BGC0001833: icosalide A biosynthetic gene cluster from Burkholderia gladioli
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Location: 1 - 48,822 nt. (total: 48,822 nt).
This entry is originally from NCBI GenBank MH790860.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001833
Short description icosalide A biosynthetic gene cluster from Burkholderia gladioli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MH790860.1
via Knock-out studies
Compounds
  • icosalide A
  • icosalide B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
icosalide A Evidence:
Copy SMILES
C36H64N4O10
icosalide B Evidence: NMR
Copy SMILES
C34H60N4O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYA44686.1
  • icoS
 14965 - 30015 (+) icosalide NRPS
    copy AA seq
    copy Nt seq
    Biosynthesis information

    Biosynthetic modules

    Name
    1
    Type
    nrps-type1
    Genes
    icoS
    Substrates
    leucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Starter), adenylation
    Name
    2
    Type
    nrps-type1
    Genes
    icoS
    Substrates
    serine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Dual), adenylation
    Name
    4
    Type
    nrps-type1
    Genes
    icoS
    Substrates
    serine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (Starter), adenylation
    Name
    5
    Type
    nrps-type1
    Genes
    icoS
    Substrates
    leucine (evidence: Structure-based inference)
    Integrated Monomers
    Domains
    condensation (LCL), adenylation
    Annotation changelog

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Corrected NRP module activity
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    2022-09-15
    Changed amino acid substrates to lower case
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Submitted
    • (ID: J2NUA2GQCUQDOJBDBQUEWJWV)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Detailed domain annotation
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