BGC0001820 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001820 (Gliocladium sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	46,319	verticillin	NRPS:Type I	100%

BGC0001820 - Region 1 - NRPS

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Location: 1 - 46,319 nt. (total: 46,319 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,320
Label		BGC0001820

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001820	1.00	NRP	verticillin	Gliocladium sp.
BGC0001585	0.36	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0002181	0.33	Terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0002219	0.32	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0001989	0.32	Other	pulcherrimin	Kluyveromyces lactis
BGC0002321	0.31	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0000900	0.31	Other	ferrichrome	Aspergillus oryzae
BGC0002157	0.31	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000798	0.30	Saccharide	dhurrin	Sorghum bicolor
BGC0001518	0.30	Terpene	astellolide A	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001820	1.00	NRP	verticillin	Gliocladium sp.
BGC0001585	0.69	Alkaloid	melinacidin IV	Escovopsis weberi
BGC0002181	0.66	Terpene	pleuromutilin	Rhodocybe pseudopiperita
BGC0002219	0.66	Terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0001989	0.65	Other	pulcherrimin	Kluyveromyces lactis
BGC0002321	0.65	Other	pulcherriminic acid, pulcherrimin, cyclodileucine, compound 3	Metschnikowia aff. pulcherrima
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0002157	0.64	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus
BGC0000798	0.64	Saccharide	dhurrin	Sorghum bicolor
BGC0001518	0.63	Terpene	astellolide A	Aspergillus oryzae RIB40

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46319:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

verP

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AMP-binding (10..405): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DACAIGASMK
Nearest Stachelhaus code(s):: Ser DACALGASMK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1087..1469): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVMAYCAILK
Nearest Stachelhaus code(s):: Ala DVFIYAAILK (47% 8Å match)
Stachelhaus code match:: 70% (weak)