BGC0001818: vazabitide A biosynthetic gene cluster from Streptomyces sp. SANK 60404
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Location: 1 - 40,455 nt. (total: 40,455 nt).
This entry is originally from NCBI GenBank LC072720.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001818
Short description vazabitide A biosynthetic gene cluster from Streptomyces sp. SANK 60404
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
LC072720.1
via
Compounds
  • vazabitide A
Species Streptomyces sp. SANK 60404 [taxonomy]
References
Chemical products information
vazabitide A Evidence:
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C12H21N3O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAV57436.1
  • vzb0
 2 - 217 (-) putative membrane protein
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    • BAV57437.1
    • vzb1
    		 353 - 1111 (-) MerR-family transcriptional regulator
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      • BAV57438.1
      • vzb2
      		 1202 - 2455 (-) putative ligase/carboxylase
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        • BAV57439.1
        • vzb3
        		 2490 - 2810 (-) branched-chain amino acid transporter
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          • BAV57440.1
          • vzb4
          		 2812 - 3645 (-) branched-chain amino acid transporter
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            • BAV57441.1
            • vzb5
            		 3685 - 4836 (-) acyl-CoA dehydrogenase
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              • BAV57442.1
              • vzb6
              		 4863 - 6014 (-) pimeloyl-CoA dehydrogenase
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                • BAV57443.1
                • vzb7
                		 6017 - 10186 (-) NRPS (C-A-PCP-TE)
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                  • BAV57444.1
                  • vzb8
                  		 10164 - 10544 (-) PCP domain protein
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                    • BAV57445.1
                    • vzb9
                    		 10523 - 11905 (-) Glutamine--scyllo-inositol transaminase
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                      • BAV57446.1
                      • vzb10
                      		 11902 - 12933 (-) hypothetical protein
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                        • BAV57447.1
                        • vzb11
                        		 12930 - 13565 (-) hypothetical protein
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                          • BAV57448.1
                          • vzb12
                          		 13562 - 14491 (-) GCN5-related N-acetyltransferase
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                            • BAV57449.1
                            • vzb13
                            		 14484 - 15827 (-) peptidase M20
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                              • BAV57450.1
                              • vzb14
                              		 15824 - 16642 (-) thioesterase
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                                • BAV57451.1
                                • vzb15
                                		 16639 - 18474 (-) NRPS (A-PCP)
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                                  • BAV57452.1
                                  • vzb16
                                  		 18510 - 18704 (-) MbtH
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                                    • BAV57453.1
                                    • vzb17
                                    		 18870 - 19550 (-) LuxR family transcriptional regulator
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                                      • BAV57454.1
                                      • vzb18
                                      		 19695 - 20984 (-) sulfate adenylyltransferase
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                                        • BAV57455.1
                                        • vzb19
                                        		 20987 - 22006 (-) sulfate adenylyltransferase
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                                          • BAV57456.1
                                          • vzb20
                                          		 22014 - 22574 (-) adenylylsulfate kinase
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                                            • BAV57457.1
                                            • vzb21
                                            		 22629 - 23360 (-) hypothetical protein
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                                              • BAV57458.1
                                              • vzb22
                                              		 23661 - 23834 (+) LysW
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                                                • BAV57459.1
                                                • vzb23
                                                		 23831 - 24709 (+) LysX
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                                                  • BAV57460.1
                                                  • vzb24
                                                  		 24697 - 25734 (+) LysY
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                                                    • BAV57461.1
                                                    • vzb25
                                                    		 25750 - 26616 (+) LysZ
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                                                      • BAV57462.1
                                                      • vzb26
                                                      		 26613 - 27731 (+) LysK
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                                                        • BAV57463.1
                                                        • vzb27
                                                        		 27731 - 28600 (+) Transketolase N-terminal domain protein
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                                                          • BAV57464.1
                                                          • vzb28
                                                          		 28597 - 29595 (+) Transketolase C-terminal domain protein
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                                                            • BAV57465.1
                                                            • vzb29
                                                            		 29762 - 30403 (-) transcriptional regulator
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                                                              • BAV57466.1
                                                              • vzb30
                                                              		 30469 - 31005 (-) hypothetical protein
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                                                                • BAV57467.1
                                                                • vzb31
                                                                		 31102 - 32559 (-) aldehyde dehydrogenase
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                                                                  • BAV57468.1
                                                                  • vzb32
                                                                  		 32630 - 33565 (-) helix-turn-helix domain protein
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                                                                    • BAV57469.1
                                                                    • vzb33
                                                                    		 33653 - 33844 (-) hypothetical protein
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                                                                      • BAV57470.1
                                                                      • vzb34
                                                                      		 33822 - 34331 (+) regulator
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                                                                        • BAV57471.1
                                                                        • vzb35
                                                                        		 34395 - 34682 (-) putative regulator
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                                                                          • BAV57472.1
                                                                          • vzb36
                                                                          		 34882 - 35127 (-) 30S ribosomal protein S18
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                                                                            • BAV57473.1
                                                                            • vzb37
                                                                            		 35132 - 36256 (-) cobalamin synthesis CobW domain containing protein
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                                                                              • BAV57474.1
                                                                              • vzb38
                                                                              		 36256 - 36516 (-) 50S ribosomal protein L31 type B
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                                                                                • BAV57475.1
                                                                                • vzb39
                                                                                		 36525 - 36725 (-) 50S ribosomal protein L33
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                                                                                  • BAV57476.1
                                                                                  • vzb40
                                                                                  		 36753 - 36989 (+) 50S ribosomal protein L28
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                                                                                    • BAV57477.1
                                                                                    • vzb41
                                                                                    		 36989 - 37294 (+) 30S ribosomal protein S14
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                                                                                      • BAV57478.1
                                                                                      • vzb42
                                                                                      		 37236 - 37832 (+) membrane protein
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                                                                                        • BAV57479.1
                                                                                        • vzb43
                                                                                        		 37829 - 37978 (-) hypothetical protein
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                                                                                          • BAV57480.1
                                                                                          • vzb44
                                                                                          		 38164 - 39324 (-) hypothetical protein
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                                                                                            • BAV57481.1
                                                                                            • vzb45
                                                                                            		 39673 - 40440 (+) DNA polymerase I
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                                                                                              Biosynthesis information

                                                                                              Biosynthetic modules

                                                                                              Name
                                                                                              Unk01
                                                                                              Type
                                                                                              nrps-type1
                                                                                              Genes
                                                                                              vzb7
                                                                                              Substrates
                                                                                              (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (evidence: Sequence-based prediction, Structure-based inference, Knock-out studies)
                                                                                              Integrated Monomers
                                                                                              Domains
                                                                                              adenylation
                                                                                              Name
                                                                                              Unk02
                                                                                              Type
                                                                                              nrps-type1
                                                                                              Genes
                                                                                              vzb15
                                                                                              Substrates
                                                                                              valine (evidence: Sequence-based prediction, Structure-based inference)
                                                                                              Integrated Monomers
                                                                                              Domains
                                                                                              adenylation
                                                                                              Annotation changelog

                                                                                              Entry version: 3

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2022-09-15
                                                                                              Merge NRPS substrate specificities from duplicate BGC0001912
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 2

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2019-10-16
                                                                                              Migrated from v1.4
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              2019-10-16
                                                                                              Updated compound(s) information (NPAtlas curation)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 1

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2018-08-06
                                                                                              Submitted
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              Detailed domain annotation
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