BGC0001844: holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 510,846 - 531,583 nt. (total: 20,738 nt).
This entry is originally from NCBI GenBank NC_014718.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001844
Short description holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NC_014718.1
510846 - 531583
via Knock-out studies
Compounds
  • holrhizin A
  • holrhizin B
  • holrhizin C
  • holrhizin D
Species Paraburkholderia rhizoxinica HKI 454 [taxonomy]
References
Chemical products information
holrhizin A Evidence: NMR [2]
Copy SMILES
C42H68N6O10
Chemical database entries
NPAtlas
holrhizin B Evidence: MS/MS [2]
Copy SMILES
C41H66N6O10
holrhizin C Evidence: MS/MS [2]
Copy SMILES
C40H64N6O10
holrhizin D Evidence: MS/MS [2]
Copy SMILES
C36H57N5O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_RS20625
 511032 - 511298 (-) non-ribosomal peptide synthetase module
    copy AA seq
    copy Nt seq
    • RBRH_RS16800
    • WP_041754829.1
    		 511808 - 531508 (-) non-ribosomal peptide synthetase
      copy AA seq
      copy Nt seq
      Biosynthesis information

      Biosynthetic modules

      Name
      1
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      valine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (Starter), adenylation
      Name
      2
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      phenylalanine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      3
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      glutamic acid (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      4
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      isoleucine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      5
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      alanine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      6
      Type
      nrps-type1
      Genes
      RBRH_RS16800
      Substrates
      isoleucine (evidence: Structure-based inference)
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Annotation changelog

      Entry version: next

      Date
      Changes
      Submitters
      Reviewers
      2024-03-19
      MIBiG v4 annotathon
      • (ID: MDO54KUBZ5B3DSV7OS7HMY7W)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Changed amino acid substrates to lower case
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Submitted
      • (ID: Z7AIIJAM3U3HR6IYDPQOINM4)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
      Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
      A domain glossary is available here, and an explanation of the visualisation is available here.
      Selected features only
      Show module domains
      Similar known gene clusters from MIBiG 4.0
      Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
      Click on reference genes to show details of similarities to genes within the current region.
      Click on an accession to open that entry in the MiBIG database.