BGC0001830 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001830 (Salinispora mooreana)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	64,171	High	rosamicin/salinipyrone A/pacificanone A	PKS

BGC0001830 - Region 1 - T1PKS

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Location: 1 - 64,171 nt. (total: 64,171 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 64,172
Label		BGC0001830

Tailoring functions

Oxidoreductases: oxygenase

spr12: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

spr5: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

spr6: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase aminotransferase glycosyltransferase methyltransferase transferase

spr10: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

spr11: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

spr13: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

spr14: methyltransferase

smcogs: SMCOG1248: methyltransferase

spr19: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

spr23: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

spr4: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: esterase

spr2: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

spr22: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

spr7: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

spr8: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

spr9: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001830.3	1.00	PKS	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000018.5	0.76	PKS	angolamycin	Streptomyces eurythermus
BGC0002086.3	0.72	PKS	rosamicin	Micromonospora carbonacea
BGC0000166.5	0.70	PKS	tylactone	Streptomyces fradiae
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001812.3	0.68	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001830.3	1.00	PKS	rosamicin, salinipyrone A, pacificanone A	Salinispora pacifica
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000018.5	0.76	PKS	angolamycin	Streptomyces eurythermus
BGC0002086.3	0.72	PKS	rosamicin	Micromonospora carbonacea
BGC0000166.5	0.70	PKS	tylactone	Streptomyces fradiae
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001812.3	0.68	PKS	tylactone	Micromonospora chalcea subsp. izumensis
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 64171:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - Me-ccmal) + (ccmal) + (Me-ohmal - redemal) + (Me-ohmal) + (ccmal)
Non-colinear ordering:: spr7 + spr8 + spr9 + spr10 + spr11

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

spr7: mmal - mmal - mmal

PKS_AT (527..825): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.8
Ethylmalonyl-CoA: 164.9
Methoxymalonyl-CoA: 149.8
2-Methylbutyryl-CoA: 118.0
trans-1,2-CPDA: 103.6
Propionyl-CoA: 85.3
Isobutyryl-CoA: 75.9
Malonyl-CoA: 74.7
CHC-CoA: 74.5
Benzoyl-CoA: 49.7
Acetyl-CoA: 35.0
fatty_acid: 26.2
inactive: 22.7
3-Methylbutyryl-CoA: 21.5

PKS_AT (1563..1861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.8
Ethylmalonyl-CoA: 164.9
Methoxymalonyl-CoA: 149.8
2-Methylbutyryl-CoA: 118.0
trans-1,2-CPDA: 103.6
Propionyl-CoA: 85.3
Isobutyryl-CoA: 75.9
Malonyl-CoA: 74.7
CHC-CoA: 74.5
Benzoyl-CoA: 49.7
Acetyl-CoA: 35.0
fatty_acid: 26.2
inactive: 22.7
3-Methylbutyryl-CoA: 21.5

PKS_AT (3098..3396): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 139.4
Methoxymalonyl-CoA: 114.5
Ethylmalonyl-CoA: 107.2
2-Methylbutyryl-CoA: 81.5
trans-1,2-CPDA: 74.5
CHC-CoA: 73.7
Malonyl-CoA: 65.9
Propionyl-CoA: 55.9
Isobutyryl-CoA: 46.3
Benzoyl-CoA: 37.2
Acetyl-CoA: 30.1
inactive: 22.5
3-Methylbutyryl-CoA: 18.2
fatty_acid: 14.6

spr8: mal

PKS_AT (580..886): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 105.0
Methoxymalonyl-CoA: 73.3
Methylmalonyl-CoA: 71.2
Isobutyryl-CoA: 42.4
Ethylmalonyl-CoA: 37.4
Propionyl-CoA: 33.3
2-Methylbutyryl-CoA: 21.5
Benzoyl-CoA: 21.3
Acetyl-CoA: 18.9
CHC-CoA: 16.8
trans-1,2-CPDA: 16.0
fatty_acid: 12.5
3-Methylbutyryl-CoA: 0.0

spr9: mmal - emal

PKS_AT (604..902): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 190.8
Ethylmalonyl-CoA: 164.9
Methoxymalonyl-CoA: 149.8
2-Methylbutyryl-CoA: 118.0
trans-1,2-CPDA: 103.6
Propionyl-CoA: 85.3
Isobutyryl-CoA: 75.9
Malonyl-CoA: 74.7
CHC-CoA: 74.5
Benzoyl-CoA: 49.7
Acetyl-CoA: 35.0
fatty_acid: 26.2
inactive: 22.7
3-Methylbutyryl-CoA: 21.5

PKS_AT (2097..2395): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 232.0
Methylmalonyl-CoA: 203.4
Methoxymalonyl-CoA: 182.2
2-Methylbutyryl-CoA: 160.7
trans-1,2-CPDA: 159.8
Propionyl-CoA: 122.0
CHC-CoA: 94.3
Malonyl-CoA: 80.7
Isobutyryl-CoA: 77.5
Acetyl-CoA: 63.2
Benzoyl-CoA: 63.0
fatty_acid: 45.7
3-Methylbutyryl-CoA: 40.6
inactive: 15.4

spr10: mmal

PKS_AT (573..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.8
Ethylmalonyl-CoA: 191.6
Methoxymalonyl-CoA: 176.4
2-Methylbutyryl-CoA: 134.9
trans-1,2-CPDA: 131.2
Propionyl-CoA: 97.2
CHC-CoA: 93.6
Malonyl-CoA: 89.2
Isobutyryl-CoA: 86.4
Benzoyl-CoA: 68.4
fatty_acid: 37.9
3-Methylbutyryl-CoA: 35.8
Acetyl-CoA: 30.9
inactive: 28.7

spr11: mal

PKS_AT (577..876): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 114.8
Methoxymalonyl-CoA: 61.1
Methylmalonyl-CoA: 51.3
Isobutyryl-CoA: 32.9
Propionyl-CoA: 29.2
2-Methylbutyryl-CoA: 20.8
fatty_acid: 17.9
Acetyl-CoA: 17.7
Benzoyl-CoA: 15.0
CHC-CoA: 8.4
Ethylmalonyl-CoA: 8.3
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor