BGC0001833: icosalide A biosynthetic gene cluster from Burkholderia gladioli
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Location: 1 - 48,822 nt. (total: 48,822 nt).
This entry is originally from NCBI GenBank MH790860.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001833
Short description icosalide A biosynthetic gene cluster from Burkholderia gladioli
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
Loci NCBI GenBank: MH790860.1
Compounds
  • icosalide A
  • icosalide B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
icosalide A
Copy SMILES
C36H64N4O10
icosalide B
Copy SMILES
C34H60N4O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AYA44686.1
  • icoS
 14965 - 30015 (+) icosalide NRPS
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NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
Release type
  • Macrolactonization
Lipid moiety β-hydroxy decanoic acid, β-hydroxy octanoic acid
NRP-synthases
Gene Modules
icoS
Module 1
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 2
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 4
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 5
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: J2NUA2GQCUQDOJBDBQUEWJWV, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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