BGC0001841 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001841 (Amycolatopsis jejuensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	14,340	detoxin P1/detoxin P2/detoxin P3	NRPS:Type I+PKS	100%

BGC0001841 - Region 1 - NRPS

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Location: 1 - 14,340 nt. (total: 14,340 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,341
Label		BGC0001841

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001841	1.00	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001840	0.34	NRP, Polyketide	detoxin S1	Streptomyces sp. NRRL S-325
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001878	0.32	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.32	Other	ferrichrome	Aspergillus oryzae
BGC0001132	0.32	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000901	0.31	Other	ferrichrome	Aspergillus niger
BGC0002157	0.31	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001841	1.00	NRP, Polyketide	detoxin P1, detoxin P2, detoxin P3	Amycolatopsis jejuensis
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001840	0.67	NRP, Polyketide	detoxin S1	Streptomyces sp. NRRL S-325
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001878	0.65	NRP, Polyketide	detoxin N2, detoxin N3	Streptomyces sp. NRRL B-1347
BGC0001249	0.65	NRP	dimethylcoprogen	Alternaria alternata
BGC0000900	0.65	Other	ferrichrome	Aspergillus oryzae
BGC0001132	0.65	NRP	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000901	0.64	Other	ferrichrome	Aspergillus niger
BGC0002157	0.64	NRP, Alkaloid	(-)-ditryptophenaline	Aspergillus flavus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14340:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Pro) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

detF

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AMP-binding (462..845): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAHFLGGLYK
Nearest Stachelhaus code(s):: Val DALFLGGTFK (59% 8Å match); Ile DAMFLGCTYK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

detG

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AMP-binding (9..384): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGGTFK
Nearest Stachelhaus code(s):: Ile DAFFLGITFK (76% 8Å match); Leu or Ile DAFFLGMTFK (65% 8Å match); Val DAFWLGGTFK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (974..1352): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFVAHVVK
Nearest Stachelhaus code(s):: Pro DVQFVAHVVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)