BGC0001828 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001828 (Streptomyces griseus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	74,735	High	griseochelin	PKS

BGC0001828 - Region 1 - T1PKS

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Location: 1 - 74,735 nt. (total: 74,735 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 74,736
Label		BGC0001828

Tailoring functions

Transferases: acylase

zinC: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: esterase

zinH: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

zinA: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

zinB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

zinD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

zinE: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

zinF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

zinT: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001828.5	1.00	PKS	griseochelin	Streptomyces griseus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001828.5	1.00	PKS	griseochelin	Streptomyces griseus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 74735:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-redmal) + (Me-ccmal - Me-ohmal - ccmal) + (redmal) + (Me-ohmal - Me-ohmal) + (Me-ohmal) + (Me-ohmal - redmal) + (Me-ohmal)
Non-colinear ordering:: zinA + zinB + zinC + zinD + zinE + zinF + zinG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

zinB: mmal - mmal - mal

PKS_AT (587..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.0
Ethylmalonyl-CoA: 186.2
Methoxymalonyl-CoA: 158.4
2-Methylbutyryl-CoA: 112.5
Malonyl-CoA: 104.1
trans-1,2-CPDA: 101.7
Propionyl-CoA: 93.0
CHC-CoA: 75.4
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.9
fatty_acid: 30.8
Acetyl-CoA: 28.9
3-Methylbutyryl-CoA: 23.5
inactive: 22.0

PKS_AT (2308..2595): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.3
Ethylmalonyl-CoA: 193.3
Methoxymalonyl-CoA: 160.8
2-Methylbutyryl-CoA: 106.6
Malonyl-CoA: 105.6
trans-1,2-CPDA: 100.3
Propionyl-CoA: 90.7
CHC-CoA: 76.7
Isobutyryl-CoA: 69.5
Benzoyl-CoA: 60.6
fatty_acid: 31.9
Acetyl-CoA: 30.8
inactive: 23.5
3-Methylbutyryl-CoA: 22.4

PKS_AT (3855..4135): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinC: mal

PKS_AT (593..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinD: mmal - mmal

PKS_AT (575..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 160.8
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 111.8
trans-1,2-CPDA: 104.1
Propionyl-CoA: 98.2
CHC-CoA: 79.1
Isobutyryl-CoA: 73.2
Benzoyl-CoA: 62.9
fatty_acid: 34.2
Acetyl-CoA: 31.7
3-Methylbutyryl-CoA: 24.5
inactive: 24.3

PKS_AT (2110..2397): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.3
Ethylmalonyl-CoA: 191.6
Methoxymalonyl-CoA: 160.0
2-Methylbutyryl-CoA: 112.5
Malonyl-CoA: 109.7
trans-1,2-CPDA: 102.6
Propionyl-CoA: 94.8
CHC-CoA: 78.7
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 62.4
fatty_acid: 33.8
Acetyl-CoA: 32.2
3-Methylbutyryl-CoA: 24.1
inactive: 22.8

zinE: mmal

PKS_AT (614..904): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 174.1
Methoxymalonyl-CoA: 154.2
2-Methylbutyryl-CoA: 120.4
trans-1,2-CPDA: 100.3
Malonyl-CoA: 93.5
Propionyl-CoA: 87.8
Isobutyryl-CoA: 82.8
CHC-CoA: 81.4
Benzoyl-CoA: 63.6
Acetyl-CoA: 47.5
fatty_acid: 46.0
3-Methylbutyryl-CoA: 34.7
inactive: 11.7

zinF: mmal - mal

PKS_AT (609..902): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.8
Ethylmalonyl-CoA: 182.9
Methoxymalonyl-CoA: 158.8
trans-1,2-CPDA: 115.0
2-Methylbutyryl-CoA: 110.7
Malonyl-CoA: 108.5
Propionyl-CoA: 96.7
CHC-CoA: 87.5
Benzoyl-CoA: 81.6
Isobutyryl-CoA: 74.0
fatty_acid: 45.4
Acetyl-CoA: 40.0
3-Methylbutyryl-CoA: 35.3
inactive: 23.1

PKS_AT (2179..2459): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinG: mmal

PKS_AT (575..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.6
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 160.1
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 108.5
trans-1,2-CPDA: 102.6
Propionyl-CoA: 95.8
CHC-CoA: 79.8
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 63.4
fatty_acid: 34.6
Acetyl-CoA: 32.2
inactive: 22.6
3-Methylbutyryl-CoA: 22.5

zinA: mmal - mmal

PKS_AT (569..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.6
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 160.1
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 108.5
trans-1,2-CPDA: 102.6
Propionyl-CoA: 95.8
CHC-CoA: 79.8
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 63.4
fatty_acid: 34.6
Acetyl-CoA: 32.2
inactive: 22.6
3-Methylbutyryl-CoA: 22.5

PKS_AT (1581..1871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.0
Ethylmalonyl-CoA: 191.7
Methoxymalonyl-CoA: 162.1
2-Methylbutyryl-CoA: 108.4
Malonyl-CoA: 107.6
trans-1,2-CPDA: 99.7
CHC-CoA: 98.0
Propionyl-CoA: 92.7
Benzoyl-CoA: 78.7
Isobutyryl-CoA: 76.8
Acetyl-CoA: 41.4
fatty_acid: 24.3
3-Methylbutyryl-CoA: 22.9
inactive: 21.8

Link to PARAS substrate predictor