BGC0001825 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001825 (Xenorhabdus nematophila AN6/1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	14,850	xenematide	NRPS:Type I	100%

BGC0001825 - Region 1 - NRPS

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Location: 1 - 14,850 nt. (total: 14,850 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,851
Label		BGC0001825

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825	1.00	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.31	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135	0.29	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.29	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.29	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.28	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286	0.28	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.28	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844	0.27	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758	0.27	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825	1.00	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132	0.64	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002135	0.63	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002437	0.63	NRP	thermoactinoamide A	Thermoactinomyces sp. AS95
BGC0002518	0.62	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001833	0.62	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286	0.62	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128	0.62	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001844	0.61	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001758	0.60	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14850:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr - Phe - D-Phe - bAla)

Direct lookup in NORINE database: strict or relaxed

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NRPS/PKS substrate predictions

XNC2_2611

Search NORINE for peptide: strict or relaxed

AMP-binding (466..888): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1536..1944): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DGFAVAAVGK
Nearest Stachelhaus code(s):: Phe DGFAVAAVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2587..2995): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: DGFAVAAVGK
Nearest Stachelhaus code(s):: Phe DGFAVAAVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4096..4513): bAla

nrpys: bAla

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: VDTVISLGDK
Nearest Stachelhaus code(s):: bAla VDTVISLGDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)