BGC0001846 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001846 (Streptomyces sp. CBMAI 2042)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	40,574	valinomycin/montanastatin	saccharide:hybrid/tailoring+NRPS:Type I	100%

BGC0001846 - Region 1 - NRPS

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Location: 1 - 40,574 nt. (total: 40,574 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 40,575
Label		BGC0001846

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001846	1.00	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0002415	0.38	NRP	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0001133	0.36	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.32	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002075	0.31	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002528	0.27	NRP	aminochelin, azotochelin, protochelin	Azotobacter vinelandii CA
BGC0001825	0.26	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417	0.26	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000357	0.25	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001824	0.25	NRP	xefoampeptides A-G	Xenorhabdus beddingii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001846	1.00	Saccharide, NRP	valinomycin, montanastatin	Streptomyces sp. CBMAI 2042
BGC0002415	0.71	NRP	vanchrobactin, trivanchrobactin, divanchrobactin	Vibrio campbellii
BGC0001133	0.69	NRP	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0002071	0.66	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002528	0.60	NRP	aminochelin, azotochelin, protochelin	Azotobacter vinelandii CA
BGC0001825	0.60	NRP	xenematide	Xenorhabdus nematophila AN6/1
BGC0000417	0.60	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0000357	0.59	NRP	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001824	0.58	NRP	xefoampeptides A-G	Xenorhabdus beddingii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 40574:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Val) + (Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

STAN_6721

Search NORINE for peptide: strict or relaxed

CAL_domain (194..628): pk

minowa: AHBA

Prediction, score:

AHBA: 19.3
shikimic_acid: 16.5
NH2: 8.5
fatty_acid: 8.1
Acetyl-CoA: 0.0

AMP-binding (1797..2190): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWVGGTFK
Nearest Stachelhaus code(s):: Val DAFWVGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

STAN_6722

Search NORINE for peptide: strict or relaxed

CAL_domain (44..349): pk

minowa: NH2

Prediction, score:

NH2: 9.3
Acetyl-CoA: 7.5
shikimic_acid: 0.0
fatty_acid: 0.0
AHBA: 0.0

AMP-binding (1726..2118): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DALWLGGTFK
Nearest Stachelhaus code(s):: Val DALWLGGTFK (100% 8Å match); bOH-Val DALWLGGTFK (71% 8Å match)
Stachelhaus code match:: 100% (strong)