BGC0001829: α,β-epoxyketone biosynthetic gene cluster from Streptomyces chromofuscus
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Location: 1 - 25,136 nt. (total: 25,136 nt).
This entry is originally from NCBI GenBank LN999909.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001829
Short description α,β-epoxyketone biosynthetic gene cluster from Streptomyces chromofuscus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: LN999909.1
Compounds
  • α,β-epoxyketone
Species Streptomyces chromofuscus [taxonomy]
References
Chemical products information
α,β-epoxyketone
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CUX96948.1
  • tmcA
 1 - 213 (+) TmcA
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  • CUX96949.1
  • tmcB
 352 - 1020 (+) TmcB
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  • CUX96950.1
  • tmcC
 1077 - 1934 (+) TmcC
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  • CUX96951.1
  • tmcD
 2574 - 3596 (+) TmcD
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  • CUX96952.1
  • tmcE
 3635 - 3865 (+) TmcE
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  • CUX96953.1
  • tmcF
 4565 - 6238 (+) TmcF
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  • CUX96954.1
  • tmcG
 6235 - 12738 (+) TmcG
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  • CUX96955.1
  • tmcH
 12735 - 18890 (+) TmcH
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  • CUX96956.1
  • tmcI
 18890 - 20185 (+) TmcI
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  • CUX96957.1
  • tmcJ
 20178 - 22154 (+) TmcJ
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  • CUX96958.1
  • tmcK
 22151 - 23377 (+) TmcK
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  • CUX96959.1
  • tmcL
 23661 - 24212 (+) TmcL
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  • CUX96960.1
  • orf_1
 24294 - 25136 (+) Orf+1
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
tmcG
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Homology
Module ?
Specificity: leucine / 4,5-dehydroleucine
Evidence for specificity:
  • Heterologous expression
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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