LOCUS BGC0001841 14340 bp DNA linear BCT 28-NOV-2019 DEFINITION TPA_exp: Amycolatopsis jejuensis detoxin P1,P2,P3 biosynthetic gene cluster, complete sequence. ACCESSION BGC0001841 VERSION BGC0001841 KEYWORDS . SOURCE Amycolatopsis jejuensis ORGANISM Amycolatopsis jejuensis Bacteria; Actinobacteria; Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis. COMMENT THIRD PARTY DATABASE: This TPA record uses data from DDBJ/EMBL/GenBank entry JNYZ01000002.1 ##antiSMASH-Data-START## Version :: False Run date :: 2022-11-08 04:53:00 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 14340 ##antiSMASH-Data-END## FEATURES Location/Qualifiers source 1..14340 /culture_collection="NRRL:B-24427" /db_xref="taxon:330084" /mol_type="genomic DNA" /organism="Amycolatopsis jejuensis" /strain="NRRL B-24427" /type_material="type strain of Amycolatopsis jejuensis" misc_feature 1..14340 /note="detoxin P1,P2,P3 biosynthetic gene cluster" subregion 1..14340 /aStool="mibig" /contig_edge="True" /label="NRP, Polyketide" /subregion_number="1" /tool="antismash" region 1..14340 /contig_edge="True" /product="unknown" /region_number="1" /subregion_numbers="1" /tool="antismash" gene 7..3789 /gene="detF" CDS 7..3789 /NRPS_PKS="Domain: Condensation_LCL (3-298). E-value: 6.5e-97. Score: 315.9. Matches aSDomain: nrpspksdomains_detF_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (462-845). E-value: 1.2e-103. Score: 338.7. Matches aSDomain: nrpspksdomains_detF_AMP-binding.1" /NRPS_PKS="Domain: PCP (951-1020). E-value: 3.2e-19. Score: 60.8. Matches aSDomain: nrpspksdomains_detF_PCP.1" /NRPS_PKS="Domain: Thioesterase (1039-1256). E-value: 5.4e-30. Score: 97.3. Matches aSDomain: nrpspksdomains_detF_Thioesterase.1" /codon_start=1 /gene="detF" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 363.8; E-value: 2e-110)" /gene_kind="biosynthetic" /product="peptide synthetase" /protein_id="DAC80524.1" /sec_met_domain="Condensation (E-value: 1e-78, bitscore: 252.5, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 3.4e-114, bitscore: 369.6, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 1.8e-13, bitscore: 39.0, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MQVSAPLSSGQQRLWTVSQLTEAGSAYNETMAFTLRGPLDRAALR RALDALAERHETLRTRFAVEDGQPVQIVLDETGFPCTVTDVTGQPEDKAALRRTEPFEP FDLASAPPARARLLIDGPEHHILLITVHHIVFDGWSRTVLLRELGVLYTAELRGDLADL PETRPYREYARAQQDWLAGPAPQPHETYWGDRLDGVPAVLDLPADRPRPARQDYRGARV RVSLGPHLTAAVKKLAREHGVTPYSAVLTCWSMLLSRLSGQDDIVVGVPTANRGGGGEY PATIGFFVNTLAVRADLGGGVTGAVLLKQVRAALRGAIDHVGLPFERVVELVNPPRSPA HTPLFQTMVAWVPTVHDLLELPGVAAEPLEVEHAPAKFDLALGMADEDGDITGHLDYAV ALFDHATAQRYARYFVRLLEQLVARPDAEATSYELLDEAERREILAWSAGPRPNRRPGG LVERFTAHADAAPDAPALVCDGRTSTYGELDQRTTRLANALRARGVGPGEVVAIHSERS TELVVAVLGVLKAGAAYLPLDPAQPPARREAMIEDARPALVLRDDPDSIAALAAEGDPK RRLVPAGPGETAYVIYTSGSTGRPKGVAVTHHSVLALFDQWLDRFGATPGEATSAWSGI GFDASVHELLLPLTTGAVLHVVPEDVRADPAALLAWLREHQVVQAFLPPSYVRWIDEDP ARAAGLALRHVLTGVEPLPEAALARFAAAVPGLRICFGYGPTEATLYATAHFDPQPVDR PAPIGRPLPGSRMYLLDERLRPVPPGIAGEVFLAGDCLARGYLHRPGLTAERFVPDPFA PGERMYRTGDLARWLPSGEAEYAGRRDDQIKLRGFRIEPGEVTAALLAVPGVREAAVLV DRAGEPKLVAGVAGGGRTLHEWRAALADRLPDYMIPSVFAEFDRLPLNPSGKLDRDAVL AQARASTAVNTVNTAAPRDHVELALHRIWRNLLLHPSIGVSDDFFDVGGTSISAIKLAH TIGTEFGRELPIRDVILHPTIEAQAALLRADEPASAGGSLIEFRRGTGRARVVCVHPAG GTAFCYLPLSAALPEDAGVVGIQSPGLGPGEEPLPSVEAMAEEYLRLVAPQPGEVLVLC GLSYGGLVAYEMGRRLAKRHPRVSVVLLDTAGTDDPAARAAIGPVPAAEFREKLVRFNG MYPGIEDAQIERYHRTYNHNRHTAREHDPGESAARVVFVQATGEDTIPGGDEFWRRRVL GEFEVVPVGCGHWDLLESAALPRVAELITAELADR" aSDomain 16..900 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detF_Condensation_LCL.1" /domain_subtype="Condensation_LCL" /evalue="6.50E-97" /label="detF_Condensation_LCL.1" /locus_tag="detF" /protein_end="298" /protein_start="3" /score="315.9" /tool="antismash" /translation="SAPLSSGQQRLWTVSQLTEAGSAYNETMAFTLRGPLDRAALRRAL DALAERHETLRTRFAVEDGQPVQIVLDETGFPCTVTDVTGQPEDKAALRRTEPFEPFDL ASAPPARARLLIDGPEHHILLITVHHIVFDGWSRTVLLRELGVLYTAELRGDLADLPET RPYREYARAQQDWLAGPAPQPHETYWGDRLDGVPAVLDLPADRPRPARQDYRGARVRVS LGPHLTAAVKKLAREHGVTPYSAVLTCWSMLLSRLSGQDDIVVGVPTANRGGGGEYPAT IGFFVNTLAVRADL" aSModule 16..3774 /complete /domains="nrpspksdomains_detF_Condensation_LCL.1" /domains="nrpspksdomains_detF_AMP-binding.1" /domains="nrpspksdomains_detF_PCP.1" /domains="nrpspksdomains_detF_Thioesterase.1" /final_module /locus_tags="detF" /tool="antismash" /type="nrps" CDS_motif 79..195 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0001" /evalue="9.70E-20" /label="C2_LCL_024-062" /locus_tag="detF" /protein_end="63" /protein_start="24" /score="63.0" /tool="antismash" /translation="SAYNETMAFTLRGPLDRAALRRALDALAERHETLRTRFA" CDS_motif 397..462 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0002" /evalue="1.60E-10" /label="C3_LCL_132-143" /locus_tag="detF" /protein_end="152" /protein_start="130" /score="33.4" /tool="antismash" /translation="VHHIVFDGWSRTVLLRELGVLY" CDS_motif 799..891 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0003" /evalue="2.20E-11" /label="C5_LCL_267-296" /locus_tag="detF" /protein_end="295" /protein_start="264" /score="36.2" /tool="antismash" /translation="DIVVGVPTANRGGGGEYPATIGFFVNTLAVR" CDS_motif 940..1059 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0004" /evalue="3.50E-17" /label="C67_LCL_14fromHMM" /locus_tag="detF" /protein_end="351" /protein_start="311" /score="54.7" /tool="antismash" /translation="RAALRGAIDHVGLPFERVVELVNPPRSPAHTPLFQTMVAW" aSDomain 1393..2541 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detF_AMP-binding.1" /evalue="1.20E-103" /label="detF_AMP-binding.1" /locus_tag="detF" /protein_end="845" /protein_start="462" /score="338.7" /tool="antismash" /translation="FTAHADAAPDAPALVCDGRTSTYGELDQRTTRLANALRARGVGPG EVVAIHSERSTELVVAVLGVLKAGAAYLPLDPAQPPARREAMIEDARPALVLRDDPDSI AALAAEGDPKRRLVPAGPGETAYVIYTSGSTGRPKGVAVTHHSVLALFDQWLDRFGATP GEATSAWSGIGFDASVHELLLPLTTGAVLHVVPEDVRADPAALLAWLREHQVVQAFLPP SYVRWIDEDPARAAGLALRHVLTGVEPLPEAALARFAAAVPGLRICFGYGPTEATLYAT AHFDPQPVDRPAPIGRPLPGSRMYLLDERLRPVPPGIAGEVFLAGDCLARGYLHRPGLT AERFVPDPFAPGERMYRTGDLARWLPSGEAEYAGRRDDQIKLR" CDS_motif 1579..1620 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0005" /evalue="1.00E-05" /label="NRPS-A_a2" /locus_tag="detF" /protein_end="538" /protein_start="524" /score="18.6" /tool="antismash" /translation="LGVLKAGAAYLPLD" CDS_motif 1768..1827 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0006" /evalue="6.90E-11" /label="NRPS-A_a3" /locus_tag="detF" /protein_end="607" /protein_start="587" /score="33.9" /tool="antismash" /translation="AYVIYTSGSTGRPKGVAVTH" CDS_motif 2335..2424 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0007" /evalue="5.90E-15" /label="NRPS-A_a6" /locus_tag="detF" /protein_end="806" /protein_start="776" /score="47.3" /tool="antismash" /translation="PPGIAGEVFLAGDCLARGYLHRPGLTAERF" CDS_motif 2506..2568 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0008" /evalue="1.30E-10" /label="NRPS-A_a8" /locus_tag="detF" /protein_end="854" /protein_start="833" /score="33.3" /tool="antismash" /translation="YAGRRDDQIKLRGFRIEPGEV" aSDomain 2860..3066 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detF_PCP.1" /evalue="3.20E-19" /label="detF_PCP.1" /locus_tag="detF" /protein_end="1020" /protein_start="951" /score="60.8" /tool="antismash" /translation="ELALHRIWRNLLLHPSIGVSDDFFDVGGTSISAIKLAHTIGTEFG RELPIRDVILHPTIEAQAALLRAD" aSDomain 3124..3774 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detF_Thioesterase.1" /evalue="5.40E-30" /label="detF_Thioesterase.1" /locus_tag="detF" /protein_end="1256" /protein_start="1039" /score="97.3" /tool="antismash" /translation="RVVCVHPAGGTAFCYLPLSAALPEDAGVVGIQSPGLGPGEEPLPS VEAMAEEYLRLVAPQPGEVLVLCGLSYGGLVAYEMGRRLAKRHPRVSVVLLDTAGTDDP AARAAIGPVPAAEFREKLVRFNGMYPGIEDAQIERYHRTYNHNRHTAREHDPGESAARV VFVQATGEDTIPGGDEFWRRRVLGEFEVVPVGCGHWDLLESAALPRVAELITAE" CDS_motif 3301..3375 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detF_0009" /evalue="6.00E-06" /label="NRPS-te1" /locus_tag="detF" /protein_end="1123" /protein_start="1098" /score="18.8" /tool="antismash" /translation="QPGEVLVLCGLSYGGLVAYEMGRRL" gene 3786..12152 /gene="detG" CDS 3786..12152 /EC_number="2.3.1.39" /NRPS_PKS="Domain: AMP-binding (9-384). E-value: 9.6e-86. Score: 279.7. Matches aSDomain: nrpspksdomains_detG_AMP-binding.1" /NRPS_PKS="Domain: PCP (488-554). E-value: 1.9e-09. Score: 29.5. Matches aSDomain: nrpspksdomains_detG_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (570-826). E-value: 1.2e-41. Score: 134.5. Matches aSDomain: nrpspksdomains_detG_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (974-1352). E-value: 1.6e-73. Score: 239.4. Matches aSDomain: nrpspksdomains_detG_AMP-binding.2" /NRPS_PKS="Domain: PCP (1450-1514). E-value: 3.7e-12. Score: 38.1. Matches aSDomain: nrpspksdomains_detG_PCP.2" /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (1530-1930). E-value: 7.6e-130. Score: 425.4. Matches aSDomain: nrpspksdomains_detG_PKS_KS.1" /NRPS_PKS="Domain: PKS_KR (2265-2423). E-value: 1e-27. Score: 89.1. Matches aSDomain: nrpspksdomains_detG_PKS_KR.1" /NRPS_PKS="Domain: PP-binding (2494-2543). E-value: 4.2e-10. Score: 31.9. Matches aSDomain: nrpspksdomains_detG_PP-binding.1" /NRPS_PKS="Domain: Thioesterase (2578-2784). E-value: 1.5e-20. Score: 66.4. Matches aSDomain: nrpspksdomains_detG_Thioesterase.1" /codon_start=1 /gene="detG" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PKS_KS" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002:AMP-dependent synthetase and ligase (Score: 246.4; E-value: 7.4e-75)" /gene_kind="biosynthetic" /product="malonyl CoA-acyl carrier protein transacylase" /protein_id="DAC80525.1" /sec_met_domain="Condensation (E-value: 2.2e-31, bitscore: 97.1, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 7.6e-91, bitscore: 292.7, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 6.2e-12, bitscore: 34.1, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 5.5e-131, bitscore: 425.4, seeds: 2284, tool: rule-based-clusters)" /transl_table=11 /translation="MTSIARRIHDRARLHPDALAVSDGSRRLTYAQLDAGAAAVAEALS RKGVRPGDAVAVALPRSAELVQVMLGVLRLGGQVVPLDRQSPPARRDVILADSGAAVVV DDELPPAELLAESAVPADPAPASFLFYTSGTTGRPKGVEVRDAGIVRLAEPGWLDPGTR FASLANPAFDAISFEVWVPLLAGGTCVILDDDTVRDPRAFADALVRERIDTMFVTATLF NAVAETVPDSFSTVRRVLVGGEQLNAAVIRRWYQANPDAPTRLQNGYGPTETTTFALSY PIPRDFDGDVVPIGRPLPGTGAVAVTPDQRVAAEGEVAELYLSGAGVAPGYRGLPAETG ERFVRLPWFDDGRARFYRTGDLVRVLPGGLFAYAGRTDRQVKVRGFRIEPGELEQRLLA HPEIRQAHVAVRRAATAELLAFVVTGGLSYDAFEAHLSDTVPSYMRPHLVFRVEELPRN ANGKVDEPALLASGFPPWRPGSSGEATSWQREILDVVEEVLGLPDARPEDTWLRSGGDS LKALRLRFAIRERWGADLAPSVVQRGTFADLASAVTAARRPPYPELAAPTIATTAPATS EQQRLWLLQQRNPGSTAYHVPLAFRITGEADLHQNVRAVVERHPALRTAFEARPEGLRQ VAKAPYDPWIEPDDDFFTAPFDLASGRLLRAAWRPETDGSSTFLLCLHHIAVDGWSLNV LFRELSGGAPNPGAHTPFDFAGWQSRWFASPAYHAQRASLAARLPDDPGSAGDASLAGR LRITTIERTRVDEWAGELGLTRFQLLLGVFASSLYAVTGRTRPRIASPVANRPMREFED SVGMFANTVRLPMAVDPDEDLDPQLRRLGAAAGTVLDHQDVAFADLEPAQAAFDYLFVL ENTDFAALKVPGCPISPQWIEAAEAKCALTLSVVERPDGFDCLWEYGDGHFTAAEAEAL GEVFARALTEGGTPAELAEPYRRGLPDHGRGEPAELAWDTVAEGFARQVARTPDAPALV GDTTLSYAELDAHAARLAAVLPDDATDVALYFRPSAEHVVALLALARLNITAVPLDPGY PPALLREVLERVQPRCVLLAPGDAFDTDIERHFVTLTDGPVPDVPARRAGRPLYTLFTS GSTGAPKGVRVPDRTLANLIQWQDAPPAATQQFSMLSFDVSFQEIFTTLCGGGRLHLVR PEWRHDVPALLDQLETAGIERLFLPYVALQLLAEHGARARRYPSRLRDVVTAGEQLVCT PAIRRWFAGLPGVRLHNHYGPTETHVVSALTLDGNPEQWPERPAIGRPVANTALRVADA TGAPLPPGQIGELLIGGLPANRCYLGEAAEEKFAELPELYYRSGDLAHFDHSGLLHFDG RADRQVKLSGHRVELGQVEAALLRHPDVVNVVVAADGDRLTAYLESRRATTTAELVAHL TPLLPPHARVDRFRVVAALPRTPSGKLDRDAAPRTPGEDLQRAAGHPSELAVLFEEVTG VPIGPDETFFAAGATSLSLMRFHLRCAEAGYRFTVADLFEHVTLRDLTRHLESGAAPAP VADSAGTDEPVAIIGMAVRLPGAPDLAAFWNLTREGRRGIEEFAATEGLVGARSLLDRP LGFDPEHFGISHRDAALMDPQQRQLLMCSVEALAHAGIARAAGRVGLIAGCGENTYFQQ MLREADPAALPDGFQLALHHEKDFLATKVAYHLDLTGPVLTTQTACSSSLVAVHQAAGM LRGGEADVMLAGGVLVDVTLAEGYRYRPQHIFSADGHCRPFSDDADGTVGGSGVGVVVL KPLSKARHDGDTVYAVITGSALTNDGAVKQGYSAPSPAGQREAIRAALQRAGRSGADVG YVETHGTGTRLGDPIEVAALREAMPDSAGCALSSVKSQIGHLGAAAGVVGLIRATLAVH HGVLPPTVDFRASNPALDLGPFRIPTEAEPWPAGPRVAGVSSFGIGGTNAHVVVESSRP VPRAPADPARRVVLSARSATALRLDAQRVADYLAAHSESYVDVLRHLQSGRAEGRWRVT AACADAAAAVAWLRTAEPQEVEAEGGRTSAPAPWDFPPPAFAERDFDFPRRATVSRLPE GDWLHQPTWVRLRRATGTAERTERILVLSGPLPAPALDAGYRRVVRVHAADHFTRSGPD TFEADPADPADLRRVLDALPGAEIDWVHTLPLGITGPVAEGSLAQARWACLDTPAALLR AIDGRPVRTWWVSAGAVPANGAVTRPEAGLLAGVTAVGPQESGVRGHWVDLPDPGLDAL AGLLTGPPPPQRVALRGGFWWTQEAVPVSASERILADGTYLILGGTGGIGTAIGEVILT RTTGRVILLAREPRLPAALEPWADRVDLLAADLTTDRIDVDGPLAGIVHAAGVPDSGLI ATRSPDPQAAKLAGALLTERLIEQHRPAVAVYCSSLSAQFGGTGQLDYAAANGFLDALA HLDGPTERLSIGWDVWRDTGMAVTALESDTRHQAHLKVGLSSEEGRRTFSRALGSGLPH LLVATTGLDAARTFHERDTQAPAPATDPEAELTEEVRALLGAAELDPDVPLYDLGADSL MLLDVVDSVKRLFGVDLDLAWLGPEVTMTALLAKLSTAEDTSDVVVQQWREGRDAVCLV HPVGGDVHAYRPLVEALDPSLGVCVIADPALNRPEPPGWSVAERARRYHAALHTQFPGY RWQLAGWSFGAWVVAGMAAEAEAAGQPVRALHLIDPPPPGASTADYDDTQLEAVFRREL GGAADDHARRLARACRANLDSMAGHELPRLTATASHVWLATEPEPGLPVADRTGWQALL PDPSRWHELPATHYRIVAATAIADALSAP" aSDomain 3813..4937 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_AMP-binding.1" /evalue="9.60E-86" /label="detG_AMP-binding.1" /locus_tag="detG" /protein_end="384" /protein_start="9" /score="279.7" /tool="antismash" /translation="DRARLHPDALAVSDGSRRLTYAQLDAGAAAVAEALSRKGVRPGDA VAVALPRSAELVQVMLGVLRLGGQVVPLDRQSPPARRDVILADSGAAVVVDDELPPAEL LAESAVPADPAPASFLFYTSGTTGRPKGVEVRDAGIVRLAEPGWLDPGTRFASLANPAF DAISFEVWVPLLAGGTCVILDDDTVRDPRAFADALVRERIDTMFVTATLFNAVAETVPD SFSTVRRVLVGGEQLNAAVIRRWYQANPDAPTRLQNGYGPTETTTFALSYPIPRDFDGD VVPIGRPLPGTGAVAVTPDQRVAAEGEVAELYLSGAGVAPGYRGLPAETGERFVRLPWF DDGRARFYRTGDLVRVLPGGLFAYAGRTDRQVKVR" aSModule 3813..5447 /complete /domains="nrpspksdomains_detG_AMP-binding.1" /domains="nrpspksdomains_detG_PCP.1" /locus_tags="detG" /starter_module /tool="antismash" /type="nrps" CDS_motif 4167..4217 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0001" /evalue="1.00E-05" /label="NRPS-A_a3" /locus_tag="detG" /protein_end="144" /protein_start="127" /score="18.2" /tool="antismash" /translation="FLFYTSGTTGRPKGVEV" CDS_motif 4590..4613 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0002" /evalue="3.20E-01" /label="NRPS-A_a5" /locus_tag="detG" /protein_end="276" /protein_start="268" /score="4.5" /tool="antismash" /translation="YGPTETTT" CDS_motif 4731..4814 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0003" /evalue="1.60E-08" /label="NRPS-A_a6" /locus_tag="detG" /protein_end="343" /protein_start="315" /score="26.9" /tool="antismash" /translation="GEVAELYLSGAGVAPGYRGLPAETGERF" CDS_motif 4902..4967 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0004" /evalue="2.00E-10" /label="NRPS-A_a8" /locus_tag="detG" /protein_end="394" /protein_start="372" /score="32.8" /tool="antismash" /translation="YAGRTDRQVKVRGFRIEPGELE" aSDomain 5250..5447 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_PCP.1" /evalue="1.90E-09" /label="detG_PCP.1" /locus_tag="detG" /protein_end="554" /protein_start="488" /score="29.5" /tool="antismash" /translation="REILDVVEEVLGLPDARPEDTWLRSGGDSLKALRLRFAIRERWGA DLAPSVVQRGTFADLASAVTA" aSDomain 5496..6263 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_Condensation_LCL.1" /domain_subtype="Condensation_LCL" /evalue="1.20E-41" /label="detG_Condensation_LCL.1" /locus_tag="detG" /protein_end="826" /protein_start="570" /score="134.5" /tool="antismash" /translation="TAPATSEQQRLWLLQQRNPGSTAYHVPLAFRITGEADLHQNVRAV VERHPALRTAFEARPEGLRQVAKAPYDPWIEPDDDFFTAPFDLASGRLLRAAWRPETDG SSTFLLCLHHIAVDGWSLNVLFRELSGGAPNPGAHTPFDFAGWQSRWFASPAYHAQRAS LAARLPDDPGSAGDASLAGRLRITTIERTRVDEWAGELGLTRFQLLLGVFASSLYAVTG RTRPRIASPVANRPMREFEDSVGMFANTVRLPMA" aSModule 5496..8327 /complete /domains="nrpspksdomains_detG_Condensation_LCL.1" /domains="nrpspksdomains_detG_AMP-binding.2" /domains="nrpspksdomains_detG_PCP.2" /locus_tags="detG" /tool="antismash" /type="nrps" CDS_motif 5559..5663 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0005" /evalue="7.00E-10" /label="C2_LCL_024-062" /locus_tag="detG" /protein_end="626" /protein_start="591" /score="31.3" /tool="antismash" /translation="TAYHVPLAFRITGEADLHQNVRAVVERHPALRTAF" CDS_motif 5829..5885 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0006" /evalue="1.30E-09" /label="C3_LCL_132-143" /locus_tag="detG" /protein_end="700" /protein_start="681" /score="30.5" /tool="antismash" /translation="LHHIAVDGWSLNVLFRELS" CDS_motif 6177..6248 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0007" /evalue="3.00E-08" /label="C5_LCL_267-296" /locus_tag="detG" /protein_end="821" /protein_start="797" /score="26.1" /tool="antismash" /translation="IASPVANRPMREFEDSVGMFANTV" aSDomain 6708..7841 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_AMP-binding.2" /evalue="1.60E-73" /label="detG_AMP-binding.2" /locus_tag="detG" /protein_end="1352" /protein_start="974" /score="239.4" /tool="antismash" /translation="FARQVARTPDAPALVGDTTLSYAELDAHAARLAAVLPDDATDVAL YFRPSAEHVVALLALARLNITAVPLDPGYPPALLREVLERVQPRCVLLAPGDAFDTDIE RHFVTLTDGPVPDVPARRAGRPLYTLFTSGSTGAPKGVRVPDRTLANLIQWQDAPPAAT QQFSMLSFDVSFQEIFTTLCGGGRLHLVRPEWRHDVPALLDQLETAGIERLFLPYVALQ LLAEHGARARRYPSRLRDVVTAGEQLVCTPAIRRWFAGLPGVRLHNHYGPTETHVVSAL TLDGNPEQWPERPAIGRPVANTALRVADATGAPLPPGQIGELLIGGLPANRCYLGEAAE EKFAELPELYYRSGDLAHFDHSGLLHFDGRADRQVKLS" CDS_motif 7089..7139 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0008" /evalue="4.80E-06" /label="NRPS-A_a3" /locus_tag="detG" /protein_end="1118" /protein_start="1101" /score="19.2" /tool="antismash" /translation="YTLFTSGSTGAPKGVRV" CDS_motif 7515..7541 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0009" /evalue="1.80E-01" /label="NRPS-A_a5" /locus_tag="detG" /protein_end="1252" /protein_start="1243" /score="5.2" /tool="antismash" /translation="YGPTETHVV" CDS_motif 7653..7721 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0010" /evalue="2.40E-03" /label="NRPS-A_a6" /locus_tag="detG" /protein_end="1312" /protein_start="1289" /score="10.4" /tool="antismash" /translation="PPGQIGELLIGGLPANRCYLGEA" CDS_motif 7809..7871 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0011" /evalue="2.50E-08" /label="NRPS-A_a8" /locus_tag="detG" /protein_end="1362" /protein_start="1341" /score="26.2" /tool="antismash" /translation="DGRADRQVKLSGHRVELGQVE" aSDomain 8136..8327 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_PCP.2" /evalue="3.70E-12" /label="detG_PCP.2" /locus_tag="detG" /protein_end="1514" /protein_start="1450" /score="38.1" /tool="antismash" /translation="ELAVLFEEVTGVPIGPDETFFAAGATSLSLMRFHLRCAEAGYRFT VADLFEHVTLRDLTRHLES" aSDomain 8376..9575 /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_PKS_KS.1" /domain_subtype="Hybrid-KS" /evalue="7.60E-130" /label="detG_PKS_KS.1" /locus_tag="detG" /protein_end="1930" /protein_start="1530" /score="425.4" /tool="antismash" /translation="VAIIGMAVRLPGAPDLAAFWNLTREGRRGIEEFAATEGLVGARSL LDRPLGFDPEHFGISHRDAALMDPQQRQLLMCSVEALAHAGIARAAGRVGLIAGCGENT YFQQMLREADPAALPDGFQLALHHEKDFLATKVAYHLDLTGPVLTTQTACSSSLVAVHQ AAGMLRGGEADVMLAGGVLVDVTLAEGYRYRPQHIFSADGHCRPFSDDADGTVGGSGVG VVVLKPLSKARHDGDTVYAVITGSALTNDGAVKQGYSAPSPAGQREAIRAALQRAGRSG ADVGYVETHGTGTRLGDPIEVAALREAMPDSAGCALSSVKSQIGHLGAAAGVVGLIRAT LAVHHGVLPPTVDFRASNPALDLGPFRIPTEAEPWPAGPRVAGVSSFGIGGTNAHVVVE S" aSModule 8376..12137 /domains="nrpspksdomains_detG_PKS_KS.1" /domains="nrpspksdomains_detG_PKS_KR.1" /domains="nrpspksdomains_detG_PP-binding.1" /domains="nrpspksdomains_detG_Thioesterase.1" /final_module /incomplete /locus_tags="detG" /tool="antismash" /type="pks" CDS_motif 8808..8855 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0012" /evalue="1.00E-04" /label="PKSI-KS_m3" /locus_tag="detG" /protein_end="1690" /protein_start="1674" /score="14.7" /tool="antismash" /translation="GPVLTTQTACSSSLVA" CDS_motif 9231..9278 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0013" /evalue="4.90E-04" /label="PKSI-KS_m5" /locus_tag="detG" /protein_end="1831" /protein_start="1815" /score="12.4" /tool="antismash" /translation="YVETHGTGTRLGDPIE" CDS_motif 10014..10088 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0014" /evalue="1.80E+00" /label="C2_DCL_024-062" /locus_tag="detG" /protein_end="2101" /protein_start="2076" /score="0.9" /tool="antismash" /translation="LVLSGPLPAPALDAGYRRVVRVHAA" aSDomain 10581..11054 /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_PKS_KR.1" /evalue="1.00E-27" /label="detG_PKS_KR.1" /locus_tag="detG" /protein_end="2423" /protein_start="2265" /score="89.1" /tool="antismash" /translation="GTYLILGGTGGIGTAIGEVILTRTTGRVILLAREPRLPAALEPWA DRVDLLAADLTTDRIDVDGPLAGIVHAAGVPDSGLIATRSPDPQAAKLAGALLTERLIE QHRPAVAVYCSSLSAQFGGTGQLDYAAANGFLDALAHLDGPTERLSIGWDVWRD" CDS_motif 10914..11003 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0015" /evalue="4.20E-12" /label="PKSI-KR_m4" /locus_tag="detG" /protein_end="2406" /protein_start="2376" /score="38.6" /tool="antismash" /translation="VYCSSLSAQFGGTGQLDYAAANGFLDALAH" aSDomain 11268..11414 /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_PP-binding.1" /evalue="4.20E-10" /label="detG_PP-binding.1" /locus_tag="detG" /protein_end="2543" /protein_start="2494" /score="31.9" /tool="antismash" /translation="ELTEEVRALLGAAELDPDVPLYDLGADSLMLLDVVDSVKRLFGVD LDLA" aSDomain 11520..12137 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_detG_Thioesterase.1" /evalue="1.50E-20" /label="detG_Thioesterase.1" /locus_tag="detG" /protein_end="2784" /protein_start="2578" /score="66.4" /tool="antismash" /translation="VCLVHPVGGDVHAYRPLVEALDPSLGVCVIADPALNRPEPPGWSV AERARRYHAALHTQFPGYRWQLAGWSFGAWVVAGMAAEAEAAGQPVRALHLIDPPPPGA STADYDDTQLEAVFRRELGGAADDHARRLARACRANLDSMAGHELPRLTATASHVWLAT EPEPGLPVADRTGWQALLPDPSRWHELPATHYRIVAATAIADA" CDS_motif 11712..11768 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_detG_0016" /evalue="2.90E-03" /label="NRPS-te1" /locus_tag="detG" /protein_end="2661" /protein_start="2642" /score="10.2" /tool="antismash" /translation="WQLAGWSFGAWVVAGMAAE" gene 12177..13049 /gene="detH" CDS 12177..13049 /EC_number="1.14.11.17" /codon_start=1 /gene="detH" /gene_functions="biosynthetic-additional (smcogs) SMCOG1121:dioxygenase, TauD/TfdA (Score: 273.9; E-value: 2.3e-83)" /gene_kind="biosynthetic-additional" /product="alpha-ketoglutarate-dependent taurine dioxygenase" /protein_id="DAC80526.1" /transl_table=11 /translation="MEQYELDAVSRITTRPAPGYRTFTVHGLTPVIGAEVSGLDLTREL TGEQLTELKTAFLDYHVLVFRDQDITGEDHKRLAASFGELRPVNPPPEHGDPYILEVAT APEAANVFGNGWHADGTADAEPSLGSMLHITRMPDPGSGGDTLFANMHLAYDMLSPKMK EFLADLTAVHDGALAFRGHQIPAGYQVPVSEHPLVVRHPETDRQLLYVNPAYTSHIPQL SADESRAVLDLLFSLVPNRPMLACRVRWAPNTLVFWDNRCVQHHATYDYYPHTRYGTRV AINGGPLKG" CDS 13066..14286 /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1007:cytochrome P450 (Score: 356.7; E-value: 2.5e-108)" /gene_kind="biosynthetic-additional" /product="putative cytochrome P450 hydroxylase" /protein_id="DAC80527.1" /sec_met_domain="p450 (E-value: 3e-25, bitscore: 76.9, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MQHNRCPVVDVRDPAVLGDPMGGYDRILAESPVCWARLPSGEEGW LITRSEDVRAVLSDPAVRNDPTGLPGPGAQTQEQAFLALGTPPEHLPYLRASLLSLDGA EHTRLRRSISHAFGAARVASLRPRVQEIVDGLLDGLDPAASVNLIDDYAYPLAMAVVCE LVGVPEKDWADWWHWGKVLVGGDPAQITPTLGEMFSYCHALVDQRRAEPRRDLLSEVVA QDDLIDVDIVAVVVFLVLAGHETMAHMLSNGALALMRDPAQRELLRTEPALWPAAVREL VRTDGPVQLARLRYAATDLVVGGVQIRAGDAVQVVLGAANRDPAQFAHPHHADVRWQAE HGGSEGSVGFGWGPHFCLGVALAKVEAEVALRSLFERFPAVHPVSEPEWVPLPRGRHRV ALDVHLR" ORIGIN 1 tcctcgatgc aggtgtccgc accgctgtcg tccggtcagc agcgtttgtg gacggtgtcc 61 cagctcaccg aggcaggctc ggcctacaac gaaaccatgg cgttcaccct tcgcggtcca 121 ctcgaccgtg cagcgttgcg ccgggccctc gacgccctcg ccgaacggca cgaaaccttg 181 cggacccgct tcgccgtcga ggacgggcaa ccggtgcaga tcgtcctcga cgagactggt 241 ttcccgtgca ctgtcaccga tgtgaccgga cagccggagg acaaggcagc gctgcgccgt 301 accgaaccgt tcgagccgtt cgacctcgca agcgctccac cggcccgggc ccggctgctc 361 atcgacggcc ccgagcacca cattctgctg atcaccgtgc accacatcgt cttcgacggc 421 tggtcccgca cggtgctcct gcgcgagctc ggcgtcctct acaccgccga gctgcgtggc 481 gacctggcgg acctgccgga gactcgtccg taccgggaat acgcacgggc acaacaggat 541 tggctcgccg gtccggctcc gcagccgcac gagacgtact ggggcgaccg gctcgatggc 601 gtcccggcag tgctggatct ccctgccgac cgcccgcgtc cggcccggca ggactatcgc 661 ggagcccggg tccgcgtctc cctcgggcca cacctcaccg ctgcggtgaa gaagctggca 721 cgcgagcacg gtgtcacgcc ctattccgcg gtcctgacct gctggtcgat gctgctgtcc 781 cggctttccg ggcaggatga catcgttgtc ggtgtgccga cggccaaccg cggcgggggc 841 ggcgagtacc cggccacgat cggatttttc gtcaacaccc ttgccgtgcg ggcggatctg 901 ggcggcggtg tgaccggcgc ggtgctgctc aagcaggtcc gggcggcgct ccggggcgcg 961 atcgaccacg tcggcctgcc gttcgagcgg gtcgtcgagc tggtgaaccc gccacgcagc 1021 ccggcgcaca cgccgttgtt ccagaccatg gtcgcgtggg tgccgacggt gcacgacctc 1081 ctggagctgc cgggagtggc cgccgaaccg ctcgaagtgg agcacgcgcc cgcgaagttc 1141 gacctggcac tcggcatggc cgacgaggac ggcgacatca ccgggcatct cgactacgcc 1201 gtcgccctct tcgaccatgc cacggcgcag cggtacgcgc ggtatttcgt ccggctgctc 1261 gaacagctcg tcgcacgtcc ggacgctgaa gccacgagct acgaactcct ggacgaggcc 1321 gaacggcgcg aaattctcgc ctggagcgcc gggccgcgcc cgaatcgccg gccgggcggg 1381 ctcgtggagc ggttcacggc ccatgccgat gctgccccgg acgcccccgc cctcgtctgc 1441 gacggccgga ccagcacgta cggcgaactc gaccagcgca ccacccggct ggccaatgcc 1501 ttgcgcgccc gcggcgtcgg gccgggcgag gtggtggcaa tccacagtga acggtcgacg 1561 gaactggtgg tcgccgtgct gggcgtgctg aaggcgggcg cggcgtacct ccccctcgac 1621 ccggcccagc cgcccgcccg gcgcgaggcg atgatcgagg acgcacgtcc ggccctcgtg 1681 ctgcgtgacg acccggattc aattgcggct ctcgccgccg aaggagaccc gaagcggcga 1741 ctggtgccgg ccgggcccgg cgaaaccgcg tacgtcatct acacctcagg ctcgaccggg 1801 cgtcccaagg gggtcgccgt cacccaccac agcgttctcg ccctgttcga ccagtggctt 1861 gaccgcttcg gcgcgacccc gggtgaggcg acgtcggcgt ggtccggcat cggcttcgac 1921 gcctcggtgc acgaactgct gcttcccctc accaccggcg ccgtgctgca cgtggtgccc 1981 gaggacgtcc gggccgatcc ggcggcactg ctggcgtggt tgcgggaaca ccaggtggtg 2041 caggcctttc tgccgccctc ctatgtccgg tggatcgacg aggacccggc ccgcgcggcc 2101 gggctggcgc tgcggcatgt gctcaccggg gtcgaacccc tgccggaggc cgcgctcgcc 2161 cggttcgccg cggccgtgcc cggcctccgg atctgtttcg gctacgggcc gaccgaggcc 2221 acgctgtacg ccaccgccca cttcgacccg cagccggtcg accgcccggc gccgatcgga 2281 cggccgctgc ccgggtcgcg gatgtacctg ctggacgaac ggctgcggcc ggtcccgccg 2341 gggatcgccg gtgaggtgtt cctggccggg gactgcctgg cgcgcgggta tctgcaccgg 2401 ccggggctca ccgcggaacg gttcgtgccg gacccgttcg cgccgggcga gcggatgtac 2461 cgcaccggtg acctggcccg ctggctgccg agcggggaag ccgagtacgc cggccgccgc 2521 gacgaccaga tcaagctgcg cgggttccgc atcgaacccg gagaggtgac ggccgcgctg 2581 ctcgcggtgc ctggggtccg cgaggcggcc gtgctggtgg accgcgccgg tgagccaaag 2641 ctcgtagccg gagtggcggg cggtggccgg acgctgcacg aatggcgcgc ggcgctggcc 2701 gaccggctcc cggactacat gatcccgtcc gtgttcgccg agttcgaccg gctgccgctc 2761 aaccccagcg gcaaactcga ccgcgacgcc gtgctggcgc aggcgcgggc gagcaccgcc 2821 gtcaacaccg tcaacaccgc cgcgccgcgc gaccacgtcg aactcgcgct gcaccggatc 2881 tggcggaacc tgctgctgca cccgtcgatc ggcgtgtcgg acgacttctt cgacgtcggc 2941 ggcacctcga tctcggcgat caagctcgcc cacaccatcg gcacggagtt cggccgtgag 3001 ctgccgatcc gggacgtgat cctgcacccg accatcgagg cgcaggccgc gctgctccgg 3061 gcggacgaac cggcaagcgc cggtggcagc ctgatcgagt tccgccgcgg caccggccgg 3121 gcgcgcgtcg tgtgcgtgca tccggcgggt gggacggcat tctgctacct gccgctcagc 3181 gcggcgctgc ccgaggacgc cggggtcgtc gggatccagt cgcccgggct cggccccggt 3241 gaggagccgc tgccgagtgt cgaggcgatg gccgaggagt acctgcggct cgtcgcgccg 3301 cagcccggtg aggtcctggt cctgtgtgga ctgtcctacg gcggcctggt cgcctacgag 3361 atgggccggc ggctcgcgaa gcggcatccg cgggtcagcg tcgtcctgct cgacaccgcg 3421 ggcaccgacg accccgccgc gcgggccgcg atcgggccgg tcccggcggc cgagttccgc 3481 gagaaactgg tgcggttcaa cggaatgtac ccgggcatcg aggacgcaca gatcgagcgc 3541 taccaccgca cgtacaacca caaccggcac accgcccgcg agcacgaccc cggcgaatcg 3601 gccgcgcggg tggtgttcgt gcaggccacc ggcgaggaca cgatcccggg tggcgacgag 3661 ttctggcgcc gccgcgtgct cggcgagttc gaggtggtcc cggtcggctg cgggcactgg 3721 gacctgctcg aaagcgccgc gctgccacgg gtcgcggagc tgatcaccgc cgaactggcg 3781 gaccgatgac ctcgatcgcc cgccgcatcc acgaccgggc ccggctgcac ccggacgcac 3841 tcgccgtgtc cgatggttcc cgccgcctca cctacgccca gctcgacgcc ggagccgccg 3901 cggtcgcgga agcgttgtcc cgcaaggggg ttcgcccggg ggatgccgtc gcggtcgcgc 3961 tgccgcggtc ggcagagctg gtgcaggtca tgctcggggt gctgcggctg ggtgggcaag 4021 tcgtgccgct ggaccggcag agcccgcccg cccgccggga cgtgatcctt gccgactcgg 4081 gggcggcggt ggtcgtcgac gacgagctgc cgcctgctga actacttgcc gaatccgccg 4141 tcccggccga ccccgctccg gcgtcgttcc tcttctacac ctccggcacg accgggcggc 4201 ccaaaggggt cgaggtgcgg gacgcgggca tcgtccggct ggccgagccg ggctggctcg 4261 accccggcac gcgcttcgcg tcactggcca atccggcatt cgacgcgatc agcttcgagg 4321 tctgggtccc gctgctcgcc ggcggcacgt gcgtgatcct cgacgacgac accgtccggg 4381 acccgcgggc gttcgccgac gcgctggtcc gcgaacgcat cgacacgatg ttcgtcaccg 4441 ccacgctgtt caacgccgtc gccgaaaccg tgccggacag cttctcgacc gtgcgccggg 4501 tcctggtcgg cggcgagcag ctcaacgcgg cggtgatccg ccgctggtac caggccaatc 4561 cggatgcgcc gacccggctg cagaacgggt acggccccac cgagaccacg acgttcgcgc 4621 tcagctaccc cattccgcgg gacttcgacg gcgacgtggt gccgatcggc cgtccacttc 4681 cgggcaccgg tgcggtggcg gtgacgccgg accagcgcgt ggccgccgag ggcgaggtcg 4741 ccgagctgta tctgtcggga gcaggggtcg cgcccggcta ccgcggcctg cccgcggaaa 4801 ccggggagcg gttcgtgcgg ctgccgtggt tcgacgacgg ccgcgcacgg ttctatcgca 4861 ccggtgacct ggtgcgcgtg ctgcccggcg ggctgttcgc ctacgccggg cggaccgacc 4921 ggcaggtgaa ggtccgcggg ttccggatcg agccgggcga gctggagcag cggctcctcg 4981 cgcatccgga gatccggcaa gcccacgtcg ccgtccgccg cgcggccacg gcggagctgc 5041 tcgccttcgt cgtcaccggc ggtctttcct acgacgcatt cgaagcgcac ttgagcgata 5101 ccgtgccgtc gtacatgcgg ccgcacctcg tcttccgggt cgaggagctg ccccggaacg 5161 cgaacgggaa ggtcgacgaa cccgcgctcc tggccagtgg attcccgccg tggcggccgg 5221 gcagcagcgg cgaagcgacg tcgtggcagc gcgagatcct ggacgtcgtc gaggaagtgc 5281 tcggccttcc ggacgcccgg cccgaggaca cctggctgcg gtccggcggt gattcgctca 5341 aggcgttgcg gctgcggttc gcgatccgcg agcgctgggg tgcggacctg gcgccgtcgg 5401 tggtccagcg tggcacgttc gccgacctcg cgtccgcggt cacggccgca cgtcgtccgc 5461 cctacccgga gcttgccgcg ccgaccatcg ccaccacagc gcccgcgacc agcgaacaac 5521 agcggctttg gctgctgcag caacgaaatc cggggtcgac ggcgtaccat gtgccgcttg 5581 ccttccggat caccggcgag gccgacctgc accagaacgt ccgcgcggtc gtcgaacggc 5641 acccggcgct gcggacggcg ttcgaagcca gacccgaggg tctgcggcag gtggcgaaag 5701 cgccgtatga cccgtggatc gaaccggacg acgacttctt caccgcaccg ttcgacctcg 5761 cgtcgggccg gctgctgcgg gcggcgtggc ggccggagac cgacggttcg agcacgtttc 5821 tgctgtgcct gcaccacatc gcggtcgacg gctggtcgct gaacgtgctc ttccgtgagc 5881 tgtccggcgg cgctccgaat cctggcgcgc acacgccgtt cgacttcgcc gggtggcagt 5941 cgcggtggtt cgcctcccct gcctaccacg cccagcgggc atcgctggcc gctcggctcc 6001 ccgacgaccc cgggtccgcc ggcgacgcgt cactcgccgg gcggctgcgg atcaccacga 6061 tcgagcgcac gcgggtcgac gaatgggccg gtgagctggg cctgacccgg ttccagctcc 6121 tgctgggcgt gttcgcctcc agcctgtacg cggtgaccgg gcggacccgg ccgcggatcg 6181 cgtcgccggt ggcgaaccgg ccgatgcggg agttcgagga cagcgtcggg atgttcgcca 6241 ataccgtgcg gctgccgatg gcggtggacc cggacgaaga cctcgacccc cagctccggc 6301 ggctcggcgc ggcggcgggc acggtattgg accaccagga cgtcgcgttc gccgacctcg 6361 aaccggcgca ggcggcgttc gactacctgt tcgtcctgga gaacaccgac ttcgccgcgc 6421 tgaaggtacc cgggtgcccg atcagtccac aatggatcga agcggccgag gccaagtgcg 6481 cgctcacgct gtcggtcgtg gaacggccgg acggcttcga ctgtctctgg gagtacggcg 6541 acggccactt caccgcggcc gaagccgagg cgctcggcga ggtgttcgcc cgcgccctca 6601 ccgaaggcgg gaccccggcc gagctggcgg agccgtaccg ccgcgggttg cccgaccacg 6661 gccgcggcga accggcagag ctggcctggg acaccgtcgc ggaagggttc gcgcggcagg 6721 tcgcacggac tcccgacgct ccggctttgg tcggcgacac gacgctgtcc tacgccgagc 6781 tggacgcgca cgcggcccgc ctcgccgctg tcctccccga cgacgccact gatgtcgcgc 6841 tgtacttccg gccgtcggcg gaacacgtcg tcgcgctgct tgcgctggcg cggctgaaca 6901 tcaccgcggt gccgctcgac cccgggtatc cgcccgcgtt gctgcgcgaa gtactcgagc 6961 gggtccagcc gcggtgtgtg ctgctcgccc cgggcgacgc cttcgacacc gacatcgaac 7021 ggcacttcgt cacgctgacc gacgggccgg tgccggacgt tccggcccgc cgcgccgggc 7081 ggccgctcta cacgctgttc acctccggct cgacgggcgc acccaagggc gtccgggtcc 7141 cggatcgcac actggccaac ctcatccaat ggcaggacgc gccgcccgcg gccacgcagc 7201 agttctcgat gctgtcgttc gacgtgtcgt tccaggagat cttcacgacc ctctgtggcg 7261 gcggccggct gcacctggtc cgcccggagt ggcggcacga cgtcccggcc ctgctcgacc 7321 agctcgaaac cgccgggatc gaacgcctct tcctgccgta tgtcgcgctc cagctgctgg 7381 ccgagcacgg cgcgcgggcc cggcgttacc cgtcgcggct gcgggacgtg gtcaccgcgg 7441 gcgagcagct ggtgtgcacc ccggcgatcc gccgctggtt cgccggcctg cccggcgtgc 7501 ggctgcacaa ccactacggt cccaccgaaa cgcacgtggt gagcgcgctg accctcgacg 7561 gcaacccgga gcagtggccc gagcggcccg cgatcggacg tccggtggcg aacaccgcac 7621 tgcgggttgc cgacgccacg ggcgcgccct tgccgccggg gcagatcggc gagctgctga 7681 tcggtggtct cccggcgaac cggtgctacc tgggcgaagc ggccgaggag aagttcgccg 7741 aactacccga gctgtactac cgcagcggcg acctcgcgca tttcgaccac tccgggctgc 7801 tgcacttcga cggccgcgcc gaccggcagg tcaagctcag cgggcaccgg gtggagctcg 7861 ggcaggtgga ggccgcgctg ctgcggcatc cggacgtcgt gaacgtcgtc gtcgcggcgg 7921 acggggaccg gctgaccgcg tacctggaat cccggcgcgc gaccaccact gccgagctcg 7981 tcgcgcacct cacgccgctg ttgccgccgc acgcgcgcgt cgaccggttc cgggtcgtcg 8041 ccgcgctgcc gcgcacgccc agcgggaagc tcgatcgcga cgcggcaccg cggacccccg 8101 gcgaagacct ccagcgggcc gccgggcacc cgagcgagct tgcggtgctg ttcgaggaag 8161 tgaccggggt gccgatcggc cccgacgaga cgttcttcgc cgccggtgcc acgagcctgt 8221 cgctgatgcg gtttcacctg cgctgcgccg aggcggggta ccggttcacc gtggccgatc 8281 ttttcgagca cgtcaccctc cgggacttga cccggcatct ggagagcggt gccgcccccg 8341 cgccggtcgc ggattcggca ggcaccgacg agccggtggc catcatcggg atggcggtac 8401 ggctgccggg cgcgccggat ctggccgcgt tttggaacct gacaagggaa ggccgccgcg 8461 gtatcgagga attcgcggcg accgaggggc tggtcggtgc gcgcagtctg ctggaccggc 8521 cgctggggtt cgaccccgaa catttcggga tcagccaccg ggacgcggcg ctgatggacc 8581 cgcagcaacg gcagctgctg atgtgctcgg tcgaagcgct ggcgcacgcc gggatcgccc 8641 gtgcggcggg gcgggtcggg ctgatcgcgg gctgcggcga gaacacgtac ttccagcaga 8701 tgctgcgcga ggccgacccg gccgcgctgc cggacggctt ccagctcgcc ctccaccacg 8761 agaaggattt cctcgccacg aaggtcgcct accatctcga tctgaccggc cccgtgctca 8821 cgacccagac cgcctgctcg agttcgctcg tcgccgtgca ccaggccgcc gggatgctgc 8881 gaggcggcga agcggacgtg atgctggcgg gcggggtcct cgtcgatgtc acgctggccg 8941 aggggtaccg ataccggccg cagcacatct tctccgcgga cgggcattgc cgcccgttca 9001 gcgacgacgc ggacgggacg gtcggcggca gcggtgtcgg cgtggtggtg ctgaagccgc 9061 tcagcaaggc acgccacgac ggcgacacgg tgtacgcggt gatcacgggc tccgcgctga 9121 ccaacgacgg cgccgtgaaa cagggttaca gcgcgccttc cccggccggg caacgagaag 9181 cgatccgggc cgcgctgcag cgagccggac ggtccggtgc ggatgtcggg tacgtggaaa 9241 cccatggaac cgggacacgt ctgggcgacc cgatcgaggt cgccgcgctg cgcgaagcga 9301 tgccggactc ggccggatgt gcgctgtcgt cggtgaagag ccagatcggc cacctcggcg 9361 cggcagcggg agtggtcggc ctgatccgcg cgacgctggc cgtccaccac ggcgtcctcc 9421 cgccgaccgt cgatttccgc gcctcgaacc ccgcgctgga cctgggcccg ttccggatcc 9481 cgaccgaggc cgagccgtgg cccgcgggcc cgcgcgtggc gggggtgagc agcttcggga 9541 tcggcgggac caacgcgcac gtggtggtgg aatcatcccg gccggtgcca cgtgcgcctg 9601 ccgatccggc ccgccgcgtg gtgctttccg cgcgcagcgc gactgccttg cgcctcgacg 9661 cccaacgggt ggcggactac ctggccgccc actctgagtc ctatgtggac gttcttcggc 9721 acctgcagtc cggccgcgcg gagggccgtt ggcgcgtgac cgcggcgtgt gccgatgcag 9781 cggcggccgt ggcgtggttg cgcacggcgg aaccacagga ggtcgaagcg gaggggggtc 9841 gtacgtcggc tccggcgccg tgggacttcc ctcccccggc ctttgccgaa cgggacttcg 9901 acttcccgcg gcgggccacc gtctcgcggc tgcccgaggg cgactggctg caccagccca 9961 cctgggtccg cctccgccgg gccaccggaa ccgccgagcg caccgaacgg atcctggtcc 10021 tcagcggccc gctacccgca ccggccttgg acgcggggta ccggcgagtc gtgcgcgtcc 10081 acgcggccga tcacttcacg aggtcggggc cggacacctt cgaagccgac cccgccgacc 10141 ccgcggacct gcgccgggtg ctcgatgcct tgcccggcgc ggagatcgac tgggtccaca 10201 cgctgccgct cggcatcacc ggacccgtcg ccgaaggctc ccttgcccaa gcgcgctggg 10261 cctgcctcga cactccggcc gcgctcctgc gggccatcga cggccgcccg gtgcggacat 10321 ggtgggtttc cgccggggcg gtacccgcga atggcgccgt cacgcggccc gaagccgggc 10381 tgctcgccgg ggtgactgcc gtggggccgc aggaaagcgg cgtacgcggg cattgggtcg 10441 atctccccga tcccggcctg gacgctctcg ccggactgct gaccgggcca cctccgccgc 10501 agcgggtcgc gttacgaggc gggttctggt ggacgcagga agcggtaccg gtgtccgcga 10561 gcgagcgcat tctcgccgac gggacgtacc tcatcctcgg cggcaccggc ggcatcggga 10621 ccgccattgg cgaggtaatc ctgacccgga ccaccggccg cgtcattctg ctggcccgcg 10681 aaccccggct cccggcggcg ctcgaaccgt gggcggaccg cgtcgacctg ctcgccgctg 10741 atctgaccac cgaccggatc gacgtcgacg gaccgctcgc cggaatcgtc cacgccgccg 10801 gggtacccga cagcggtctc atcgccaccc gcagcccgga cccgcaggcc gccaaactcg 10861 ccggtgcctt gctcaccgag cggctgatcg aacagcaccg gcccgcggtc gccgtttact 10921 gttcctcgct gtccgcccag ttcggcggca ccggacagct ggattacgcc gctgccaacg 10981 gattcctcga cgcactcgcc cacctcgacg gcccgaccga gcggctgtcg atcggctggg 11041 acgtatggcg cgacaccggc atggccgtca ccgccttgga atccgacacc cggcaccagg 11101 cgcacctgaa ggtcggcctc agctccgaag aaggtcgccg caccttctct cgcgcgctcg 11161 ggtccggact gccgcacctg ctcgtcgcaa ccaccggtct cgacgccgcc cgcacgttcc 11221 acgagcgcga cacccaagcc ccggccccgg ccaccgatcc cgaagcggaa ctcaccgagg 11281 aagtccgcgc gcttctcggc gccgccgaac tcgacccgga cgtgccgctg tacgacctcg 11341 gcgccgattc cctgatgctg ctggacgtcg tcgactcggt gaaacgcctc ttcggtgtcg 11401 acctcgacct tgcctggctc ggccccgagg tgacgatgac cgcgctgctc gcgaagttgt 11461 ccaccgccga ggacaccagc gacgtcgtgg tgcagcaatg gcgtgaagga cgggacgcgg 11521 tgtgtctcgt gcatccggtc ggcggtgacg tgcatgcgta ccgtccgctc gtcgaggccc 11581 tggacccgag cctcggtgtc tgcgtgatcg ccgaccctgc cttgaaccgg ccggaaccac 11641 cgggctggtc cgtcgcagaa cgggcccgcc ggtaccacgc cgccctgcac actcaattcc 11701 ccggctaccg ctggcaactg gccggatggt cgttcggtgc ctgggtggtg gccgggatgg 11761 ccgccgaggc cgaggcggcc gggcaaccgg tgcgggcact gcacctcatc gaccccccgc 11821 cgcccggcgc cagtaccgcg gactacgacg acacccagct ggaggccgtg ttccggcggg 11881 agctcggcgg cgccgccgac gaccacgccc ggcggctcgc ccgggcctgc cgcgccaacc 11941 tcgacagcat ggccggacac gagctgcccc ggctcaccgc gaccgccagc cacgtctggc 12001 tggccaccga acccgaaccc ggcctgccgg tcgccgaccg caccggctgg caggccctgc 12061 tccccgaccc gagccgctgg cacgaactgc ccgcgacgca ctaccgcatc gtggcggcca 12121 ccgccatcgc cgacgcactg tccgccccct gaaacccctg ggagggaaag gaaaccatgg 12181 agcagtacga actcgacgcc gtcagccgga tcacgacgcg gcccgcgccc ggctaccgga 12241 cgttcaccgt ccacggcctc accccggtga tcggcgccga ggtctccggc ctcgacctga 12301 cccgcgaact caccggcgaa cagctcaccg agctgaagac cgccttcctc gactatcacg 12361 tcctcgtgtt ccgcgaccag gacatcaccg gcgaggacca caaacggctg gccgcgagct 12421 tcggtgagct gcgcccggtc aacccgccgc ccgaacacgg cgacccgtac attctggagg 12481 tcgcgaccgc gcccgaagcg gccaacgtct tcggcaacgg ctggcacgcc gacggcaccg 12541 ccgacgccga gccatccctc ggctcgatgc tccatatcac gcgcatgccc gacccgggca 12601 gcggcggcga caccctgttc gccaacatgc acctcgccta cgacatgctg tcgccgaaga 12661 tgaaggagtt tctcgcggac ctcacggcgg tgcacgacgg cgcgctcgcg ttccgcggtc 12721 accagatccc ggcgggctac caggtcccgg tgagcgagca cccgctggtc gtgcggcacc 12781 cggaaaccga ccggcagctg ctgtacgtca accccgccta cacctcgcac atcccccagc 12841 tctcggccga cgagagccgc gcggtcctcg acctgttgtt ctccctggtg ccgaaccggc 12901 cgatgctcgc gtgccgcgtg cggtgggcgc cgaacacgct ggtgttctgg gacaaccgct 12961 gcgtccagca ccacgcgacc tacgactact acccgcacac ccgctacggc acccgcgtcg 13021 cgatcaacgg cggcccgctc aagggctgac cagggaagga tttccgtgca gcacaaccgg 13081 tgccccgtcg tggacgtgcg cgacccggcc gtcctcggcg acccgatggg cggctacgac 13141 cgcatcctcg ccgagtcgcc ggtctgctgg gcccgcctgc ccagcggcga ggaaggctgg 13201 ctgatcaccc ggagcgagga cgtccgcgcc gtcctgtccg atccggccgt gcgcaacgat 13261 cccaccggcc tgcccggacc aggcgcacaa acccaggagc aggccttcct cgcgctgggc 13321 actccgccgg agcatctgcc atacctgcgc gcgagcctgc tcagcctcga cggcgccgaa 13381 cacacccgcc tgcgccgcag catcagccac gcgttcggcg ccgcgcgggt cgcgagcctg 13441 cgcccgcggg tgcaggagat cgtcgacggg ctcctcgacg gcctcgaccc ggccgcctcg 13501 gtgaacctca tcgacgacta cgcctatccg ctggccatgg ccgtggtctg cgaactggtc 13561 ggcgtccccg aaaaggactg ggcggactgg tggcactggg gcaaggtgct ggtcggcggc 13621 gatccggcgc agatcacgcc cacgctcggc gagatgttct cctactgcca cgccctcgtc 13681 gaccagcgcc gcgccgagcc gcgccgcgat ctgctcagcg aggtggtcgc ccaggacgac 13741 ctcatcgacg tcgacatcgt ggccgtcgtg gtgttcctcg tgctggccgg gcacgaaacc 13801 atggcgcaca tgctgtccaa cggagcgctc gcgctcatgc gcgatcccgc ccagcgagag 13861 ctgctgcgca ccgagcccgc actgtggccg gcggcggtcc gcgaactggt gcgcaccgac 13921 ggtccggtgc agctggcccg cctccgctat gccgcaaccg accttgtggt cggcggtgtg 13981 cagatccggg ccggggacgc ggtgcaggtc gttctcggcg cagccaaccg ggatcccgcg 14041 cagttcgccc atccgcacca cgccgacgtg cggtggcagg ccgagcacgg cggcagcgaa 14101 ggcagtgtcg gattcggctg gggaccgcat ttctgcctcg gggtcgcact ggcgaaagtg 14161 gaggccgagg tcgcgctgcg gagcctgttc gagcgctttc ccgccgtgca cccggtgtcc 14221 gaaccggaat gggtgccgtt gccacgagga cggcaccggg tcgcgctgga cgtgcacctg 14281 cgctaacgcg cgaaggcccc gaccggcatc atcacgtccg cgctcgccgc tccacagtcg //