Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0001829.1:
Cluster 1NRP / Polyketide125136

BGC0001829, alpha,beta-epoxyketone biosynthetic gene cluster from Streptomyces chromofuscus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: alpha,beta-epoxyketone

Class-specific details

Biosynthetic class(es):
NRP / Polyketide
Polyketide synthase subclass:
Modular Type I

Gene cluster description

alpha,beta-epoxyketone (BGC0001829). Gene Cluster 1. Biosynthetic class = NRP/Polyketide. GenBank LN999909. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Zabala D et al. (2016) A Flavin-Dependent Decarboxylase-Dehydrogenase-Monooxygenase Assembles the Warhead of alpha,beta-Epoxyketone Proteasome Inhibitors. J Am Chem Soc 138(13):4342-5. doi: 10.1021/jacs.6b01619. Epub 2016