BGC0001844: holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 491,808 - 551,508 nt. (total: 59,701 nt).
This entry is originally from NCBI GenBank NC_014718.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001844
Short description holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NC_014718.1
510846 - 531583
via Knock-out studies
Compounds
  • holrhizin A
  • holrhizin B
  • holrhizin C
  • holrhizin D
Species Paraburkholderia rhizoxinica HKI 454 [taxonomy]
References
Chemical products information
holrhizin A Evidence: NMR [2]
Copy SMILES
C42H68N6O10
Chemical database entries
NPAtlas
holrhizin B Evidence: MS/MS [2]
Copy SMILES
C41H66N6O10
holrhizin C Evidence: MS/MS [2]
Copy SMILES
C40H64N6O10
holrhizin D Evidence: MS/MS [2]
Copy SMILES
C36H57N5O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_RS20620
  • WP_232509423.1
 510838 - 510993 (-) hypothetical protein
    copy AA seq
    copy Nt seq
    • RBRH_RS20625
    		 <511032 - 511298 (-) non-ribosomal peptide synthetase module
      copy AA seq
      copy Nt seq
      • RBRH_RS16800
      • WP_041754829.1
      		 511808 - 531508 (-) non-ribosomal peptide synthetase
        copy AA seq
        copy Nt seq
        Biosynthesis information

        Biosynthetic modules

        Name
        1
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        valine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Starter), adenylation
        Name
        2
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        phenylalanine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        3
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        glutamic acid (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        4
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        5
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        alanine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        6
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2024-03-19
        MIBiG v4 annotathon
        • (ID: MDO54KUBZ5B3DSV7OS7HMY7W)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Changed amino acid substrates to lower case
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Submitted
        • (ID: Z7AIIJAM3U3HR6IYDPQOINM4)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Tailoring functions
        Tailoring enzymes detected in this region
        Ligases: ligase
        RBRH_RS16800: condensation domain-containing protein
        smcogs
        SMCOG1127: condensation domain-containing protein
        Similar known clusters from MIBiG 4.0
        Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
        Detailed help and explanations are available here.

        Click on reference genes to show details of similarities to genes within the current region.
        Double click on a reference drawing to reverse the display of the genes.

        Click on an accession to open that entry in the MIBiG database.


        Location:

        Identifier
        Identity
        Coverage
        Detailed domain annotation
        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
        A domain glossary is available here, and an explanation of the visualisation is available here.
        Selected features only
        Show module domains