BGC0001834: argyrin biosynthetic gene cluster from Cystobacter sp. SBCb004
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Location: 1 - 33,648 nt. (total: 33,648 nt).
This entry is originally from NCBI GenBank MK047651.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001834
Short description argyrin biosynthetic gene cluster from Cystobacter sp. SBCb004
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MK047651.1
via Knock-out studies, Heterologous expression
Compounds
  • argyrin
Species Cystobacter sp. SBCb004 [taxonomy]
References
Chemical products information
argyrin Evidence: NMR, Mass spectrometry, Total synthesis
(no structure information available)
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QCE43601.1
  • arg1
 524 - 2536 (+) radical SAM-dependent methyltransferase
  • Tailoring
  • Other in vivo study
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  • QCE43602.1
  • arg2
 2649 - 13265 (+) nonribosomal peptide synthetase (NRPS), subunit 1
  • Scaffold biosynthesis
  • Other in vivo study
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  • QCE43603.1
  • arg3
 13304 - 31144 (+) nonribosomal peptide synthetase (NRPS), subunit 2
  • Scaffold biosynthesis
  • Other in vivo study
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  • QCE43604.1
  • arg4
 31182 - 32192 (+) O-methyltransferase
  • Tailoring
  • Other in vivo study
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  • QCE43605.1
  • arg5
 32252 - 33403 (+) tryptophan 2,3-dioxygenase
  • Tailoring
  • Other in vivo study
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Biosynthesis information

Biosynthetic modules

Name
1
Type
nrps-type1
Genes
arg2
Substrates
alanine, valine, 2-Aminobutyric acid (evidence: Structure-based inference)
Integrated Monomers
Domains
adenylation, epimerase
Name
2
Type
nrps-type1
Genes
arg2
Substrates
serine (evidence: Feeding study)
Integrated Monomers
Domains
condensation (DCL), adenylation
Name
3
Type
nrps-type1
Genes
arg2
Substrates
glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation, adenylation, methyltransferase
Name
4
Type
nrps-type1
Genes
arg3
Substrates
alanine, serine, glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
5
Type
nrps-type1
Genes
arg3
Substrates
cysteine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (Heterocyclization), adenylation, oxidase
Name
6
Type
nrps-type1
Genes
arg3
Substrates
tryptophan (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
7
Type
nrps-type1
Genes
arg3
Substrates
tryptophan (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation
Name
8
Type
nrps-type1
Genes
arg3
Substrates
glycine (evidence: Structure-based inference)
Integrated Monomers
Domains
condensation (LCL), adenylation
Annotation changelog

Entry version: 3

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 2

Date
Changes
Submitters
Reviewers
2022-09-15
Un-retire entry
  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Changed amino acid substrates to lower case
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2019-10-16
Submitted
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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