BGC0001840 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001840 (Streptomyces sp. NRRL S-325)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	21,472	detoxin S1	NRPS:Type I+PKS	100%

BGC0001840 - Region 1 - NRPS

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Location: 1 - 21,472 nt. (total: 21,472 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 21,473
Label		BGC0001840

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001840	1.00	NRP, Polyketide	detoxin S1	Streptomyces sp. NRRL S-325
BGC0001841	0.38	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002031	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001185	0.32	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0002075	0.31	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343	0.31	NRP	enterobactin	Pseudomonas sp. J465
BGC0002002	0.29	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000401	0.29	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132	0.29	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001840	1.00	NRP, Polyketide	detoxin S1	Streptomyces sp. NRRL S-325
BGC0001841	0.71	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002031	0.66	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001185	0.65	NRP	bacillibactin	Bacillus velezensis FZB42
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343	0.64	NRP	enterobactin	Pseudomonas sp. J465
BGC0002002	0.63	NRP	1,6-phenazinedimethanol, fontizine A	Serratia fonticola
BGC0000401	0.62	NRP	paenibactin	Paenibacillus elgii B69
BGC0001132	0.62	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 21472:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Pro) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg16_19

Search NORINE for peptide: strict or relaxed

AMP-binding (28..428): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGATFK
Nearest Stachelhaus code(s):: Ile DAFFLGITFK (85% 8Å match); Val DAFWLGATFK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1094..1497): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg16_20

Search NORINE for peptide: strict or relaxed

AMP-binding (548..942): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAHFLGGLYK
Nearest Stachelhaus code(s):: Val DALFLGGTFK (62% 8Å match); Ile DAMFLGCTYK (59% 8Å match)
Stachelhaus code match:: 70% (weak)