binding protein
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                            • ATU31791.1
                            • ulm14
                            		 12168 - 14918 (+) ABC transporter permease
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                              • ATU31792.1
                              • ulm15
                              		 14960 - 15373 (+) hypothetical protein
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                                • ATU31793.1
                                • ulm16
                                		 15577 - 16917 (+) beta-lactamase
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                                  • ATU31794.1
                                  • ulmA
                                  		 16976 - 31105 (+) NRPS
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                                    • ATU31795.1
                                    • ulmB
                                    		 31162 - 39159 (+) NRPS
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                                      • ATU31796.1
                                      • ulm19
                                      		 39208 - 39417 (+) MbtH protein
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                                        • ATU31797.1
                                        • ulm20
                                        		 39485 - 40471 (+) dioxygenase
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                                          • ATU31798.1
                                          • ulm21
                                          		 40461 - 40847 (+) SnoaL-like polyketide cyclase
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                                            • ATU31799.1
                                            • ulm22
                                            		 40940 - 42043 (+) branched chain amino acid aminotransferase
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                                              • ATU31800.1
                                              • ulm23
                                              		 42112 - 42561 (+) hypothetical protein
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                                                • ATU31801.1
                                                • ulm24
                                                		 42758 - 44263 (+) tryptophan halogenase
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                                                  • ATU31802.1
                                                  • ulm25
                                                  		 44316 - 45572 (+) sodium/hydrogen exchanger
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                                                    • ATU31803.1
                                                    • ulm26
                                                    		 45578 - 46150 (+) flavin reductase
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                                                      • ATU31804.1
                                                      • ulm27
                                                      		 46256 - 47134 (+) amidinotransferase
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                                                        • ATU31805.1
                                                        • ulm28
                                                        		 47225 - 48925 (+) 2-isopropylmalate synthase
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                                                          • ATU31806.1
                                                          • ulm29
                                                          		 48922 - 49722 (+) indole-3-glycerol phosphate synthase
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                                                            • ATU31821.1
                                                            • ulm30
                                                            		 49812 - 50972 (-) anthranilate phosphoribosyltransferase
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                                                              • ATU31807.1
                                                              • ulm31
                                                              		 51071 - 52549 (+) GntR family transcriptional regulator
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                                                                • ATU31820.1
                                                                • ulm32
                                                                		 52399 - 53049 (-) aminotransferase
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                                                                  • ATU31819.1
                                                                  • ulm33
                                                                  		 53049 - 54632 (-) anthranilate synthase
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                                                                    • ATU31808.1
                                                                    • ulm34
                                                                    		 54902 - 55243 (-) transposase
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                                                                      • ATU31809.1
                                                                      • ulm35
                                                                      		 55304 - 55924 (-) transposase
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                                                                        • ATU31810.1
                                                                        • ulm36
                                                                        		 56376 - 57737 (+) phospho-2-dehydro-3-deoxyheptonate aldolase
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                                                                          Biosynthesis information

                                                                          Biosynthetic modules

                                                                          Name
                                                                          Unk01
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmA
                                                                          Substrates
                                                                          6-chlorotryptophan (evidence: Structure-based inference [1])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk02
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmA
                                                                          Substrates
                                                                          valine (evidence: Structure-based inference, Sequence-based prediction)
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk03
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmA
                                                                          Substrates
                                                                          leucine, homoleucine (evidence: Structure-based inference, Sequence-based prediction)
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk04
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmA
                                                                          Substrates
                                                                          allo-isoleucine (evidence: Structure-based inference [1])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk05
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmB
                                                                          Substrates
                                                                          ornithine (evidence: Structure-based inference [1])
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Name
                                                                          Unk06
                                                                          Type
                                                                          nrps-type1
                                                                          Genes
                                                                          ulmB
                                                                          Substrates
                                                                          asparagine (evidence: Structure-based inference, Sequence-based prediction)
                                                                          Integrated Monomers
                                                                          Domains
                                                                          adenylation
                                                                          Annotation changelog

                                                                          Entry version: 4

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-10-07
                                                                          Update chemical activity to schema version 2.11
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 3

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2022-09-15
                                                                          Updated bioactivity data
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2022-09-15
                                                                          Added NRP substrate specificities
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2018-08-06
                                                                          Submitted
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          Detailed domain annotation
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