BGC0001828 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001828 (Streptomyces griseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	74,735	ebelactone	Polyketide	11%

BGC0001828 - Region 1 - T1PKS

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Location: 1 - 74,735 nt. (total: 74,735 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 74,736
Label		BGC0001828

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001828.1	0.75	Polyketide	griseochelin	Streptomyces griseus
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000067.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.28	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001858.1	0.25	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001913.1	0.25	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001162.1	0.25	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001283.1	0.25	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001012.1	0.24	NRP, Polyketide	meridamycin	Streptomyces violaceusniger

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001828.1	0.91	Polyketide	griseochelin	Streptomyces griseus
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.62	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001858.1	0.59	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001913.1	0.59	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0001162.1	0.58	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001283.1	0.58	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001012.1	0.57	NRP, Polyketide	meridamycin	Streptomyces violaceusniger

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 74735:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-redmal) + (Me-ccmal - Me-ohmal - ccmal) + (Me-ohmal - Me-ohmal) + (redmal) + (Me-ohmal) + (Me-ohmal - redmal) + (Me-ohmal)
Non-colinear ordering:: zinA + zinB + zinD + zinC + zinE + zinF + zinG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

zinB

PKS_AT (587..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.0
Ethylmalonyl-CoA: 186.2
Methoxymalonyl-CoA: 158.4
2-Methylbutyryl-CoA: 112.5
Malonyl-CoA: 104.1
trans-1,2-CPDA: 101.7
Propionyl-CoA: 93.0
CHC-CoA: 75.4
Isobutyryl-CoA: 72.1
Benzoyl-CoA: 61.9
fatty_acid: 30.8
Acetyl-CoA: 28.9
3-Methylbutyryl-CoA: 23.5
inactive: 22.0

PKS_AT (2308..2595): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.3
Ethylmalonyl-CoA: 193.3
Methoxymalonyl-CoA: 160.8
2-Methylbutyryl-CoA: 106.6
Malonyl-CoA: 105.6
trans-1,2-CPDA: 100.3
Propionyl-CoA: 90.7
CHC-CoA: 76.7
Isobutyryl-CoA: 69.5
Benzoyl-CoA: 60.6
fatty_acid: 31.9
Acetyl-CoA: 30.8
inactive: 23.5
3-Methylbutyryl-CoA: 22.4

PKS_AT (3855..4135): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinC

PKS_AT (593..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinD

PKS_AT (575..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 194.2
Methoxymalonyl-CoA: 160.8
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 111.8
trans-1,2-CPDA: 104.1
Propionyl-CoA: 98.2
CHC-CoA: 79.1
Isobutyryl-CoA: 73.2
Benzoyl-CoA: 62.9
fatty_acid: 34.2
Acetyl-CoA: 31.7
3-Methylbutyryl-CoA: 24.5
inactive: 24.3

PKS_AT (2110..2397): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.3
Ethylmalonyl-CoA: 191.6
Methoxymalonyl-CoA: 160.0
2-Methylbutyryl-CoA: 112.5
Malonyl-CoA: 109.7
trans-1,2-CPDA: 102.6
Propionyl-CoA: 94.8
CHC-CoA: 78.7
Isobutyryl-CoA: 72.8
Benzoyl-CoA: 62.4
fatty_acid: 33.8
Acetyl-CoA: 32.2
3-Methylbutyryl-CoA: 24.1
inactive: 22.8

zinE

PKS_AT (614..904): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 174.1
Methoxymalonyl-CoA: 154.2
2-Methylbutyryl-CoA: 120.4
trans-1,2-CPDA: 100.3
Malonyl-CoA: 93.5
Propionyl-CoA: 87.8
Isobutyryl-CoA: 82.8
CHC-CoA: 81.4
Benzoyl-CoA: 63.6
Acetyl-CoA: 47.5
fatty_acid: 46.0
3-Methylbutyryl-CoA: 34.7
inactive: 11.7

zinF

PKS_AT (609..902): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.8
Ethylmalonyl-CoA: 182.9
Methoxymalonyl-CoA: 158.8
trans-1,2-CPDA: 115.0
2-Methylbutyryl-CoA: 110.7
Malonyl-CoA: 108.5
Propionyl-CoA: 96.7
CHC-CoA: 87.5
Benzoyl-CoA: 81.6
Isobutyryl-CoA: 74.0
fatty_acid: 45.4
Acetyl-CoA: 40.0
3-Methylbutyryl-CoA: 35.3
inactive: 23.1

PKS_AT (2179..2459): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Methylbutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.7
inactive: 76.4
Methylmalonyl-CoA: 52.9
Methoxymalonyl-CoA: 42.9
Isobutyryl-CoA: 32.6
Ethylmalonyl-CoA: 23.7
Propionyl-CoA: 23.0
Benzoyl-CoA: 14.8
Acetyl-CoA: 14.8
trans-1,2-CPDA: 14.2
fatty_acid: 12.3
CHC-CoA: 5.5
2-Methylbutyryl-CoA: 4.8
3-Methylbutyryl-CoA: 0.0

zinG

PKS_AT (575..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.6
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 160.1
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 108.5
trans-1,2-CPDA: 102.6
Propionyl-CoA: 95.8
CHC-CoA: 79.8
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 63.4
fatty_acid: 34.6
Acetyl-CoA: 32.2
inactive: 22.6
3-Methylbutyryl-CoA: 22.5

zinA

PKS_AT (569..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.6
Ethylmalonyl-CoA: 192.8
Methoxymalonyl-CoA: 160.1
2-Methylbutyryl-CoA: 113.3
Malonyl-CoA: 108.5
trans-1,2-CPDA: 102.6
Propionyl-CoA: 95.8
CHC-CoA: 79.8
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 63.4
fatty_acid: 34.6
Acetyl-CoA: 32.2
inactive: 22.6
3-Methylbutyryl-CoA: 22.5

PKS_AT (1581..1871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.0
Ethylmalonyl-CoA: 191.7
Methoxymalonyl-CoA: 162.1
2-Methylbutyryl-CoA: 108.4
Malonyl-CoA: 107.6
trans-1,2-CPDA: 99.7
CHC-CoA: 98.0
Propionyl-CoA: 92.7
Benzoyl-CoA: 78.7
Isobutyryl-CoA: 76.8
Acetyl-CoA: 41.4
fatty_acid: 24.3
3-Methylbutyryl-CoA: 22.9
inactive: 21.8