BGC0001823: weishanmycin biosynthetic gene cluster from Streptomyces sp. CB02120-2
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Location: 1 - 76,440 nt. (total: 76,440 nt).
This entry is originally from NCBI GenBank MF925482.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001823
Short description weishanmycin biosynthetic gene cluster from Streptomyces sp. CB02120-2
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: MF925482.1
Compounds
  • weishanmycin
Species Streptomyces sp. CB02120-2 [taxonomy]
References
Chemical products information
weishanmycin
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ATY69607.1
 4325 - 5209 (+) SAM-dependent methyltransferase
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  • ATY69606.1
  • wsmA
 5414 - 6073 (-) Crp/Fnr/Fnr family transcriptional regulator
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  • ATY69605.1
  • wsmB
 6228 - 6800 (-) YdeI-like protein
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  • ATY69604.1
  • wsmC
 6814 - 7569 (-) phosphopantetheinyl transferase
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  • ATY69603.1
  • wsmD
 7809 - 9005 (+) HMG-CoA synthase
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  • ATY69602.1
  • wsmE
 8996 - 9802 (+) enoyl-CoA hydratase
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  • ATY69601.1
  • wsmF
 9807 - 10679 (+) acyltransferase
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  • ATY69600.1
  • wsmG
 10742 - 17185 (+) type I polyketide synthase
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  • ATY69599.1
  • wsmH
 17465 - 19030 (+) antibiotic efflux protein
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  • ATY69598.1
  • wsmI
 19169 - 19975 (+) hypothetical protein
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  • ATY69597.1
  • wsmJ
 19980 - 22301 (+) acyltransferase/oxidoreductase
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  • ATY69596.1
  • wsmK
 22406 - 23314 (+) hypothetical protein
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  • ATY69595.1
  • wsmL
 23396 - 23761 (-) glyoxalase/bleomycin resistance protein
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  • ATY69594.1
  • wsmM
 23928 - 24638 (+) N-acetylglucosaminyl deacetylase
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  • ATY69593.1
  • wsmN
 24698 - 25447 (-) methyltransferase
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  • ATY69592.1
  • wsmO
 25444 - 26811 (-) putative alpha/beta hydrolase
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  • ATY69591.1
  • wsmP
 26906 - 27157 (+) peptidyl carrier protein
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  • ATY69590.1
  • wsmQ
 27180 - 28760 (+) adenylation protein
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  • ATY69589.1
  • wsmR
 28854 - 51185 (+) type I polyketide synthase
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  • ATY69588.1
  • wsmS
 51182 - 52426 (+) HMG-CoA synthase
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  • ATY69587.1
  • wsmT
 52449 - 52694 (+) acyl carrier protein
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  • ATY69586.1
  • wsmU
 52691 - 53917 (+) beta-ketoacyl-ACP synthase
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  • ATY69585.1
  • wsmV
 53883 - 54638 (-) type II thioesterase
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  • ATY69584.1
  • wsmW
 54635 - 61369 (-) hybrid nonribosomal peptide synthetase/type I polyketide synthase
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  • ATY69583.1
  • wsmX
 61366 - 61791 (-) truncated hemoglobin
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  • ATY69582.1
  • wsmY
 61973 - 63199 (+) cytochrome P450 oxygenase
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  • ATY69581.1
  • wsmZ1
 63196 - 63420 (+) ferredoxin
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  • ATY69580.1
  • wsmZ2
 63479 - 64837 (+) crotonyl-CoA carboxylase/reductase
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  • ATY69579.1
  • wsmZ3
 64834 - 65826 (+) ketoacyl-acyl carrier protein synthase III
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  • ATY69578.1
  • wsmZ4
 65823 - 66707 (+) 3-hydroxyacyl-CoA dehydrogenase
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  • ATY69577.1
 66739 - 68166 (-) peptidase M1
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
wsmW
Module ?
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
wsmQ
Module ?
Specificity: D-alanine / 1-aminocyclopropane-1-carboxylic acid / glycine / alanine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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