BGC0001827 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001827 (Sarocladium sp. 'schorii')

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	48,922	High	xenovulene A	PKS

BGC0001827 - Region 1 - T1PKS

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Location: 1 - 48,922 nt. (total: 48,922 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 48,923
Label		BGC0001827

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

asl5: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

asr2: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

Ligases: synthase

aspks1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001827.3	1.00	PKS	xenovulene A	Sarocladium sp. 'schorii'
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.62	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001827.3	1.00	PKS	xenovulene A	Sarocladium sp. 'schorii'
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002175.3	0.62	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.62	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 45735:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

aspks1: mal

PKS_AT (940..1243): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 61.2
inactive: 58.6
Methoxymalonyl-CoA: 56.0
Methylmalonyl-CoA: 53.3
Ethylmalonyl-CoA: 31.4
Benzoyl-CoA: 25.0
Propionyl-CoA: 20.1
fatty_acid: 20.0
2-Methylbutyryl-CoA: 19.9
CHC-CoA: 18.4
trans-1,2-CPDA: 16.6
Isobutyryl-CoA: 15.0
3-Methylbutyryl-CoA: 14.8
Acetyl-CoA: 0.0

Link to PARAS substrate predictor