BGC0001848 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001848 (Micromonospora sp. B006)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	other,T3PKS,terpene-precursor	1	58,198	High	diazaquinomycin H/diazaquinomycin J	other:other

BGC0001848 - Region 1 - T3PKS,other,terpene-precursor

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Location: 1 - 58,198 nt. (total: 58,198 nt) Show pHMM detection rules used

Region on contig edge.

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

Terpene

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 58,199
Label		BGC0001848

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MicB006_2893: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

MicB006_2897: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MicB006_2899: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MicB006_2935: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: hydrolase

MicB006_2898: isochorismatase

smcogs: SMCOG1027: isochorismatase

Lyases: lyase

MicB006_2941: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Isomerases: isomerase

MicB006_2906: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase synthetase

MicB006_2915: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

MicB006_2921: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

MicB006_2931: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

MicB006_2938: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

MicB006_2924: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001848.4	1.60	other (other)	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000679.5	1.29	terpene	diazepinomicin	Micromonospora sp. M42
BGC0000286.3	0.66	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000673.3	0.66	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0001080.5	0.54	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002493.3	0.54	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0001078.5	0.54	PKS, terpene	furaquinocin B	Streptomyces sp. KO-3988
BGC0002276.2	0.50	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002561.3	0.49	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0002309.2	0.49	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001848.4	1.00	other (other)	diazaquinomycin H, diazaquinomycin J	Micromonospora sp. B006
BGC0000679.5	0.80	terpene	diazepinomicin	Micromonospora sp. M42
BGC0002458.3	0.66	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0002493.3	0.61	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000286.3	0.58	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0002474.2	0.56	NRPS	agrobactin	Agrobacterium tumefaciens
BGC0000673.3	0.55	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0002826.2	0.54	other (other)	closoxazole A, closoxazole B	Clostridium cavendishii DSM 21758
BGC0001444.5	0.52	other (shikimate-derived)	caboxamycin	Streptomyces sp. NTK 937

Similar known clusters from MIBiG 4.0

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MicB006_2921: PT_FPPS_like

Domain 1 (42 - 357): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Terpene

NRPS/PKS substrate predictions

MicB006_2901: X

AMP-binding (70..270): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TGAWFGESLK
Nearest Stachelhaus code(s):: nohBza or oh-nitroBza AGAWYAEPLK (71% 8Å match)
Stachelhaus code match:: 60% (weak)

MicB006_2938: X

AMP-binding (16..423): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SRTESTLPVK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate