BGC0001824 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001824 (Xenorhabdus beddingii)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	17,537	xefoampeptides A-G	NRPS:Type I	100%

BGC0001824 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 17,537 nt. (total: 17,537 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,538
Label		BGC0001824

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001824	1.00	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001825	0.30	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.27	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833	0.26	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.26	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000404	0.26	NRP	penicillin	Penicillium chrysogenum
BGC0000313	0.26	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.26	NRP	enniatin	Fusarium equiseti
BGC0002415	0.25	NRP	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0000357	0.25	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001824	1.00	NRP	xefoampeptides A-G	Xenorhabdus beddingii
BGC0001825	0.64	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.61	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833	0.60	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128	0.59	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000404	0.59	NRP	penicillin	Penicillium chrysogenum
BGC0000313	0.59	NRP	beauvericin	Beauveria bassiana
BGC0000342	0.59	NRP	enniatin	Fusarium equiseti
BGC0002415	0.59	NRP	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0000357	0.58	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 17537:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Leu - Leu - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Xbed_01550

Search NORINE for peptide: strict or relaxed

AMP-binding (462..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFILGAVCK
Nearest Stachelhaus code(s):: Leu DAFILGAVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1978..2379): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAMMAGCVCK
Nearest Stachelhaus code(s):: Leu DAMMAGCVCK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3032..3430): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLYNLSGVWK
Nearest Stachelhaus code(s):: Leu DLYNLSGVWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)