BGC0001844: holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
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Location: 491,808 - 551,508 nt. (total: 59,701 nt).
This entry is originally from NCBI GenBank NC_014718.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001844
Short description holrhizin A biosynthetic gene cluster from Paraburkholderia rhizoxinica HKI 454
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NC_014718.1
510846 - 531583
via Knock-out studies
Compounds
  • holrhizin A
  • holrhizin B
  • holrhizin C
  • holrhizin D
Species Paraburkholderia rhizoxinica HKI 454 [taxonomy]
References
Chemical products information
holrhizin A Evidence: NMR [2]
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C42H68N6O10
Chemical database entries
NPAtlas
holrhizin B Evidence: MS/MS [2]
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C41H66N6O10
holrhizin C Evidence: MS/MS [2]
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C40H64N6O10
holrhizin D Evidence: MS/MS [2]
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C36H57N5O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_RS20620
  • WP_232509423.1
 510838 - 510993 (-) hypothetical protein
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    • RBRH_RS20625
    		 <511032 - 511298 (-) non-ribosomal peptide synthetase module
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      • RBRH_RS16800
      • WP_041754829.1
      		 511808 - 531508 (-) non-ribosomal peptide synthetase
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        Biosynthesis information

        Biosynthetic modules

        Name
        1
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        valine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (Starter), adenylation
        Name
        2
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        phenylalanine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        3
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        glutamic acid (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        4
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        5
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        alanine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Name
        6
        Type
        nrps-type1
        Genes
        RBRH_RS16800
        Substrates
        isoleucine (evidence: Structure-based inference)
        Integrated Monomers
        Domains
        condensation (LCL), adenylation
        Annotation changelog

        Entry version: 4

        Date
        Changes
        Submitters
        Reviewers
        2024-03-19
        MIBiG v4 annotathon
        • (ID: MDO54KUBZ5B3DSV7OS7HMY7W)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 3

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Changed amino acid substrates to lower case
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2019-10-16
        Submitted
        • (ID: Z7AIIJAM3U3HR6IYDPQOINM4)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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